Long-Term Effectiveness of Liraglutide for Treatment of Type 2 Diabetes in a Real-Life Setting: A 24-Month, Multicenter, Non-interventional, Retrospective Study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12-21

AUTHORS

Annunziata Lapolla, Cesare Berra, Massimo Boemi, Antonio Carlo Bossi, Riccardo Candido, Graziano Di Cianni, Simona Frontoni, Stefano Genovese, Paola Ponzani, Vincenzo Provenzano, Giuseppina T. Russo, Luigi Sciangula, Natalino Simioni, Cristiano Bette, Antonio Nicolucci, On behalf of the NN2211-4118 Study Group

ABSTRACT

IntroductionThe aim of the study was to evaluate whether the reduction in glycated hemoglobin (HbA1c) observed in clinical trials with liraglutide in type 2 diabetes (T2D) could be attained in routine clinical practice.MethodsReaL was a multicenter, non-interventional, observational, retrospective, longitudinal study on the effectiveness of liraglutide, a human glucagon-like peptide-1 analog, in individuals with T2D treated in daily practice in Italy. Between 26 March and 16 November 2015, data were taken from clinical records of patients aged ≥ 18 years with treatment follow-up data of up to 24 months and who received their first prescription of liraglutide in 2011.ResultsA total of 1723 patients were included in the analysis. At baseline, mean age was 58.9 years, duration of diabetes was 9.6 years, and HbA1c was 8.3%. At 12 months, 36.1% of patients were prescribed the maximum 1.8 mg dose; 43.5% [95% confidence interval (CI): 40.9; 46.2] of patients attained the primary outcome of a reduction in HbA1c of ≥ 1% point at 12 months. At 24 months, 40.9% (95% CI 38.1; 43.7) of patients had attained the HbA1c target of ≤ 7%. Additionally, body weight significantly decreased by 3.4 kg (95% CI − 3.6; − 3.1, p < 0.0001).ConclusionIn this observational study conducted in routine clinical practice for up to 2 years, treatment with liraglutide improved HbA1c and reduced body weight in a similar fashion to that observed under randomized clinical trial conditions. The data support the use of liraglutide as an effective treatment for T2D in clinical practice.FundingNovo Nordisk S.p.A.Trial RegistrationClinicalTrials.gov identifier, NCT02255266. More... »

PAGES

243-253

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12325-017-0652-2

DOI

http://dx.doi.org/10.1007/s12325-017-0652-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1099738161

