New ursane triterpenoids from Ficus pandurata and their binding affinity for human cannabinoid and opioid receptors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-07

AUTHORS

Amgad I. M. Khedr, Sabrin R. M. Ibrahim, Gamal A. Mohamed, Hany E. A. Ahmed, Amany S. Ahmad, Mahmoud A. Ramadan, Atef E. Abd El-Baky, Koji Yamada, Samir A. Ross

ABSTRACT

Phytochemical investigation of Ficus pandurata Hance (Moraceae) fruits has led to the isolation of two new triterpenoids, ficupanduratin A [1β-hydroxy-3β-acetoxy-11α-methoxy-urs-12-ene] (11) and ficupanduratin B [21α-hydroxy-3β-acetoxy-11α-methoxy-urs-12-ene] (17), along with 20 known compounds: α-amyrin acetate (1), α-amyrin (2), 3β-acetoxy-20-taraxasten-22-one (3), 3β-acetoxy-11α-methoxy-olean-12-ene (4), 3β-acetoxy-11α-methoxy-12-ursene (5), 11-oxo-α-amyrin acetate (6), 11-oxo-β-amyrin acetate (7), palmitic acid (8), stigmast-4,22-diene-3,6-dione (9), stigmast-4-ene-3,6-dione (10), stigmasterol (12), β-sitosterol (13), stigmast-22-ene-3,6-dione (14), stigmastane-3,6-dione (15), 3β,21β-dihydroxy-11α-methoxy-olean-12-ene (16), 3β-hydroxy-11α-methoxyurs-12-ene (18), 6-hydroxystigmast-4,22-diene-3-one (19), 6-hydroxystigmast-4-ene-3-one (20), 11α,21α-dihydroxy-3β-acetoxy-urs-12-ene (21), and β-sitosterol-3-O-β-D-glucopyranoside (22). Compound 21 is reported for the first time from a natural source. The structures of the 20 compounds were elucidated on the basis of IR, 1D ((1)H and (13)C), 2D ((1)H-(1)H COSY, HSQC, HMBC and NOESY) NMR and MS spectroscopic data, in addition to comparison with literature data. The isolated compounds were evaluated for their anti-microbial, anti-malarial, anti-leishmanial, and cytotoxic activities. In addition, their radioligand displacement affinity on opioid and cannabinoid receptors was assessed. Compounds 4, 11, and 15 exhibited good affinity towards the CB2 receptor, with displacement values of 69.7, 62.5 and 86.5 %, respectively. Furthermore, the binding mode of the active compounds in the active site of the CB2 cannabinoid receptors was investigated through molecular modelling. More... »

PAGES

897-911

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12272-016-0784-y

DOI

http://dx.doi.org/10.1007/s12272-016-0784-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037626683

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27350550


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0305", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Organic Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cercopithecus aethiops", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ficus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fruit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plant Extracts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Secondary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Tertiary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Cannabinoid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Opioid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Triterpenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vero Cells", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Port Said University", 
          "id": "https://www.grid.ac/institutes/grid.440879.6", 
          "name": [
            "Department of Pharmacognosy, Faculty of Pharmacy, Port Said University, 42526, Port Said, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khedr", 
        "givenName": "Amgad I. M.", 
        "id": "sg:person.01352234123.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352234123.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assiut University", 
          "id": "https://www.grid.ac/institutes/grid.252487.e", 
          "name": [
            "Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, 30078, Al Madinah Al Munawarah, Saudi Arabia", 
            "Department of Pharmacognosy, Faculty of Pharmacy, Assuit University, 71526, Assuit, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ibrahim", 
        "givenName": "Sabrin R. M.", 
        "id": "sg:person.01216541777.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216541777.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Al Azhar University", 
          "id": "https://www.grid.ac/institutes/grid.411303.4", 
          "name": [
            "Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, 21589, Jeddah, Saudi Arabia", 
            "Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assuit Branch, 71524, Assuit, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mohamed", 
        "givenName": "Gamal A.", 
        "id": "sg:person.01243521744.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243521744.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Al Azhar University", 
          "id": "https://www.grid.ac/institutes/grid.411303.4", 
          "name": [
            "Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, 30078, Al Madinah Al Munawarah, Saudi Arabia", 
            "Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahmed", 
        "givenName": "Hany E. A.", 
        "id": "sg:person.01277352445.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277352445.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assiut University", 
          "id": "https://www.grid.ac/institutes/grid.252487.e", 
          "name": [
            "Department of Pharmacognosy, Faculty of Pharmacy, Assuit University, 71526, Assuit, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahmad", 
        "givenName": "Amany S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assiut University", 
          "id": "https://www.grid.ac/institutes/grid.252487.e", 
          "name": [
            "Department of Pharmacognosy, Faculty of Pharmacy, Assuit University, 71526, Assuit, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ramadan", 
        "givenName": "Mahmoud A.", 
        "id": "sg:person.01365227326.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365227326.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Port Said University", 
          "id": "https://www.grid.ac/institutes/grid.440879.6", 
          "name": [
            "Department of Biochemistry, Faculty of Pharmacy, Port Said University, 42526, Port Said, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "El-Baky", 
        "givenName": "Atef E. Abd", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagasaki University", 
          "id": "https://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Garden for Medicinal Plants, Graduate School of Biomedical Sciences, Nagasaki University, Bunkyo-machi 1-14, 852-8521, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamada", 
        "givenName": "Koji", 
        "id": "sg:person.0717770760.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717770760.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Mississippi", 
          "id": "https://www.grid.ac/institutes/grid.251313.7", 
          "name": [
            "National Center for Natural Products Research, and Department of Pharmacognosy, School of Pharmacy, University of Mississippi, 38677, University, MS, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ross", 
        "givenName": "Samir A.", 
