Cardiac Strain in a Swine Model of Regional Hibernating Myocardium: Effects of CoQ10 on Contractile Reserve Following Bypass Surgery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-08

AUTHORS

Laura Hocum Stone, Tammy A. Butterick, Cayla Duffy, Corey Swingen, Herbert B. Ward, Rosemary F. Kelly, Edward O. McFalls

ABSTRACT

There is conflicting clinical evidence whether administration of coenzyme Q10 (CoQ10) improves function following coronary artery bypass graft surgery (CABG). Using a swine model of hibernating myocardium, we tested whether daily CoQ10 would improve contractile function by MRI at 4-week post-CABG. Twelve pigs underwent a thoracotomy and had a constrictor placed on the left anterior descending (LAD). At 12 weeks, they underwent off-pump bypass and received daily dietary supplements of either CoQ10 (10 mg/kg/day) or placebo. At 4-week post-CABG, circumferential strain measurements in the hibernating LAD region from placebo and CoQ10 groups were not different and increased to a similar extent with dobutamine (-14.7 ± 0.6 versus -14.8 ± 0.1, respectively (NS)). Post-sacrifice, oxidant stress markers were obtained in the mitochondrial isolates and protein carbonyl in the placebo, and CoQ10 groups were 6.14 ± 0.36 and 5.05 ± 0.32 nmol/mg, respectively (NS). In summary, CoQ10 did not improve contractile reserve or reduce oxidant stress at 4-week post-CABG. More... »

PAGES

368-373

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12265-016-9696-y

DOI

http://dx.doi.org/10.1007/s12265-016-9696-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041201357

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27184805


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