Comparative Study of ROCK1 and ROCK2 in Hippocampal Spine Formation and Synaptic Function View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-02

AUTHORS

Jinglan Yan, Youcan Pan, Xiaoyan Zheng, Chuanan Zhu, Yu Zhang, Guoqi Shi, Lin Yao, Yongjun Chen, Nenggui Xu

ABSTRACT

Rho-associated kinases (ROCKs) are serine-threonine protein kinases that act downstream of small Rho GTPases to regulate the dynamics of the actin cytoskeleton. Two ROCK isoforms (ROCK1 and ROCK2) are expressed in the mammalian central nervous system. Although ROCK activity has been implicated in synapse formation, whether the distinct ROCK isoforms have different roles in synapse formation and function in vivo is not clear. Here, we used a genetic approach to address this long-standing question. Both Rock1+/- and Rock2+/- mice had impaired glutamatergic transmission, reduced spine density, and fewer excitatory synapses in hippocampal CA1 pyramidal neurons. In addition, both Rock1+/- and Rock2+/- mice showed deficits in long-term potentiation at hippocampal CA1 synapses and were impaired in spatial learning and memory based on the water maze and contextual fear conditioning tests. However, the spine morphology of CA1 pyramidal neurons was altered only in Rock2+/- but not Rock1+/- mice. In this study we compared the roles of ROCK1 and ROCK2 in synapse formation and function in vivo for the first time. Our results provide a better understanding of the functions of distinct ROCK isoforms in synapse formation and function. More... »

PAGES

1-12

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12264-019-00351-2

DOI

http://dx.doi.org/10.1007/s12264-019-00351-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112504388

