Clinical Efficacy and Safety of Current Interventions for Choroidal Neovascularization Associated with Rare Diseases: A Systematic Literature Review View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-05

AUTHORS

Natalie Bennett, Lokho John, Nishkarsh Likhar, Rumjhum Agrawal, Winfried M. Amoaku

ABSTRACT

INTRODUCTION: The aim of this systematic literature review was to evaluate the efficacy and safety of interventions for the treatment of choroidal neovascularization (CNV) secondary to etiologies other than age-related macular degeneration and pathologic myopia. METHODS: Relevant randomized controlled trials (RCTs) and prospective observational studies were identified by searching MEDLINE, MEDLINE In-Process, EMBASE, and CENTRAL. RESULTS: The search identified 5 RCTs; no relevant observational studies were identified. The studies differed in terms of underlying cause of CNV, patient numbers (n = 9-178), follow-up time (2-36 months) and quality assessment. In the largest RCT (n = 178 across a range of rare CNV etiologies), intravitreal ranibizumab showed superior efficacy versus sham from baseline to month 2 [mean best-corrected visual acuity (BCVA): + 9.5 vs. - 0.4 letters; p < 0.001]; the gain was maintained up to month 12. In the treatment of CNV secondary to presumed ocular histoplasmosis syndrome (POHS), both intravitreal ranibizumab and photodynamic therapy (PDT) showed significant improvement from baseline BCVA over the 12-month period (n = 9); however, all patients in the PDT group required rescue ranibizumab therapy. Unlicensed intravitreal bevacizumab was associated with a statistically significant improvement in BCVA compared to PDT at 12 months (p < 0.001) in patients with CNV secondary to multifocal choroiditis (n = 27). The use of steroids before PDT showed better BCVA outcomes than PDT alone (p < 0.05) in patients with idiopathic CNV (n = 20). Argon green laser therapy showed limited efficacy in patients with CNV secondary to OHS (n = 134). CONCLUSION: There is evidence from a relatively large, good-quality study to support the use of intravitreal ranibizumab for the treatment of CNV secondary to rare diseases. However, the limited number of RCTs for this indication and differences in study characteristics between RCTs mean that there is uncertainty regarding comparative clinical effectiveness of interventions. RCTs with an active comparator are required to fully establish the comparative effectiveness of treatments for CNV secondary to rare diseases. FUNDING: Novartis Pharmaceuticals UK Ltd, Surrey, UK. More... »

PAGES

591-603

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12325-018-0698-9

DOI

http://dx.doi.org/10.1007/s12325-018-0698-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103605898

