pH-sensitive zwitterionic coating of gold nanocages improves tumor targeting and photothermal treatment efficacy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-05-22

AUTHORS

Ji-Gang Piao, Feng Gao, Yunong Li, Lei Yu, Dong Liu, Zi-Bin Tan, Yujie Xiong, Lihua Yang, Ye-Zi You

ABSTRACT

Stealth coating materials effectively extend a nanoparticle’s systemic circulation lifetime yet limit its cellular internalization, which promotes and prevents tumor targeting, respectively. Here, this contradiction was resolved by using an acutely pH-sensitive zwitterionic stealth ligand capable of responding to small differences in extracellular pH between blood and tumors. Using a photothermal gold nanocage (AuNC) as a model nanotherapeutic, we found that stealth-AuNC nanoparticles showed both significantly enhanced cell uptake efficiency in acidic tumors and a markedly extended systemic circulation lifetime compared to its unaltered analogue. As a result, stealth-AuNC nanoparticles administered intravenously showed significantly enhanced accumulation within the tumor, leading to significantly improved photothermal therapeutic efficacy in mouse models. These results suggests that pH-sensitive zwitterionic ligands with sufficient sensitivity for responding to small differences in extracellular pH between blood and tumors are ideal stealth materials for simultaneously conferring both extended systemic circulation and enhanced cellular internalization, reducing the need for active targeting moieties. More... »

PAGES

3193-3204

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12274-017-1736-7

DOI

http://dx.doi.org/10.1007/s12274-017-1736-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091099765


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