Assessment of the Ki67 labeling index: a Japanese validation ring study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-05-03

AUTHORS

Naoki Niikura, Takashi Sakatani, Nobuyuki Arima, Yasuyo Ohi, Naoko Honma, Naoki Kanomata, Kazuya Yoshida, Takayuki Kadoya, Kentaro Tamaki, Nobue Kumaki, Takayuki Iwamoto, Tomoharu Sugie, Takuya Moriya

ABSTRACT

BackgroundA lack of consistent methods to evaluate Ki67 expression is problematic in terms of accurately predicting prognosis in breast cancer. Accordingly, this study aimed to identify the causes of discrepancies in Ki67 labeling index measurements by different observers under different conditions using breast cancer samples.Patients and methodsThis Japanese study group compared and assessed immunohistochemical (IHC) analysis of the Ki67 labeling index when measured by different pathologists. Six pathologists (pathologists A–F) in Japan participated in this ring study. One hundred and ten surgical cases of estrogen receptor-positive and human epidermal growth factor receptor 2-negative invasive breast cancer treated in 2007 were identified from the breast cancer database of Tokai University Hospital and were included in this study.ResultsFor all 6 pathologists, the Ki67 labeling index were significantly different between grade 3 and grade 1 cases and between grade 3 and grade 2 cases, whereas the index tended to be different between grade 1 and grade 2 cases. Further, the Ki67 labeling indexes measured by the 6 pathologists were strongly correlated (ρ: 0.73–0.88). The IHC scores recorded by pathologist A were in moderate to good agreement with those recorded by the others in patients with a Ki67 labeling index of <13.25 % and in those with a Ki67 labeling index of >13.25 % (κ = 0.429–0.660). The Ki67 low and high concordance rates between pathologist A and the others were 0.452–0.778 and 0.862–0.979, respectively. The most pertinent reason for discrepancy in scores seemed to be the selection of the area for counting and the quality of nuclear staining.ConclusionThe Ki67 labeling index measured by 6 pathologists without method standardization was in fair to good agreement. We plan to undertake a second ring study, pending recommendations by the international Ki67 panel. More... »

PAGES

92-100

Journal

TITLE

Breast Cancer

ISSUE

1

VOLUME

23

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12282-014-0536-0

DOI

http://dx.doi.org/10.1007/s12282-014-0536-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051812100