        "id": "sg:person.013317722457.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013317722457.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0031-9422(00)89569-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002306865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/14786410802362204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003033599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/bot.2008.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004655659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4314/bcse.v19i2.21137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005253299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4314/bcse.v19i2.21137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005253299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hlca.200490097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006290100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4172/1948-593x.s12-005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006431780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10286020310001608958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010246943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00044-013-0536-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011599856", 
          "https://doi.org/10.1007/s00044-013-0536-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2621.2001.tb11332.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012921010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phytochem.2004.12.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013012770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrc.1347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013724201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13880209.2014.898078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013823316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-8741(94)90060-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014465654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-8741(94)90060-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014465654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bmc.3366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014675335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3329/icpj.v1i9.11613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015660374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3329/icpj.v1i9.11613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015660374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phytol.2013.04.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015757685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/14786419.2014.902820", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017427667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02624436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017444703", 
          "https://doi.org/10.1007/bf02624436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02624436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017444703", 
          "https://doi.org/10.1007/bf02624436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamcr.2011.05.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018179202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/365061a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020160837", 
          "https://doi.org/10.1038/365061a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.47.498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024433246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phytol.2015.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024961050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coph.2009.09.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026457413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jep.2011.01.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027467157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/14786419.2014.915831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028971547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2191-2858-2-32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030883092", 
          "https://doi.org/10.1186/2191-2858-2-32"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0031-9422(99)00557-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031982115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0031-9422(98)00578-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032852395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0706414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034013461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0706414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034013461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.steroids.2006.01.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034310496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s0103-50532000000200017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034887015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.49.581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035705668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules18044247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035718866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/3-540-26573-2_3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036648227", 
          "https://doi.org/10.1007/3-540-26573-2_3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s0103-50532010000800004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036803499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/14786410902757899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037113461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules17032587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037364688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules17032587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037364688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3329/dujs.v60i1.10327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038317901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3329/dujs.v60i1.10327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038317901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5381.2009.00271.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038340456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5381.2009.00271.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038340456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1472-765x.2000.00731.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039083724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phytol.2012.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040257712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phytol.2015.12.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040554026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10286029908039875", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040929390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1202793", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041128869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1752-153x-7-153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041141957", 