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29270781


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycated Hemoglobin A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypoglycemic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Italy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liraglutide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Longitudinal Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Medicine, University of Padua, Padua, Italy", 
          "id": "http://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Department of Medicine, University of Padua, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lapolla", 
        "givenName": "Annunziata", 
        "id": "sg:person.01151465236.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151465236.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital, Rozzano, MI, Italy", 
          "id": "http://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Humanitas Research Hospital, Rozzano, MI, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berra", 
        "givenName": "Cesare", 
        "id": "sg:person.010770266010.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010770266010.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "IRCCS INRCA, Ancona, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "IRCCS INRCA, Ancona, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boemi", 
        "givenName": "Massimo", 
        "id": "sg:person.0732771746.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732771746.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "ASST Bergamo Ovest, Treviglio, BG, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "ASST Bergamo Ovest, Treviglio, BG, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bossi", 
        "givenName": "Antonio Carlo", 
        "id": "sg:person.01027040777.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027040777.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy", 
          "id": "http://www.grid.ac/institutes/grid.460062.6", 
          "name": [
            "Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Candido", 
        "givenName": "Riccardo", 
        "id": "sg:person.01026702544.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026702544.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale di Livorno, Livorno, Italy", 
          "id": "http://www.grid.ac/institutes/grid.416020.1", 
          "name": [
            "Ospedale di Livorno, Livorno, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Cianni", 
        "givenName": "Graziano", 
        "id": "sg:person.01342152665.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342152665.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Systems Medicine, University Tor Vergata, SG Calibita Fatebenefratelli, Rome, Italy", 
          "id": "http://www.grid.ac/institutes/grid.6530.0", 
          "name": [
            "Department of Systems Medicine, University Tor Vergata, SG Calibita Fatebenefratelli, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frontoni", 
        "givenName": "Simona", 
        "id": "sg:person.01066472430.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066472430.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "IRCCS Centro Cardiologico Monzino, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.418230.c", 
          "name": [
            "IRCCS Centro Cardiologico Monzino, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Genovese", 
        "givenName": "Stefano", 
        "id": "sg:person.0764303560.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764303560.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale La Colletta, ASL3 Genovese, Arenzano, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Ospedale La Colletta, ASL3 Genovese, Arenzano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ponzani", 
        "givenName": "Paola", 
        "id": "sg:person.014167267624.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014167267624.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro Regionale di Riferimento Diabetologia ed Impianto Microinfusori Sicilia, Partinico, Palermo, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Centro Regionale di Riferimento Diabetologia ed Impianto Microinfusori Sicilia, Partinico, Palermo, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Provenzano", 
        "givenName": "Vincenzo", 
        "id": "sg:person.01126310423.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126310423.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy", 
          "id": "http://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Russo", 
        "givenName": "Giuseppina T.", 
        "id": "sg:person.0624012711.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624012711.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "IRCCS Multimedica-Ospedale di Castellanza, Varese, Italy", 
          "id": "http://www.grid.ac/institutes/grid.420421.1", 
          "name": [
            "IRCCS Multimedica-Ospedale di Castellanza, Varese, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sciangula", 
        "givenName": "Luigi", 
        "id": "sg:person.0717402700.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717402700.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Presidio Ospedaliero di Cittadella, Cittadella, Padua, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Presidio Ospedaliero di Cittadella, Cittadella, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simioni", 
        "givenName": "Natalino", 
        "id": "sg:person.01124540240.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124540240.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novo Nordisk Spa, Rome, Italy", 
          "id": "http://www.grid.ac/institutes/grid.488334.0", 
          "name": [
            "Novo Nordisk Spa, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bette", 
        "givenName": "Cristiano", 
        "id": "sg:person.01176176547.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176176547.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CORESEARCH-Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy", 
