A case of femoral diaphyseal fracture after long-term treatment with zoledronic acid View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01

AUTHORS

Kazuo Ishizuna, Daisuke Ota, Atsushi Fukuuchi, Megumi Teraoka, Akiko Fujii, Masaya Mori, Tsunehiro Nishi

ABSTRACT

We report here a case of femoral diaphyseal fracture thought to be caused by oversuppression of bone remodeling due to long-term bisphosphonate treatment. The patient was a 63-year-old postmenopausal woman. She had undergone left lumpectomy and sentinel node biopsy for left breast cancer at age 57. The case was diagnosed as pT2N0M0, stage IIA breast cancer. The biopsy sample was positive for hormone receptors and negative for HER2 protein. Postoperatively, exemestane was administered as adjuvant therapy. Right axillary lymph node metastasis was found at age 59, and right axillary lymph node dissection was performed. Postoperatively, epirubicin/cyclophosphamide and paclitaxel were administered. Subsequently, letrozole was administered. However, bone metastases to the first thoracic vertebra and right ilium were found at age 60, and zoledronic acid administration (4 mg/month) for bone metastasis was initiated. The patient developed a transverse fracture in the proximal left femoral diaphysis when she walked on a flat surface after zoledronic acid was administered for 2 years, 10 months. She was treated with an intramedullary nail for left femoral diaphyseal fracture. Cancellous bone of the medullary cavity was histopathologically examined, but there were no metastatic lesions from the breast cancer and no osteoblasts or osteoclasts were observed. Zoledronic acid was immediately discontinued in this patient. In recent years, cases of atypical femoral diaphyseal fractures caused by minor trauma in patients undergoing long-term bisphosphonate treatment have been reported. Thus, careful observation is required for patients who are anticipating bisphosphonate treatment. More... »

PAGES

90-94

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12282-011-0304-3

DOI

http://dx.doi.org/10.1007/s12282-011-0304-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020770206

