Determination of piroxicam from rat articular tissue and plasma based on LC–MS/MS View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-12

AUTHORS

Han Sol Kim, Ha Ra Cho, Myoung Jin Ho, Myung Joo Kang, Yong Seok Choi

ABSTRACT

Osteoarthritis (OA) is the most common type of arthritis. To manage OA, in general, oral administration of non-steroidal anti-inflammatory drugs (NSAIDs) is used. Recently, the analgesic and anti-inflammatory efficacy of piroxicam (PX), a long-acting NSAID, by intra-articular (IA) administration in OA was reported, and the possibility that PX is distributed in articular tissues at a certain concentration was raised. Thus, herein, novel LC-MS/MS methods to detect PX in rat articular tissue and plasma are presented. For articular tissue, solvent extraction with acetonitrile for 12 h was employed and a protein precipitation method was used for the preparation of a plasma sample. The developed methods were validated by following the FDA guidelines, and the validated methods were successfully applied to a PK study of IA PX. The present study presents, to our knowledge, the first method of determining a drug in articular tissue. Additionally, the level of PX in articular tissue after IA PX administration was experimentally confirmed for the first time using the present methods. Therefore, the present methods provide a new direction for in vivo evaluation for IA PX formulations and contribute to the development of alternative IA PX formulations with better effects for the treatment of OA. More... »

PAGES

1653-1662

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12272-016-0845-2

DOI

http://dx.doi.org/10.1007/s12272-016-0845-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012347907

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27752829


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Inflammatory Agents, Non-Steroidal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cartilage, Articular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatography, Liquid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Intra-Articular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Piroxicam", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tandem Mass Spectrometry", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Dankook University", 
          "id": "https://www.grid.ac/institutes/grid.411982.7", 
          "name": [
            "College of Pharmacy, Dankook University, 31116, Cheonan, Chungnam, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Han Sol", 
        "id": "sg:person.015076766125.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015076766125.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dankook University", 
          "id": "https://www.grid.ac/institutes/grid.411982.7", 
          "name": [
            "College of Pharmacy, Dankook University, 31116, Cheonan, Chungnam, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Ha Ra", 
        "id": "sg:person.01075350111.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075350111.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dankook University", 
          "id": "https://www.grid.ac/institutes/grid.411982.7", 
          "name": [
            "College of Pharmacy, Dankook University, 31116, Cheonan, Chungnam, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ho", 
        "givenName": "Myoung Jin", 
        "id": "sg:person.0603242247.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603242247.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dankook University", 
          "id": "https://www.grid.ac/institutes/grid.411982.7", 
          "name": [
            "College of Pharmacy, Dankook University, 31116, Cheonan, Chungnam, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kang", 
        "givenName": "Myung Joo", 
        "id": "sg:person.0751012456.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751012456.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dankook University", 
          "id": "https://www.grid.ac/institutes/grid.411982.7", 
          "name": [
            "College of Pharmacy, Dankook University, 31116, Cheonan, Chungnam, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Yong Seok", 
        "id": "sg:person.0651772704.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651772704.56"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1136/bmj.325.7365.619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009981204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.11094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011985479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semarthrit.2015.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012009829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03013953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014934788", 
          "https://doi.org/10.1007/bf03013953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03013953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014934788", 
          "https://doi.org/10.1007/bf03013953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/clpt.1985.4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017139461", 
          "https://doi.org/10.1038/clpt.1985.4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-198427030-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018799345", 
          "https://doi.org/10.2165/00003495-198427030-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.4869683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019738987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4062/biomolther.2014.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019851830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-6576.1996.tb05554.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020851342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jat/29.7.599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022434925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2298/hemind130306034n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022704952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.berh.2014.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024163074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(14)60802-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029377549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12272-015-0681-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036791991", 
          "https://doi.org/10.1007/s12272-015-0681-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0954-6820.1984.tb04973.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041186549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0954-6820.1984.tb04973.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041186549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jps.20341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046710243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.joca.2003.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048837773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-005-1136-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049665666", 
          "https://doi.org/10.1007/s10067-005-1136-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-005-1136-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049665666", 
          "https://doi.org/10.1007/s10067-005-1136-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1081/jlc-100102370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058432444"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "Osteoarthritis (OA) is the most common type of arthritis. To manage OA, in general, oral administration of non-steroidal anti-inflammatory drugs (NSAIDs) is used. Recently, the analgesic and anti-inflammatory efficacy of piroxicam (PX), a long-acting NSAID, by intra-articular (IA) administration in OA was reported, and the possibility that PX is distributed in articular tissues at a certain concentration was raised. Thus, herein, novel LC-MS/MS methods to detect PX in rat articular tissue and plasma are presented. For articular tissue, solvent extraction with acetonitrile for 12\u00a0h was employed and a protein precipitation method was used for the preparation of a plasma sample. The developed methods were validated by following the FDA guidelines, and the validated methods were successfully applied to a PK study of IA PX. The present study presents, to our knowledge, the first method of determining a drug in articular tissue. Additionally, the level of PX in articular tissue after IA PX administration was experimentally confirmed for the first time using the present methods. Therefore, the present methods provide a new direction for in vivo evaluation for IA PX formulations and contribute to the development of alternative IA PX formulations with better effects for the treatment of OA.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12272-016-0845-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1090680", 
        "issn": [
          "0253-6269", 
          "1976-3786"
        ], 
        "name": "Archives of Pharmacal Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "39"
      }
    ], 
    "name": "Determination of piroxicam from rat articular tissue and plasma based on LC\u2013MS/MS", 
    "pagination": "1653-1662", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3ad44d14c0c479f19b9b2059b648131fc4f8be695a17b734fe916696f7011ceb"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27752829"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8000036"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12272-016-0845-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012347907"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12272-016-0845-2", 
      "https://app.dimensions.ai/details/publication/pub.1012347907"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87104_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12272-016-0845-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12272-016-0845-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12272-016-0845-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12272-016-0845-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12272-016-0845-2'