          "id": "http://www.grid.ac/institutes/grid.512242.2", 
          "name": [
            "CORESEARCH-Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nicolucci", 
        "givenName": "Antonio", 
        "id": "sg:person.01112613263.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112613263.43"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "On behalf of the NN2211-4118 Study Group", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00592-013-0489-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048723410", 
          "https://doi.org/10.1007/s00592-013-0489-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-009-1472-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013300593", 
          "https://doi.org/10.1007/s00125-009-1472-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13300-016-0180-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038595753", 
          "https://doi.org/10.1007/s13300-016-0180-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2012.140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011731640", 
          "https://doi.org/10.1038/nrendo.2012.140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12170-009-0041-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040603460", 
          "https://doi.org/10.1007/s12170-009-0041-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12325-015-0245-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033044892", 
          "https://doi.org/10.1007/s12325-015-0245-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12-21", 
    "datePublishedReg": "2017-12-21", 
    "description": "IntroductionThe aim of the study was to evaluate whether the reduction in glycated hemoglobin (HbA1c) observed in clinical trials with liraglutide in type 2 diabetes (T2D) could be attained in routine clinical practice.MethodsReaL was a multicenter, non-interventional, observational, retrospective, longitudinal study on the effectiveness of liraglutide, a human glucagon-like peptide-1 analog, in individuals with T2D treated in daily practice in Italy. Between 26 March and 16 November 2015, data were taken from clinical records of patients aged \u2265\u00a018\u00a0years with treatment follow-up data of up to 24\u00a0months and who received their first prescription of liraglutide in 2011.ResultsA total of 1723 patients were included in the analysis. At baseline, mean age was 58.9\u00a0years, duration of diabetes was 9.6\u00a0years, and HbA1c was 8.3%. At 12\u00a0months, 36.1% of patients were prescribed the maximum 1.8\u00a0mg dose; 43.5% [95% confidence interval (CI): 40.9; 46.2] of patients attained the primary outcome of a reduction in HbA1c of \u2265\u00a01% point at 12\u00a0months. At 24\u00a0months, 40.9% (95% CI 38.1; 43.7) of patients had attained the HbA1c target of \u2264\u00a07%. Additionally, body weight significantly decreased by 3.4\u00a0kg (95% CI \u2212 3.6; \u2212 3.1, p\u00a0<\u00a00.0001).ConclusionIn this observational study conducted in routine clinical practice for up to 2\u00a0years, treatment with liraglutide improved HbA1c and reduced body weight in a similar fashion to that observed under randomized clinical trial conditions. The data support the use of liraglutide as an effective treatment for T2D in clinical practice.FundingNovo Nordisk S.p.A.Trial RegistrationClinicalTrials.gov identifier, NCT02255266.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s12325-017-0652-2", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1096634", 
        "issn": [
          "0741-238X", 
          "1865-8652"
        ], 
        "name": "Advances in Therapy", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "35"
      }
    ], 
    "keywords": [
      "type 2 diabetes", 
      "routine clinical practice", 
      "clinical practice", 
      "body weight", 
      "human glucagon-like peptide-1 analog", 
      "glucagon-like peptide-1 analog", 
      "effectiveness of liraglutide", 
      "use of liraglutide", 
      "duration of diabetes", 
      "peptide-1 analog", 
      "clinical trial conditions", 
      "first prescription", 
      "primary outcome", 
      "retrospective study", 
      "clinical records", 
      "mean age", 
      "IntroductionThe aim", 
      "clinical trials", 
      "observational study", 
      "liraglutide", 
      "effective treatment", 
      "patients", 
      "real-life setting", 
      "diabetes", 
      "term effectiveness", 
      "daily practice", 
      "months", 
      "multicenter", 
      "longitudinal study", 
      "T2D", 
      "treatment", 
      "trial conditions", 
      "years", 
      "HbA1c", 
      "ConclusionIn", 
      "study", 
      "dose", 
      "trials", 
      "baseline", 
      "similar fashion", 
      "hemoglobin", 
      "age", 
      "outcomes", 
      "prescription", 
      "total", 
      "weight", 
      "duration", 
      "practice", 
      "reduction", 
      "aim", 
      "data", 
      "setting", 
      "individuals", 
      "target", 
      "records", 
      "effectiveness", 
      "fashion", 
      "use", 
      "analogues", 
      "Non", 
      "Italy", 
      "analysis", 
      "identifiers", 
      "conditions", 
      "point"
    ], 
    "name": "Long-Term Effectiveness of Liraglutide for Treatment of Type 2 Diabetes in a Real-Life Setting: A 24-Month, Multicenter, Non-interventional, Retrospective Study", 
    "pagination": "243-253", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1099738161"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12325-017-0652-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29270781"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12325-017-0652-2", 
      "https://app.dimensions.ai/details/publication/pub.1099738161"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_720.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s12325-017-0652-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12325-017-0652-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12325-017-0652-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12325-017-0652-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12325-017-0652-2'


