Translocation detection in lymphoma diagnosis by split-signal FISH: a standardised approach View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-08-29

AUTHORS

Anke van Rijk, David Mason, Margaret Jones, José Cabeçadas, Mateus Crespo, Juan Cruz Cigudosa, Juan Fernando Garcia, Lorenzo Leoncini, Mario Cocco, Martin-Leo Hansmann, Anja Mottok, Christiane Copie Bergman, Maryse Baia, Dimitra Anagnostou, Evi Pouliou, Stephen Hamilton Dutoit, Mette Hjøllund Christiansen, Tim Svenstrup Poulsen, Steen Hauge Matthiesen, Jacques van Dongen, J. Han van Krieken

ABSTRACT

Lymphomas originating from the lymphatic system comprise about 30 entities classified according to the World Health Organization (WHO). The histopathological diagnosis is generally considered difficult and prone to mistakes. Since non-random chromosomal translocations are specifically involved in different lymphoma entities, their detection will be increasingly important. Hence, a split-signal fluorescence in situ hybridisation (FISH) procedure would be helpful in discriminating the most difficult classifications. The Euro-FISH programme, a concerted action of nine European laboratories, has validated a robust, standardised protocol to improve the diagnostic approach on lymphoma entities. Therefore, 16 fluorescent probes and 10 WHO entities, supplemented with reactive cases, were selected. The results of the Euro-FISH programme show that all probes were correctly cytogenetically located, that the standardised protocol is robust, resulting in reliable results in approximately 90% of cases, and that the procedure could be implemented in every laboratory, bringing the relatively easy interpretation of split-signal probes within the reach of many pathology laboratories. More... »

PAGES

119-126

Journal

TITLE

Journal of Hematopathology

ISSUE

2

VOLUME

1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12308-008-0017-5

DOI

http://dx.doi.org/10.1007/s12308-008-0017-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027364084

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19669210


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16 Health Organization
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18 action
19 approach
20 cases
21 chromosomal translocations
22 classification
23 concerted action
24 detection
25 diagnosis
26 diagnostic approach
27 different lymphoma entities
28 difficult classification
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32 fluorescence
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34 histopathological diagnosis
35 hybridisation procedure
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37 laboratory
38 lymphatic system
39 lymphoma
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41 lymphoma entities
42 mistakes
43 non-random chromosomal translocations
44 organization
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47 procedure
48 program
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50 reach
51 reactive cases
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53 results
54 situ hybridisation procedure
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