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24794952


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Hormonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Japan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ki-67 Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Grading", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Observer Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, ErbB-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Estrogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Breast and Endocrine Surgery, Tokai University School of Medicine, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan", 
            "Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niikura", 
        "givenName": "Naoki", 
        "id": "sg:person.01326170074.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326170074.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Jichi Medical University, Shimotsuke, Tochigi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan", 
            "Department of Pathology, Jichi Medical University, Shimotsuke, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakatani", 
        "givenName": "Takashi", 
        "id": "sg:person.0721206366.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721206366.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Kumamoto City Hospital, Kumamoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415532.4", 
          "name": [
            "Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan", 
            "Department of Pathology, Kumamoto City Hospital, Kumamoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arima", 
        "givenName": "Nobuyuki", 
        "id": "sg:person.016542450374.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016542450374.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Hakuaikai Medical Corporation, Sagara Hospital, Kagoshima, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan", 
            "Department of Pathology, Hakuaikai Medical Corporation, Sagara Hospital, Kagoshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohi", 
        "givenName": "Yasuyo", 
        "id": "sg:person.010707775024.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010707775024.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.420122.7", 
          "name": [
            "Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan", 
            "Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Honma", 
        "givenName": "Naoko", 
        "id": "sg:person.01211667405.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211667405.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Kawasaki Medical School, Kurashiki, Okayama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415086.e", 
          "name": [
            "Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan", 
            "Department of Pathology, Kawasaki Medical School, Kurashiki, Okayama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kanomata", 
        "givenName": "Naoki", 
        "id": "sg:person.01232455655.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232455655.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Breast Center, Northern Fukushima Medical Center, Fukushima, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan", 
            "Breast Center, Northern Fukushima Medical Center, Fukushima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Kazuya", 
        "id": "sg:person.01274374531.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274374531.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan", 
            "Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kadoya", 
        "givenName": "Takayuki", 
        "id": "sg:person.01101016506.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101016506.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Breast Surgery, Nahanishi Clinic, Okinawa, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan", 
            "Department of Breast Surgery, Nahanishi Clinic, Okinawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tamaki", 
        "givenName": "Kentaro", 
        "id": "sg:person.01345663202.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345663202.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kumaki", 
        "givenName": "Nobue", 
        "id": "sg:person.0646462256.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646462256.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412342.2", 
          "name": [
            "Department of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iwamoto", 
        "givenName": "Takayuki", 
        "id": "sg:person.01336535253.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336535253.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Breast Surgery, Kansai Medical University Hirakata Hospital, Hirakata, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "Department of Breast Surgery, Kansai Medical University Hirakata Hospital, Hirakata, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugie", 
        "givenName": "Tomoharu", 
        "id": "sg:person.0772725001.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772725001.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Kawasaki Medical School, Kurashiki, Okayama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415086.e", 
          "name": [
            "Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan", 
            "Department of Pathology, Kawasaki Medical School, Kurashiki, Okayama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moriya", 
        "givenName": "Takuya", 
        "id": "sg:person.01362514353.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362514353.82"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bjc.2012.166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000550332", 
          "https://doi.org/10.1038/bjc.2012.166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr2719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037594226", 
