Chemotherapy with Modified Docetaxel, Cisplatin, and 5-Fluorouracil in Patients with Metastatic Head and Neck Cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-01

AUTHORS

Jen-Tsun Lin, Guam-Min Lai, Tung-Hao Chang, Mu-Tai Liu, Chu-Ping Bi, Jer-Wei Wang, Mu-Kuan Chen

ABSTRACT

INTRODUCTION: This retrospective study evaluates the efficacy of palliative chemotherapy with a modified docetaxel, cisplatin, 5-fluorouracil (5-FU; "TPF" regimen) regimen (mTPF; reduced doses of docetaxel, cisplatin, and 5-FU with reduction of intravenous 5-FU from 4 days to 2 days) in Asian patients with recurrent and metastatic squamous cell carcinoma of head and neck (HNSCC) after surgery and adjuvant chemoradiation. METHODS: The mTPF regimen was used in this study. Fifty-five patients (from January 2007 to October 2009) received docetaxel on day 1, followed by cisplatin and 5-FU administered continuous infusion on day 2 for another 48 hours every 3 weeks for three to six cycles. RESULTS: The disease control rate was 81%. The overall response rate was 56%. Five patients achieved complete remission; 26 patients had partial remission; 14 patients had stable disease. Ten patients had disease progression. The metastatic sites that responded well to mTPF regimen (either complete or partial remission) were: neck lymph node, lung, liver, and skin. The median follow-up was 15 months (range 1-28 months). The median overall survival was 10 months (range 2-28 months). The common nonhematological toxicity was alopecia and the most common hematological adverse event was neutropenia. Thirty-one patients (56%) had grade 3-4 neutropenia. CONCLUSION: The mTPF chemotherapy regimen is efficacious for the palliative treatment of recurrent and metastatic HNSCC in Asian patients. More... »

PAGES

71-77

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12325-011-0085-2

DOI

http://dx.doi.org/10.1007/s12325-011-0085-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030072496