 

This table displays all metadata directly associated to this object as RDF triples.

351 TRIPLES      22 PREDICATES      112 URIs      98 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12325-017-0652-2 schema:about N1a6bf771601a4c4abba1b87af4437105
2 N3cf7fe07bfcd4acf924b5a0724a8488b
3 N4499d17927d24429b997c99800969772
4 N4828cf28f8674ea385f61b0abaa45cf2
5 N531eba2ee6d84a03b26fa0b9525fcccc
6 N54fa48c9c46e4c6fbb8d602b6d67f734
7 N621a99ec79394990916bb43555f96a9d
8 N89c386540a684cfda7a4542691aa7234
9 Nac2b54e8a41a41e186886d7d609a5064
10 Nb3551aec71ff4e0784764c2f0e3389fe
11 Nbc152f1df3b94c12ac6ae1a44276ec53
12 Nd48fddf431fc4a189d3740c10b036538
13 Ndfc16f677639429bb456ec2e7f4fa794
14 Necaebe9944944eaf9b646a2ecb793e30
15 Nfd5c8fae2a864ecc8d3ed081e91a42d6
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author Nc889a841710f43429e93e4d4144273e3
19 schema:citation sg:pub.10.1007/s00125-009-1472-y
20 sg:pub.10.1007/s00592-013-0489-3
21 sg:pub.10.1007/s12170-009-0041-8
22 sg:pub.10.1007/s12325-015-0245-x
23 sg:pub.10.1007/s13300-016-0180-0
24 sg:pub.10.1038/nrendo.2012.140
25 schema:datePublished 2017-12-21
26 schema:datePublishedReg 2017-12-21
27 schema:description IntroductionThe aim of the study was to evaluate whether the reduction in glycated hemoglobin (HbA1c) observed in clinical trials with liraglutide in type 2 diabetes (T2D) could be attained in routine clinical practice.MethodsReaL was a multicenter, non-interventional, observational, retrospective, longitudinal study on the effectiveness of liraglutide, a human glucagon-like peptide-1 analog, in individuals with T2D treated in daily practice in Italy. Between 26 March and 16 November 2015, data were taken from clinical records of patients aged ≥ 18 years with treatment follow-up data of up to 24 months and who received their first prescription of liraglutide in 2011.ResultsA total of 1723 patients were included in the analysis. At baseline, mean age was 58.9 years, duration of diabetes was 9.6 years, and HbA1c was 8.3%. At 12 months, 36.1% of patients were prescribed the maximum 1.8 mg dose; 43.5% [95% confidence interval (CI): 40.9; 46.2] of patients attained the primary outcome of a reduction in HbA1c of ≥ 1% point at 12 months. At 24 months, 40.9% (95% CI 38.1; 43.7) of patients had attained the HbA1c target of ≤ 7%. Additionally, body weight significantly decreased by 3.4 kg (95% CI − 3.6; − 3.1, p < 0.0001).ConclusionIn this observational study conducted in routine clinical practice for up to 2 years, treatment with liraglutide improved HbA1c and reduced body weight in a similar fashion to that observed under randomized clinical trial conditions. The data support the use of liraglutide as an effective treatment for T2D in clinical practice.FundingNovo Nordisk S.p.A.Trial RegistrationClinicalTrials.gov identifier, NCT02255266.
28 schema:genre article
29 schema:inLanguage en
30 schema:isAccessibleForFree true
31 schema:isPartOf N1641612f0d0e4f6ea7ce6c08c598ac4d
32 Nea011e8ed4a9402b8226e6b3b8fadbcd
33 sg:journal.1096634
34 schema:keywords ConclusionIn
35 HbA1c
36 IntroductionThe aim
37 Italy
38 Non
39 T2D
40 age
41 aim
42 analogues
43 analysis
44 baseline
45 body weight
46 clinical practice
47 clinical records
48 clinical trial conditions
49 clinical trials
50 conditions
51 daily practice
52 data
53 diabetes
54 dose
55 duration
56 duration of diabetes
57 effective treatment
58 effectiveness
59 effectiveness of liraglutide
60 fashion
61 first prescription
62 glucagon-like peptide-1 analog
63 hemoglobin
64 human glucagon-like peptide-1 analog
65 identifiers
66 individuals
67 liraglutide
68 longitudinal study
69 mean age
70 months
71 multicenter
72 observational study
73 outcomes
74 patients
75 peptide-1 analog
76 point
77 practice
78 prescription
79 primary outcome
80 real-life setting
81 records
82 reduction
83 retrospective study
84 routine clinical practice
85 setting
86 similar fashion
87 study
88 target
89 term effectiveness
90 total
91 treatment
92 trial conditions
93 trials
94 type 2 diabetes
95 use
96 use of liraglutide
97 weight
98 years
99 schema:name Long-Term Effectiveness of Liraglutide for Treatment of Type 2 Diabetes in a Real-Life Setting: A 24-Month, Multicenter, Non-interventional, Retrospective Study
100 schema:pagination 243-253
101 schema:productId N81809d8349c043778f31a3e881a5896f