          "https://doi.org/10.1186/bcr2719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12282-012-0387-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032437219", 
          "https://doi.org/10.1007/s12282-012-0387-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12282-013-0460-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020443153", 
          "https://doi.org/10.1007/s12282-013-0460-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030523104", 
          "https://doi.org/10.1038/sj.bjc.6603756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-013-2691-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045256731", 
          "https://doi.org/10.1007/s10549-013-2691-y"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-05-03", 
    "datePublishedReg": "2014-05-03", 
    "description": "BackgroundA lack of consistent methods to evaluate Ki67 expression is problematic in terms of accurately predicting prognosis in breast cancer. Accordingly, this study aimed to identify the causes of discrepancies in Ki67 labeling index measurements by different observers under different conditions using breast cancer samples.Patients and methodsThis Japanese study group compared and assessed immunohistochemical (IHC) analysis of the Ki67 labeling index when measured by different pathologists. Six pathologists (pathologists A\u2013F) in Japan participated in this ring study. One hundred and ten surgical cases of estrogen receptor-positive and human epidermal growth factor receptor 2-negative invasive breast cancer treated in 2007 were identified from the breast cancer database of Tokai University Hospital and were included in this study.ResultsFor all 6 pathologists, the Ki67 labeling index were significantly different between grade 3 and grade 1 cases and between grade 3 and grade 2 cases, whereas the index tended to be different between grade 1 and grade 2 cases. Further, the Ki67 labeling indexes measured by the 6 pathologists were strongly correlated (\u03c1: 0.73\u20130.88). The IHC scores recorded by pathologist A were in moderate to good agreement with those recorded by the others in patients with a Ki67 labeling index of <13.25\u00a0% and in those with a Ki67 labeling index of >13.25\u00a0% (\u03ba\u00a0=\u00a00.429\u20130.660). The Ki67 low and high concordance rates between pathologist A and the others were 0.452\u20130.778 and 0.862\u20130.979, respectively. The most pertinent reason for discrepancy in scores seemed to be the selection of the area for counting and the quality of nuclear staining.ConclusionThe Ki67 labeling index measured by 6 pathologists without method standardization was in fair to good agreement. We plan to undertake a second ring study, pending recommendations by the international Ki67 panel.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s12282-014-0536-0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6120062", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6120807", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1021080", 
        "issn": [
          "1340-6868", 
          "1880-4233"
        ], 
        "name": "Breast Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "keywords": [
      "Ki67 labeling index", 
      "grade 2 cases", 
      "labeling index", 
      "breast cancer", 
      "grade 3", 
      "human epidermal growth factor receptor", 
      "Japanese Study Group", 
      "invasive breast cancer", 
      "grade 1 cases", 
      "Tokai University Hospital", 
      "breast cancer samples", 
      "epidermal growth factor receptor", 
      "high concordance rate", 
      "growth factor receptor", 
      "University Hospital", 
      "Cancer Database", 
      "study group", 
      "surgical cases", 
      "immunohistochemical analysis", 
      "IHC score", 
      "pathologist A", 
      "ring studies", 
      "grade 1", 
      "BackgroundA lack", 
      "concordance rate", 
      "cancer samples", 
      "breast cancer database", 
      "nuclear staining", 
      "factor receptor", 
      "pathologists", 
      "different pathologists", 
      "patients", 
      "cancer", 
      "scores", 
      "index", 
      "causes of discrepancies", 
      "prognosis", 
      "method standardization", 
      "estrogen", 
      "hospital", 
      "Ki67", 
      "study", 
      "cases", 
      "different observers", 
      "receptors", 
      "staining", 
      "cause", 
      "group", 
      "expression", 
      "index measurements", 
      "pertinent reasons", 
      "assessment", 
      "recommendations", 
      "database", 
      "rate", 
      "lack", 
      "discrepancy", 
      "consistent method", 
      "panel", 
      "standardization", 
      "samples", 
      "quality", 
      "reasons", 
      "counting", 
      "Japan", 
      "analysis", 
      "area", 
      "conditions", 
      "observer", 
      "selection", 
      "method", 
      "measurements", 
      "different conditions", 
      "terms", 
      "agreement", 
      "good agreement"
    ], 
    "name": "Assessment of the Ki67 labeling index: a Japanese validation ring study", 
    "pagination": "92-100", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051812100"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12282-014-0536-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24794952"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12282-014-0536-0", 
      "https://app.dimensions.ai/details/publication/pub.1051812100"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_624.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s12282-014-0536-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12282-014-0536-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12282-014-0536-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12282-014-0536-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12282-014-0536-0'