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29687336


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Ophthalmology and Optometry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Novartis (United Kingdom)", 
          "id": "https://www.grid.ac/institutes/grid.418607.c", 
          "name": [
            "Novartis Pharmaceuticals UK Limited, 200 Frimley Business Park, GU16 7SR, Camberley, Surrey, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bennett", 
        "givenName": "Natalie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (India)", 
          "id": "https://www.grid.ac/institutes/grid.464975.d", 
          "name": [
            "Novartis Healthcare Pvt. Ltd., Hyderabad, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "John", 
        "givenName": "Lokho", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (India)", 
          "id": "https://www.grid.ac/institutes/grid.464975.d", 
          "name": [
            "Novartis Healthcare Pvt. Ltd., Hyderabad, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Likhar", 
        "givenName": "Nishkarsh", 
        "id": "sg:person.0647344633.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647344633.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (India)", 
          "id": "https://www.grid.ac/institutes/grid.464975.d", 
          "name": [
            "Novartis Healthcare Pvt. Ltd., Hyderabad, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Agrawal", 
        "givenName": "Rumjhum", 
        "id": "sg:person.01065353245.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065353245.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Ophthalmology, DCN, B Floor Eye and ENT Centre, University of Nottingham, University Hospital, QMC, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amoaku", 
        "givenName": "Winfried M.", 
        "id": "sg:person.016406676667.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016406676667.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1136/bjo.74.10.579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002618182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9394(84)90243-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004591644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0161-6420(96)30515-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004731223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmjopen-2015-007746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008611114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/eye.2013.155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014696884", 
          "https://doi.org/10.1038/eye.2013.155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bjo.59.5.257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016116190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.preteyeres.2015.06.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016275029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eurger.2014.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016651458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/opth.s49437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017277817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0161-6420(96)30561-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017794482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archophthalmol.2010.205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021239611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00941723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021732396", 
          "https://doi.org/10.1007/bf00941723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0301-4738.36474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023189326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0161-6420(96)30645-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023192032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.02-1092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026686745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ophtha.2013.10.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026804808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajo.2004.11.064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029008870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archopht.122.4.477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029351509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ophtha.2013.01.068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029516116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)61231-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029791557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0161-6420(86)33611-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031254773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ophtha.2013.08.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034402795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0905010106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035217355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9394(81)90283-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036307148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajo.2013.04.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036762386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bjo.2006.103135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041143024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/iae.0b013e31818358b2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041324286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/iae.0b013e31818358b2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041324286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa054481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041610759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajo.2003.09.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042271298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archopht.123.1.78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044102277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archopht.1984.01040031440019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047238661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ophtha.2015.01.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049817281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/mvre.2002.2407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050125708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ophtha.2007.06.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050875177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000455271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053770510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3928/23258160-20121221-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071729758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074550509", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074692371", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0974-9233.58422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078147785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/opth.s113414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083879368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/iae.0000000000001744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090659163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/iae.0000000000001744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090659163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-017-3183-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091504135", 
          "https://doi.org/10.1007/s11010-017-3183-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-05", 
    "datePublishedReg": "2018-05-01", 
    "description": "INTRODUCTION: The aim of this systematic literature review was to evaluate the efficacy and safety of interventions for the treatment of choroidal neovascularization (CNV) secondary to etiologies other than age-related macular degeneration and pathologic myopia.\nMETHODS: Relevant randomized controlled trials (RCTs) and prospective observational studies were identified by searching MEDLINE, MEDLINE In-Process, EMBASE, and CENTRAL.\nRESULTS: The search identified 5 RCTs; no relevant observational studies were identified. The studies differed in terms of underlying cause of CNV, patient numbers (n\u2009=\u20099-178), follow-up time (2-36\u00a0months) and quality assessment. In the largest RCT (n\u2009=\u2009178 across a range of rare CNV etiologies), intravitreal ranibizumab showed superior efficacy versus sham from baseline to month 2 [mean best-corrected visual acuity (BCVA): +\u20099.5 vs. -\u20090.4 letters; p\u2009<\u20090.001]; the gain was maintained up to month 12. In the treatment of CNV secondary to presumed ocular histoplasmosis syndrome (POHS), both intravitreal ranibizumab and photodynamic therapy (PDT) showed significant improvement from baseline BCVA over the 12-month period (n\u2009=\u20099); however, all patients in the PDT group required rescue ranibizumab therapy. Unlicensed intravitreal bevacizumab was associated with a statistically significant improvement in BCVA compared to PDT at 12\u00a0months (p\u2009<\u20090.001) in patients with CNV secondary to multifocal choroiditis (n\u2009=\u200927). The use of steroids before PDT showed better BCVA outcomes than PDT alone (p\u2009<\u20090.05) in patients with idiopathic CNV (n\u2009=\u200920). Argon green laser therapy showed limited efficacy in patients with CNV secondary to OHS (n\u2009=\u2009134).\nCONCLUSION: There is evidence from a relatively large, good-quality study to support the use of intravitreal ranibizumab for the treatment of CNV secondary to rare diseases. However, the limited number of RCTs for this indication and differences in study characteristics between RCTs mean that there is uncertainty regarding comparative clinical effectiveness of interventions. RCTs with an active comparator are required to fully establish the comparative effectiveness of treatments for CNV secondary to rare diseases.\nFUNDING: Novartis Pharmaceuticals UK Ltd, Surrey, UK.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12325-018-0698-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096634", 
        "issn": [
          "0741-238X", 
          "1865-8652"
        ], 
        "name": "Advances in Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "35"
      }
    ], 
    "name": "Clinical Efficacy and Safety of Current Interventions for Choroidal Neovascularization Associated with Rare Diseases: A Systematic Literature Review", 
    "pagination": "591-603", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a2b562a10c74341d6b2ff4dbeadb8c0a3c34115802df9128652ccbb4ff284c6d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29687336"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8611864"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12325-018-0698-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103605898"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12325-018-0698-9", 
      "https://app.dimensions.ai/details/publication/pub.1103605898"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000604.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12325-018-0698-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12325-018-0698-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12325-018-0698-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12325-018-0698-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12325-018-0698-9'


 

This table displays all metadata directly associated to this object as RDF triples.