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22009549


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Density Conservation Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diaphyses", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diphosphonates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Femoral Fractures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Imidazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Mitsui Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415980.1", 
          "name": [
            "Department of Breast Endocrine Surgery, Mitsui Memorial Hospital, Kandaizumicho-1, Chiyoda-ku, 101-8643, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishizuna", 
        "givenName": "Kazuo", 
        "id": "sg:person.01254146330.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254146330.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mitsui Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415980.1", 
          "name": [
            "Department of Breast Endocrine Surgery, Mitsui Memorial Hospital, Kandaizumicho-1, Chiyoda-ku, 101-8643, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ota", 
        "givenName": "Daisuke", 
        "id": "sg:person.01322261530.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322261530.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mitsui Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415980.1", 
          "name": [
            "Department of Breast Endocrine Surgery, Mitsui Memorial Hospital, Kandaizumicho-1, Chiyoda-ku, 101-8643, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukuuchi", 
        "givenName": "Atsushi", 
        "id": "sg:person.0577160670.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577160670.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mitsui Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415980.1", 
          "name": [
            "Department of Breast Endocrine Surgery, Mitsui Memorial Hospital, Kandaizumicho-1, Chiyoda-ku, 101-8643, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Teraoka", 
        "givenName": "Megumi", 
        "id": "sg:person.01230735700.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230735700.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mitsui Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415980.1", 
          "name": [
            "Department of Pathology, Mitsui Memorial Hospital, Kandaizumicho-1, Chiyoda-ku, 101-8643, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujii", 
        "givenName": "Akiko", 
        "id": "sg:person.01323012336.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323012336.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mitsui Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415980.1", 
          "name": [
            "Department of Pathology, Mitsui Memorial Hospital, Kandaizumicho-1, Chiyoda-ku, 101-8643, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mori", 
        "givenName": "Masaya", 
        "id": "sg:person.011212247232.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011212247232.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mitsui Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415980.1", 
          "name": [
            "Department of Breast Endocrine Surgery, Mitsui Memorial Hospital, Kandaizumicho-1, Chiyoda-ku, 101-8643, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishi", 
        "givenName": "Tsunehiro", 
        "id": "sg:person.01027635670.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027635670.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/ageing/afp106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001983090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.joms.2006.10.061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004679572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc0707493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009601896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00223-009-9263-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017723997", 
          "https://doi.org/10.1007/s00223-009-9263-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00223-009-9263-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017723997", 
          "https://doi.org/10.1007/s00223-009-9263-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00223-009-9263-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017723997", 
          "https://doi.org/10.1007/s00223-009-9263-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11420-008-9077-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019681031", 
          "https://doi.org/10.1007/s11420-008-9077-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11420-008-9077-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019681031", 
          "https://doi.org/10.1007/s11420-008-9077-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.injury.2007.08.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032691406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2265.2009.03581.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036690387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2265.2009.03581.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036690387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199612123352401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037742282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.2003.18.3.512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040177224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bot.0b013e318172841c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040390612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bot.0b013e318172841c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040390612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-009-0986-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042157593", 
          "https://doi.org/10.1007/s00198-009-0986-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-009-0986-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042157593", 
          "https://doi.org/10.1007/s00198-009-0986-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00198-009-0986-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042157593", 
          "https://doi.org/10.1007/s00198-009-0986-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s8756-3282(99)00116-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047104255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.05.116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052737086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1001086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053020064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.040126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053575389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/036354658201000407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063823686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/036354658201000407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063823686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2004-0952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064287920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.3.846", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074262164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074574398", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077528430", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1996.14.9.2552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082966142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.6.2038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083277768"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-01", 
    "datePublishedReg": "2015-01-01", 
    "description": "We report here a case of femoral diaphyseal fracture thought to be caused by oversuppression of bone remodeling due to long-term bisphosphonate treatment. The patient was a 63-year-old postmenopausal woman. She had undergone left lumpectomy and sentinel node biopsy for left breast cancer at age 57. The case was diagnosed as pT2N0M0, stage IIA breast cancer. The biopsy sample was positive for hormone receptors and negative for HER2 protein. Postoperatively, exemestane was administered as adjuvant therapy. Right axillary lymph node metastasis was found at age 59, and right axillary lymph node dissection was performed. Postoperatively, epirubicin/cyclophosphamide and paclitaxel were administered. Subsequently, letrozole was administered. However, bone metastases to the first thoracic vertebra and right ilium were found at age 60, and zoledronic acid administration (4 mg/month) for bone metastasis was initiated. The patient developed a transverse fracture in the proximal left femoral diaphysis when she walked on a flat surface after zoledronic acid was administered for 2 years, 10 months. She was treated with an intramedullary nail for left femoral diaphyseal fracture. Cancellous bone of the medullary cavity was histopathologically examined, but there were no metastatic lesions from the breast cancer and no osteoblasts or osteoclasts were observed. Zoledronic acid was immediately discontinued in this patient. In recent years, cases of atypical femoral diaphyseal fractures caused by minor trauma in patients undergoing long-term bisphosphonate treatment have been reported. Thus, careful observation is required for patients who are anticipating bisphosphonate treatment.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12282-011-0304-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1021080", 
        "issn": [
          "1340-6868", 
          "1880-4233"
        ], 
        "name": "Breast Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "name": "A case of femoral diaphyseal fracture after long-term treatment with zoledronic acid", 
    "pagination": "90-94", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "62f72e1e7ecec30581a6814797af6fac33a64d7258e4840bd9627d83cd8d6874"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22009549"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100888201"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12282-011-0304-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020770206"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12282-011-0304-3", 
      "https://app.dimensions.ai/details/publication/pub.1020770206"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000521.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12282-011-0304-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12282-011-0304-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12282-011-0304-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12282-011-0304-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12282-011-0304-3'


 

This table displays all metadata directly associated to this object as RDF triples.