102 N8fabd169f6f6429283c248d0384d3f44
103 N9c8e251ac34c4627817ed740dc427f82
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099738161
105 https://doi.org/10.1007/s12325-017-0652-2
106 schema:sdDatePublished 2022-05-20T07:32
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher N2d86a1bf4ff247afa2c79bbc36a2905c
109 schema:url https://doi.org/10.1007/s12325-017-0652-2
110 sgo:license sg:explorer/license/
111 sgo:sdDataset articles
112 rdf:type schema:ScholarlyArticle
113 N05db7307bd344e0fa21b4519cf1f3ecd rdf:first sg:person.01066472430.21
114 rdf:rest Nc513768200c947f88fde61656376af98
115 N0dbfd7e7486040c5b2d833a068b04ddc rdf:first sg:person.0717402700.51
116 rdf:rest N747e6f77bb07428db035b0ac49ac0ec7
117 N13cba459b05748c9a51513df406e7cac rdf:first sg:person.01112613263.43
118 rdf:rest N8c0a9529079a431eb1e3f618e7fef9e0
119 N1641612f0d0e4f6ea7ce6c08c598ac4d schema:issueNumber 2
120 rdf:type schema:PublicationIssue
121 N19166ad18d424c92b929a8e9508ea23e rdf:first sg:person.01176176547.25
122 rdf:rest N13cba459b05748c9a51513df406e7cac
123 N1a6bf771601a4c4abba1b87af4437105 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Treatment Outcome
125 rdf:type schema:DefinedTerm
126 N2d86a1bf4ff247afa2c79bbc36a2905c schema:name Springer Nature - SN SciGraph project
127 rdf:type schema:Organization
128 N3cf7fe07bfcd4acf924b5a0724a8488b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Female
130 rdf:type schema:DefinedTerm
131 N440c87836b1949c2a45fd0f6ed14c5fa rdf:first sg:person.01026702544.26
132 rdf:rest N6b0a4efb13db410198c2a6fc74ffa3ea
133 N4499d17927d24429b997c99800969772 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Male
135 rdf:type schema:DefinedTerm
136 N4828cf28f8674ea385f61b0abaa45cf2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Liraglutide
138 rdf:type schema:DefinedTerm
139 N531eba2ee6d84a03b26fa0b9525fcccc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Glycated Hemoglobin A
141 rdf:type schema:DefinedTerm
142 N54fa48c9c46e4c6fbb8d602b6d67f734 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Diabetes Mellitus, Type 2
144 rdf:type schema:DefinedTerm
145 N621a99ec79394990916bb43555f96a9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Longitudinal Studies
147 rdf:type schema:DefinedTerm
148 N6b0a4efb13db410198c2a6fc74ffa3ea rdf:first sg:person.01342152665.26
149 rdf:rest N05db7307bd344e0fa21b4519cf1f3ecd
150 N6ff34cb935384ddc8a7aa48713af9b33 rdf:first sg:person.0624012711.83
151 rdf:rest N0dbfd7e7486040c5b2d833a068b04ddc
152 N747e6f77bb07428db035b0ac49ac0ec7 rdf:first sg:person.01124540240.20
153 rdf:rest N19166ad18d424c92b929a8e9508ea23e
154 N81809d8349c043778f31a3e881a5896f schema:name pubmed_id
155 schema:value 29270781
156 rdf:type schema:PropertyValue
157 N89c386540a684cfda7a4542691aa7234 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Humans
159 rdf:type schema:DefinedTerm
160 N8c0a9529079a431eb1e3f618e7fef9e0 rdf:first Nf95936971cc24405810b0d7a49612588
161 rdf:rest rdf:nil
162 N8fabd169f6f6429283c248d0384d3f44 schema:name dimensions_id
163 schema:value pub.1099738161
164 rdf:type schema:PropertyValue
165 N9a0a9e1444c144acb778da8d7100132d rdf:first sg:person.01027040777.42
166 rdf:rest N440c87836b1949c2a45fd0f6ed14c5fa
167 N9c8e251ac34c4627817ed740dc427f82 schema:name doi
168 schema:value 10.1007/s12325-017-0652-2
169 rdf:type schema:PropertyValue
170 Na863f94b6e304160a4b0d9a2dde62fb4 rdf:first sg:person.010770266010.93
171 rdf:rest Nd54dc72cac574477910ffef41a47d0cf
172 Nac2b54e8a41a41e186886d7d609a5064 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Aged
174 rdf:type schema:DefinedTerm
175 Nb3551aec71ff4e0784764c2f0e3389fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Middle Aged
177 rdf:type schema:DefinedTerm
178 Nbc152f1df3b94c12ac6ae1a44276ec53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Retrospective Studies
180 rdf:type schema:DefinedTerm
181 Nc513768200c947f88fde61656376af98 rdf:first sg:person.0764303560.93
182 rdf:rest Nd7b02de87faa4dddabe130fa8550e5c9
183 Nc6ebc98f2b404842bb05936c60fc05b2 rdf:first sg:person.01126310423.41
184 rdf:rest N6ff34cb935384ddc8a7aa48713af9b33
185 Nc889a841710f43429e93e4d4144273e3 rdf:first sg:person.01151465236.25
186 rdf:rest Na863f94b6e304160a4b0d9a2dde62fb4
187 Nd48fddf431fc4a189d3740c10b036538 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Italy