227 TRIPLES      21 PREDICATES      71 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12325-018-0698-9 schema:about anzsrc-for:11
2 anzsrc-for:1113
3 schema:author N7562fc8e39c14c2aa33be7e0bdee29a3
4 schema:citation sg:pub.10.1007/bf00941723
5 sg:pub.10.1007/s11010-017-3183-x
6 sg:pub.10.1038/eye.2013.155
7 https://app.dimensions.ai/details/publication/pub.1074550509
8 https://app.dimensions.ai/details/publication/pub.1074692371
9 https://doi.org/10.1001/archopht.122.4.477
10 https://doi.org/10.1001/archopht.123.1.78
11 https://doi.org/10.1001/archopht.1984.01040031440019
12 https://doi.org/10.1001/archophthalmol.2010.205
13 https://doi.org/10.1006/mvre.2002.2407
14 https://doi.org/10.1016/0002-9394(81)90283-x
15 https://doi.org/10.1016/0002-9394(84)90243-5
16 https://doi.org/10.1016/j.ajo.2003.09.042
17 https://doi.org/10.1016/j.ajo.2004.11.064
18 https://doi.org/10.1016/j.ajo.2013.04.040
19 https://doi.org/10.1016/j.eurger.2014.09.007
20 https://doi.org/10.1016/j.ophtha.2007.06.047
21 https://doi.org/10.1016/j.ophtha.2013.01.068
22 https://doi.org/10.1016/j.ophtha.2013.08.011
23 https://doi.org/10.1016/j.ophtha.2013.10.023
24 https://doi.org/10.1016/j.ophtha.2015.01.025
25 https://doi.org/10.1016/j.preteyeres.2015.06.002
26 https://doi.org/10.1016/s0002-9440(10)61231-x
27 https://doi.org/10.1016/s0161-6420(86)33611-x
28 https://doi.org/10.1016/s0161-6420(96)30515-0
29 https://doi.org/10.1016/s0161-6420(96)30561-7
30 https://doi.org/10.1016/s0161-6420(96)30645-3
31 https://doi.org/10.1056/nejmoa054481
32 https://doi.org/10.1073/pnas.0905010106
33 https://doi.org/10.1097/iae.0000000000001744
34 https://doi.org/10.1097/iae.0b013e31818358b2
35 https://doi.org/10.1136/bjo.2006.103135
36 https://doi.org/10.1136/bjo.59.5.257
37 https://doi.org/10.1136/bjo.74.10.579
38 https://doi.org/10.1136/bmjopen-2015-007746
39 https://doi.org/10.1159/000455271
40 https://doi.org/10.1167/iovs.02-1092
41 https://doi.org/10.2147/opth.s113414
42 https://doi.org/10.2147/opth.s49437
43 https://doi.org/10.3928/23258160-20121221-07
44 https://doi.org/10.4103/0301-4738.36474
45 https://doi.org/10.4103/0974-9233.58422
46 schema:datePublished 2018-05
47 schema:datePublishedReg 2018-05-01
48 schema:description INTRODUCTION: The aim of this systematic literature review was to evaluate the efficacy and safety of interventions for the treatment of choroidal neovascularization (CNV) secondary to etiologies other than age-related macular degeneration and pathologic myopia. METHODS: Relevant randomized controlled trials (RCTs) and prospective observational studies were identified by searching MEDLINE, MEDLINE In-Process, EMBASE, and CENTRAL. RESULTS: The search identified 5 RCTs; no relevant observational studies were identified. The studies differed in terms of underlying cause of CNV, patient numbers (n = 9-178), follow-up time (2-36 months) and quality assessment. In the largest RCT (n = 178 across a range of rare CNV etiologies), intravitreal ranibizumab showed superior efficacy versus sham from baseline to month 2 [mean best-corrected visual acuity (BCVA): + 9.5 vs. - 0.4 letters; p < 0.001]; the gain was maintained up to month 12. In the treatment of CNV secondary to presumed ocular histoplasmosis syndrome (POHS), both intravitreal ranibizumab and photodynamic therapy (PDT) showed significant improvement from baseline BCVA over the 12-month period (n = 9); however, all patients in the PDT group required rescue ranibizumab therapy. Unlicensed intravitreal bevacizumab was associated with a statistically significant improvement in BCVA compared to PDT at 12 months (p < 0.001) in patients with CNV secondary to multifocal choroiditis (n = 27). The use of steroids before PDT showed better BCVA outcomes than PDT alone (p < 0.05) in patients with idiopathic CNV (n = 20). Argon green laser therapy showed limited efficacy in patients with CNV secondary to OHS (n = 134). CONCLUSION: There is evidence from a relatively large, good-quality study to support the use of intravitreal ranibizumab for the treatment of CNV secondary to rare diseases. However, the limited number of RCTs for this indication and differences in study characteristics between RCTs mean that there is uncertainty regarding comparative clinical effectiveness of interventions. RCTs with an active comparator are required to fully establish the comparative effectiveness of treatments for CNV secondary to rare diseases. FUNDING: Novartis Pharmaceuticals UK Ltd, Surrey, UK.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree false
52 schema:isPartOf N1a2ce2f4417e4373b0e44a96c4a2c18d
53 Nef1304ce458d4ede82e3bab9edfebc63
54 sg:journal.1096634
55 schema:name Clinical Efficacy and Safety of Current Interventions for Choroidal Neovascularization Associated with Rare Diseases: A Systematic Literature Review
56 schema:pagination 591-603
57 schema:productId N047b341cf82d42b9925e1aea2316d724
58 N24e5f764fb39449c82bf2e8c11fdf7ab
