Ontology type: schema:ScholarlyArticle
2015-11
AUTHORSSeung-Jin Jung, Seung-Hwan Park, Eun Je Lee, Jeong Hoon Park, Young Bae Kong, Jong Kook Rho, Min Goo Hur, Seung Dae Yang, Yong Dae Park
ABSTRACTβ-amyloid (Aβ) plaques in the brain are composed of Aβ40 and Aβ42 peptides, and are the defining pathological feature of Alzheimer's disease (AD). Fluorescent probes that can detect Aβ plaques have gained increasing interest as potential tools for in vitro and in vivo monitoring of the progression of AD. In this study, chalcone-mimic fluorescent probe 5 was designed and prepared. Probe 5 exhibited an approximately 50-fold increase in emission intensity after mixing with Aβ42 aggregates, a high affinity for Aβ42 aggregates (K D = 1.59 μM), and reasonable lipophilicity (log P value = 2.55). Probe 5 also exhibited specific staining of Aβ plaques in the transgenic mice (APP/PS1) brain sections. Ex vivo fluorescence imaging of the brain from normal and TG mice revealed that probe 5 was able to penetrate the BBB and stain the Aβ plaques. These results suggest that chalcone-mimic probe 5 possessed the requirements of a fluorescent probe for Aβ plaques and may be useful in AD research. More... »
PAGES1992-1998
http://scigraph.springernature.com/pub.10.1007/s12272-015-0617-4
DOIhttp://dx.doi.org/10.1007/s12272-015-0617-4
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26012373
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"description": "\u03b2-amyloid (A\u03b2) plaques in the brain are composed of A\u03b240 and A\u03b242 peptides, and are the defining pathological feature of Alzheimer's disease (AD). Fluorescent probes that can detect A\u03b2 plaques have gained increasing interest as potential tools for in vitro and in vivo monitoring of the progression of AD. In this study, chalcone-mimic fluorescent probe 5 was designed and prepared. Probe 5 exhibited an approximately 50-fold increase in emission intensity after mixing with A\u03b242 aggregates, a high affinity for A\u03b242 aggregates (K D\u00a0=\u00a01.59\u00a0\u03bcM), and reasonable lipophilicity (log P value\u00a0=\u00a02.55). Probe 5 also exhibited specific staining of A\u03b2 plaques in the transgenic mice (APP/PS1) brain sections. Ex vivo fluorescence imaging of the brain from normal and TG mice revealed that probe 5 was able to penetrate the BBB and stain the A\u03b2 plaques. These results suggest that chalcone-mimic probe 5 possessed the requirements of a fluorescent probe for A\u03b2 plaques and may be useful in AD research. ",
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