The Expression of HDAC1 and HDAC2 During Cerebellar Cortical Development View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-08

AUTHORS

Ji Young Janice Yoo, Matt Larouche, Dan Goldowitz

ABSTRACT

Histone deacetylases (HDACs) are epigenetic regulatory proteins that repress gene transcription by changing DNA conformation. The regulation of gene expression through histone deacetylation is an important mechanism for the development of the central nervous system. Although the disruption of the balance in epigenetic gene regulation has been implicated in many CNS developmental abnormalities and diseases, the expression pattern of HDACs in various cell types in the brain during its maturation process has had limited exploration. Therefore, in this study, we investigate the cell type-specific and developmental stage-specific expression pattern of HDAC1 and HDAC2 in the mouse cerebellum. Our experimental results show that the cerebellar progenitors and glial cells express high levels of HDAC1 and low levels of HDAC2. On the other hand, the post-mitotic migrating neuronal cells of the cerebellar cortex show strong HDAC2 and weak HDAC1 expressions. In more differentiated neuronal cells, including Purkinje cells, granule cells, unipolar brush cells, and GABAergic interneurons, we found a consistent expression pattern, high levels of HDAC2 and low levels of HDAC1. Therefore, our data provide support for the potential important roles of HDAC1 in cell proliferation and HDAC2 in migration and differentiation. More... »

PAGES

534-546

References to SciGraph publications

  • 2011-09. Expression of Histone Deacetylases in Cellular Compartments of the Mouse Brain and the Effects of Ischemia in TRANSLATIONAL STROKE RESEARCH
  • 2007-01. Distribution of histone deacetylases 1–11 in the rat brain in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2007-03. Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3β activity in NATURE MEDICINE
  • 2010-02. Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation in NATURE CELL BIOLOGY
  • 2002-06. Cytodifferentiation of bergmann glia and its relationship with purkinje cells in ANATOMICAL SCIENCE INTERNATIONAL
  • 2009-12. Dynamic distribution and stem cell characteristics of Sox1-expressing cells in the cerebellar cortex in CELL RESEARCH
  • 2000-01. The language of covalent histone modifications in NATURE
  • 2009-08. Focal Nature of Neurological Disorders Necessitates Isotype-Selective Histone Deacetylase (HDAC) Inhibitors in MOLECULAR NEUROBIOLOGY
  • 2008-09-18. S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons in NATURE
  • 2009-05. HDAC2 negatively regulates memory formation and synaptic plasticity in NATURE
  • 2007-02. Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells in EXPERIMENTAL BRAIN RESEARCH
  • 2008-12. Development of Cerebellar GABAergic Interneurons: Origin and Shaping of the “Minibrain” Local Connections in THE CEREBELLUM
  • 2008-03. The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2008-10. Therapeutic application of histone deacetylase inhibitors for central nervous system disorders in NATURE REVIEWS DRUG DISCOVERY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12311-013-0459-x

    DOI

    http://dx.doi.org/10.1007/s12311-013-0459-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007555873

