Repeat lumpectomy for ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery: the impact of radiotherapy on second IBTR View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-11

AUTHORS

Makoto Ishitobi, Yasuhiro Okumura, Reiki Nishimura, Katsuhiko Nakatsukasa, Masahiko Tanabe, Atsushi Yoshida, Norikazu Masuda, Tadahiko Shien, Satoru Tanaka, Yoshifumi Komoike, Nobuyuki Arima, Tetsuya Taguchi, Hideo Inaji, Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society

ABSTRACT

OBJECTIVES: There are limited data on the outcomes of patients treated with repeat lumpectomy at the time of ipsilateral breast tumor recurrence (IBTR). Especially, the impact of radiotherapy (RT) on a second IBTR is unknown. METHODS: We retrospectively analyzed 143 patients from 8 institutions in Japan who underwent repeat lumpectomy after IBTR. The risk factors of a second IBTR were assessed. RESULTS: The median follow-up period was 4.8 years. The 5-year second IBTR-free survival rate was 80.7 %. There was a significant difference in the second IBTR-free survival rate according to RT (p = 0.0003, log-rank test). The 5-year second IBTR-free survival rates for patients who received RT after initial surgery, RT after salvage surgery, and no RT were 78.0, 93.5, and 52.7 %, respectively. Multivariate analysis revealed that RT was a significantly independent predictive factor of second IBTR-free survival. CONCLUSION: Repeat lumpectomy plus RT is a reasonable option in patients who did not undergo RT at the initial surgery. In contrast, caution is needed when RT is omitted in patients who have undergone repeat lumpectomy. More... »

PAGES

754-760

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12282-013-0454-6

DOI

http://dx.doi.org/10.1007/s12282-013-0454-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005282051

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23483442


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