 

This table displays all metadata directly associated to this object as RDF triples.

191 TRIPLES      21 PREDICATES      56 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12272-016-0845-2 schema:about N04b8751fc2b7417fbd6eaa5911d64d45
2 N3cbc5a56341d4aae94a2fb00ef800bb5
3 N4fa7d0397d53493bb88c02328ab32290
4 N79d44631e7cf42f5a3e6edc9a8b5bf7a
5 N7ea6e4cbf35b4ac09f0b6b1a3d7481b7
6 N7ff814b332d2450fb6ac66939044d376
7 N9d4dc46dea5e41b8b7ff4be152010946
8 Nd7ffd60af45b4acbaba4454e0b176fb9
9 anzsrc-for:11
10 anzsrc-for:1103
11 schema:author Nbf856de9fc4a47dba8f8f126c3969423
12 schema:citation sg:pub.10.1007/bf03013953
13 sg:pub.10.1007/s10067-005-1136-3
14 sg:pub.10.1007/s12272-015-0681-9
15 sg:pub.10.1038/clpt.1985.4
16 sg:pub.10.2165/00003495-198427030-00004
17 https://doi.org/10.1002/art.11094
18 https://doi.org/10.1002/jps.20341
19 https://doi.org/10.1016/j.berh.2014.08.002
20 https://doi.org/10.1016/j.joca.2003.09.007
21 https://doi.org/10.1016/j.semarthrit.2015.11.009
22 https://doi.org/10.1016/s0140-6736(14)60802-3
23 https://doi.org/10.1063/1.4869683
24 https://doi.org/10.1081/jlc-100102370
25 https://doi.org/10.1093/jat/29.7.599
26 https://doi.org/10.1111/j.0954-6820.1984.tb04973.x
27 https://doi.org/10.1111/j.1399-6576.1996.tb05554.x
28 https://doi.org/10.1136/bmj.325.7365.619
29 https://doi.org/10.2298/hemind130306034n
30 https://doi.org/10.4062/biomolther.2014.037
31 schema:datePublished 2016-12
32 schema:datePublishedReg 2016-12-01
33 schema:description Osteoarthritis (OA) is the most common type of arthritis. To manage OA, in general, oral administration of non-steroidal anti-inflammatory drugs (NSAIDs) is used. Recently, the analgesic and anti-inflammatory efficacy of piroxicam (PX), a long-acting NSAID, by intra-articular (IA) administration in OA was reported, and the possibility that PX is distributed in articular tissues at a certain concentration was raised. Thus, herein, novel LC-MS/MS methods to detect PX in rat articular tissue and plasma are presented. For articular tissue, solvent extraction with acetonitrile for 12 h was employed and a protein precipitation method was used for the preparation of a plasma sample. The developed methods were validated by following the FDA guidelines, and the validated methods were successfully applied to a PK study of IA PX. The present study presents, to our knowledge, the first method of determining a drug in articular tissue. Additionally, the level of PX in articular tissue after IA PX administration was experimentally confirmed for the first time using the present methods. Therefore, the present methods provide a new direction for in vivo evaluation for IA PX formulations and contribute to the development of alternative IA PX formulations with better effects for the treatment of OA.
34 schema:genre research_article
35 schema:inLanguage en
36 schema:isAccessibleForFree false
37 schema:isPartOf N08e4283c3b35429d8cdc8b184804de33
38 N45445fb941004b8d8c12bd15eb4b033c
39 sg:journal.1090680
40 schema:name Determination of piroxicam from rat articular tissue and plasma based on LC–MS/MS
41 schema:pagination 1653-1662
42 schema:productId N0c0db8db761942208002b3090ab29fc3
43 N68cacd16ab324905b3993943083d5e43
44 N912457796c314980aa23dabf5caf02ae
45 Nab4430dfc77242058311a0b3fc92a457
46 Nd77bace23dbe4c0b8192ba45955b48db
47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012347907
48 https://doi.org/10.1007/s12272-016-0845-2
49 schema:sdDatePublished 2019-04-11T12:25
50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
51 schema:sdPublisher N20f7becdd572442482b43ef890b63bbf
52 schema:url https://link.springer.com/10.1007%2Fs12272-016-0845-2
53 sgo:license sg:explorer/license/