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23436026


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals, Newborn", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Astrocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cerebellar Cortex", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Enzymologic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histone Deacetylase 1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histone Deacetylase 2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred ICR", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neuroglia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurons", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stem Cells", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, 950 W. 28th Avenue, V5Z 4H4, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoo", 
            "givenName": "Ji Young Janice", 
            "id": "sg:person.01074325553.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074325553.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, 950 W. 28th Avenue, V5Z 4H4, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Larouche", 
            "givenName": "Matt", 
            "id": "sg:person.01263650054.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263650054.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, 950 W. 28th Avenue, V5Z 4H4, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Goldowitz", 
            "givenName": "Dan", 
            "id": "sg:person.010263544144.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010263544144.63"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.neuron.2008.12.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001823107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2681", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002162150", 
              "https://doi.org/10.1038/nrd2681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0097-09.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002730123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.conb.2010.01.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002831876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.0022-7722.2002.00021.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003840612", 
              "https://doi.org/10.1046/j.0022-7722.2002.00021.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1046-2023(03)00083-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003946603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1046-2023(03)00083-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003946603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1046-2023(03)00083-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003946603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rstb.2008.2262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004834623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(00)80778-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005227519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/21.11.2672", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005993293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1535-6108(03)00165-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006377613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01220-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006965382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2009.119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008076864", 
              "https://doi.org/10.1038/cr.2009.119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dvdy.21626", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008460729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008955012", 
              "https://doi.org/10.1038/ncb2013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008955012", 
              "https://doi.org/10.1038/ncb2013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2004.02.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009145923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010076032", 
              "https://doi.org/10.1038/nm1552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2004.02725.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011221994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2004.02725.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011221994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011581954", 
              "https://doi.org/10.1038/nature07925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011581954", 
              "https://doi.org/10.1038/nature07925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2008.12.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012905305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cne.10384", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013689470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0166-2236(98)01313-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014962964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1000478107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014998210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.23.8.2669-2679.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016737012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cne.10874", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017126143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.552310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018236321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00221-006-0831-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018430012", 
              "https://doi.org/10.1007/s00221-006-0831-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00221-006-0831-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018430012", 
              "https://doi.org/10.1007/s00221-006-0831-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainres.2006.04.127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018946136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-009-8067-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022118869", 
              "https://doi.org/10.1007/s12035-009-8067-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-009-8067-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022118869", 
              "https://doi.org/10.1007/s12035-009-8067-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20021321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023132286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20021321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023132286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00494-07", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025598271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/47412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025852070", 
