The association between physical health-related quality of life, physical functioning, and risk of contralateral breast cancer among older women View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-11-19

AUTHORS

Nita H. Mukand, Naomi Y. Ko, Nadia A. Nabulsi, Colin C. Hubbard, Brian C.-H. Chiu, Kent F. Hoskins, Gregory S. Calip

ABSTRACT

BackgroundPhysical limitations prior to cancer diagnosis may lead to suboptimal health outcomes. Our objective was to evaluate the impacts of poor physical health-related quality of life (HRQOL) and physical functioning (PF) on the risk of contralateral breast cancer (CBC).MethodsWe performed a nested case–control study of women with invasive unilateral breast cancer (UBC) who did not receive prophylactic contralateral mastectomy using the Surveillance, Epidemiology and End Results Medicare Health Outcomes Survey data resource. Among 2938 women aged ≥ 65 years diagnosed with first stage I–III UBC between 1997 and 2011, we identified 100 subsequent CBC cases and 915 matched controls without CBC using incidence density sampling without replacement. Pre-diagnosis physical HRQOL and PF were determined using Medical Outcomes Trust Short Form-36 (SF-36)/Veterans Rand 12-Item Health Survey (VR-12) responses within 2 years prior to first UBC diagnosis. We estimated adjusted odds ratios (OR) and 95% confidence intervals (CI) using conditional logistic regression models.ResultsCases and controls were similar with respect to comorbidities, stage, surgery, and radiation treatments, but differed by hormone receptor status (ER/PR-negative, 23% and 11%, respectively) of first UBC. Cases had modestly lower mean pre-diagnosis physical HRQOL (− 1.8) and PF (− 2.2) scores. In multivariable models, we observed an increased CBC risk associated with low physical HRQOL (lowest vs. highest quartile, OR = 1.8; 95% CI 0.8–4.3), but CIs included 1.0. Low PF was associated with a 2.7-fold (95% CI 1.1–6.7) increased CBC risk.ConclusionsFindings indicate that low physical HRQOL, specifically poor PF, is associated with CBC risk. Efforts to understand and minimize declines in PF post-breast cancer are well motivated. More... »

PAGES

287-295

References to SciGraph publications

  • 2010-07-13. Relationship between diabetes and risk of second primary contralateral breast cancer in BREAST CANCER RESEARCH AND TREATMENT
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  • 2016-07-12. Systemic therapy for breast cancer and risk of subsequent contralateral breast cancer in the WECARE Study in BREAST CANCER RESEARCH
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  • 2005-01-25. Comparison of nested case-control and survival analysis methodologies for analysis of time-dependent exposure in BMC MEDICAL RESEARCH METHODOLOGY
  • 2018-04-19. A new algorithm to build bridges between two patient-reported health outcome instruments: the MOS SF-36® and the VR-12 Health Survey in QUALITY OF LIFE RESEARCH
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  • 2019-07-19. National trends of synchronous bilateral breast cancer incidence in the United States in BREAST CANCER RESEARCH AND TREATMENT
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    http://scigraph.springernature.com/pub.10.1007/s12282-021-01309-x

    DOI

    http://dx.doi.org/10.1007/s12282-021-01309-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1142692683

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34797467


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