59 N3bdb01eafb9044eea2ddd8981aa8ac23
60 Nb0f3debe8fda4e6981d3445857f9cb91
61 Nfeaa6a910bce47dca0ce8ccecfa6a9af
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103605898
63 https://doi.org/10.1007/s12325-018-0698-9
64 schema:sdDatePublished 2019-04-10T23:40
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher Nee86fa9b27f2460fa1bfc737e7aebf2c
67 schema:url https://link.springer.com/10.1007%2Fs12325-018-0698-9
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N047b341cf82d42b9925e1aea2316d724 schema:name readcube_id
72 schema:value a2b562a10c74341d6b2ff4dbeadb8c0a3c34115802df9128652ccbb4ff284c6d
73 rdf:type schema:PropertyValue
74 N10ac2378ad3e4a6bbb6a7bcf6493be40 rdf:first sg:person.0647344633.23
75 rdf:rest Nbc5c0893ad8547cb859929ac0a695333
76 N1a2ce2f4417e4373b0e44a96c4a2c18d schema:issueNumber 5
77 rdf:type schema:PublicationIssue
78 N24e5f764fb39449c82bf2e8c11fdf7ab schema:name nlm_unique_id
79 schema:value 8611864
80 rdf:type schema:PropertyValue
81 N25dc1dbbaf614805b1497eb37c283d0f schema:name Ophthalmology, DCN, B Floor Eye and ENT Centre, University of Nottingham, University Hospital, QMC, Nottingham, UK
82 rdf:type schema:Organization
83 N3bdb01eafb9044eea2ddd8981aa8ac23 schema:name doi
84 schema:value 10.1007/s12325-018-0698-9
85 rdf:type schema:PropertyValue
86 N427b483b92df49c99005f106e725ced4 schema:affiliation https://www.grid.ac/institutes/grid.418607.c
87 schema:familyName Bennett
88 schema:givenName Natalie
89 rdf:type schema:Person
90 N7562fc8e39c14c2aa33be7e0bdee29a3 rdf:first N427b483b92df49c99005f106e725ced4
91 rdf:rest Ndb9184d8acb446f2892b46e52d7a0f67
92 Na7c2681270774099938f2a10c98157f3 rdf:first sg:person.016406676667.37
93 rdf:rest rdf:nil
94 Nb0f3debe8fda4e6981d3445857f9cb91 schema:name dimensions_id
95 schema:value pub.1103605898
96 rdf:type schema:PropertyValue
97 Nbc5c0893ad8547cb859929ac0a695333 rdf:first sg:person.01065353245.86
98 rdf:rest Na7c2681270774099938f2a10c98157f3
99 Ndb9184d8acb446f2892b46e52d7a0f67 rdf:first Nf02c69c3f9194342979142a385abf331
100 rdf:rest N10ac2378ad3e4a6bbb6a7bcf6493be40
101 Nee86fa9b27f2460fa1bfc737e7aebf2c schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 Nef1304ce458d4ede82e3bab9edfebc63 schema:volumeNumber 35
104 rdf:type schema:PublicationVolume
105 Nf02c69c3f9194342979142a385abf331 schema:affiliation https://www.grid.ac/institutes/grid.464975.d
106 schema:familyName John
107 schema:givenName Lokho
108 rdf:type schema:Person
109 Nfeaa6a910bce47dca0ce8ccecfa6a9af schema:name pubmed_id
110 schema:value 29687336
111 rdf:type schema:PropertyValue
112 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
113 schema:name Medical and Health Sciences
114 rdf:type schema:DefinedTerm
115 anzsrc-for:1113 schema:inDefinedTermSet anzsrc-for:
116 schema:name Ophthalmology and Optometry
117 rdf:type schema:DefinedTerm
118 sg:journal.1096634 schema:issn 0741-238X
119 1865-8652
120 schema:name Advances in Therapy
121 rdf:type schema:Periodical
122 sg:person.01065353245.86 schema:affiliation https://www.grid.ac/institutes/grid.464975.d
123 schema:familyName Agrawal
124 schema:givenName Rumjhum
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065353245.86
126 rdf:type schema:Person
127 sg:person.016406676667.37 schema:affiliation N25dc1dbbaf614805b1497eb37c283d0f
128 schema:familyName Amoaku
129 schema:givenName Winfried M.
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016406676667.37
131 rdf:type schema:Person
132 sg:person.0647344633.23 schema:affiliation https://www.grid.ac/institutes/grid.464975.d
133 schema:familyName Likhar
134 schema:givenName Nishkarsh
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647344633.23
136 rdf:type schema:Person
137 sg:pub.10.1007/bf00941723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021732396
138 https://doi.org/10.1007/bf00941723
139 rdf:type schema:CreativeWork
140 sg:pub.10.1007/s11010-017-3183-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1091504135
141 https://doi.org/10.1007/s11010-017-3183-x
142 rdf:type schema:CreativeWork
143 sg:pub.10.1038/eye.2013.155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014696884
144 https://doi.org/10.1038/eye.2013.155
145 rdf:type schema:CreativeWork
146 https://app.dimensions.ai/details/publication/pub.1074550509 schema:CreativeWork
147 https://app.dimensions.ai/details/publication/pub.1074692371 schema:CreativeWork
148 https://doi.org/10.1001/archopht.122.4.477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029351509
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1001/archopht.123.1.78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044102277
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1001/archopht.1984.01040031440019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047238661
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1001/archophthalmol.2010.205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021239611
