Preparation and gene delivery of alkaline amino acids-based cationic liposomes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-07

AUTHORS

Li Li, Yu Nie, Rong Zhu, Sanjun Shi, Kui Luo, Bin He, Yang Yang, Junxiao Yang, Zhongwei Gu

ABSTRACT

Cationic lipids 1, 2, and 3, based on hydrophobic cholesterol linked to L-lysine, L-histidine or L-arginine, respectively, were designed and tested as gene delivery vectors. Physicochemical and biological properties of all liposomes and lipoplexes were evaluated, including lipid-DNA interactions, size, morphology, zeta potential, acid-base buffering capability, protection of DNA from DNase I digestion, and cytotoxity. The efficiency of luciferase gene transfection of lipoplexes 1-3 was compared with that of commercial dioleoyl-trimethylammonium propane (DOTAP) and polyethyleneimine (PEI) in 293T cells and HepG2 cells with or without poly(ethylene glycol) PEG stabilizer. The complexation and protection of DNA of liposome 3 was the strongest among the three liposomes. The efficiency of gene transfection of liposomes 1-3 was two-to threefold higher than that of PEI and/or DOTAP in 293T cells. Liposomes 1 and 3 in PEG as stabilizer showed sixfold higher transfection efficiency than that of PEI and/or DOTAP, whereas liposome 2 showed very low transfection efficiency. In HepG2 cells, the transfection efficiency of all the cationic liposomes was much lower than that of DOTAP. In conclusion, lipids 1-3 were efficient and non-toxic gene vectors; the headgroup of cationic lipids and the stabilizer of liposome formulation had an important influence on gene transfection. More... »

PAGES

924-931

Journal

TITLE

Archives of Pharmacal Research

ISSUE

7

VOLUME

31

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12272-001-1248-8

    DOI

    http://dx.doi.org/10.1007/s12272-001-1248-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052120994

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18704337


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