              "https://doi.org/10.1038/47412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/47412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025852070", 
              "https://doi.org/10.1038/47412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0902750106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027708524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cne.901790104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028590818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cne.901790104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028590818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2006.08.082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029434732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1563807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029849617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1610-06.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031870097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0407643101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035479407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12311-008-0079-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037411439", 
              "https://doi.org/10.1007/s12311-008-0079-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m101287200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037618835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2346", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037857855", 
              "https://doi.org/10.1038/nrm2346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-8993(96)01007-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037906689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02686117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038842874", 
              "https://doi.org/10.1007/bf02686117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02686117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038842874", 
              "https://doi.org/10.1007/bf02686117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.5747-03.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040819949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041414087", 
              "https://doi.org/10.1038/nature07238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12975-011-0087-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041423217", 
              "https://doi.org/10.1007/s12975-011-0087-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12975-011-0087-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041423217", 
              "https://doi.org/10.1007/s12975-011-0087-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-0312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044396952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.02.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044999579"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-4827(86)90520-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045953058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fbp.0b013e32833c20c0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050703067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fbp.0b013e32833c20c0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050703067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fbp.0b013e32833c20c0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050703067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2010.136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051338475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2010.136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051338475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0002668", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051733003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tips.2010.09.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052064672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-4695(19991105)41:2<281::aid-neu10>3.0.co;2-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052331437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1387/ijdb.082649rb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067190957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1387/ijdb.092971cm", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067191133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077952474", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082470995", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-08", 
        "datePublishedReg": "2013-08-01", 
        "description": "Histone deacetylases (HDACs) are epigenetic regulatory proteins that repress gene transcription by changing DNA conformation. The regulation of gene expression through histone deacetylation is an important mechanism for the development of the central nervous system. Although the disruption of the balance in epigenetic gene regulation has been implicated in many CNS developmental abnormalities and diseases, the expression pattern of HDACs in various cell types in the brain during its maturation process has had limited exploration. Therefore, in this study, we investigate the cell type-specific and developmental stage-specific expression pattern of HDAC1 and HDAC2 in the mouse cerebellum. Our experimental results show that the cerebellar progenitors and glial cells express high levels of HDAC1 and low levels of HDAC2. On the other hand, the post-mitotic migrating neuronal cells of the cerebellar cortex show strong HDAC2 and weak HDAC1 expressions. In more differentiated neuronal cells, including Purkinje cells, granule cells, unipolar brush cells, and GABAergic interneurons, we found a consistent expression pattern, high levels of HDAC2 and low levels of HDAC1. Therefore, our data provide support for the potential important roles of HDAC1 in cell proliferation and HDAC2 in migration and differentiation. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s12311-013-0459-x", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1028483", 
            "issn": [
              "1473-4222", 
              "1473-4230"
            ], 
            "name": "The Cerebellum", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "12"
          }
        ], 
        "name": "The Expression of HDAC1 and HDAC2 During Cerebellar Cortical Development", 
