Slovak Trial on Cardiovascular Risk Reduction Following National Guidelines with CaDUET® (The STRONG DUET Study) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-01-15

AUTHORS

Jan Fedacko, Daniel Pella, Peter Jarcuska, Frantisek Sabol, Jan Kmec, Tomas Lopuchovsky, Lucia Merkovska, Lucia Jedlickova, Martin Janicko, Matej Sajty

ABSTRACT

IntroductionThe efficacy and safety of single-pill amlodipine/atorvastatin for reducing blood pressure (BP), low-density lipoprotein cholesterol (LDLC), and predicted 10-year cardiovascular (CV) risk have been demonstrated in low CV risk countries. The Slovak Trial on Cardiovascular Risk Reduction Following National Guidelines with CaDUET® (amlodipine besylate/atorvastatin calcium; Pfizer, Morrisville, PA, USA; STRONG DUET) study evaluated its clinical utility in Slovakia, one of the highest CV risk regions in Europe.MethodsThis was a two-phase study involving 100 outpatient cardiologist and internist departments in Slovakia. Phase 1 assessed BP control and CV risk profiles in adults with treated hypertension, and phase 2 was an open-label, multicenter, observational study. In the phase 2 study, patients with treated but uncontrolled hypertension and three or more coronary heart disease risk factors received single-pill amlodipine/atorvastatin (5/10 or 10/10 mg) for 12 weeks. Major outcomes were the percentage of patients achieving target BP (≤140/90 mmHg) and/or LDL-C (≤3 mmol/L) and reductions in predicted 10-year CV risk.ResultsOf the 4,672 phase 1 patients, 80.8% had uncontrolled hypertension and 61.4% had dyslipidemia. Of the 1,406 phase 2 patients, 90.3% of patients achieved target BP at week 12, 66.3% achieved target LDL-C, and 60.7% achieved both. The mean 10-year CV risk was reduced by 49% (P < 0.0001); treatment was well-tolerated and safe.ConclusionSingle-pill amlodipine/atorvastatin was associated with significant improvements in BP, LDL-C target attainment, and 10-year CV risk in patients with uncontrolled hypertension in Slovakia. The treatment was well-tolerated and safe. Use of single-pill amlodipine/atorvastatin in high CV-risk countries could lead to significant improvements in CV risk management. More... »

PAGES

60-70

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12325-012-0075-z

DOI

http://dx.doi.org/10.1007/s12325-012-0075-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013784344

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23328937


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