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22161550


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Head and Neck Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Squamous Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Palliative Care", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Remission Induction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Taxoids", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chung Shan Medical University", 
          "id": "https://www.grid.ac/institutes/grid.411641.7", 
          "name": [
            "Division of Hematology and Oncology, Department of Medicine, ChangHua Christian Hospital, ChangHua, Taiwan", 
            "School of Medicine, Chung Shan Medical University, Taichung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Jen-Tsun", 
        "id": "sg:person.01361571534.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361571534.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Changhua Christian Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413814.b", 
          "name": [
            "Division of Hematology and Oncology, Department of Medicine, ChangHua Christian Hospital, ChangHua, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lai", 
        "givenName": "Guam-Min", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Changhua Christian Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413814.b", 
          "name": [
            "Department of Radiation Oncology, ChangHua Christian Hospital, ChangHua, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chang", 
        "givenName": "Tung-Hao", 
        "id": "sg:person.01177166674.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177166674.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Changhua Christian Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413814.b", 
          "name": [
            "Department of Radiation Oncology, ChangHua Christian Hospital, ChangHua, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Mu-Tai", 
        "id": "sg:person.0700376474.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700376474.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Changhua Christian Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413814.b", 
          "name": [
            "Department of Radiation Oncology, ChangHua Christian Hospital, ChangHua, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bi", 
        "givenName": "Chu-Ping", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Changhua Christian Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413814.b", 
          "name": [
            "Department of Otorhinolaryngology-Head and Neck Surgery, ChangHua Christian Hospital, 35 Nan-Hsiao Street, 500, ChangHua, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Jer-Wei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Changhua Christian Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413814.b", 
          "name": [
            "School of Medicine, Chung Shan Medical University, Taichung, Taiwan", 
            "Department of Otorhinolaryngology-Head and Neck Surgery, ChangHua Christian Hospital, 35 Nan-Hsiao Street, 500, ChangHua, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Mu-Kuan", 
        "id": "sg:person.01140011433.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140011433.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.oraloncology.2008.05.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009088430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djp007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017259792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa071028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021180850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021781121", 
          "https://doi.org/10.1038/sj.bjc.6690715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021781121", 
          "https://doi.org/10.1038/sj.bjc.6690715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2004.05.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022542045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdn456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025164065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clon.2004.09.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026490737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e32832c9c51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029257106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e32832c9c51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029257106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e32832c9c51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029257106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-010-1401-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037875844", 
          "https://doi.org/10.1007/s00280-010-1401-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mlg.0000208366.34683.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039597444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mlg.0000208366.34683.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039597444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mlg.0000208366.34683.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039597444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.00.1990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046275705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.00.1990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046275705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djh306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049402297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.10574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052498734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1023/a:1008355315205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056303404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1023/a:1008360323986", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056303445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.20.6.1593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4143/crt.2007.39.3.93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072255719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4143/crt.2007.39.3.93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072255719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1989.7.11.1748", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079217876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.annonc.a058908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082564512"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-01", 
    "datePublishedReg": "2012-01-01", 
    "description": "INTRODUCTION: This retrospective study evaluates the efficacy of palliative chemotherapy with a modified docetaxel, cisplatin, 5-fluorouracil (5-FU; \"TPF\" regimen) regimen (mTPF; reduced doses of docetaxel, cisplatin, and 5-FU with reduction of intravenous 5-FU from 4 days to 2 days) in Asian patients with recurrent and metastatic squamous cell carcinoma of head and neck (HNSCC) after surgery and adjuvant chemoradiation.\nMETHODS: The mTPF regimen was used in this study. Fifty-five patients (from January 2007 to October 2009) received docetaxel on day 1, followed by cisplatin and 5-FU administered continuous infusion on day 2 for another 48 hours every 3 weeks for three to six cycles.\nRESULTS: The disease control rate was 81%. The overall response rate was 56%. Five patients achieved complete remission; 26 patients had partial remission; 14 patients had stable disease. Ten patients had disease progression. The metastatic sites that responded well to mTPF regimen (either complete or partial remission) were: neck lymph node, lung, liver, and skin. The median follow-up was 15 months (range 1-28 months). The median overall survival was 10 months (range 2-28 months). The common nonhematological toxicity was alopecia and the most common hematological adverse event was neutropenia. Thirty-one patients (56%) had grade 3-4 neutropenia.\nCONCLUSION: The mTPF chemotherapy regimen is efficacious for the palliative treatment of recurrent and metastatic HNSCC in Asian patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12325-011-0085-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096634", 
        "issn": [
          "0741-238X", 
          "1865-8652"
        ], 
        "name": "Advances in Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "29"
      }
    ], 
    "name": "Chemotherapy with Modified Docetaxel, Cisplatin, and 5-Fluorouracil in Patients with Metastatic Head and Neck Cancer", 
    "pagination": "71-77", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8f4364f302d7890648829942864d598d25df2e45f8eecf85a5c35b03c8b7d266"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22161550"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8611864"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12325-011-0085-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030072496"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12325-011-0085-2", 
      "https://app.dimensions.ai/details/publication/pub.1030072496"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000522.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12325-011-0085-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12325-011-0085-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12325-011-0085-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12325-011-0085-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12325-011-0085-2'


 

This table displays all metadata directly associated to this object as RDF triples.