        "pagination": "534-546", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "23fdab6fceb6e019ca45139f7b1eaeecaf75de0279b087c87f502c7cd45c9198"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23436026"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101089443"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12311-013-0459-x"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1007555873"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12311-013-0459-x", 
          "https://app.dimensions.ai/details/publication/pub.1007555873"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T17:33", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000520.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs12311-013-0459-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12311-013-0459-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12311-013-0459-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12311-013-0459-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12311-013-0459-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    322 TRIPLES      21 PREDICATES      100 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12311-013-0459-x schema:about N06f0a0303e414146b994db3fff2f2a28
    2 N1122191aadd342728d70e46fc68b684e
    3 N196a2ee6297f40bcbc8a657e4bbf77bd
    4 N1ab50755b75d4ec6bee31345a22c8e9a
    5 N27fc2ade0eba4d709f084bc6d6525915
    6 N44bb88a42bcf4ba4910fe3c05f488681
    7 N491b38812500453daf9a15c252cb626b
    8 N56d5264472e840f284a05a343208cd29
    9 N68ccdc6db9604783b38744b3f7f255eb
    10 Nafbb40168125402d9982396535e4a75b
    11 Nd659b0bfac1f41dba6d1a25e399b1341
    12 Ne7bef297fa204148972cd8eea884e1ae
    13 Nea5a92722d3a494e82103412a7986559
    14 Nf59254c50f3a40df9946acddf758686e
    15 anzsrc-for:06
    16 anzsrc-for:0604
    17 schema:author N5c3a85c5279645308fb026afb837b949
    18 schema:citation sg:pub.10.1007/bf02686117
    19 sg:pub.10.1007/s00221-006-0831-x
    20 sg:pub.10.1007/s12035-009-8067-y
    21 sg:pub.10.1007/s12311-008-0079-z
    22 sg:pub.10.1007/s12975-011-0087-z
    23 sg:pub.10.1038/47412
    24 sg:pub.10.1038/cr.2009.119
    25 sg:pub.10.1038/nature07238
    26 sg:pub.10.1038/nature07925
    27 sg:pub.10.1038/ncb2013
    28 sg:pub.10.1038/nm1552
    29 sg:pub.10.1038/nrd2681
    30 sg:pub.10.1038/nrm2346
    31 sg:pub.10.1046/j.0022-7722.2002.00021.x
    32 https://app.dimensions.ai/details/publication/pub.1077952474
    33 https://app.dimensions.ai/details/publication/pub.1082470995
    34 https://doi.org/10.1002/(sici)1097-4695(19991105)41:2<281::aid-neu10>3.0.co;2-5
    35 https://doi.org/10.1002/cne.10384
    36 https://doi.org/10.1002/cne.10874
    37 https://doi.org/10.1002/cne.901790104
    38 https://doi.org/10.1002/dvdy.21626
    39 https://doi.org/10.1016/0014-4827(86)90520-3
    40 https://doi.org/10.1016/j.brainres.2006.04.127
    41 https://doi.org/10.1016/j.conb.2010.01.003
    42 https://doi.org/10.1016/j.jmb.2004.02.006
    43 https://doi.org/10.1016/j.molcel.2008.02.030
    44 https://doi.org/10.1016/j.neuron.2008.12.007
    45 https://doi.org/10.1016/j.neuroscience.2006.08.082
    46 https://doi.org/10.1016/j.neuroscience.2008.12.016
    47 https://doi.org/10.1016/j.tips.2010.09.003
    48 https://doi.org/10.1016/s0006-8993(96)01007-4
    49 https://doi.org/10.1016/s0166-2236(98)01313-7
    50 https://doi.org/10.1016/s0896-6273(00)80778-3
    51 https://doi.org/10.1016/s1046-2023(03)00083-5
    52 https://doi.org/10.1016/s1535-6108(03)00165-x
    53 https://doi.org/10.1038/emboj.2010.136
    54 https://doi.org/10.1042/bj20021321
    55 https://doi.org/10.1073/pnas.0407643101
    56 https://doi.org/10.1073/pnas.0902750106
    57 https://doi.org/10.1073/pnas.1000478107
    58 https://doi.org/10.1074/jbc.m101287200
    59 https://doi.org/10.1093/emboj/21.11.2672
    60 https://doi.org/10.1097/fbp.0b013e32833c20c0
    61 https://doi.org/10.1098/rstb.2008.2262
    62 https://doi.org/10.1101/gad.1563807
    63 https://doi.org/10.1101/gad.552310
    64 https://doi.org/10.1111/j.1471-4159.2004.02725.x
    65 https://doi.org/10.1128/mcb.00494-07
    66 https://doi.org/10.1128/mcb.01220-06
    67 https://doi.org/10.1128/mcb.23.8.2669-2679.2003
    68 https://doi.org/10.1158/0008-5472.can-07-0312
    69 https://doi.org/10.1371/journal.pone.0002668
    70 https://doi.org/10.1387/ijdb.082649rb
    71 https://doi.org/10.1387/ijdb.092971cm
    72 https://doi.org/10.1523/jneurosci.0097-09.2009
    73 https://doi.org/10.1523/jneurosci.1610-06.2006
    74 https://doi.org/10.1523/jneurosci.5747-03.2004
    75 schema:datePublished 2013-08
    76 schema:datePublishedReg 2013-08-01
    77 schema:description Histone deacetylases (HDACs) are epigenetic regulatory proteins that repress gene transcription by changing DNA conformation. The regulation of gene expression through histone deacetylation is an important mechanism for the development of the central nervous system. Although the disruption of the balance in epigenetic gene regulation has been implicated in many CNS developmental abnormalities and diseases, the expression pattern of HDACs in various cell types in the brain during its maturation process has had limited exploration. Therefore, in this study, we investigate the cell type-specific and developmental stage-specific expression pattern of HDAC1 and HDAC2 in the mouse cerebellum. Our experimental results show that the cerebellar progenitors and glial cells express high levels of HDAC1 and low levels of HDAC2. On the other hand, the post-mitotic migrating neuronal cells of the cerebellar cortex show strong HDAC2 and weak HDAC1 expressions. In more differentiated neuronal cells, including Purkinje cells, granule cells, unipolar brush cells, and GABAergic interneurons, we found a consistent expression pattern, high levels of HDAC2 and low levels of HDAC1. Therefore, our data provide support for the potential important roles of HDAC1 in cell proliferation and HDAC2 in migration and differentiation.
    78 schema:genre research_article
    79 schema:inLanguage en
    80 schema:isAccessibleForFree false
    81 schema:isPartOf N47bc257f0106459691abda9e2dca92e9
    82 Nff92c288d08c433894b3cd8b01ab71db
    83 sg:journal.1028483
    84 schema:name The Expression of HDAC1 and HDAC2 During Cerebellar Cortical Development
    85 schema:pagination 534-546
    86 schema:productId N0557489970974120a2703734807ab66f
    87 N19378e28fb5043f3b4b761da132256b0
    88 N7ce23063e6024717972f95245e2ce12a
    89 N860529d079274be3b36525d11d068192
    90 Nbe7608cb806e44a1a729dc9da4bcbb69
    91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007555873
    92 https://doi.org/10.1007/s12311-013-0459-x
    93 schema:sdDatePublished 2019-04-10T17:33
    94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    95 schema:sdPublisher Naae5070b06b84691ae8c0756f7c39a32