54 sgo:sdDataset articles
55 rdf:type schema:ScholarlyArticle
56 N04b8751fc2b7417fbd6eaa5911d64d45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
57 schema:name Animals
58 rdf:type schema:DefinedTerm
59 N08e4283c3b35429d8cdc8b184804de33 schema:issueNumber 12
60 rdf:type schema:PublicationIssue
61 N0c0db8db761942208002b3090ab29fc3 schema:name readcube_id
62 schema:value 3ad44d14c0c479f19b9b2059b648131fc4f8be695a17b734fe916696f7011ceb
63 rdf:type schema:PropertyValue
64 N20f7becdd572442482b43ef890b63bbf schema:name Springer Nature - SN SciGraph project
65 rdf:type schema:Organization
66 N3cbc5a56341d4aae94a2fb00ef800bb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Chromatography, Liquid
68 rdf:type schema:DefinedTerm
69 N45445fb941004b8d8c12bd15eb4b033c schema:volumeNumber 39
70 rdf:type schema:PublicationVolume
71 N4fa7d0397d53493bb88c02328ab32290 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Piroxicam
73 rdf:type schema:DefinedTerm
74 N68cacd16ab324905b3993943083d5e43 schema:name doi
75 schema:value 10.1007/s12272-016-0845-2
76 rdf:type schema:PropertyValue
77 N79d44631e7cf42f5a3e6edc9a8b5bf7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Anti-Inflammatory Agents, Non-Steroidal
79 rdf:type schema:DefinedTerm
80 N7ea6e4cbf35b4ac09f0b6b1a3d7481b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Cartilage, Articular
82 rdf:type schema:DefinedTerm
83 N7ff814b332d2450fb6ac66939044d376 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Rats
85 rdf:type schema:DefinedTerm
86 N912457796c314980aa23dabf5caf02ae schema:name dimensions_id
87 schema:value pub.1012347907
88 rdf:type schema:PropertyValue
89 N9d4dc46dea5e41b8b7ff4be152010946 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Injections, Intra-Articular
91 rdf:type schema:DefinedTerm
92 Nab4430dfc77242058311a0b3fc92a457 schema:name pubmed_id
93 schema:value 27752829
94 rdf:type schema:PropertyValue
95 Nbb950c1d6de6406cb9a050cef43236c2 rdf:first sg:person.0751012456.28
96 rdf:rest Nd266c81b3de14f9ba602f31442cab004
97 Nbf856de9fc4a47dba8f8f126c3969423 rdf:first sg:person.015076766125.00
98 rdf:rest Nec8a5877a629471fa82f8d78d7a1fe03
99 Nd266c81b3de14f9ba602f31442cab004 rdf:first sg:person.0651772704.56
100 rdf:rest rdf:nil
101 Nd77bace23dbe4c0b8192ba45955b48db schema:name nlm_unique_id
102 schema:value 8000036
103 rdf:type schema:PropertyValue
104 Nd7ffd60af45b4acbaba4454e0b176fb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Tandem Mass Spectrometry
106 rdf:type schema:DefinedTerm
107 Nec8a5877a629471fa82f8d78d7a1fe03 rdf:first sg:person.01075350111.49
108 rdf:rest Nee62c9ec8edb4350bf219e67dfeaad72
109 Nee62c9ec8edb4350bf219e67dfeaad72 rdf:first sg:person.0603242247.31
110 rdf:rest Nbb950c1d6de6406cb9a050cef43236c2
111 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
112 schema:name Medical and Health Sciences
113 rdf:type schema:DefinedTerm
114 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
115 schema:name Clinical Sciences
116 rdf:type schema:DefinedTerm
117 sg:journal.1090680 schema:issn 0253-6269
118 1976-3786
119 schema:name Archives of Pharmacal Research
120 rdf:type schema:Periodical
121 sg:person.01075350111.49 schema:affiliation https://www.grid.ac/institutes/grid.411982.7
122 schema:familyName Cho
123 schema:givenName Ha Ra
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075350111.49
125 rdf:type schema:Person
126 sg:person.015076766125.00 schema:affiliation https://www.grid.ac/institutes/grid.411982.7
127 schema:familyName Kim
128 schema:givenName Han Sol
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015076766125.00
130 rdf:type schema:Person
131 sg:person.0603242247.31 schema:affiliation https://www.grid.ac/institutes/grid.411982.7