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30826947


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Guangzhou University of Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.411866.c", 
          "name": [
            "South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, 510006, Guangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yan", 
        "givenName": "Jinglan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangdong Provincial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413402.0", 
          "name": [
            "South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, 510006, Guangzhou, China", 
            "Guangdong Provincial Hospital of Chinese Medicine, 510006, Guangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pan", 
        "givenName": "Youcan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangzhou University of Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.411866.c", 
          "name": [
            "South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, 510006, Guangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zheng", 
        "givenName": "Xiaoyan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangzhou University of Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.411866.c", 
          "name": [
            "South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, 510006, Guangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Chuanan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangzhou University of Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.411866.c", 
          "name": [
            "South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, 510006, Guangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Yu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangzhou University of Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.411866.c", 
          "name": [
            "South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, 510006, Guangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Guoqi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangzhou University of Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.411866.c", 
          "name": [
            "School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, 510006, Guangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yao", 
        "givenName": "Lin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Southern Medical University", 
          "id": "https://www.grid.ac/institutes/grid.284723.8", 
          "name": [
            "South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, 510006, Guangzhou, China", 
            "Guangdong Province Key Laboratory of Psychiatric Disorders, Southern Medical University, 510515, Guangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Yongjun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangzhou University of Chinese Medicine", 
          "id": "https://www.grid.ac/institutes/grid.411866.c", 
          "name": [
            "South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, 510006, Guangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Nenggui", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1128/mcb.23.14.5043-5055.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000390230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002417644", 
          "https://doi.org/10.1038/nature01148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002417644", 
          "https://doi.org/10.1038/nature01148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0008704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002760752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1956.sp005610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003622669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2090-13.2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005706175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2017.01.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006145777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms3136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006817521", 
          "https://doi.org/10.1038/ncomms3136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201504046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007179533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2013.10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007433388", 
          "https://doi.org/10.1038/cddis.2013.10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2013.03.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010043502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mod.2012.10.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014405648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2014.05.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015101864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(03)00097-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015973900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(03)00097-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015973900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mp.2014.131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019775597", 
          "https://doi.org/10.1038/mp.2014.131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cm.20472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021186114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cm.20472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021186114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-0270(97)00163-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021432585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m007074200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022223564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(02)01182-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024766707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13229-015-0036-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027168665", 
          "https://doi.org/10.1186/s13229-015-0036-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13229-015-0036-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027168665", 
          "https://doi.org/10.1186/s13229-015-0036-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2011.281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028632304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1073858407303611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028742259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1073858407303611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028742259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200411179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029107842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00399.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030080945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.34.20246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030487068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2478/s11658-006-0002-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030503567", 
          "https://doi.org/10.2478/s11658-006-0002-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2478/s11658-006-0002-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030503567", 
          "https://doi.org/10.2478/s11658-006-0002-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2013.08.056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030726812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0735-7044.108.4.810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031552072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2010.07270.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032177446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2010.07270.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032177446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0608755103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033277215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2013.10.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033375326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200901084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033928301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropharm.2008.07.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033972729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mp.2011.154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034396329", 
          "https://doi.org/10.1038/mp.2011.154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ijnp/pyw108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044858908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nlm.2013.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045113322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.279.5350.509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047090124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2011.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048415610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0018579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050467509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(00)81248-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051450553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2006.127365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051788557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/cvs371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053097543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/21592799.2015.1133266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058420172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddw102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059645874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075500034", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.09-08-02982.1989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079333981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1996.tb00574.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082890075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1616024114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084777359"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03-02", 
    "datePublishedReg": "2019-03-02", 
    "description": "Rho-associated kinases (ROCKs) are serine-threonine protein kinases that act downstream of small Rho GTPases to regulate the dynamics of the actin cytoskeleton. Two ROCK isoforms (ROCK1 and ROCK2) are expressed in the mammalian central nervous system. Although ROCK activity has been implicated in synapse formation, whether the distinct ROCK isoforms have different roles in synapse formation and function in vivo is not clear. Here, we used a genetic approach to address this long-standing question. Both Rock1+/- and Rock2+/- mice had impaired glutamatergic transmission, reduced spine density, and fewer excitatory synapses in hippocampal CA1 pyramidal neurons. In addition, both Rock1+/- and Rock2+/- mice showed deficits in long-term potentiation at hippocampal CA1 synapses and were impaired in spatial learning and memory based on the water maze and contextual fear conditioning tests. However, the spine morphology of CA1 pyramidal neurons was altered only in Rock2+/- but not Rock1+/- mice. In this study we compared the roles of ROCK1 and ROCK2 in synapse formation and function in vivo for the first time. Our results provide a better understanding of the functions of distinct ROCK isoforms in synapse formation and function.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12264-019-00351-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1297436", 
        "issn": [
          "1673-7067", 
          "1995-8218"
        ], 
        "name": "Neuroscience Bulletin", 
        "type": "Periodical"
      }
    ], 
    "name": "Comparative Study of ROCK1 and ROCK2 in Hippocampal Spine Formation and Synaptic Function", 
    "pagination": "1-12", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "475766e74506aea5761c867a94ab6bb53977380d03e45057a9c7d56426e8e3db"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30826947"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101256850"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12264-019-00351-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112504388"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12264-019-00351-2", 
      "https://app.dimensions.ai/details/publication/pub.1112504388"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000350_0000000350/records_77567_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12264-019-00351-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12264-019-00351-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12264-019-00351-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12264-019-00351-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12264-019-00351-2'


 

This table displays all metadata directly associated to this object as RDF triples.