223 TRIPLES      21 PREDICATES      62 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12282-011-0304-3 schema:about N0192974c4908405194fc2b2a6395b023
2 N01a2fecd3be64236a338163f9be64e08
3 N04e8f6cda43b4dfa857aa0cb1489b8cf
4 N2ed5d5ffa8a74d1b911bda6ab3ce6d1f
5 N5857ae4cda10411fbca1dc42ccf0a03b
6 N5a2c8af243c24c6198c75c1bcb563155
7 N64d345f95e8a4fedbea48643f268f512
8 N7e5e2c4f4c85419ab874ac0541c05487
9 N8bd6e907ad97444dac118a79cc20754b
10 Ne6a88ff6098c41038554f4acadb50f41
11 Nf0e09e9079384ecc8756ce99bfe919d9
12 anzsrc-for:11
13 anzsrc-for:1112
14 schema:author N51a10a70f3ae478c84f4d6063049f1f3
15 schema:citation sg:pub.10.1007/s00198-009-0986-y
16 sg:pub.10.1007/s00223-009-9263-5
17 sg:pub.10.1007/s11420-008-9077-4
18 https://app.dimensions.ai/details/publication/pub.1074574398
19 https://app.dimensions.ai/details/publication/pub.1077528430
20 https://doi.org/10.1016/j.injury.2007.08.036
21 https://doi.org/10.1016/j.joms.2006.10.061
22 https://doi.org/10.1016/s8756-3282(99)00116-7
23 https://doi.org/10.1056/nejm199612123352401
24 https://doi.org/10.1056/nejmc0707493
25 https://doi.org/10.1056/nejmoa1001086
26 https://doi.org/10.1093/ageing/afp106
27 https://doi.org/10.1097/bot.0b013e318172841c
28 https://doi.org/10.1111/j.1365-2265.2009.03581.x
29 https://doi.org/10.1177/036354658201000407
30 https://doi.org/10.1200/jco.1996.14.9.2552
31 https://doi.org/10.1200/jco.1998.16.6.2038
32 https://doi.org/10.1200/jco.1999.17.3.846
33 https://doi.org/10.1200/jco.2005.05.116
34 https://doi.org/10.1210/jc.2004-0952
35 https://doi.org/10.1359/jbmr.040126
36 https://doi.org/10.1359/jbmr.2003.18.3.512
37 schema:datePublished 2015-01
38 schema:datePublishedReg 2015-01-01
39 schema:description We report here a case of femoral diaphyseal fracture thought to be caused by oversuppression of bone remodeling due to long-term bisphosphonate treatment. The patient was a 63-year-old postmenopausal woman. She had undergone left lumpectomy and sentinel node biopsy for left breast cancer at age 57. The case was diagnosed as pT2N0M0, stage IIA breast cancer. The biopsy sample was positive for hormone receptors and negative for HER2 protein. Postoperatively, exemestane was administered as adjuvant therapy. Right axillary lymph node metastasis was found at age 59, and right axillary lymph node dissection was performed. Postoperatively, epirubicin/cyclophosphamide and paclitaxel were administered. Subsequently, letrozole was administered. However, bone metastases to the first thoracic vertebra and right ilium were found at age 60, and zoledronic acid administration (4 mg/month) for bone metastasis was initiated. The patient developed a transverse fracture in the proximal left femoral diaphysis when she walked on a flat surface after zoledronic acid was administered for 2 years, 10 months. She was treated with an intramedullary nail for left femoral diaphyseal fracture. Cancellous bone of the medullary cavity was histopathologically examined, but there were no metastatic lesions from the breast cancer and no osteoblasts or osteoclasts were observed. Zoledronic acid was immediately discontinued in this patient. In recent years, cases of atypical femoral diaphyseal fractures caused by minor trauma in patients undergoing long-term bisphosphonate treatment have been reported. Thus, careful observation is required for patients who are anticipating bisphosphonate treatment.
40 schema:genre research_article
41 schema:inLanguage en
42 schema:isAccessibleForFree false
43 schema:isPartOf Nbb6f98a50a1446a8a5dc2c69df2da5f8
44 Nd54323583a5943cfbefecc3d54a97208
45 sg:journal.1021080
46 schema:name A case of femoral diaphyseal fracture after long-term treatment with zoledronic acid
47 schema:pagination 90-94
48 schema:productId N2bf9524a18f14c13a8bbfa922c208573
49 N33320390dd644e8c8a0ffa2a95e708c1
50 N961b6f821eec44688b66c2ed281dfbf9
51 Nb61a58b5193847718107eb1bd488aa4f
52 Nb9fb5d60b08e4c9081caff5b1d44b9ab
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020770206
54 https://doi.org/10.1007/s12282-011-0304-3
55 schema:sdDatePublished 2019-04-10T15:03
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher N717ea16c5d034b02b190f312bb4b00ac
58 schema:url http://link.springer.com/10.1007%2Fs12282-011-0304-3
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N0192974c4908405194fc2b2a6395b023 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Time Factors