    96 schema:url http://link.springer.com/10.1007%2Fs12311-013-0459-x
    97 sgo:license sg:explorer/license/
    98 sgo:sdDataset articles
    99 rdf:type schema:ScholarlyArticle
    100 N0557489970974120a2703734807ab66f schema:name nlm_unique_id
    101 schema:value 101089443
    102 rdf:type schema:PropertyValue
    103 N06f0a0303e414146b994db3fff2f2a28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Histone Deacetylase 2
    105 rdf:type schema:DefinedTerm
    106 N1122191aadd342728d70e46fc68b684e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Neuroglia
    108 rdf:type schema:DefinedTerm
    109 N19378e28fb5043f3b4b761da132256b0 schema:name doi
    110 schema:value 10.1007/s12311-013-0459-x
    111 rdf:type schema:PropertyValue
    112 N196a2ee6297f40bcbc8a657e4bbf77bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Animals
    114 rdf:type schema:DefinedTerm
    115 N19b1561e2c0e4787a51e3715410bcf1e rdf:first sg:person.010263544144.63
    116 rdf:rest rdf:nil
    117 N1ab50755b75d4ec6bee31345a22c8e9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Cerebellar Cortex
    119 rdf:type schema:DefinedTerm
    120 N27fc2ade0eba4d709f084bc6d6525915 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Cell Differentiation
    122 rdf:type schema:DefinedTerm
    123 N44bb88a42bcf4ba4910fe3c05f488681 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Animals, Newborn
    125 rdf:type schema:DefinedTerm
    126 N47bc257f0106459691abda9e2dca92e9 schema:volumeNumber 12
    127 rdf:type schema:PublicationVolume
    128 N491b38812500453daf9a15c252cb626b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Stem Cells
    130 rdf:type schema:DefinedTerm
    131 N56d5264472e840f284a05a343208cd29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Mice, Inbred ICR
    133 rdf:type schema:DefinedTerm
    134 N5c3a85c5279645308fb026afb837b949 rdf:first sg:person.01074325553.86
    135 rdf:rest Nca333c4b704f4710bd114cd46f0c6bfa
    136 N68ccdc6db9604783b38744b3f7f255eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Mice
    138 rdf:type schema:DefinedTerm
    139 N7ce23063e6024717972f95245e2ce12a schema:name dimensions_id
    140 schema:value pub.1007555873
    141 rdf:type schema:PropertyValue
    142 N860529d079274be3b36525d11d068192 schema:name readcube_id
    143 schema:value 23fdab6fceb6e019ca45139f7b1eaeecaf75de0279b087c87f502c7cd45c9198
    144 rdf:type schema:PropertyValue
    145 Naae5070b06b84691ae8c0756f7c39a32 schema:name Springer Nature - SN SciGraph project
    146 rdf:type schema:Organization
    147 Nafbb40168125402d9982396535e4a75b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Mice, Inbred C57BL
    149 rdf:type schema:DefinedTerm
    150 Nbe7608cb806e44a1a729dc9da4bcbb69 schema:name pubmed_id
    151 schema:value 23436026
    152 rdf:type schema:PropertyValue
    153 Nca333c4b704f4710bd114cd46f0c6bfa rdf:first sg:person.01263650054.50
    154 rdf:rest N19b1561e2c0e4787a51e3715410bcf1e
    155 Nd659b0bfac1f41dba6d1a25e399b1341 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Histone Deacetylase 1
    157 rdf:type schema:DefinedTerm
    158 Ne7bef297fa204148972cd8eea884e1ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Neurons
    160 rdf:type schema:DefinedTerm
    161 Nea5a92722d3a494e82103412a7986559 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Gene Expression Regulation, Enzymologic
    163 rdf:type schema:DefinedTerm
    164 Nf59254c50f3a40df9946acddf758686e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Astrocytes
    166 rdf:type schema:DefinedTerm
    167 Nff92c288d08c433894b3cd8b01ab71db schema:issueNumber 4
    168 rdf:type schema:PublicationIssue
    169 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    170 schema:name Biological Sciences
    171 rdf:type schema:DefinedTerm
    172 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    173 schema:name Genetics
    174 rdf:type schema:DefinedTerm
    175 sg:journal.1028483 schema:issn 1473-4222
    176 1473-4230
    177 schema:name The Cerebellum
    178 rdf:type schema:Periodical
    179 sg:person.010263544144.63 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    180 schema:familyName Goldowitz
    181 schema:givenName Dan
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010263544144.63
    183 rdf:type schema:Person
    184 sg:person.01074325553.86 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    185 schema:familyName Yoo
    186 schema:givenName Ji Young Janice
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074325553.86
    188 rdf:type schema:Person
    189 sg:person.01263650054.50 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    190 schema:familyName Larouche
    191 schema:givenName Matt
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263650054.50
    193 rdf:type schema:Person
    194 sg:pub.10.1007/bf02686117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038842874
    195 https://doi.org/10.1007/bf02686117
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1007/s00221-006-0831-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018430012
    198 https://doi.org/10.1007/s00221-006-0831-x
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1007/s12035-009-8067-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1022118869
    201 https://doi.org/10.1007/s12035-009-8067-y
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1007/s12311-008-0079-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1037411439
    204 https://doi.org/10.1007/s12311-008-0079-z
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1007/s12975-011-0087-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1041423217
    207 https://doi.org/10.1007/s12975-011-0087-z
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/47412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025852070
    210 https://doi.org/10.1038/47412
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/cr.2009.119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008076864
    213 https://doi.org/10.1038/cr.2009.119
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/nature07238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041414087
    216 https://doi.org/10.1038/nature07238
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/nature07925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011581954
    219 https://doi.org/10.1038/nature07925
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/ncb2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008955012
    222 https://doi.org/10.1038/ncb2013
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/nm1552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010076032
