Diagnostic Criteria for Primary Autoimmune Cerebellar Ataxia—Guidelines from an International Task Force on Immune-Mediated Cerebellar Ataxias View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-04-23

AUTHORS

Marios Hadjivassiliou, Francesc Graus, Jerome Honnorat, Sven Jarius, Maarten Titulaer, Mario Manto, Nigel Hoggard, Ptolemaios Sarrigiannis, Hiroshi Mitoma

ABSTRACT

Aside from well-characterized immune-mediated ataxias with a clear trigger and/or association with specific neuronal antibodies, a large number of idiopathic ataxias are suspected to be immune mediated but remain undiagnosed due to lack of diagnostic biomarkers. Primary autoimmune cerebellar ataxia (PACA) is the term used to describe this later group. An International Task Force comprising experts in the field of immune ataxias was commissioned by the Society for Research on the Cerebellum and Ataxias (SRCA) in order to devise diagnostic criteria aiming to improve the diagnosis of PACA. The proposed diagnostic criteria for PACA are based on clinical (mode of onset, pattern of cerebellar involvement, presence of other autoimmune diseases), imaging findings (MRI and if available MR spectroscopy showing preferential, but not exclusive involvement of vermis) and laboratory investigations (CSF pleocytosis and/or CSF-restricted IgG oligoclonal bands) parameters. The aim is to enable clinicians to consider PACA when encountering a patient with progressive ataxia and no other diagnosis given that such consideration might have important therapeutic implications. More... »

PAGES

605-610

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12311-020-01132-8

DOI

http://dx.doi.org/10.1007/s12311-020-01132-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1126922911

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32328884


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