64 rdf:type schema:DefinedTerm
65 N01a2fecd3be64236a338163f9be64e08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Female
67 rdf:type schema:DefinedTerm
68 N04e8f6cda43b4dfa857aa0cb1489b8cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Diaphyses
70 rdf:type schema:DefinedTerm
71 N2bf9524a18f14c13a8bbfa922c208573 schema:name pubmed_id
72 schema:value 22009549
73 rdf:type schema:PropertyValue
74 N2ed5d5ffa8a74d1b911bda6ab3ce6d1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Bone Neoplasms
76 rdf:type schema:DefinedTerm
77 N33320390dd644e8c8a0ffa2a95e708c1 schema:name readcube_id
78 schema:value 62f72e1e7ecec30581a6814797af6fac33a64d7258e4840bd9627d83cd8d6874
79 rdf:type schema:PropertyValue
80 N51a10a70f3ae478c84f4d6063049f1f3 rdf:first sg:person.01254146330.77
81 rdf:rest Nc3b78533981c42edb3093ef04c01633c
82 N5857ae4cda10411fbca1dc42ccf0a03b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Imidazoles
84 rdf:type schema:DefinedTerm
85 N5a2c8af243c24c6198c75c1bcb563155 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Middle Aged
87 rdf:type schema:DefinedTerm
88 N64d345f95e8a4fedbea48643f268f512 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Femoral Fractures
90 rdf:type schema:DefinedTerm
91 N717ea16c5d034b02b190f312bb4b00ac schema:name Springer Nature - SN SciGraph project
92 rdf:type schema:Organization
93 N7e5e2c4f4c85419ab874ac0541c05487 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Bone Density Conservation Agents
95 rdf:type schema:DefinedTerm
96 N8bd6e907ad97444dac118a79cc20754b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Diphosphonates
98 rdf:type schema:DefinedTerm
99 N8ddf487016e3427ca9fc92e1583fe0a9 rdf:first sg:person.01027635670.00
100 rdf:rest rdf:nil
101 N961b6f821eec44688b66c2ed281dfbf9 schema:name dimensions_id
102 schema:value pub.1020770206
103 rdf:type schema:PropertyValue
104 Na5bffabec7244fb5ae85c0cf04330291 rdf:first sg:person.0577160670.06
105 rdf:rest Nd81aa18992ec4f529239774511610fc2
106 Nb4a4076835114b4cafe4539d1bbc0665 rdf:first sg:person.01323012336.93
107 rdf:rest Ncc30453b90594ad88cc58da25c4ad56b
108 Nb61a58b5193847718107eb1bd488aa4f schema:name doi
109 schema:value 10.1007/s12282-011-0304-3
110 rdf:type schema:PropertyValue
111 Nb9fb5d60b08e4c9081caff5b1d44b9ab schema:name nlm_unique_id
112 schema:value 100888201
113 rdf:type schema:PropertyValue
114 Nbb6f98a50a1446a8a5dc2c69df2da5f8 schema:volumeNumber 22
115 rdf:type schema:PublicationVolume
116 Nc3b78533981c42edb3093ef04c01633c rdf:first sg:person.01322261530.73
117 rdf:rest Na5bffabec7244fb5ae85c0cf04330291
118 Ncc30453b90594ad88cc58da25c4ad56b rdf:first sg:person.011212247232.09
119 rdf:rest N8ddf487016e3427ca9fc92e1583fe0a9
120 Nd54323583a5943cfbefecc3d54a97208 schema:issueNumber 1
121 rdf:type schema:PublicationIssue
122 Nd81aa18992ec4f529239774511610fc2 rdf:first sg:person.01230735700.55
123 rdf:rest Nb4a4076835114b4cafe4539d1bbc0665
124 Ne6a88ff6098c41038554f4acadb50f41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Humans
126 rdf:type schema:DefinedTerm
127 Nf0e09e9079384ecc8756ce99bfe919d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Breast Neoplasms
129 rdf:type schema:DefinedTerm
130 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
131 schema:name Medical and Health Sciences
132 rdf:type schema:DefinedTerm
133 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
134 schema:name Oncology and Carcinogenesis
135 rdf:type schema:DefinedTerm
136 sg:journal.1021080 schema:issn 1340-6868
137 1880-4233
138 schema:name Breast Cancer
139 rdf:type schema:Periodical
140 sg:person.01027635670.00 schema:affiliation https://www.grid.ac/institutes/grid.415980.1
141 schema:familyName Nishi
142 schema:givenName Tsunehiro
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027635670.00
144 rdf:type schema:Person
145 sg:person.011212247232.09 schema:affiliation https://www.grid.ac/institutes/grid.415980.1
146 schema:familyName Mori
147 schema:givenName Masaya
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011212247232.09
149 rdf:type schema:Person
150 sg:person.01230735700.55 schema:affiliation https://www.grid.ac/institutes/grid.415980.1
151 schema:familyName Teraoka
152 schema:givenName Megumi
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230735700.55
154 rdf:type schema:Person
