Anti-inflammatory effect of sargachromanol G isolated from Sargassum siliquastrum in RAW 264.7 cells View Full Text


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Article Info

DATE

2012-08

AUTHORS

Weon-Jong Yoon, Soo-Jin Heo, Sang-Chul Han, Hye-Ja Lee, Gyeoung-Jin Kang, Hee-Kyoung Kang, Jin-Won Hyun, Young-Sang Koh, Eun-Sook Yoo

ABSTRACT

A study on the anti-inflammatory activity of brown alga Sargassum siliquastrum led to the isolation of sargachromanol G (SG). In this study, the anti-inflammatory effect and the action mechanism of SG have been investigated in murine macrophage cell line RAW 264.7. SG dosedependently inhibited the production of inflammatory markers [nitric oxide (NO), inducible nitric oxide synthase (iNOS), prostaglandin E(2) (PGE(2)), and cyclooxygenase-2 (COX-2)] and pro-inflammatory cytokines [tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6] induced by LPS treatment. To further elucidate the mechanism of this inhibitory effect of SG, we studied LPS-induced nuclear factor-κB (NF-κB) activation and mitogen-activated protein kinases (MAPKs) phosphorylation. SG inhibited the phosphorylation IκB-α and NF-κB (p65 and p50) and MAPK (ERK1/2, JNK, and p38) in a dose dependent manner. These results suggest that the anti-inflammatory activity of SG results from its modulation of pro-inflammatory cytokines and mediators via the suppression of NF-κB activation and MAPK phosphorylation. More... »

PAGES

1421-1430

References to SciGraph publications

  • 2008-11. New regulators of NF-κB in inflammation in NATURE REVIEWS IMMUNOLOGY
  • 2008. Compartmentalised MAPK Pathways in PROTEIN-PROTEIN INTERACTIONS AS NEW DRUG TARGETS
  • 2006-11. Comparative Cytotoxicity of Alachlor on RTG-2 Trout and SH-SY5Y Human Cells in ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12272-012-0812-5

    DOI

    http://dx.doi.org/10.1007/s12272-012-0812-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023416199

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22941485


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