 

This table displays all metadata directly associated to this object as RDF triples.

360 TRIPLES      22 PREDICATES      127 URIs      113 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12282-014-0536-0 schema:about N165219ed005f4519b0b992ed8b3a1916
2 N21c8243df58b4683bc0f7e0419ef2b67
3 N27990a5417d945439a7ae3c8da084df0
4 N3a72dddf88724721b8e978ada99f4cbe
5 N3f00a5b13cf246e7b2c73a8c08605140
6 N4086e79deed44121bf75abfcad90c999
7 N41dc8c803cf94adf8630f88393a51aaa
8 N5764cb89dc634fdea43115fec06ab5d8
9 N5e91e4b8fccf431aa9ad111be0490d91
10 N5f82055647eb47e2a2e3b3b29b98bd31
11 N6f6d7b5b3b484322981dcdd2de3c51b5
12 N7d721e7d2c524534b7f898d2cb4aafa0
13 N80f0e390e9854c019fe18f643d3d615a
14 N959902fc5e61404ba4b985236dfb0c43
15 N9d00d11c897240c99dfc7c4f1188c159
16 Nadbf249e3aee4613bcf50f1f18fb635f
17 Ncb2aa1a966874450b18484735654aeca
18 Nd3ccf67ee74d45c89d4cb060479a644b
19 Nfe21d4abe62342aeaed7796399d6dd0e
20 anzsrc-for:11
21 anzsrc-for:1112
22 schema:author N03b1164b8a23412b91e0429a71dce801
23 schema:citation sg:pub.10.1007/s10549-013-2691-y
24 sg:pub.10.1007/s12282-012-0387-5
25 sg:pub.10.1007/s12282-013-0460-8
26 sg:pub.10.1038/bjc.2012.166
27 sg:pub.10.1038/sj.bjc.6603756
28 sg:pub.10.1186/bcr2719
29 schema:datePublished 2014-05-03
30 schema:datePublishedReg 2014-05-03
31 schema:description BackgroundA lack of consistent methods to evaluate Ki67 expression is problematic in terms of accurately predicting prognosis in breast cancer. Accordingly, this study aimed to identify the causes of discrepancies in Ki67 labeling index measurements by different observers under different conditions using breast cancer samples.Patients and methodsThis Japanese study group compared and assessed immunohistochemical (IHC) analysis of the Ki67 labeling index when measured by different pathologists. Six pathologists (pathologists A–F) in Japan participated in this ring study. One hundred and ten surgical cases of estrogen receptor-positive and human epidermal growth factor receptor 2-negative invasive breast cancer treated in 2007 were identified from the breast cancer database of Tokai University Hospital and were included in this study.ResultsFor all 6 pathologists, the Ki67 labeling index were significantly different between grade 3 and grade 1 cases and between grade 3 and grade 2 cases, whereas the index tended to be different between grade 1 and grade 2 cases. Further, the Ki67 labeling indexes measured by the 6 pathologists were strongly correlated (ρ: 0.73–0.88). The IHC scores recorded by pathologist A were in moderate to good agreement with those recorded by the others in patients with a Ki67 labeling index of <13.25 % and in those with a Ki67 labeling index of >13.25 % (κ = 0.429–0.660). The Ki67 low and high concordance rates between pathologist A and the others were 0.452–0.778 and 0.862–0.979, respectively. The most pertinent reason for discrepancy in scores seemed to be the selection of the area for counting and the quality of nuclear staining.ConclusionThe Ki67 labeling index measured by 6 pathologists without method standardization was in fair to good agreement. We plan to undertake a second ring study, pending recommendations by the international Ki67 panel.
32 schema:genre article
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf N1ef8f30dff04467bb9399bddb6443f64
36 N4d8e7ce616dd4fad9744fdfb0cfc7b9c
37 sg:journal.1021080
38 schema:keywords BackgroundA lack
39 Cancer Database
40 IHC score
41 Japan
42 Japanese Study Group
43 Ki67
44 Ki67 labeling index
45 Tokai University Hospital
46 University Hospital
47 agreement
48 analysis
49 area
50 assessment
51 breast cancer
52 breast cancer database
53 breast cancer samples
54 cancer
55 cancer samples
56 cases
57 cause
58 causes of discrepancies
59 concordance rate
60 conditions
61 consistent method
62 counting
63 database
64 different conditions
65 different observers
66 different pathologists
67 discrepancy
68 epidermal growth factor receptor
69 estrogen
70 expression
71 factor receptor
72 good agreement
73 grade 1
74 grade 1 cases
75 grade 2 cases
76 grade 3
77 group
78 growth factor receptor
79 high concordance rate
80 hospital
81 human epidermal growth factor receptor
82 immunohistochemical analysis
83 index
84 index measurements
85 invasive breast cancer
86 labeling index
87 lack
88 measurements
89 method
90 method standardization
91 nuclear staining
92 observer
93 panel
94 pathologist A
95 pathologists
96 patients
97 pertinent reasons