          "https://doi.org/10.1186/1752-153x-7-153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/biof.5520280303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043285045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0029-1186102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045699286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkl999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045899264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phytochem.2012.07.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047138538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.48.593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047632520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047634683", 
          "https://doi.org/10.1038/nature09746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jep.2015.11.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047879647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phytochem.2007.10.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049137579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/14786419.2015.1072711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050052017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.steroids.2005.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050328313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b515312n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050397683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.53.561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051324651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phytol.2010.12.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051396720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0707567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051477731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phytol.2015.03.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052501827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4172/2329-6836.1000169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052726165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/13880200701212916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053190286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.54.740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053230466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo0057351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055985998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo0057351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055985998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo020262e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056016945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo020262e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056016945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np0004808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056227947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np0004808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056227947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np300653d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056232110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np990165p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056239695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np990165p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056239695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0033-1351099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057294319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2003-39703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057422144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2003-39705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057422146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/138920112798868719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069178004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3998/ark.5550190.0008.f27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071816713"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-07", 
    "datePublishedReg": "2016-07-01", 
    "description": "Phytochemical investigation of Ficus pandurata Hance (Moraceae) fruits has led to the isolation of two new triterpenoids, ficupanduratin A [1\u03b2-hydroxy-3\u03b2-acetoxy-11\u03b1-methoxy-urs-12-ene] (11) and ficupanduratin B [21\u03b1-hydroxy-3\u03b2-acetoxy-11\u03b1-methoxy-urs-12-ene] (17), along with 20 known compounds: \u03b1-amyrin acetate (1), \u03b1-amyrin (2), 3\u03b2-acetoxy-20-taraxasten-22-one (3), 3\u03b2-acetoxy-11\u03b1-methoxy-olean-12-ene (4), 3\u03b2-acetoxy-11\u03b1-methoxy-12-ursene (5), 11-oxo-\u03b1-amyrin acetate (6), 11-oxo-\u03b2-amyrin acetate (7), palmitic acid (8), stigmast-4,22-diene-3,6-dione (9), stigmast-4-ene-3,6-dione (10), stigmasterol (12), \u03b2-sitosterol (13), stigmast-22-ene-3,6-dione (14), stigmastane-3,6-dione (15), 3\u03b2,21\u03b2-dihydroxy-11\u03b1-methoxy-olean-12-ene (16), 3\u03b2-hydroxy-11\u03b1-methoxyurs-12-ene (18), 6-hydroxystigmast-4,22-diene-3-one (19), 6-hydroxystigmast-4-ene-3-one (20), 11\u03b1,21\u03b1-dihydroxy-3\u03b2-acetoxy-urs-12-ene (21), and \u03b2-sitosterol-3-O-\u03b2-D-glucopyranoside (22). Compound 21 is reported for the first time from a natural source. The structures of the 20 compounds were elucidated on the basis of IR, 1D ((1)H and (13)C), 2D ((1)H-(1)H COSY, HSQC, HMBC and NOESY) NMR and MS spectroscopic data, in addition to comparison with literature data. The isolated compounds were evaluated for their anti-microbial, anti-malarial, anti-leishmanial, and cytotoxic activities. In addition, their radioligand displacement affinity on opioid and cannabinoid receptors was assessed. Compounds 4, 11, and 15 exhibited good affinity towards the CB2 receptor, with displacement values of 69.7, 62.5 and 86.5\u00a0%, respectively. Furthermore, the binding mode of the active compounds in the active site of the CB2 cannabinoid receptors was investigated through molecular modelling. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12272-016-0784-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6058325", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2437959", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5860413", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6137240", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1090680", 
        "issn": [
          "0253-6269", 
          "1976-3786"
        ], 
        "name": "Archives of Pharmacal Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "39"
      }
    ], 
    "name": "New ursane triterpenoids from Ficus pandurata and their binding affinity for human cannabinoid and opioid receptors", 
    "pagination": "897-911", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b33dcbd6d0b0da4875186413e00e9917d7578b33a9873bd455da95a868a7945f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27350550"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8000036"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12272-016-0784-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037626683"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12272-016-0784-y", 
      "https://app.dimensions.ai/details/publication/pub.1037626683"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70053_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12272-016-0784-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12272-016-0784-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12272-016-0784-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12272-016-0784-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12272-016-0784-y'


 

This table displays all metadata directly associated to this object as RDF triples.