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1006/mvre.2002.2407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050125708
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/0002-9394(81)90283-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036307148
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/0002-9394(84)90243-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004591644
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/j.ajo.2003.09.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042271298
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/j.ajo.2004.11.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029008870
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/j.ajo.2013.04.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036762386
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/j.eurger.2014.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016651458
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/j.ophtha.2007.06.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050875177
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/j.ophtha.2013.01.068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029516116
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.ophtha.2013.08.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034402795
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.ophtha.2013.10.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026804808
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.ophtha.2015.01.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049817281
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.preteyeres.2015.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016275029
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/s0002-9440(10)61231-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029791557
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/s0161-6420(86)33611-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031254773
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/s0161-6420(96)30515-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004731223
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/s0161-6420(96)30561-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017794482
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/s0161-6420(96)30645-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023192032
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1056/nejmoa054481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041610759
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1073/pnas.0905010106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035217355
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1097/iae.0000000000001744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090659163
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1097/iae.0b013e31818358b2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041324286
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1136/bjo.2006.103135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041143024
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1136/bjo.59.5.257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016116190
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1136/bjo.74.10.579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002618182
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1136/bmjopen-2015-007746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008611114
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1159/000455271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053770510
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1167/iovs.02-1092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026686745
211 rdf:type schema:CreativeWork
212 https://doi.org/10.2147/opth.s113414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083879368
213 rdf:type schema:CreativeWork
214 https://doi.org/10.2147/opth.s49437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017277817
215 rdf:type schema:CreativeWork
216 https://doi.org/10.3928/23258160-20121221-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071729758
217 rdf:type schema:CreativeWork
218 https://doi.org/10.4103/0301-4738.36474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023189326
219 rdf:type schema:CreativeWork
220 https://doi.org/10.4103/0974-9233.58422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078147785
221 rdf:type schema:CreativeWork
222 https://www.grid.ac/institutes/grid.418607.c schema:alternateName Novartis (United Kingdom)
223 schema:name Novartis Pharmaceuticals UK Limited, 200 Frimley Business Park, GU16 7SR, Camberley, Surrey, UK
224 rdf:type schema:Organization
225 https://www.grid.ac/institutes/grid.464975.d schema:alternateName Novartis (India)
226 schema:name Novartis Healthcare Pvt. Ltd., Hyderabad, India
227 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...