98 prognosis
99 quality
100 rate
101 reasons
102 receptors
103 recommendations
104 ring studies
105 samples
106 scores
107 selection
108 staining
109 standardization
110 study
111 study group
112 surgical cases
113 terms
114 schema:name Assessment of the Ki67 labeling index: a Japanese validation ring study
115 schema:pagination 92-100
116 schema:productId N1c673e5a440e48029c985cd528da73b4
117 N716be631f265415885b0d7154737b5a4
118 N7df16e43268d4a64804efb678c671d8c
119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051812100
120 https://doi.org/10.1007/s12282-014-0536-0
121 schema:sdDatePublished 2022-06-01T22:11
122 schema:sdLicense https://scigraph.springernature.com/explorer/license/
123 schema:sdPublisher Na8a13315a79b4b24877fc5a7215dd4b8
124 schema:url https://doi.org/10.1007/s12282-014-0536-0
125 sgo:license sg:explorer/license/
126 sgo:sdDataset articles
127 rdf:type schema:ScholarlyArticle
128 N03b1164b8a23412b91e0429a71dce801 rdf:first sg:person.01326170074.88
129 rdf:rest Nebfc8ba3a123473d9951fb99ce1cf5ef
130 N08547d8a5edc462c96c0e169e481f41f rdf:first sg:person.01336535253.17
131 rdf:rest N92278c2432b44b9fa798b33b24317e08
132 N1385270c58434f9782ff8c0ff3cc43e7 rdf:first sg:person.016542450374.76
133 rdf:rest N8c6c10d43e83459baa0e501554a1bd64
134 N165219ed005f4519b0b992ed8b3a1916 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Receptors, Estrogen
136 rdf:type schema:DefinedTerm
137 N1c673e5a440e48029c985cd528da73b4 schema:name dimensions_id
138 schema:value pub.1051812100
139 rdf:type schema:PropertyValue
140 N1ef8f30dff04467bb9399bddb6443f64 schema:issueNumber 1
141 rdf:type schema:PublicationIssue
142 N21c8243df58b4683bc0f7e0419ef2b67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Antineoplastic Agents, Hormonal
144 rdf:type schema:DefinedTerm
145 N27990a5417d945439a7ae3c8da084df0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Neoplasm Grading
147 rdf:type schema:DefinedTerm
148 N286eb838cc8a49e1bba5c7acb8cc115f rdf:first sg:person.01274374531.37
149 rdf:rest Nf7209e52a2334f8989c232628c16804d
150 N3a72dddf88724721b8e978ada99f4cbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Immunohistochemistry
152 rdf:type schema:DefinedTerm
153 N3f00a5b13cf246e7b2c73a8c08605140 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Neoplasm Staging
155 rdf:type schema:DefinedTerm
156 N4086e79deed44121bf75abfcad90c999 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Prognosis
158 rdf:type schema:DefinedTerm
159 N41dc8c803cf94adf8630f88393a51aaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Ki-67 Antigen
161 rdf:type schema:DefinedTerm
162 N488cb64d49db4e90923e770a494f582e rdf:first sg:person.01232455655.21
163 rdf:rest N286eb838cc8a49e1bba5c7acb8cc115f
164 N4d8e7ce616dd4fad9744fdfb0cfc7b9c schema:volumeNumber 23
165 rdf:type schema:PublicationVolume
166 N5764cb89dc634fdea43115fec06ab5d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Middle Aged
168 rdf:type schema:DefinedTerm
169 N5e91e4b8fccf431aa9ad111be0490d91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Receptor, ErbB-2
171 rdf:type schema:DefinedTerm
172 N5f82055647eb47e2a2e3b3b29b98bd31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Breast Neoplasms
174 rdf:type schema:DefinedTerm
175 N6f6d7b5b3b484322981dcdd2de3c51b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Japan
177 rdf:type schema:DefinedTerm
178 N716be631f265415885b0d7154737b5a4 schema:name doi
179 schema:value 10.1007/s12282-014-0536-0
180 rdf:type schema:PropertyValue
181 N7d721e7d2c524534b7f898d2cb4aafa0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Disease-Free Survival
183 rdf:type schema:DefinedTerm
184 N7df16e43268d4a64804efb678c671d8c schema:name pubmed_id
185 schema:value 24794952
186 rdf:type schema:PropertyValue
187 N80bbd613a33c4465831aa01d951fa251 rdf:first sg:person.01362514353.82
188 rdf:rest rdf:nil
189 N80f0e390e9854c019fe18f643d3d615a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Chemotherapy, Adjuvant
191 rdf:type schema:DefinedTerm
192 N8c6c10d43e83459baa0e501554a1bd64 rdf:first sg:person.010707775024.95
193 rdf:rest Nb0fbf53464f44e99b189800a61845655
194 N92278c2432b44b9fa798b33b24317e08 rdf:first sg:person.0772725001.72
195 rdf:rest N80bbd613a33c4465831aa01d951fa251
196 N959902fc5e61404ba4b985236dfb0c43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Carcinoma
198 rdf:type schema:DefinedTerm
199 N9d00d11c897240c99dfc7c4f1188c159 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Antineoplastic Agents
