Antiulcerogenic activity of fractions and 3,15-Dioxo-21α-hydroxy friedelane isolated from Maytenus robusta (Celastraceae) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-01

AUTHORS

Sérgio Faloni de Andrade, Eros Comunello, Vânia Floriani Noldin, Franco Delle Monache, Valdir Cechinel Filho, Rivaldo Niero

ABSTRACT

The hexane, chloroform, ethyl acetate and aqueous-soluble fractions from leaves of Maytenus robusta (Celastraceae) were evaluated for their protective actions against ethanol-induced gastric lesions in rats. The treatment with all fractions (150 mg/kg) and omeprazol (30 mg/kg) significantly reduced the lesion index, the total lesion area, and the percentage of lesion, in comparison with the control group (p<0.05). Since the ethyl acetate-soluble fraction was found to be most active in the pylorus ligated model, this fraction was further investigated and resulted in the isolation of triterpene 3,15-dioxo-21α-hydroxy friedelane. The triterpene was evaluated in the HCl/ethanol-induced ulcer model in mice. In this assay, both the groups treated with 3,15-dioxo-21α-hydroxy friedelane and omeprazol, at a dose of 30 mg/kg, presented a significant reduction in lesion index, total lesion area, and in the percentage of the lesion, when compared with the control group (p<0.05). The result suggests that the antiulcer effect observed in the extract and fractions may be attributed, at least in part, to this compound. Further experiments are underway to determine which antiulcer mechanisms involved in gastroprotection. More... »

PAGES

41-46

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12272-008-1118-5

DOI

http://dx.doi.org/10.1007/s12272-008-1118-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035050504

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18277606


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