Effect of nitric oxide on the expression of apelin receptor mRNA in rat caudate nucleus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-05

AUTHORS

Bo Bai, Yu-Hong Liu, Hai-Qing Liu

ABSTRACT

ObjectiveTo investigate the effect of nitric oxide (NO) on the expression of apelin receptor mRNA, as well as their correlation, in the caudate nucleus of rat.MethodsL-Arginine (L-Arg), NG-nitro-L-arginine methyl ester (L-NAME) and normal saline (NS) was separately microinjected into rat caudate nucleus. Expressions of neuronal NO synthase (nNOS) mRNA and apelin receptor mRNA were detected by RT-PCR at 4, 8, 12, 24 and 48 h after microinjection, and their correlation was determined.ResultsThe expressions of nNOS mRNA and apelin receptor mRNA were both significantly increased after microinjection of L-Arg, but significantly decreased after microinjection of L-NAME compared with the NS control group. The nNOS mRNA had a positive correlation with the expression of apelin receptor mRNA after microinjection of L-Arg and L-NAME.ConclusionThe activity of NOS in the central nervous system, especially in the caudate nucleus, is one of the key factors for NO to exert many kinds of biological actions, such as modulation of central pain, as a neurotransmitter. The neurobiological action of NO in rat caudate nucleus may be associated with apelin receptors. More... »

PAGES

180-184

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12264-007-0027-9

DOI

http://dx.doi.org/10.1007/s12264-007-0027-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044154079

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17612598


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