A Critical Overview of the Biological Effects of Mitomycin C Application on the Cornea Following Refractive Surgery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Esther Arranz-Marquez, Andreas Katsanos, Vassilios P. Kozobolis, Anastasios G. P. Konstas, Miguel A. Teus

ABSTRACT

During the last 2 decades, modifying the shape of the cornea by means of laser photoablation has emerged as a successful and popular treatment option for refractive errors. Corneal surface ablation techniques such as photorefractive keratectomy (PRK) and laser-assisted subepithelial keratomileusis (LASEK) offer good refractive results while having a minimal impact on corneal biomechanical stability. Past limitations of these techniques included the long-term regression of refractive outcome and a vigorous healing response that reduced corneal clarity in some patients (giving rise to what is clinically described as "haze"). Mitomycin C (MMC) was introduced as a healing modulator and applied on the corneal surface after refractive surgery to address these drawbacks. This article critically reviews the available evidence on the biological effects, safety, and clinical benefits of the off-label use of MMC in corneal refractive surgery. More... »

PAGES

786-797

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12325-019-00905-w

DOI

http://dx.doi.org/10.1007/s12325-019-00905-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112683397

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30859502


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