266 TRIPLES      21 PREDICATES      73 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12264-019-00351-2 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N9c7ddedacc274c59bf86331302d02354
4 schema:citation sg:pub.10.1038/cddis.2013.10
5 sg:pub.10.1038/mp.2011.154
6 sg:pub.10.1038/mp.2014.131
7 sg:pub.10.1038/nature01148
8 sg:pub.10.1038/ncomms3136
9 sg:pub.10.1186/s13229-015-0036-x
10 sg:pub.10.2478/s11658-006-0002-x
11 https://app.dimensions.ai/details/publication/pub.1075500034
12 https://doi.org/10.1002/cm.20472
13 https://doi.org/10.1002/j.1460-2075.1996.tb00574.x
14 https://doi.org/10.1016/j.brainres.2014.05.024
15 https://doi.org/10.1016/j.ejphar.2017.01.021
16 https://doi.org/10.1016/j.mod.2012.10.005
17 https://doi.org/10.1016/j.neulet.2013.08.056
18 https://doi.org/10.1016/j.neuron.2011.05.002
19 https://doi.org/10.1016/j.neuron.2013.03.028
20 https://doi.org/10.1016/j.neuropharm.2008.07.031
21 https://doi.org/10.1016/j.neuroscience.2013.10.016
22 https://doi.org/10.1016/j.nlm.2013.03.005
23 https://doi.org/10.1016/s0165-0270(97)00163-5
24 https://doi.org/10.1016/s0896-6273(00)81248-9
25 https://doi.org/10.1016/s0896-6273(02)01182-0
26 https://doi.org/10.1016/s0955-0674(03)00097-8
27 https://doi.org/10.1037/0735-7044.108.4.810
28 https://doi.org/10.1038/emboj.2011.281
29 https://doi.org/10.1073/pnas.0608755103
30 https://doi.org/10.1073/pnas.1616024114
31 https://doi.org/10.1074/jbc.271.34.20246
32 https://doi.org/10.1074/jbc.m007074200
33 https://doi.org/10.1080/21592799.2015.1133266
34 https://doi.org/10.1083/jcb.200411179
35 https://doi.org/10.1083/jcb.200901084
36 https://doi.org/10.1083/jcb.201504046
37 https://doi.org/10.1093/cvr/cvs371
38 https://doi.org/10.1093/hmg/ddw102
39 https://doi.org/10.1093/ijnp/pyw108
40 https://doi.org/10.1111/j.1460-9568.2010.07270.x
41 https://doi.org/10.1113/jphysiol.1956.sp005610
42 https://doi.org/10.1113/jphysiol.2006.127365
43 https://doi.org/10.1126/science.279.5350.509
44 https://doi.org/10.1128/mcb.23.14.5043-5055.2003
45 https://doi.org/10.1152/ajpcell.00399.2009
46 https://doi.org/10.1177/1073858407303611
47 https://doi.org/10.1371/journal.pone.0008704
48 https://doi.org/10.1371/journal.pone.0018579
49 https://doi.org/10.1523/jneurosci.09-08-02982.1989
50 https://doi.org/10.1523/jneurosci.2090-13.2013
51 schema:datePublished 2019-03-02
52 schema:datePublishedReg 2019-03-02
53 schema:description Rho-associated kinases (ROCKs) are serine-threonine protein kinases that act downstream of small Rho GTPases to regulate the dynamics of the actin cytoskeleton. Two ROCK isoforms (ROCK1 and ROCK2) are expressed in the mammalian central nervous system. Although ROCK activity has been implicated in synapse formation, whether the distinct ROCK isoforms have different roles in synapse formation and function in vivo is not clear. Here, we used a genetic approach to address this long-standing question. Both Rock1<sup>+/-</sup> and Rock2<sup>+/-</sup> mice had impaired glutamatergic transmission, reduced spine density, and fewer excitatory synapses in hippocampal CA1 pyramidal neurons. In addition, both Rock1<sup>+/-</sup> and Rock2<sup>+/-</sup> mice showed deficits in long-term potentiation at hippocampal CA1 synapses and were impaired in spatial learning and memory based on the water maze and contextual fear conditioning tests. However, the spine morphology of CA1 pyramidal neurons was altered only in Rock2<sup>+/-</sup> but not Rock1<sup>+/-</sup> mice. In this study we compared the roles of ROCK1 and ROCK2 in synapse formation and function in vivo for the first time. Our results provide a better understanding of the functions of distinct ROCK isoforms in synapse formation and function.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree false
57 schema:isPartOf sg:journal.1297436
58 schema:name Comparative Study of ROCK1 and ROCK2 in Hippocampal Spine Formation and Synaptic Function
59 schema:pagination 1-12
60 schema:productId N0ee1c7d68e5643db8b5dc209bfbdada4
61 N16525067d3174a1593a0f62abb112cec
62 N33c94bae292b48bf8583c08e495c240e
63 N8f9cfeaf86c24500ba66826db6973eb6
64 Nc1c2cedb01da43258ad11508974a7f3e
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112504388
66 https://doi.org/10.1007/s12264-019-00351-2
67 schema:sdDatePublished 2019-04-11T10:49
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher Nfc4b70cd8ef441d7ac33c866d5c304ae
70 schema:url https://link.springer.com/10.1007%2Fs12264-019-00351-2
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N0ee1c7d68e5643db8b5dc209bfbdada4 schema:name nlm_unique_id
75 schema:value 101256850
76 rdf:type schema:PropertyValue
77 N11bfe927d2924bc88f6903983ec1bde9 schema:affiliation https://www.grid.ac/institutes/grid.413402.0
78 schema:familyName Pan
79 schema:givenName Youcan
80 rdf:type schema:Person
81 N16525067d3174a1593a0f62abb112cec schema:name dimensions_id
82 schema:value pub.1112504388
83 rdf:type schema:PropertyValue
84 N1fa0b58fc4bb484e8d84591e9fd68227 schema:affiliation https://www.grid.ac/institutes/grid.411866.c
85 schema:familyName Zheng
86 schema:givenName Xiaoyan
87 rdf:type schema:Person
88 N33c94bae292b48bf8583c08e495c240e schema:name doi
89 schema:value 10.1007/s12264-019-00351-2
90 rdf:type schema:PropertyValue
91 N4e6281ea7e864e84ba0bdf241471e8e0 rdf:first Nb8bdd143f8bf471a8f23db0fcca4cddc
92 rdf:rest N91be958accfb4a6d9a1550a28b9b52dd