189 rdf:type schema:DefinedTerm
190 Nd54dc72cac574477910ffef41a47d0cf rdf:first sg:person.0732771746.34
191 rdf:rest N9a0a9e1444c144acb778da8d7100132d
192 Nd7b02de87faa4dddabe130fa8550e5c9 rdf:first sg:person.014167267624.83
193 rdf:rest Nc6ebc98f2b404842bb05936c60fc05b2
194 Ndfc16f677639429bb456ec2e7f4fa794 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Hypoglycemic Agents
196 rdf:type schema:DefinedTerm
197 Nea011e8ed4a9402b8226e6b3b8fadbcd schema:volumeNumber 35
198 rdf:type schema:PublicationVolume
199 Necaebe9944944eaf9b646a2ecb793e30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Body Weight
201 rdf:type schema:DefinedTerm
202 Nf95936971cc24405810b0d7a49612588 schema:familyName On behalf of the NN2211-4118 Study Group
203 rdf:type schema:Person
204 Nfd5c8fae2a864ecc8d3ed081e91a42d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Adult
206 rdf:type schema:DefinedTerm
207 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
208 schema:name Medical and Health Sciences
209 rdf:type schema:DefinedTerm
210 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
211 schema:name Clinical Sciences
212 rdf:type schema:DefinedTerm
213 sg:journal.1096634 schema:issn 0741-238X
214 1865-8652
215 schema:name Advances in Therapy
216 schema:publisher Springer Nature
217 rdf:type schema:Periodical
218 sg:person.01026702544.26 schema:affiliation grid-institutes:grid.460062.6
219 schema:familyName Candido
220 schema:givenName Riccardo
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026702544.26
222 rdf:type schema:Person
223 sg:person.01027040777.42 schema:affiliation grid-institutes:None
224 schema:familyName Bossi
225 schema:givenName Antonio Carlo
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027040777.42
227 rdf:type schema:Person
228 sg:person.01066472430.21 schema:affiliation grid-institutes:grid.6530.0
229 schema:familyName Frontoni
230 schema:givenName Simona
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066472430.21
232 rdf:type schema:Person
233 sg:person.010770266010.93 schema:affiliation grid-institutes:grid.417728.f
234 schema:familyName Berra
235 schema:givenName Cesare
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010770266010.93
237 rdf:type schema:Person
238 sg:person.01112613263.43 schema:affiliation grid-institutes:grid.512242.2
239 schema:familyName Nicolucci
240 schema:givenName Antonio
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112613263.43
242 rdf:type schema:Person
243 sg:person.01124540240.20 schema:affiliation grid-institutes:None
244 schema:familyName Simioni
245 schema:givenName Natalino
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124540240.20
247 rdf:type schema:Person
248 sg:person.01126310423.41 schema:affiliation grid-institutes:None
249 schema:familyName Provenzano
250 schema:givenName Vincenzo
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126310423.41
252 rdf:type schema:Person
253 sg:person.01151465236.25 schema:affiliation grid-institutes:grid.5608.b
254 schema:familyName Lapolla
255 schema:givenName Annunziata
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151465236.25
257 rdf:type schema:Person
258 sg:person.01176176547.25 schema:affiliation grid-institutes:grid.488334.0
259 schema:familyName Bette
260 schema:givenName Cristiano
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176176547.25
262 rdf:type schema:Person
263 sg:person.01342152665.26 schema:affiliation grid-institutes:grid.416020.1
264 schema:familyName Di Cianni
265 schema:givenName Graziano
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342152665.26
267 rdf:type schema:Person
268 sg:person.014167267624.83 schema:affiliation grid-institutes:None
269 schema:familyName Ponzani
270 schema:givenName Paola
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014167267624.83
272 rdf:type schema:Person
273 sg:person.0624012711.83 schema:affiliation grid-institutes:grid.10438.3e
274 schema:familyName Russo
275 schema:givenName Giuseppina T.
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624012711.83
277 rdf:type schema:Person
278 sg:person.0717402700.51 schema:affiliation grid-institutes:grid.420421.1
279 schema:familyName Sciangula
280 schema:givenName Luigi
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717402700.51
282 rdf:type schema:Person