    225 https://doi.org/10.1038/nm1552
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/nrd2681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002162150
    228 https://doi.org/10.1038/nrd2681
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/nrm2346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037857855
    231 https://doi.org/10.1038/nrm2346
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1046/j.0022-7722.2002.00021.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003840612
    234 https://doi.org/10.1046/j.0022-7722.2002.00021.x
    235 rdf:type schema:CreativeWork
    236 https://app.dimensions.ai/details/publication/pub.1077952474 schema:CreativeWork
    237 https://app.dimensions.ai/details/publication/pub.1082470995 schema:CreativeWork
    238 https://doi.org/10.1002/(sici)1097-4695(19991105)41:2<281::aid-neu10>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052331437
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1002/cne.10384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013689470
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1002/cne.10874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017126143
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1002/cne.901790104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028590818
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1002/dvdy.21626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008460729
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/0014-4827(86)90520-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045953058
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.brainres.2006.04.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018946136
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/j.conb.2010.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002831876
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/j.jmb.2004.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009145923
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/j.molcel.2008.02.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044999579
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/j.neuron.2008.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001823107
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/j.neuroscience.2006.08.082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029434732
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1016/j.neuroscience.2008.12.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012905305
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/j.tips.2010.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052064672
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/s0006-8993(96)01007-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037906689
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/s0166-2236(98)01313-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014962964
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/s0896-6273(00)80778-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005227519
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/s1046-2023(03)00083-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003946603
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/s1535-6108(03)00165-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006377613
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1038/emboj.2010.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051338475
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1042/bj20021321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023132286
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1073/pnas.0407643101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035479407
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1073/pnas.0902750106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027708524
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1073/pnas.1000478107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014998210
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1074/jbc.m101287200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037618835
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1093/emboj/21.11.2672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005993293
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1097/fbp.0b013e32833c20c0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050703067
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1098/rstb.2008.2262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004834623
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1101/gad.1563807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029849617
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1101/gad.552310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018236321
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1111/j.1471-4159.2004.02725.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011221994
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1128/mcb.00494-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025598271
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1128/mcb.01220-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006965382
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1128/mcb.23.8.2669-2679.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016737012
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1158/0008-5472.can-07-0312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044396952
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1371/journal.pone.0002668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051733003
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1387/ijdb.082649rb schema:sameAs https://app.dimensions.ai/details/publication/pub.1067190957
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1387/ijdb.092971cm schema:sameAs https://app.dimensions.ai/details/publication/pub.1067191133
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1523/jneurosci.0097-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002730123
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1523/jneurosci.1610-06.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031870097
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1523/jneurosci.5747-03.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040819949
    319 rdf:type schema:CreativeWork
    320 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
    321 schema:name Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, 950 W. 28th Avenue, V5Z 4H4, Vancouver, BC, Canada
    322 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...