93 N516ce9fc28bc477c996aced904ea9001 schema:affiliation https://www.grid.ac/institutes/grid.411866.c
94 schema:familyName Yao
95 schema:givenName Lin
96 rdf:type schema:Person
97 N6398df81398f43f3babd363feda8ce55 schema:affiliation https://www.grid.ac/institutes/grid.411866.c
98 schema:familyName Zhu
99 schema:givenName Chuanan
100 rdf:type schema:Person
101 N6f1a036f43004c6aa03e8d5ee57ce19a rdf:first N6398df81398f43f3babd363feda8ce55
102 rdf:rest N4e6281ea7e864e84ba0bdf241471e8e0
103 N79ad3c4988284c8ab6753b7a94d4af72 rdf:first N516ce9fc28bc477c996aced904ea9001
104 rdf:rest Nf201c543b879418190c3838dc666dff8
105 N844f5cda3138466cbe74b01ceafd1c39 schema:affiliation https://www.grid.ac/institutes/grid.411866.c
106 schema:familyName Yan
107 schema:givenName Jinglan
108 rdf:type schema:Person
109 N860941cfa0374a68add3a2e946440f89 schema:affiliation https://www.grid.ac/institutes/grid.411866.c
110 schema:familyName Shi
111 schema:givenName Guoqi
112 rdf:type schema:Person
113 N8f9cfeaf86c24500ba66826db6973eb6 schema:name readcube_id
114 schema:value 475766e74506aea5761c867a94ab6bb53977380d03e45057a9c7d56426e8e3db
115 rdf:type schema:PropertyValue
116 N91be958accfb4a6d9a1550a28b9b52dd rdf:first N860941cfa0374a68add3a2e946440f89
117 rdf:rest N79ad3c4988284c8ab6753b7a94d4af72
118 N9c7ddedacc274c59bf86331302d02354 rdf:first N844f5cda3138466cbe74b01ceafd1c39
119 rdf:rest Nd12fdb899cd8478c9ca7fb8191467409
120 Nb8bdd143f8bf471a8f23db0fcca4cddc schema:affiliation https://www.grid.ac/institutes/grid.411866.c
121 schema:familyName Zhang
122 schema:givenName Yu
123 rdf:type schema:Person
124 Nb9864aecb6f44c8db8e0b42507626c9a rdf:first N1fa0b58fc4bb484e8d84591e9fd68227
125 rdf:rest N6f1a036f43004c6aa03e8d5ee57ce19a
126 Nc1c2cedb01da43258ad11508974a7f3e schema:name pubmed_id
127 schema:value 30826947
128 rdf:type schema:PropertyValue
129 Nc764406892084e8a87ea15cd34445fac schema:affiliation https://www.grid.ac/institutes/grid.411866.c
130 schema:familyName Xu
131 schema:givenName Nenggui
132 rdf:type schema:Person
133 Nce3d15e84bad42a3b30243b271ddf913 rdf:first Nc764406892084e8a87ea15cd34445fac
134 rdf:rest rdf:nil
135 Nd12fdb899cd8478c9ca7fb8191467409 rdf:first N11bfe927d2924bc88f6903983ec1bde9
136 rdf:rest Nb9864aecb6f44c8db8e0b42507626c9a
137 Nf201c543b879418190c3838dc666dff8 rdf:first Nf9accf0e191b4db888c19f018fe585a1
138 rdf:rest Nce3d15e84bad42a3b30243b271ddf913
139 Nf9accf0e191b4db888c19f018fe585a1 schema:affiliation https://www.grid.ac/institutes/grid.284723.8
140 schema:familyName Chen
141 schema:givenName Yongjun
142 rdf:type schema:Person
143 Nfc4b70cd8ef441d7ac33c866d5c304ae schema:name Springer Nature - SN SciGraph project
144 rdf:type schema:Organization
145 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
146 schema:name Medical and Health Sciences
147 rdf:type schema:DefinedTerm
148 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
149 schema:name Neurosciences
150 rdf:type schema:DefinedTerm
151 sg:journal.1297436 schema:issn 1673-7067
152 1995-8218
153 schema:name Neuroscience Bulletin
154 rdf:type schema:Periodical
155 sg:pub.10.1038/cddis.2013.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007433388
156 https://doi.org/10.1038/cddis.2013.10
157 rdf:type schema:CreativeWork
158 sg:pub.10.1038/mp.2011.154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034396329
159 https://doi.org/10.1038/mp.2011.154
160 rdf:type schema:CreativeWork
161 sg:pub.10.1038/mp.2014.131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019775597
162 https://doi.org/10.1038/mp.2014.131
163 rdf:type schema:CreativeWork
164 sg:pub.10.1038/nature01148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002417644
165 https://doi.org/10.1038/nature01148
166 rdf:type schema:CreativeWork
167 sg:pub.10.1038/ncomms3136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006817521
168 https://doi.org/10.1038/ncomms3136
169 rdf:type schema:CreativeWork
170 sg:pub.10.1186/s13229-015-0036-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027168665
171 https://doi.org/10.1186/s13229-015-0036-x
172 rdf:type schema:CreativeWork
173 sg:pub.10.2478/s11658-006-0002-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030503567
174 https://doi.org/10.2478/s11658-006-0002-x
175 rdf:type schema:CreativeWork
176 https://app.dimensions.ai/details/publication/pub.1075500034 schema:CreativeWork
177 https://doi.org/10.1002/cm.20472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021186114
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1002/j.1460-2075.1996.tb00574.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082890075
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.brainres.2014.05.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015101864
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.ejphar.2017.01.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006145777
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.mod.2012.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014405648
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.neulet.2013.08.056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030726812
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.neuron.2011.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048415610
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.neuron.2013.03.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010043502