155 sg:person.01254146330.77 schema:affiliation https://www.grid.ac/institutes/grid.415980.1
156 schema:familyName Ishizuna
157 schema:givenName Kazuo
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254146330.77
159 rdf:type schema:Person
160 sg:person.01322261530.73 schema:affiliation https://www.grid.ac/institutes/grid.415980.1
161 schema:familyName Ota
162 schema:givenName Daisuke
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322261530.73
164 rdf:type schema:Person
165 sg:person.01323012336.93 schema:affiliation https://www.grid.ac/institutes/grid.415980.1
166 schema:familyName Fujii
167 schema:givenName Akiko
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323012336.93
169 rdf:type schema:Person
170 sg:person.0577160670.06 schema:affiliation https://www.grid.ac/institutes/grid.415980.1
171 schema:familyName Fukuuchi
172 schema:givenName Atsushi
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577160670.06
174 rdf:type schema:Person
175 sg:pub.10.1007/s00198-009-0986-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1042157593
176 https://doi.org/10.1007/s00198-009-0986-y
177 rdf:type schema:CreativeWork
178 sg:pub.10.1007/s00223-009-9263-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017723997
179 https://doi.org/10.1007/s00223-009-9263-5
180 rdf:type schema:CreativeWork
181 sg:pub.10.1007/s11420-008-9077-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019681031
182 https://doi.org/10.1007/s11420-008-9077-4
183 rdf:type schema:CreativeWork
184 https://app.dimensions.ai/details/publication/pub.1074574398 schema:CreativeWork
185 https://app.dimensions.ai/details/publication/pub.1077528430 schema:CreativeWork
186 https://doi.org/10.1016/j.injury.2007.08.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032691406
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.joms.2006.10.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004679572
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/s8756-3282(99)00116-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047104255
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1056/nejm199612123352401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037742282
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1056/nejmc0707493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009601896
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1056/nejmoa1001086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053020064
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1093/ageing/afp106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001983090
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1097/bot.0b013e318172841c schema:sameAs https://app.dimensions.ai/details/publication/pub.1040390612
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1111/j.1365-2265.2009.03581.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036690387
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1177/036354658201000407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063823686
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1200/jco.1996.14.9.2552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082966142
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1200/jco.1998.16.6.2038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083277768
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1200/jco.1999.17.3.846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074262164
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1200/jco.2005.05.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052737086
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1210/jc.2004-0952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064287920
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1359/jbmr.040126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053575389
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1359/jbmr.2003.18.3.512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040177224
219 rdf:type schema:CreativeWork
220 https://www.grid.ac/institutes/grid.415980.1 schema:alternateName Mitsui Memorial Hospital
221 schema:name Department of Breast Endocrine Surgery, Mitsui Memorial Hospital, Kandaizumicho-1, Chiyoda-ku, 101-8643, Tokyo, Japan
222 Department of Pathology, Mitsui Memorial Hospital, Kandaizumicho-1, Chiyoda-ku, 101-8643, Tokyo, Japan
223 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...