242 TRIPLES      21 PREDICATES      65 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12325-011-0085-2 schema:about N2860a5aaf59c49bcbc995d7bcc8b41ea
2 N441d962eff7f4ba2b6a8f5c45028bade
3 N5f540913162c4e78ba58b49e4c99b409
4 N6a0be5c596c541c59a35a0cddf495156
5 N6f755962140543ac8ed467c0464ac91f
6 N73c60b7dad244def9173af16559f4a99
7 N7d22a2b651a940da996eceb4e37101f3
8 N848f006a1082421889f46dc5598bd210
9 N87d6e110f4da41bf99e05c864cbec87a
10 N9929a4cd97524d8f8fcd41f705a999b3
11 N9a6cc677fbec496fbd6b4479dd003f6f
12 N9be67af22eb14a0592d1f3644f943904
13 Nab7f43b84cf54f47b4dab3625887ab7f
14 Ndab097d917b24ae985cdd036611c5737
15 Nee7a72cd128948b5ba4599e92b44c5d6
16 Nf5eab9b47b0f4cea9687d3058980d914
17 Nfb9511abe8f84ba58913c228861241b1
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author N7851d5bc0822496997017f98151653f6
21 schema:citation sg:pub.10.1007/s00280-010-1401-2
22 sg:pub.10.1038/sj.bjc.6690715
23 https://doi.org/10.1002/cncr.10574
24 https://doi.org/10.1016/j.clon.2004.09.013
25 https://doi.org/10.1016/j.ejca.2004.05.019
26 https://doi.org/10.1016/j.oraloncology.2008.05.014
27 https://doi.org/10.1023/a:1008355315205
28 https://doi.org/10.1023/a:1008360323986
29 https://doi.org/10.1056/nejmoa071028
30 https://doi.org/10.1093/annonc/mdn456
31 https://doi.org/10.1093/jnci/djh306
32 https://doi.org/10.1093/jnci/djp007
33 https://doi.org/10.1093/oxfordjournals.annonc.a058908
34 https://doi.org/10.1097/01.mlg.0000208366.34683.58
35 https://doi.org/10.1097/cad.0b013e32832c9c51
36 https://doi.org/10.1200/jco.1989.7.11.1748
37 https://doi.org/10.1200/jco.20.6.1593
38 https://doi.org/10.1200/jco.2004.00.1990
39 https://doi.org/10.4143/crt.2007.39.3.93
40 schema:datePublished 2012-01
41 schema:datePublishedReg 2012-01-01
42 schema:description INTRODUCTION: This retrospective study evaluates the efficacy of palliative chemotherapy with a modified docetaxel, cisplatin, 5-fluorouracil (5-FU; "TPF" regimen) regimen (mTPF; reduced doses of docetaxel, cisplatin, and 5-FU with reduction of intravenous 5-FU from 4 days to 2 days) in Asian patients with recurrent and metastatic squamous cell carcinoma of head and neck (HNSCC) after surgery and adjuvant chemoradiation. METHODS: The mTPF regimen was used in this study. Fifty-five patients (from January 2007 to October 2009) received docetaxel on day 1, followed by cisplatin and 5-FU administered continuous infusion on day 2 for another 48 hours every 3 weeks for three to six cycles. RESULTS: The disease control rate was 81%. The overall response rate was 56%. Five patients achieved complete remission; 26 patients had partial remission; 14 patients had stable disease. Ten patients had disease progression. The metastatic sites that responded well to mTPF regimen (either complete or partial remission) were: neck lymph node, lung, liver, and skin. The median follow-up was 15 months (range 1-28 months). The median overall survival was 10 months (range 2-28 months). The common nonhematological toxicity was alopecia and the most common hematological adverse event was neutropenia. Thirty-one patients (56%) had grade 3-4 neutropenia. CONCLUSION: The mTPF chemotherapy regimen is efficacious for the palliative treatment of recurrent and metastatic HNSCC in Asian patients.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree false
46 schema:isPartOf N1311d37679d24f179d6dbaefefa5c23d
47 N14ae9d3ab9c647ec860deeb659aad456
48 sg:journal.1096634
49 schema:name Chemotherapy with Modified Docetaxel, Cisplatin, and 5-Fluorouracil in Patients with Metastatic Head and Neck Cancer
50 schema:pagination 71-77
51 schema:productId N6260038911354b4e9550cc97988aca6b
52 N73cf396f0e594dfcb38975d11167f17c
53 N7cac4e25175648969bc156273d6f749d
54 Naac806e76543465b8be244af7540eea9
55 Nd6f72a2d5c6e432bb6af3ccb1f3e45b8
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030072496
57 https://doi.org/10.1007/s12325-011-0085-2
58 schema:sdDatePublished 2019-04-10T13:20
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher Nb863f97b27e642219a9c341b7735f48a
61 schema:url http://link.springer.com/10.1007%2Fs12325-011-0085-2
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N0653fbaf642a4811a6bc7b70b7f6e078 schema:affiliation https://www.grid.ac/institutes/grid.413814.b
66 schema:familyName Bi
67 schema:givenName Chu-Ping
68 rdf:type schema:Person
69 N08af55be98b04ca49e9f5d817c21dce1 schema:affiliation https://www.grid.ac/institutes/grid.413814.b
70 schema:familyName Wang
71 schema:givenName Jer-Wei
72 rdf:type schema:Person
73 N1311d37679d24f179d6dbaefefa5c23d schema:issueNumber 1
