RANKL Expression Is Increased in Circulating Mononuclear Cells of Patients with Calcific Aortic Stenosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-08

AUTHORS

Marcello Rattazzi, Elisabetta Faggin, Elisa Bertacco, Roberta Buso, Massimo Puato, Mario Plebani, Martina Zaninotto, Davide Condotta, Giacomo Zoppellaro, Leopoldo Pagliani, Giuseppe Tarantini, Sabino Iliceto, Elisa Covolo, Giuseppe Faggian, Francesco Onorati, Mikhail Dodonov, Alessandro Daniotti, Paola Pantano, Zoran Olivari, Giovanni Benfari, Paolo Pauletto

ABSTRACT

We aimed to investigate whether the expression of the OPG/RANK/RANKL triad in peripheral blood mononuclear cells (PBMC) and circulating levels of markers of ectopic mineralization (OPG, FGF-23, PPi) are modified in patients with calcific aortic valve disease (CAVD). We found that patients affected by CAVD (n = 50) had significantly higher circulating levels of OPG as compared to control individuals (p = 0.003). No differences between the two groups were found in FGF-23 and PPi levels. RANKL expression was higher in the PBMC from CAVD patients (p = 0.018) and was directly correlated with the amount of valve calcification (p = 0.032). In vitro studies showed that treatment of valve interstitial cells (VIC) with RANKL plus phosphate was followed by increase in matrix mineralization (p = 0.001). In conclusion, RANKL expression is increased in PBMC of patients with CAVD, is directly correlated with the degree of valve calcification, and promotes pro-calcific differentiation of VIC. More... »

PAGES

329-338

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12265-018-9804-2

DOI

http://dx.doi.org/10.1007/s12265-018-9804-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104044054

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29777507


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