Histological features of skin and subcutaneous tissue in patients with breast cancer who have received neoadjuvant chemotherapy and their relationship ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-07-25

AUTHORS

Ayako Nakagawa, Hiroshi Fujimoto, Takeshi Nagashima, Takafumi Sangai, Mamoru Takada, Takahito Masuda, Ryotaro Teranaka, Satoshi Ota, Jun Matsushima, Shinsuke Akita, Masayuki Ohtsuka

ABSTRACT

BackgroundLymphedema is a major complication of treatment for breast cancer. Although chemotherapy can cause lymphedema, there have been few reports about histological changes in skin and subcutaneous tissue after chemotherapy. The aim of our study was to determine whether chemotherapy affects blood and lymphatic vessels in the skin and subcutaneous fat and to investigate the relationship between these changes and extent of post-chemotherapy edema.MethodsWe compared histological findings in skin and subcutaneous fat of mastectomy specimens from 38 patients who had received NAC (neoadjuvant chemotherapy) and 56 who had not (non-NAC) attending our institution from 2007 to 2016. Patients whose tumor may have affected the area examined were excluded. Blood and lymphatic vessels were identified by CD31 and D2-40, respectively. We assessed microvessel density (MVD), lymphatic microvessel density (MLVD), lumen cross-sectional area (LA), and amount of endothelium (AE) in blood and lymphatic vessels. To minimize surgical effects, we measured edema, defined as ≥ 15% thicker dorsal subcutaneous tissue than baseline, on the contralateral side.ResultsMVD, LA, and AE of blood vessels were greater and MLVD not significantly different in the skin of NAC patients than in that of non-NAC patients. MVD was greater and AE of blood vessels less in subcutaneous fat of NAC patients than in that of non-NAC patients. Patients with edema had significantly less AE of blood vessels in skin than did those without it.ConclusionsThese pathological findings can help to identify patients who will develop edema and improve their treatment. More... »

PAGES

77-84

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12282-019-00996-x

DOI

http://dx.doi.org/10.1007/s12282-019-00996-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1119862477

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31346921


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53 complications
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55 cross-sectional area
56 density
57 dorsal subcutaneous tissue
58 edema
59 effect
60 endothelium
61 extent
62 fat
63 features
64 findings
65 histological changes
66 histological features
67 histological findings
68 institutions
69 lumen cross-sectional area
70 lymphatic microvessel density
71 lymphatic vessels
72 lymphedema
73 major complications
74 mastectomy
75 microvessel density
76 neoadjuvant chemotherapy
77 pathological findings
78 patients
79 post-treatment edema
80 relationship
81 report
82 side
83 skin
84 study
85 subcutaneous fat
86 subcutaneous tissue
87 surgical effect
88 tissue
89 treatment
90 tumors
91 vessels
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