430 TRIPLES      21 PREDICATES      116 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12272-016-0784-y schema:about N0aff23e0bb7e4d0f9344c0c48471c16e
2 N12237a3abf4e4352815295197452b4d3
3 N3d7b7d63c8354f1dad4ae890f8651117
4 N4574e98b58574ea7bba2d2fa5a2c3afd
5 N5dd0863d5f7d43ce8aaa52987acd4552
6 N656b464f24604e7094f485369e48e5af
7 N71a91f88da60478d852e1db321470423
8 N93561f2204f94d0195d997d802562bef
9 N98bce009e9094a0a85101add302468cc
10 Na4f714817f534af9b6329ab4562e3269
11 Nb51ac106f82e4bc89f2694e69924a1f9
12 Nb9c48619044349a19921086f593bd076
13 Nff3bd2b7f01e431a948dad9079af664d
14 Nffc72da8483844f1be5450e3cabc02ed
15 anzsrc-for:03
16 anzsrc-for:0305
17 schema:author N24d87c012c5a41499b5878efbf097f68
18 schema:citation sg:pub.10.1007/3-540-26573-2_3
19 sg:pub.10.1007/bf02624436
20 sg:pub.10.1007/s00044-013-0536-1
21 sg:pub.10.1038/365061a0
22 sg:pub.10.1038/nature09746
23 sg:pub.10.1186/1752-153x-7-153
24 sg:pub.10.1186/2191-2858-2-32
25 https://doi.org/10.1002/biof.5520280303
26 https://doi.org/10.1002/bmc.3366
27 https://doi.org/10.1002/hlca.200490097
28 https://doi.org/10.1002/mrc.1347
29 https://doi.org/10.1016/0378-8741(94)90060-4
30 https://doi.org/10.1016/j.bbamcr.2011.05.010
31 https://doi.org/10.1016/j.coph.2009.09.009
32 https://doi.org/10.1016/j.jep.2011.01.046
33 https://doi.org/10.1016/j.jep.2015.11.026
34 https://doi.org/10.1016/j.phytochem.2004.12.026
35 https://doi.org/10.1016/j.phytochem.2007.10.016
36 https://doi.org/10.1016/j.phytochem.2012.07.010
37 https://doi.org/10.1016/j.phytol.2010.12.008
38 https://doi.org/10.1016/j.phytol.2012.04.012
39 https://doi.org/10.1016/j.phytol.2013.04.009
40 https://doi.org/10.1016/j.phytol.2015.03.001
41 https://doi.org/10.1016/j.phytol.2015.09.006
42 https://doi.org/10.1016/j.phytol.2015.12.010
43 https://doi.org/10.1016/j.steroids.2005.09.004
44 https://doi.org/10.1016/j.steroids.2006.01.016
45 https://doi.org/10.1016/s0031-9422(00)89569-2
46 https://doi.org/10.1016/s0031-9422(98)00578-0
47 https://doi.org/10.1016/s0031-9422(99)00557-9
48 https://doi.org/10.1021/jo0057351
49 https://doi.org/10.1021/jo020262e
50 https://doi.org/10.1021/np0004808
51 https://doi.org/10.1021/np300653d
52 https://doi.org/10.1021/np990165p
53 https://doi.org/10.1038/sj.bjp.0706414
54 https://doi.org/10.1038/sj.bjp.0707567
55 https://doi.org/10.1039/b515312n
56 https://doi.org/10.1046/j.1472-765x.2000.00731.x
57 https://doi.org/10.1055/s-0029-1186102
58 https://doi.org/10.1055/s-0033-1351099
59 https://doi.org/10.1055/s-2003-39703
60 https://doi.org/10.1055/s-2003-39705
61 https://doi.org/10.1080/10286020310001608958
62 https://doi.org/10.1080/10286029908039875
63 https://doi.org/10.1080/13880200701212916
64 https://doi.org/10.1080/14786410802362204
65 https://doi.org/10.1080/14786410902757899
66 https://doi.org/10.1080/14786419.2014.902820
67 https://doi.org/10.1080/14786419.2014.915831
68 https://doi.org/10.1080/14786419.2015.1072711
69 https://doi.org/10.1093/nar/gkl999
70 https://doi.org/10.1111/j.1365-2621.2001.tb11332.x
71 https://doi.org/10.1111/j.1476-5381.2009.00271.x
72 https://doi.org/10.1126/science.1202793
73 https://doi.org/10.1248/cpb.47.498
74 https://doi.org/10.1248/cpb.48.593
75 https://doi.org/10.1248/cpb.49.581
76 https://doi.org/10.1248/cpb.53.561
77 https://doi.org/10.1248/cpb.54.740
78 https://doi.org/10.1515/bot.2008.054
79 https://doi.org/10.1590/s0103-50532000000200017
80 https://doi.org/10.1590/s0103-50532010000800004
81 https://doi.org/10.2174/138920112798868719
82 https://doi.org/10.3109/13880209.2014.898078
83 https://doi.org/10.3329/dujs.v60i1.10327
84 https://doi.org/10.3329/icpj.v1i9.11613
85 https://doi.org/10.3390/molecules17032587
86 https://doi.org/10.3390/molecules18044247
87 https://doi.org/10.3998/ark.5550190.0008.f27
88 https://doi.org/10.4172/1948-593x.s12-005
89 https://doi.org/10.4172/2329-6836.1000169
90 https://doi.org/10.4314/bcse.v19i2.21137
91 schema:datePublished 2016-07
92 schema:datePublishedReg 2016-07-01
93 schema:description Phytochemical investigation of Ficus pandurata Hance (Moraceae) fruits has led to the isolation of two new triterpenoids, ficupanduratin A [1β-hydroxy-3β-acetoxy-11α-methoxy-urs-12-ene] (11) and ficupanduratin B [21α-hydroxy-3β-acetoxy-11α-methoxy-urs-12-ene] (17), along with 20 known compounds: α-amyrin acetate (1), α-amyrin (2), 3β-acetoxy-20-taraxasten-22-one (3), 3β-acetoxy-11α-methoxy-olean-12-ene (4), 3β-acetoxy-11α-methoxy-12-ursene (5), 11-oxo-α-amyrin acetate (6), 11-oxo-β-amyrin acetate (7), palmitic acid (8), stigmast-4,22-diene-3,6-dione (9), stigmast-4-ene-3,6-dione (10), stigmasterol (12), β-sitosterol (13), stigmast-22-ene-3,6-dione (14), stigmastane-3,6-dione (15), 3β,21β-dihydroxy-11α-methoxy-olean-12-ene (16), 3β-hydroxy-11α-methoxyurs-12-ene (18), 6-hydroxystigmast-4,22-diene-3-one (19), 6-hydroxystigmast-4-ene-3-one (20), 11α,21α-dihydroxy-3β-acetoxy-urs-12-ene (21), and β-sitosterol-3-O-β-D-glucopyranoside (22). Compound 21 is reported for the first time from a natural source. The structures of the 20 compounds were elucidated on the basis of IR, 1D ((1)H and (13)C), 2D ((1)H-(1)H COSY, HSQC, HMBC and NOESY) NMR and MS spectroscopic data, in addition to comparison with literature data. The isolated compounds were evaluated for their anti-microbial, anti-malarial, anti-leishmanial, and cytotoxic activities. In addition, their radioligand displacement affinity on opioid and cannabinoid receptors was assessed. Compounds 4, 11, and 15 exhibited good affinity towards the CB2 receptor, with displacement values of 69.7, 62.5 and 86.5 %, respectively. Furthermore, the binding mode of the active compounds in the active site of the CB2 cannabinoid receptors was investigated through molecular modelling.