74 rdf:type schema:PublicationIssue
75 N14ae9d3ab9c647ec860deeb659aad456 schema:volumeNumber 29
76 rdf:type schema:PublicationVolume
77 N2860a5aaf59c49bcbc995d7bcc8b41ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Aged
79 rdf:type schema:DefinedTerm
80 N2f841f6855324783b9c72d96d21fbdb3 schema:affiliation https://www.grid.ac/institutes/grid.413814.b
81 schema:familyName Lai
82 schema:givenName Guam-Min
83 rdf:type schema:Person
84 N441d962eff7f4ba2b6a8f5c45028bade schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Neoplasms, Squamous Cell
86 rdf:type schema:DefinedTerm
87 N44aeadd7cbfa48098e4bd6a48b16b3ec rdf:first sg:person.01177166674.31
88 rdf:rest Nffbbc440b0a74ff4aadac5cffd849f57
89 N5f540913162c4e78ba58b49e4c99b409 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Cisplatin
91 rdf:type schema:DefinedTerm
92 N6260038911354b4e9550cc97988aca6b schema:name doi
93 schema:value 10.1007/s12325-011-0085-2
94 rdf:type schema:PropertyValue
95 N6a0be5c596c541c59a35a0cddf495156 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Humans
97 rdf:type schema:DefinedTerm
98 N6f755962140543ac8ed467c0464ac91f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Middle Aged
100 rdf:type schema:DefinedTerm
101 N73c60b7dad244def9173af16559f4a99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Adult
103 rdf:type schema:DefinedTerm
104 N73cf396f0e594dfcb38975d11167f17c schema:name nlm_unique_id
105 schema:value 8611864
106 rdf:type schema:PropertyValue
107 N73d355945c504ba1a8cb5bacb9a4d84a rdf:first N08af55be98b04ca49e9f5d817c21dce1
108 rdf:rest N97e481b30d2544c79736ee72cee032b0
109 N7851d5bc0822496997017f98151653f6 rdf:first sg:person.01361571534.74
110 rdf:rest Nbd44e3dd94b342158c334a5f00c90b57
111 N7cac4e25175648969bc156273d6f749d schema:name pubmed_id
112 schema:value 22161550
113 rdf:type schema:PropertyValue
114 N7d22a2b651a940da996eceb4e37101f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Survival Rate
116 rdf:type schema:DefinedTerm
117 N848f006a1082421889f46dc5598bd210 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Fluorouracil
119 rdf:type schema:DefinedTerm
120 N87d6e110f4da41bf99e05c864cbec87a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Disease Progression
122 rdf:type schema:DefinedTerm
123 N97e481b30d2544c79736ee72cee032b0 rdf:first sg:person.01140011433.09
124 rdf:rest rdf:nil
125 N9929a4cd97524d8f8fcd41f705a999b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Antineoplastic Combined Chemotherapy Protocols
127 rdf:type schema:DefinedTerm
128 N9a6cc677fbec496fbd6b4479dd003f6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Palliative Care
130 rdf:type schema:DefinedTerm
131 N9be67af22eb14a0592d1f3644f943904 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Remission Induction
133 rdf:type schema:DefinedTerm
134 N9f28595583e5497f89f7cc71ff6ec926 rdf:first N0653fbaf642a4811a6bc7b70b7f6e078
135 rdf:rest N73d355945c504ba1a8cb5bacb9a4d84a
136 Naac806e76543465b8be244af7540eea9 schema:name readcube_id
137 schema:value 8f4364f302d7890648829942864d598d25df2e45f8eecf85a5c35b03c8b7d266
138 rdf:type schema:PropertyValue
139 Nab7f43b84cf54f47b4dab3625887ab7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Taxoids
141 rdf:type schema:DefinedTerm
142 Nb863f97b27e642219a9c341b7735f48a schema:name Springer Nature - SN SciGraph project
143 rdf:type schema:Organization
144 Nbd44e3dd94b342158c334a5f00c90b57 rdf:first N2f841f6855324783b9c72d96d21fbdb3
145 rdf:rest N44aeadd7cbfa48098e4bd6a48b16b3ec
146 Nd6f72a2d5c6e432bb6af3ccb1f3e45b8 schema:name dimensions_id
147 schema:value pub.1030072496
148 rdf:type schema:PropertyValue
149 Ndab097d917b24ae985cdd036611c5737 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Neoplasm Metastasis
151 rdf:type schema:DefinedTerm
152 Nee7a72cd128948b5ba4599e92b44c5d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Male
154 rdf:type schema:DefinedTerm
155 Nf5eab9b47b0f4cea9687d3058980d914 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Retrospective Studies
157 rdf:type schema:DefinedTerm
158 Nfb9511abe8f84ba58913c228861241b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Head and Neck Neoplasms
160 rdf:type schema:DefinedTerm
161 Nffbbc440b0a74ff4aadac5cffd849f57 rdf:first sg:person.0700376474.04
162 rdf:rest N9f28595583e5497f89f7cc71ff6ec926
163 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
164 schema:name Medical and Health Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
167 schema:name Oncology and Carcinogenesis
168 rdf:type schema:DefinedTerm
169 sg:journal.1096634 schema:issn 0741-238X
170 1865-8652