201 rdf:type schema:DefinedTerm
202 Na8a13315a79b4b24877fc5a7215dd4b8 schema:name Springer Nature - SN SciGraph project
203 rdf:type schema:Organization
204 Naa299e6337564ea7947fb1a131ac14a7 rdf:first sg:person.0646462256.82
205 rdf:rest N08547d8a5edc462c96c0e169e481f41f
206 Nadbf249e3aee4613bcf50f1f18fb635f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Reproducibility of Results
208 rdf:type schema:DefinedTerm
209 Nb0fbf53464f44e99b189800a61845655 rdf:first sg:person.01211667405.04
210 rdf:rest N488cb64d49db4e90923e770a494f582e
211 Ncb2aa1a966874450b18484735654aeca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Observer Variation
213 rdf:type schema:DefinedTerm
214 Nd3ccf67ee74d45c89d4cb060479a644b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Female
216 rdf:type schema:DefinedTerm
217 Ne3e10d21b5174278a40a9f0f6e9849cb rdf:first sg:person.01345663202.28
218 rdf:rest Naa299e6337564ea7947fb1a131ac14a7
219 Nebfc8ba3a123473d9951fb99ce1cf5ef rdf:first sg:person.0721206366.21
220 rdf:rest N1385270c58434f9782ff8c0ff3cc43e7
221 Nf7209e52a2334f8989c232628c16804d rdf:first sg:person.01101016506.11
222 rdf:rest Ne3e10d21b5174278a40a9f0f6e9849cb
223 Nfe21d4abe62342aeaed7796399d6dd0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Humans
225 rdf:type schema:DefinedTerm
226 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
227 schema:name Medical and Health Sciences
228 rdf:type schema:DefinedTerm
229 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
230 schema:name Oncology and Carcinogenesis
231 rdf:type schema:DefinedTerm
232 sg:grant.6120062 http://pending.schema.org/fundedItem sg:pub.10.1007/s12282-014-0536-0
233 rdf:type schema:MonetaryGrant
234 sg:grant.6120807 http://pending.schema.org/fundedItem sg:pub.10.1007/s12282-014-0536-0
235 rdf:type schema:MonetaryGrant
236 sg:journal.1021080 schema:issn 1340-6868
237 1880-4233
238 schema:name Breast Cancer
239 schema:publisher Springer Nature
240 rdf:type schema:Periodical
241 sg:person.010707775024.95 schema:affiliation grid-institutes:None
242 schema:familyName Ohi
243 schema:givenName Yasuyo
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010707775024.95
245 rdf:type schema:Person
246 sg:person.01101016506.11 schema:affiliation grid-institutes:None
247 schema:familyName Kadoya
248 schema:givenName Takayuki
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101016506.11
250 rdf:type schema:Person
251 sg:person.01211667405.04 schema:affiliation grid-institutes:grid.420122.7
252 schema:familyName Honma
253 schema:givenName Naoko
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211667405.04
255 rdf:type schema:Person
256 sg:person.01232455655.21 schema:affiliation grid-institutes:grid.415086.e
257 schema:familyName Kanomata
258 schema:givenName Naoki
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232455655.21
260 rdf:type schema:Person
261 sg:person.01274374531.37 schema:affiliation grid-institutes:None
262 schema:familyName Yoshida
263 schema:givenName Kazuya
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274374531.37
265 rdf:type schema:Person
266 sg:person.01326170074.88 schema:affiliation grid-institutes:None
267 schema:familyName Niikura
268 schema:givenName Naoki
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326170074.88
270 rdf:type schema:Person
271 sg:person.01336535253.17 schema:affiliation grid-institutes:grid.412342.2
272 schema:familyName Iwamoto
273 schema:givenName Takayuki
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336535253.17
275 rdf:type schema:Person
276 sg:person.01345663202.28 schema:affiliation grid-institutes:None
277 schema:familyName Tamaki
278 schema:givenName Kentaro
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345663202.28
280 rdf:type schema:Person
281 sg:person.01362514353.82 schema:affiliation grid-institutes:grid.415086.e
282 schema:familyName Moriya
283 schema:givenName Takuya
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362514353.82
285 rdf:type schema:Person
286 sg:person.016542450374.76 schema:affiliation grid-institutes:grid.415532.4
287 schema:familyName Arima
288 schema:givenName Nobuyuki
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016542450374.76
290 rdf:type schema:Person
291 sg:person.0646462256.82 schema:affiliation grid-institutes:grid.265061.6
292 schema:familyName Kumaki
293 schema:givenName Nobue
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646462256.82