94 schema:genre research_article
95 schema:inLanguage en
96 schema:isAccessibleForFree true
97 schema:isPartOf N5b60a8cea0684a6fbf12d9a2cfc1453a
98 N673b4b67bc3e4cc385bf25e8569ff3ce
99 sg:journal.1090680
100 schema:name New ursane triterpenoids from Ficus pandurata and their binding affinity for human cannabinoid and opioid receptors
101 schema:pagination 897-911
102 schema:productId N0b16500097a44ee096ce3557ff769605
103 N5e330de27ce7423f8816d65f28cf9bf5
104 Na08142e9e4674b16a30bccea8d222586
105 Nce1e85a618b848f1b480830b2ef9a078
106 Nf146825781354b2baee805752b498e7f
107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037626683
108 https://doi.org/10.1007/s12272-016-0784-y
109 schema:sdDatePublished 2019-04-11T12:41
110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
111 schema:sdPublisher N40076cfe2e3d4b129f881e839165a2e6
112 schema:url https://link.springer.com/10.1007%2Fs12272-016-0784-y
113 sgo:license sg:explorer/license/
114 sgo:sdDataset articles
115 rdf:type schema:ScholarlyArticle
116 N0aff23e0bb7e4d0f9344c0c48471c16e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Dose-Response Relationship, Drug
118 rdf:type schema:DefinedTerm
119 N0b16500097a44ee096ce3557ff769605 schema:name dimensions_id
120 schema:value pub.1037626683
121 rdf:type schema:PropertyValue
122 N0f81165c9b9f446b99cb0c1cf59cd468 rdf:first Nd6313a8f2b464f119a8b7cb028e76cf1
123 rdf:rest N72e615283b4b43a389f145e6c4c1e5c2
124 N12237a3abf4e4352815295197452b4d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Humans
126 rdf:type schema:DefinedTerm
127 N24d87c012c5a41499b5878efbf097f68 rdf:first sg:person.01352234123.83
128 rdf:rest Nd5274297a0e9434d87016cf12ead4842
129 N3d7b7d63c8354f1dad4ae890f8651117 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Triterpenes
131 rdf:type schema:DefinedTerm
132 N40076cfe2e3d4b129f881e839165a2e6 schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 N4574e98b58574ea7bba2d2fa5a2c3afd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Receptors, Opioid
136 rdf:type schema:DefinedTerm
137 N5b60a8cea0684a6fbf12d9a2cfc1453a schema:volumeNumber 39
138 rdf:type schema:PublicationVolume
139 N5dd0863d5f7d43ce8aaa52987acd4552 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Receptors, Cannabinoid
141 rdf:type schema:DefinedTerm
142 N5e330de27ce7423f8816d65f28cf9bf5 schema:name doi
143 schema:value 10.1007/s12272-016-0784-y
144 rdf:type schema:PropertyValue
145 N656b464f24604e7094f485369e48e5af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Protein Structure, Secondary
147 rdf:type schema:DefinedTerm
148 N673b4b67bc3e4cc385bf25e8569ff3ce schema:issueNumber 7
149 rdf:type schema:PublicationIssue
150 N71a91f88da60478d852e1db321470423 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Vero Cells
152 rdf:type schema:DefinedTerm
153 N72e615283b4b43a389f145e6c4c1e5c2 rdf:first sg:person.0717770760.24
154 rdf:rest Nc81c41ae744340e4853aa29bdcc7fed2
155 N8ad1ec8c181743faa2233563339df78d schema:affiliation https://www.grid.ac/institutes/grid.252487.e
156 schema:familyName Ahmad
157 schema:givenName Amany S.
158 rdf:type schema:Person
159 N93561f2204f94d0195d997d802562bef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Fruit
161 rdf:type schema:DefinedTerm
162 N98bce009e9094a0a85101add302468cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Protein Binding
164 rdf:type schema:DefinedTerm
165 Na08142e9e4674b16a30bccea8d222586 schema:name readcube_id
166 schema:value b33dcbd6d0b0da4875186413e00e9917d7578b33a9873bd455da95a868a7945f
167 rdf:type schema:PropertyValue
168 Na4f714817f534af9b6329ab4562e3269 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Cercopithecus aethiops
170 rdf:type schema:DefinedTerm
171 Na68e415b699049a3bb695061c30fd265 rdf:first N8ad1ec8c181743faa2233563339df78d
172 rdf:rest Nbf7a21082d564f019123363036ba5009
173 Nb51ac106f82e4bc89f2694e69924a1f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Ficus
175 rdf:type schema:DefinedTerm
176 Nb9c48619044349a19921086f593bd076 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Plant Extracts
178 rdf:type schema:DefinedTerm
179 Nbf7a21082d564f019123363036ba5009 rdf:first sg:person.01365227326.37
180 rdf:rest N0f81165c9b9f446b99cb0c1cf59cd468
181 Nc81c41ae744340e4853aa29bdcc7fed2 rdf:first sg:person.013317722457.41
182 rdf:rest rdf:nil
183 Nce1e85a618b848f1b480830b2ef9a078 schema:name nlm_unique_id
184 schema:value 8000036
185 rdf:type schema:PropertyValue
186 Nd5274297a0e9434d87016cf12ead4842 rdf:first sg:person.01216541777.80