171 schema:name Advances in Therapy
172 rdf:type schema:Periodical
173 sg:person.01140011433.09 schema:affiliation https://www.grid.ac/institutes/grid.413814.b
174 schema:familyName Chen
175 schema:givenName Mu-Kuan
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140011433.09
177 rdf:type schema:Person
178 sg:person.01177166674.31 schema:affiliation https://www.grid.ac/institutes/grid.413814.b
179 schema:familyName Chang
180 schema:givenName Tung-Hao
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177166674.31
182 rdf:type schema:Person
183 sg:person.01361571534.74 schema:affiliation https://www.grid.ac/institutes/grid.411641.7
184 schema:familyName Lin
185 schema:givenName Jen-Tsun
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361571534.74
187 rdf:type schema:Person
188 sg:person.0700376474.04 schema:affiliation https://www.grid.ac/institutes/grid.413814.b
189 schema:familyName Liu
190 schema:givenName Mu-Tai
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700376474.04
192 rdf:type schema:Person
193 sg:pub.10.1007/s00280-010-1401-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037875844
194 https://doi.org/10.1007/s00280-010-1401-2
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/sj.bjc.6690715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021781121
197 https://doi.org/10.1038/sj.bjc.6690715
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1002/cncr.10574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052498734
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.clon.2004.09.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026490737
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.ejca.2004.05.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022542045
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.oraloncology.2008.05.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009088430
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1023/a:1008355315205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056303404
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1023/a:1008360323986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056303445
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1056/nejmoa071028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021180850
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1093/annonc/mdn456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025164065
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1093/jnci/djh306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049402297
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1093/jnci/djp007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017259792
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1093/oxfordjournals.annonc.a058908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082564512
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1097/01.mlg.0000208366.34683.58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039597444
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1097/cad.0b013e32832c9c51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029257106
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1200/jco.1989.7.11.1748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079217876
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1200/jco.20.6.1593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202885
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1200/jco.2004.00.1990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046275705
230 rdf:type schema:CreativeWork
231 https://doi.org/10.4143/crt.2007.39.3.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072255719
232 rdf:type schema:CreativeWork
233 https://www.grid.ac/institutes/grid.411641.7 schema:alternateName Chung Shan Medical University
234 schema:name Division of Hematology and Oncology, Department of Medicine, ChangHua Christian Hospital, ChangHua, Taiwan
235 School of Medicine, Chung Shan Medical University, Taichung, Taiwan
236 rdf:type schema:Organization
237 https://www.grid.ac/institutes/grid.413814.b schema:alternateName Changhua Christian Hospital
238 schema:name Department of Otorhinolaryngology-Head and Neck Surgery, ChangHua Christian Hospital, 35 Nan-Hsiao Street, 500, ChangHua, Taiwan
239 Department of Radiation Oncology, ChangHua Christian Hospital, ChangHua, Taiwan
240 Division of Hematology and Oncology, Department of Medicine, ChangHua Christian Hospital, ChangHua, Taiwan
241 School of Medicine, Chung Shan Medical University, Taichung, Taiwan
242 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...