283 sg:person.0732771746.34 schema:affiliation grid-institutes:None
284 schema:familyName Boemi
285 schema:givenName Massimo
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732771746.34
287 rdf:type schema:Person
288 sg:person.0764303560.93 schema:affiliation grid-institutes:grid.418230.c
289 schema:familyName Genovese
290 schema:givenName Stefano
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764303560.93
292 rdf:type schema:Person
293 sg:pub.10.1007/s00125-009-1472-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1013300593
294 https://doi.org/10.1007/s00125-009-1472-y
295 rdf:type schema:CreativeWork
296 sg:pub.10.1007/s00592-013-0489-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048723410
297 https://doi.org/10.1007/s00592-013-0489-3
298 rdf:type schema:CreativeWork
299 sg:pub.10.1007/s12170-009-0041-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040603460
300 https://doi.org/10.1007/s12170-009-0041-8
301 rdf:type schema:CreativeWork
302 sg:pub.10.1007/s12325-015-0245-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033044892
303 https://doi.org/10.1007/s12325-015-0245-x
304 rdf:type schema:CreativeWork
305 sg:pub.10.1007/s13300-016-0180-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038595753
306 https://doi.org/10.1007/s13300-016-0180-0
307 rdf:type schema:CreativeWork
308 sg:pub.10.1038/nrendo.2012.140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011731640
309 https://doi.org/10.1038/nrendo.2012.140
310 rdf:type schema:CreativeWork
311 grid-institutes:None schema:alternateName ASST Bergamo Ovest, Treviglio, BG, Italy
312 Centro Regionale di Riferimento Diabetologia ed Impianto Microinfusori Sicilia, Partinico, Palermo, Italy
313 IRCCS INRCA, Ancona, Italy
314 Ospedale La Colletta, ASL3 Genovese, Arenzano, Italy
315 Presidio Ospedaliero di Cittadella, Cittadella, Padua, Italy
316 schema:name ASST Bergamo Ovest, Treviglio, BG, Italy
317 Centro Regionale di Riferimento Diabetologia ed Impianto Microinfusori Sicilia, Partinico, Palermo, Italy
318 IRCCS INRCA, Ancona, Italy
319 Ospedale La Colletta, ASL3 Genovese, Arenzano, Italy
320 Presidio Ospedaliero di Cittadella, Cittadella, Padua, Italy
321 rdf:type schema:Organization
322 grid-institutes:grid.10438.3e schema:alternateName Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
323 schema:name Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
324 rdf:type schema:Organization
325 grid-institutes:grid.416020.1 schema:alternateName Ospedale di Livorno, Livorno, Italy
326 schema:name Ospedale di Livorno, Livorno, Italy
327 rdf:type schema:Organization
328 grid-institutes:grid.417728.f schema:alternateName Humanitas Research Hospital, Rozzano, MI, Italy
329 schema:name Humanitas Research Hospital, Rozzano, MI, Italy
330 rdf:type schema:Organization
331 grid-institutes:grid.418230.c schema:alternateName IRCCS Centro Cardiologico Monzino, Milan, Italy
332 schema:name IRCCS Centro Cardiologico Monzino, Milan, Italy
333 rdf:type schema:Organization
334 grid-institutes:grid.420421.1 schema:alternateName IRCCS Multimedica-Ospedale di Castellanza, Varese, Italy
335 schema:name IRCCS Multimedica-Ospedale di Castellanza, Varese, Italy
336 rdf:type schema:Organization
337 grid-institutes:grid.460062.6 schema:alternateName Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy
338 schema:name Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy
339 rdf:type schema:Organization
340 grid-institutes:grid.488334.0 schema:alternateName Novo Nordisk Spa, Rome, Italy
341 schema:name Novo Nordisk Spa, Rome, Italy
342 rdf:type schema:Organization
343 grid-institutes:grid.512242.2 schema:alternateName CORESEARCH-Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy
344 schema:name CORESEARCH-Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy
345 rdf:type schema:Organization
346 grid-institutes:grid.5608.b schema:alternateName Department of Medicine, University of Padua, Padua, Italy
347 schema:name Department of Medicine, University of Padua, Padua, Italy
348 rdf:type schema:Organization
349 grid-institutes:grid.6530.0 schema:alternateName Department of Systems Medicine, University Tor Vergata, SG Calibita Fatebenefratelli, Rome, Italy
350 schema:name Department of Systems Medicine, University Tor Vergata, SG Calibita Fatebenefratelli, Rome, Italy
351 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...