132 schema:familyName Ho
133 schema:givenName Myoung Jin
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603242247.31
135 rdf:type schema:Person
136 sg:person.0651772704.56 schema:affiliation https://www.grid.ac/institutes/grid.411982.7
137 schema:familyName Choi
138 schema:givenName Yong Seok
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651772704.56
140 rdf:type schema:Person
141 sg:person.0751012456.28 schema:affiliation https://www.grid.ac/institutes/grid.411982.7
142 schema:familyName Kang
143 schema:givenName Myung Joo
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751012456.28
145 rdf:type schema:Person
146 sg:pub.10.1007/bf03013953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014934788
147 https://doi.org/10.1007/bf03013953
148 rdf:type schema:CreativeWork
149 sg:pub.10.1007/s10067-005-1136-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049665666
150 https://doi.org/10.1007/s10067-005-1136-3
151 rdf:type schema:CreativeWork
152 sg:pub.10.1007/s12272-015-0681-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036791991
153 https://doi.org/10.1007/s12272-015-0681-9
154 rdf:type schema:CreativeWork
155 sg:pub.10.1038/clpt.1985.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017139461
156 https://doi.org/10.1038/clpt.1985.4
157 rdf:type schema:CreativeWork
158 sg:pub.10.2165/00003495-198427030-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018799345
159 https://doi.org/10.2165/00003495-198427030-00004
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1002/art.11094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011985479
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1002/jps.20341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046710243
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/j.berh.2014.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024163074
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/j.joca.2003.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048837773
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1016/j.semarthrit.2015.11.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012009829
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/s0140-6736(14)60802-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029377549
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1063/1.4869683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019738987
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1081/jlc-100102370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058432444
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1093/jat/29.7.599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022434925
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1111/j.0954-6820.1984.tb04973.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041186549
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1111/j.1399-6576.1996.tb05554.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020851342
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1136/bmj.325.7365.619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009981204
184 rdf:type schema:CreativeWork
185 https://doi.org/10.2298/hemind130306034n schema:sameAs https://app.dimensions.ai/details/publication/pub.1022704952
186 rdf:type schema:CreativeWork
187 https://doi.org/10.4062/biomolther.2014.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019851830
188 rdf:type schema:CreativeWork
189 https://www.grid.ac/institutes/grid.411982.7 schema:alternateName Dankook University
190 schema:name College of Pharmacy, Dankook University, 31116, Cheonan, Chungnam, South Korea
191 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...