Enzymatic synthesis of novel isobavachalcone glucosides via a UDP-glycosyltransferase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-12

AUTHORS

Hong-Mei Li, Jae Kyoung Lee, Li-Juan Nie, Qiang Huo, Tao Ma, Jae Kyung Sohng, Young-Soo Hong, Cheng-Zhu Wu

ABSTRACT

Glycosylation is often used to improve a natural product's properties such as water solubility, chemical stability, pharmacological potency, and structure diversification. In this study, we studied the enzymatic synthesis of novel isobavachalcone glucosides using a UDP-glycosyltransferase (YjiC) from Bacillus licheniformis DSM-13. The chemical structures of compounds 1 and 2 were elucidated by spectroscopic techniques, including LC-MS, MS, and NMR. Meanwhile, the parameters of glycosylation reaction such as incubation time, UDP-glucose concentration, and pH of buffer were also optimized during this study. Furthermore, the compounds 1 and 2 exhibited weak anti-proliferative activities against five human cancer cell lines, with IC50 values ranging from 58.6 to 86.6 μM. More... »

PAGES

2208-2215

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12272-015-0658-8

DOI

http://dx.doi.org/10.1007/s12272-015-0658-8

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26374247


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