Development of a Novel Human Cell-Derived Tissue-Engineered Heart Valve for Transcatheter Aortic Valve Replacement: an In Vitro and In Vivo ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12

AUTHORS

V. Lintas, E. S. Fioretta, S. E. Motta, P. E. Dijkman, M. Pensalfini, E. Mazza, E. Caliskan, H. Rodriguez, M. Lipiski, M. Sauer, N. Cesarovic, S. P. Hoerstrup, M. Y. Emmert

ABSTRACT

Transcatheter aortic valve replacement (TAVR) is being extended to younger patients. However, TAVR-compatible bioprostheses are based on xenogeneic materials with limited durability. Off-the-shelf tissue-engineered heart valves (TEHVs) with remodeling capacity may overcome the shortcomings of current TAVR devices. Here, we develop for the first time a TEHV for TAVR, based on human cell-derived extracellular matrix and integrated into a state-of-the-art stent for TAVR. The TEHVs, characterized by a dense acellular collagenous matrix, demonstrated in vitro functionality under aortic pressure conditions (n = 4). Next, transapical TAVR feasibility and in vivo TEHV functionality were assessed in acute studies (n = 5) in sheep. The valves successfully coped with the aortic environment, showing normal leaflet motion, free coronary flow, and absence of stenosis or paravalvular leak. At explantation, TEHVs presented full structural integrity and initial cell infiltration. Its long-term performance proven, such TEHV could fulfill the need for next-generation lifelong TAVR prostheses. More... »

PAGES

470-482

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12265-018-9821-1

DOI

http://dx.doi.org/10.1007/s12265-018-9821-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106131854

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30105605


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