Dual human epidermal growth factor receptor 2 blockade for the treatment of HER2-positive breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-04

AUTHORS

Ricardo H. Alvarez, Gabriel N. Hortobagyi

ABSTRACT

The introduction of trastuzumab into clinical practice changed the natural course of HER2-positive breast cancer. Currently, treatment with trastuzumab represents the standard of care for HER2-positive breast cancer and this treatment has been approved in the adjuvant, neoadjuvant, and metastatic settings. Besides trastuzumab, two other anti-HER2 agents-lapatinib and pertuzumab-have been approved for the treatment of HER2-positive advanced breast cancer. Strong biologic data support the concept of dual HER2 blockade, with different anti-HER2 agents demonstrating complementary mechanisms of action. Several neoadjuvant and metastatic studies performed in HER2-positive breast cancer using dual HER2 blockade have been proven to outperform anti-HER2 monotherapies. These dual combinations of agents represent a promising therapeutic strategy that is now reaching clinical practice. In this review we describe the results of studies utilizing dual blockade in patients with HER2-positive breast cancer. More... »

PAGES

103-110

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12282-013-0446-6

DOI

http://dx.doi.org/10.1007/s12282-013-0446-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024666363

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23377763


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