295 rdf:type schema:Person
296 sg:person.0721206366.21 schema:affiliation grid-institutes:grid.410804.9
297 schema:familyName Sakatani
298 schema:givenName Takashi
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721206366.21
300 rdf:type schema:Person
301 sg:person.0772725001.72 schema:affiliation grid-institutes:grid.410783.9
302 schema:familyName Sugie
303 schema:givenName Tomoharu
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772725001.72
305 rdf:type schema:Person
306 sg:pub.10.1007/s10549-013-2691-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1045256731
307 https://doi.org/10.1007/s10549-013-2691-y
308 rdf:type schema:CreativeWork
309 sg:pub.10.1007/s12282-012-0387-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032437219
310 https://doi.org/10.1007/s12282-012-0387-5
311 rdf:type schema:CreativeWork
312 sg:pub.10.1007/s12282-013-0460-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020443153
313 https://doi.org/10.1007/s12282-013-0460-8
314 rdf:type schema:CreativeWork
315 sg:pub.10.1038/bjc.2012.166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000550332
316 https://doi.org/10.1038/bjc.2012.166
317 rdf:type schema:CreativeWork
318 sg:pub.10.1038/sj.bjc.6603756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030523104
319 https://doi.org/10.1038/sj.bjc.6603756
320 rdf:type schema:CreativeWork
321 sg:pub.10.1186/bcr2719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037594226
322 https://doi.org/10.1186/bcr2719
323 rdf:type schema:CreativeWork
324 grid-institutes:None schema:alternateName Breast Center, Northern Fukushima Medical Center, Fukushima, Japan
325 Department of Breast Surgery, Nahanishi Clinic, Okinawa, Japan
326 Department of Pathology, Hakuaikai Medical Corporation, Sagara Hospital, Kagoshima, Japan
327 Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima, Japan
328 Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan
329 schema:name Breast Center, Northern Fukushima Medical Center, Fukushima, Japan
330 Department of Breast Surgery, Nahanishi Clinic, Okinawa, Japan
331 Department of Breast and Endocrine Surgery, Tokai University School of Medicine, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan
332 Department of Pathology, Hakuaikai Medical Corporation, Sagara Hospital, Kagoshima, Japan
333 Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima, Japan
334 Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan
335 rdf:type schema:Organization
336 grid-institutes:grid.265061.6 schema:alternateName Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
337 schema:name Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
338 rdf:type schema:Organization
339 grid-institutes:grid.410783.9 schema:alternateName Department of Breast Surgery, Kansai Medical University Hirakata Hospital, Hirakata, Japan
340 schema:name Department of Breast Surgery, Kansai Medical University Hirakata Hospital, Hirakata, Japan
341 rdf:type schema:Organization
342 grid-institutes:grid.410804.9 schema:alternateName Department of Pathology, Jichi Medical University, Shimotsuke, Tochigi, Japan
343 schema:name Department of Pathology, Jichi Medical University, Shimotsuke, Tochigi, Japan
344 Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan
345 rdf:type schema:Organization
346 grid-institutes:grid.412342.2 schema:alternateName Department of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan
347 schema:name Department of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan
348 rdf:type schema:Organization
349 grid-institutes:grid.415086.e schema:alternateName Department of Pathology, Kawasaki Medical School, Kurashiki, Okayama, Japan
350 schema:name Department of Pathology, Kawasaki Medical School, Kurashiki, Okayama, Japan
351 Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan
352 rdf:type schema:Organization
353 grid-institutes:grid.415532.4 schema:alternateName Department of Pathology, Kumamoto City Hospital, Kumamoto, Japan
354 schema:name Department of Pathology, Kumamoto City Hospital, Kumamoto, Japan
355 Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan
356 rdf:type schema:Organization
357 grid-institutes:grid.420122.7 schema:alternateName Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
358 schema:name Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
359 Study Group of Standard Measurement of Ki67, The Japanese Society of Breast Cancer, Tokyo, Japan
360 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...