187 rdf:rest Nd7cbe1e7afda4536969df742daf4490e
188 Nd6313a8f2b464f119a8b7cb028e76cf1 schema:affiliation https://www.grid.ac/institutes/grid.440879.6
189 schema:familyName El-Baky
190 schema:givenName Atef E. Abd
191 rdf:type schema:Person
192 Nd7cbe1e7afda4536969df742daf4490e rdf:first sg:person.01243521744.66
193 rdf:rest Ne36e944a2dbe40e48e128f553859238e
194 Ne36e944a2dbe40e48e128f553859238e rdf:first sg:person.01277352445.95
195 rdf:rest Na68e415b699049a3bb695061c30fd265
196 Nf146825781354b2baee805752b498e7f schema:name pubmed_id
197 schema:value 27350550
198 rdf:type schema:PropertyValue
199 Nff3bd2b7f01e431a948dad9079af664d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Animals
201 rdf:type schema:DefinedTerm
202 Nffc72da8483844f1be5450e3cabc02ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Protein Structure, Tertiary
204 rdf:type schema:DefinedTerm
205 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
206 schema:name Chemical Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:0305 schema:inDefinedTermSet anzsrc-for:
209 schema:name Organic Chemistry
210 rdf:type schema:DefinedTerm
211 sg:grant.2437959 http://pending.schema.org/fundedItem sg:pub.10.1007/s12272-016-0784-y
212 rdf:type schema:MonetaryGrant
213 sg:grant.5860413 http://pending.schema.org/fundedItem sg:pub.10.1007/s12272-016-0784-y
214 rdf:type schema:MonetaryGrant
215 sg:grant.6058325 http://pending.schema.org/fundedItem sg:pub.10.1007/s12272-016-0784-y
216 rdf:type schema:MonetaryGrant
217 sg:grant.6137240 http://pending.schema.org/fundedItem sg:pub.10.1007/s12272-016-0784-y
218 rdf:type schema:MonetaryGrant
219 sg:journal.1090680 schema:issn 0253-6269
220 1976-3786
221 schema:name Archives of Pharmacal Research
222 rdf:type schema:Periodical
223 sg:person.01216541777.80 schema:affiliation https://www.grid.ac/institutes/grid.252487.e
224 schema:familyName Ibrahim
225 schema:givenName Sabrin R. M.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216541777.80
227 rdf:type schema:Person
228 sg:person.01243521744.66 schema:affiliation https://www.grid.ac/institutes/grid.411303.4
229 schema:familyName Mohamed
230 schema:givenName Gamal A.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243521744.66
232 rdf:type schema:Person
233 sg:person.01277352445.95 schema:affiliation https://www.grid.ac/institutes/grid.411303.4
234 schema:familyName Ahmed
235 schema:givenName Hany E. A.
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277352445.95
237 rdf:type schema:Person
238 sg:person.013317722457.41 schema:affiliation https://www.grid.ac/institutes/grid.251313.7
239 schema:familyName Ross
240 schema:givenName Samir A.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013317722457.41
242 rdf:type schema:Person
243 sg:person.01352234123.83 schema:affiliation https://www.grid.ac/institutes/grid.440879.6
244 schema:familyName Khedr
245 schema:givenName Amgad I. M.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352234123.83
247 rdf:type schema:Person
248 sg:person.01365227326.37 schema:affiliation https://www.grid.ac/institutes/grid.252487.e
249 schema:familyName Ramadan
250 schema:givenName Mahmoud A.
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365227326.37
252 rdf:type schema:Person
253 sg:person.0717770760.24 schema:affiliation https://www.grid.ac/institutes/grid.174567.6
254 schema:familyName Yamada
255 schema:givenName Koji
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717770760.24
257 rdf:type schema:Person
258 sg:pub.10.1007/3-540-26573-2_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036648227
259 https://doi.org/10.1007/3-540-26573-2_3
260 rdf:type schema:CreativeWork
261 sg:pub.10.1007/bf02624436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017444703
262 https://doi.org/10.1007/bf02624436
263 rdf:type schema:CreativeWork
264 sg:pub.10.1007/s00044-013-0536-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011599856
265 https://doi.org/10.1007/s00044-013-0536-1
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/365061a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020160837
268 https://doi.org/10.1038/365061a0
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/nature09746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047634683
271 https://doi.org/10.1038/nature09746
272 rdf:type schema:CreativeWork
273 sg:pub.10.1186/1752-153x-7-153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041141957
274 https://doi.org/10.1186/1752-153x-7-153
275 rdf:type schema:CreativeWork
276 sg:pub.10.1186/2191-2858-2-32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030883092
277 https://doi.org/10.1186/2191-2858-2-32
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1002/biof.5520280303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043285045
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1002/bmc.3366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014675335
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1002/hlca.200490097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006290100
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1002/mrc.1347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013724201