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.neuropharm.2008.07.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033972729
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.neuroscience.2013.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033375326
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.nlm.2013.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045113322
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/s0165-0270(97)00163-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021432585
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/s0896-6273(00)81248-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051450553
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/s0896-6273(02)01182-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024766707
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/s0955-0674(03)00097-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015973900
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1037/0735-7044.108.4.810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031552072
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1038/emboj.2011.281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028632304
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1073/pnas.0608755103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033277215
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1073/pnas.1616024114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084777359
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1074/jbc.271.34.20246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030487068
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1074/jbc.m007074200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022223564
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1080/21592799.2015.1133266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058420172
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1083/jcb.200411179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029107842
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1083/jcb.200901084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033928301
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1083/jcb.201504046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007179533
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1093/cvr/cvs371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053097543
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1093/hmg/ddw102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059645874
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1093/ijnp/pyw108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044858908
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1111/j.1460-9568.2010.07270.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032177446
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1113/jphysiol.1956.sp005610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003622669
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1113/jphysiol.2006.127365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051788557
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1126/science.279.5350.509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047090124
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1128/mcb.23.14.5043-5055.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000390230
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1152/ajpcell.00399.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030080945
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1177/1073858407303611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028742259
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1371/journal.pone.0008704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002760752
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1371/journal.pone.0018579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050467509
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1523/jneurosci.09-08-02982.1989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079333981
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1523/jneurosci.2090-13.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005706175
254 rdf:type schema:CreativeWork
255 https://www.grid.ac/institutes/grid.284723.8 schema:alternateName Southern Medical University
256 schema:name Guangdong Province Key Laboratory of Psychiatric Disorders, Southern Medical University, 510515, Guangzhou, China
257 South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, 510006, Guangzhou, China
258 rdf:type schema:Organization
259 https://www.grid.ac/institutes/grid.411866.c schema:alternateName Guangzhou University of Chinese Medicine
260 schema:name School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, 510006, Guangzhou, China
261 South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, 510006, Guangzhou, China
262 rdf:type schema:Organization
263 https://www.grid.ac/institutes/grid.413402.0 schema:alternateName Guangdong Provincial Hospital
264 schema:name Guangdong Provincial Hospital of Chinese Medicine, 510006, Guangzhou, China
265 South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, 510006, Guangzhou, China
266 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...