A new dimeric neolignan from Magnolia grandiflora L. seeds View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-06

AUTHORS

Hong-Mei Li, Su-Rong Zhao, Qiang Huo, Tao Ma, Hao Liu, Jae kyoung Lee, Young-Soo Hong, Cheng-Zhu Wu

ABSTRACT

Bioassay-guided fractionation of the MeOH extract of Magnolia grandiflora seeds resulted in the isolation of a new dimeric neolignan, named bishonokiol A (1), as well as two known neolignans magnolol (2) and honokiol (3). The structures of the compounds were determined on the basis of data obtained using NMR and MS. Bishonokiol A (1) showed potent anti-proliferative activities in four human cancer cell lines, with IC50 values ranging from 5.1 to 7.5 µM. Additionally, bishonokiol A (1) induced apoptosis, as well as down-regulated the expression of the anti-apoptotic protein Bcl-2 and caspase-3 cleavage in HepG2 cell line. More... »

PAGES

1066-1071

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12272-014-0476-4

DOI

http://dx.doi.org/10.1007/s12272-014-0476-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018424352

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25193624


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