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/0378-8741(94)90060-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014465654
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.bbamcr.2011.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018179202
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.coph.2009.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026457413
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.jep.2011.01.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027467157
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.jep.2015.11.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047879647
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.phytochem.2004.12.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013012770
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.phytochem.2007.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049137579
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.phytochem.2012.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047138538
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.phytol.2010.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051396720
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.phytol.2012.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040257712
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.phytol.2013.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015757685
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.phytol.2015.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052501827
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.phytol.2015.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024961050
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.phytol.2015.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040554026
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.steroids.2005.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050328313
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.steroids.2006.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034310496
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/s0031-9422(00)89569-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002306865
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/s0031-9422(98)00578-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032852395
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/s0031-9422(99)00557-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031982115
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1021/jo0057351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055985998
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1021/jo020262e schema:sameAs https://app.dimensions.ai/details/publication/pub.1056016945
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1021/np0004808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056227947
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1021/np300653d schema:sameAs https://app.dimensions.ai/details/publication/pub.1056232110
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1021/np990165p schema:sameAs https://app.dimensions.ai/details/publication/pub.1056239695
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1038/sj.bjp.0706414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034013461
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1038/sj.bjp.0707567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051477731
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1039/b515312n schema:sameAs https://app.dimensions.ai/details/publication/pub.1050397683
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1046/j.1472-765x.2000.00731.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039083724
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1055/s-0029-1186102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045699286
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1055/s-0033-1351099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057294319
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1055/s-2003-39703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057422144
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1055/s-2003-39705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057422146
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1080/10286020310001608958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010246943
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1080/10286029908039875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040929390
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1080/13880200701212916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053190286
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1080/14786410802362204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003033599
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1080/14786410902757899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037113461
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1080/14786419.2014.902820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017427667
