Willingness of Japanese patients with breast cancer to have genetic testing of BRCA without burden of expenses View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-07

AUTHORS

Hiroshi Nakagomi, Ikuko Sakamoto, Yosuke Hirotsu, Kenji Amemiya, Hitoshi Mochizuki, Masayuki Inoue, Satoko Nakagomi, Takeo Kubota, Masao Omata

ABSTRACT

BACKGROUND: Genetic analysis for individuals who are at risk for hereditary breast and ovarian cancer syndrome (HBOC) has becoming widely accepted. The poor introduction of the genetic testing of BRCA in Japan compared with western countries could be due to insufficient recognition of its importance, prejudice against a heredity disease, especially in non-urban districts, and its high cost. There is few available data regarding the acceptance or willingness to have genetic testing among Japanese who are at risk and living outside Tokyo. METHODS: Of 670 patients seen and detailed family history taken at our hospital, located non-urban, 30 (4 %) gave the family history of breast cancer in more than 2 members within the second degree relatives ("stronger" family history group), 92 (14 %) in 1 member ("weaker" group), and 548 (82 %) in none of members ("sporadic" group). Then, we selected 107 (24 from "stronger", 50 from "weaker", 33 from "sporadic" family history group) to see if they are willing to receive cost-free genetic testing of BRCA 1 and BRCA2. RESULTS: Ninety-two of 107 (86 %) patients agreed and 15 (14 %) refused. The rate of refusal for BRCA testing was higher in "stronger family history group" (6/24, 25 %) compared to "weaker" (7/50, 14 %) or "sporadic" (2/33, 6 %) (p = 0.04), respectively. CONCLUSIONS: These data indicate that the currently available preventive measures and/or counseling system may not be sufficient enough to convince the high risk population to receive the genetic testing or to overcome the prejudice in non-urban area in Japan, even if served free. More... »

PAGES

649-653

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12282-015-0618-7

DOI

http://dx.doi.org/10.1007/s12282-015-0618-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040291123

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26025266


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    "description": "BACKGROUND: Genetic analysis for individuals who are at risk for hereditary breast and ovarian cancer syndrome (HBOC) has becoming widely accepted. The poor introduction of the genetic testing of BRCA in Japan compared with western countries could be due to insufficient recognition of its importance, prejudice against a heredity disease, especially in non-urban districts, and its high cost. There is few available data regarding the acceptance or willingness to have genetic testing among Japanese who are at risk and living outside Tokyo.\nMETHODS: Of 670 patients seen and detailed family history taken at our hospital, located non-urban, 30 (4\u00a0%) gave the family history of breast cancer in more than 2 members within the second degree relatives (\"stronger\" family history group), 92 (14\u00a0%) in 1 member (\"weaker\" group), and 548 (82\u00a0%) in none of members (\"sporadic\" group). Then, we selected 107 (24 from \"stronger\", 50 from \"weaker\", 33 from \"sporadic\" family history group) to see if they are willing to receive cost-free genetic testing of BRCA 1 and BRCA2.\nRESULTS: Ninety-two of 107 (86\u00a0%) patients agreed and 15 (14\u00a0%) refused. The rate of refusal for BRCA testing was higher in \"stronger family history group\" (6/24, 25\u00a0%) compared to \"weaker\" (7/50, 14\u00a0%) or \"sporadic\" (2/33, 6\u00a0%) (p\u00a0=\u00a00.04), respectively.\nCONCLUSIONS: These data indicate that the currently available preventive measures and/or counseling system may not be sufficient enough to convince the high risk population to receive the genetic testing or to overcome the prejudice in non-urban area in Japan, even if served free.", 
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38 schema:description BACKGROUND: Genetic analysis for individuals who are at risk for hereditary breast and ovarian cancer syndrome (HBOC) has becoming widely accepted. The poor introduction of the genetic testing of BRCA in Japan compared with western countries could be due to insufficient recognition of its importance, prejudice against a heredity disease, especially in non-urban districts, and its high cost. There is few available data regarding the acceptance or willingness to have genetic testing among Japanese who are at risk and living outside Tokyo. METHODS: Of 670 patients seen and detailed family history taken at our hospital, located non-urban, 30 (4 %) gave the family history of breast cancer in more than 2 members within the second degree relatives ("stronger" family history group), 92 (14 %) in 1 member ("weaker" group), and 548 (82 %) in none of members ("sporadic" group). Then, we selected 107 (24 from "stronger", 50 from "weaker", 33 from "sporadic" family history group) to see if they are willing to receive cost-free genetic testing of BRCA 1 and BRCA2. RESULTS: Ninety-two of 107 (86 %) patients agreed and 15 (14 %) refused. The rate of refusal for BRCA testing was higher in "stronger family history group" (6/24, 25 %) compared to "weaker" (7/50, 14 %) or "sporadic" (2/33, 6 %) (p = 0.04), respectively. CONCLUSIONS: These data indicate that the currently available preventive measures and/or counseling system may not be sufficient enough to convince the high risk population to receive the genetic testing or to overcome the prejudice in non-urban area in Japan, even if served free.
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