Solubility enhancement and physicochemical characterization of carvedilol solid dispersion with Gelucire 50/13 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-01

AUTHORS

Raja Hemanth Kumar Potluri, Suresh Bandari, Raju Jukanti, Prabhakar Reddy Veerareddy

ABSTRACT

The objective of the study was enhancement of dissolution of poorly soluble carvedilol by solid dispersions (SDs) with Gelucire 50/13 using solvent evaporation method. The solubility of carvedilol showed linear increase with increasing concentrations of Gelucire indicating A(L) type solubility diagrams. SDs characterized for physicochemical characteristics using differential scanning calorimetry and X-ray diffractometry revealed transformation of crystalline form of drug to amorphous form which was confirmed by scanning electron micrographs. Further fourier transform infrared spectroscopy results suggested there is no drug carrier interaction. From the dissolution parameters such as mean dissolution time, dissolution efficiency and drug release rate, improved dissolution characteristics for SDs were observed compared with physical mixture and pure drug. Thus SDs of carvedilol in Gelucire 50/13 showed enhanced solubility and dissolution rate compared to pure drug. More... »

PAGES

51-57

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12272-011-0106-3

DOI

http://dx.doi.org/10.1007/s12272-011-0106-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053128446

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21468915


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