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1080/14786419.2014.915831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028971547
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1080/14786419.2015.1072711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050052017
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1093/nar/gkl999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045899264
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1111/j.1365-2621.2001.tb11332.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012921010
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1111/j.1476-5381.2009.00271.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038340456
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1126/science.1202793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041128869
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1248/cpb.47.498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024433246
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1248/cpb.48.593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047632520
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1248/cpb.49.581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035705668
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1248/cpb.53.561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051324651
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1248/cpb.54.740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053230466
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1515/bot.2008.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004655659
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1590/s0103-50532000000200017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034887015
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1590/s0103-50532010000800004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036803499
390 rdf:type schema:CreativeWork
391 https://doi.org/10.2174/138920112798868719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069178004
392 rdf:type schema:CreativeWork
393 https://doi.org/10.3109/13880209.2014.898078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013823316
394 rdf:type schema:CreativeWork
395 https://doi.org/10.3329/dujs.v60i1.10327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038317901
396 rdf:type schema:CreativeWork
397 https://doi.org/10.3329/icpj.v1i9.11613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015660374
398 rdf:type schema:CreativeWork
399 https://doi.org/10.3390/molecules17032587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037364688
400 rdf:type schema:CreativeWork
401 https://doi.org/10.3390/molecules18044247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035718866
402 rdf:type schema:CreativeWork
403 https://doi.org/10.3998/ark.5550190.0008.f27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071816713
404 rdf:type schema:CreativeWork
405 https://doi.org/10.4172/1948-593x.s12-005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006431780
406 rdf:type schema:CreativeWork
407 https://doi.org/10.4172/2329-6836.1000169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052726165
408 rdf:type schema:CreativeWork
409 https://doi.org/10.4314/bcse.v19i2.21137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005253299
410 rdf:type schema:CreativeWork
411 https://www.grid.ac/institutes/grid.174567.6 schema:alternateName Nagasaki University
412 schema:name Garden for Medicinal Plants, Graduate School of Biomedical Sciences, Nagasaki University, Bunkyo-machi 1-14, 852-8521, Nagasaki, Japan
413 rdf:type schema:Organization
414 https://www.grid.ac/institutes/grid.251313.7 schema:alternateName University of Mississippi
415 schema:name National Center for Natural Products Research, and Department of Pharmacognosy, School of Pharmacy, University of Mississippi, 38677, University, MS, USA
416 rdf:type schema:Organization
417 https://www.grid.ac/institutes/grid.252487.e schema:alternateName Assiut University
418 schema:name Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, 30078, Al Madinah Al Munawarah, Saudi Arabia
419 Department of Pharmacognosy, Faculty of Pharmacy, Assuit University, 71526, Assuit, Egypt
420 rdf:type schema:Organization
421 https://www.grid.ac/institutes/grid.411303.4 schema:alternateName Al Azhar University
422 schema:name Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, 21589, Jeddah, Saudi Arabia
423 Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, 30078, Al Madinah Al Munawarah, Saudi Arabia
424 Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assuit Branch, 71524, Assuit, Egypt
425 Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
426 rdf:type schema:Organization
427 https://www.grid.ac/institutes/grid.440879.6 schema:alternateName Port Said University
428 schema:name Department of Biochemistry, Faculty of Pharmacy, Port Said University, 42526, Port Said, Egypt
429 Department of Pharmacognosy, Faculty of Pharmacy, Port Said University, 42526, Port Said, Egypt
430 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...