trans-Resveratrol induces apoptosis in human breast cancer cells MCF-7 by the activation of MAP kinases pathways View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-12

AUTHORS

G. Filomeni, I. Graziani, G. Rotilio, M. R. Ciriolo

ABSTRACT

Polyphenols represent a large class of plant-derived molecules with a general chemical structure that act as potent free radical scavengers. They have long been recognized to possess several therapeutic activities ranging from anti-thrombotic to antioxidant. Moreover, the capability of polyphenols to act as reducing or oxidizing molecules depends on the presence of environmental metals and on the concentrations used. In this work we demonstrated that the stilbene trans-resveratrol was able to commit human breast cancer MCF-7 cells to apoptosis. Mainly, we evidenced a pivotal role of the mitochondria in this phenomenon as cytochrome c release into the cytosol was found after the treatment. We further showed that trans-resveratrol was able to affect cellular redox state. In particular, it induced an early production of ROS and lipid oxidation, and only later compromised the GSH/GSSG ratio. This mode of action was mirrored by a temporally different activation of JNK and p38(MAPK), with the former rapidly induced and the latter weakly activated at long intervals. The results obtained demonstrate a pro-apoptotic activity for trans-resveratrol, and suggest a preferential activation of different classes of MAP kinases in response to different oxidative stimuli (ROS versus GSH/GSSG alteration). More... »

PAGES

295-305

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12263-007-0059-9

DOI

http://dx.doi.org/10.1007/s12263-007-0059-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032367243

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18850184


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Rome Tor Vergata", 
          "id": "https://www.grid.ac/institutes/grid.6530.0", 
          "name": [
            "Department of Biology, University of Rome \u201cTor Vergata\u201d, via della Ricerca Scientifica, 00133, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Filomeni", 
        "givenName": "G.", 
        "id": "sg:person.01000133353.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000133353.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Rome Tor Vergata", 
          "id": "https://www.grid.ac/institutes/grid.6530.0", 
          "name": [
            "Department of Biology, University of Rome \u201cTor Vergata\u201d, via della Ricerca Scientifica, 00133, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Graziani", 
        "givenName": "I.", 
        "id": "sg:person.0715461251.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715461251.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Department of Biology, University of Rome \u201cTor Vergata\u201d, via della Ricerca Scientifica, 00133, Rome, Italy", 
            "IRCCS San Raffaele Pisana, via della Pisana, 235, 00163, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rotilio", 
        "givenName": "G.", 
        "id": "sg:person.01143656332.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143656332.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Department of Biology, University of Rome \u201cTor Vergata\u201d, via della Ricerca Scientifica, 00133, Rome, Italy", 
            "IRCCS San Raffaele Pisana, via della Pisana, 235, 00163, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ciriolo", 
        "givenName": "M. R.", 
        "id": "sg:person.01176146700.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176146700.80"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1089/15230860260196218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000926454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m505537200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002277679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m505537200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002277679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/33308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003642003", 
          "https://doi.org/10.1038/33308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/33308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003642003", 
          "https://doi.org/10.1038/33308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1054/mehy.1999.0982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004689696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.drup.2004.01.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006053904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tox.2004.07.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007338613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgi040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009681898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m602641200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009722351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2004.10.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010328975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-5-45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012567609", 
          "https://doi.org/10.1186/1476-4598-5-45"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m501443200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013691243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m501443200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013691243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.taap.2005.01.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013914166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(00)00511-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014792551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cbic.200400421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017954344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m304896200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018433432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-2273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019935241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2005.12.059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021190908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1999.4471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022073112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2004.04.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024439401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-2952(02)01176-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025753634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.taap.2003.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026205113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-3067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026554988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.164.12.6509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027905820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031918545", 
          "https://doi.org/10.1038/sj.cdd.4401754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031918545", 
          "https://doi.org/10.1038/sj.cdd.4401754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031918545", 
          "https://doi.org/10.1038/sj.cdd.4401754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2005.03.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035405582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(88)90253-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035769994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(88)90253-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035769994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.02-0105fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036583515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1999.tb08737.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037514703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1999.tb08737.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037514703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.04-2915fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039129680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(91)90198-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041435308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(91)90198-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041435308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10715760000301141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042361525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/arch.940290203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042700594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2005.7.1630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044022489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1081/dmr-120000652", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044193703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2005.7.472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044678598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-483x(02)00198-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044901601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/152165400300001471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046063582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4615-5335-9_10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047047209", 
          "https://doi.org/10.1007/978-1-4615-5335-9_10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4615-5335-9_10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047047209", 
          "https://doi.org/10.1007/978-1-4615-5335-9_10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-003-0726-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047060975", 
          "https://doi.org/10.1007/s00280-003-0726-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.00-0675fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048548513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049721637", 
          "https://doi.org/10.1038/sj.onc.1207307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049721637", 
          "https://doi.org/10.1038/sj.onc.1207307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/abab:135:3:181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051287971", 
          "https://doi.org/10.1385/abab:135:3:181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.abb.2005.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051835139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.abb.2005.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051835139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.10932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052657146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(86)90461-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052959155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(86)90461-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052959155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np50051a014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056234409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/tx980271b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056300919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/tx980271b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056300919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/152308601317203567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059212208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/15230860260196209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059212291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2005.7.446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059230248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.275.5297.218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062555467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.8564259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064743866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1381612043384880", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069165271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.12.4.865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071510646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.23.4.1143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071515127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074782129", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074813255", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074834928", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.60.1.217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074835752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/132.9.2814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075120301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076575074", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076588066", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076750128", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083296933", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-12", 
    "datePublishedReg": "2007-12-01", 
    "description": "Polyphenols represent a large class of plant-derived molecules with a general chemical structure that act as potent free radical scavengers. They have long been recognized to possess several therapeutic activities ranging from anti-thrombotic to antioxidant. Moreover, the capability of polyphenols to act as reducing or oxidizing molecules depends on the presence of environmental metals and on the concentrations used. In this work we demonstrated that the stilbene trans-resveratrol was able to commit human breast cancer MCF-7 cells to apoptosis. Mainly, we evidenced a pivotal role of the mitochondria in this phenomenon as cytochrome c release into the cytosol was found after the treatment. We further showed that trans-resveratrol was able to affect cellular redox state. In particular, it induced an early production of ROS and lipid oxidation, and only later compromised the GSH/GSSG ratio. This mode of action was mirrored by a temporally different activation of JNK and p38(MAPK), with the former rapidly induced and the latter weakly activated at long intervals. The results obtained demonstrate a pro-apoptotic activity for trans-resveratrol, and suggest a preferential activation of different classes of MAP kinases in response to different oxidative stimuli (ROS versus GSH/GSSG alteration).", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12263-007-0059-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1037294", 
        "issn": [
          "1555-8932", 
          "1865-3499"
        ], 
        "name": "Genes & Nutrition", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "name": "trans-Resveratrol induces apoptosis in human breast cancer cells MCF-7 by the activation of MAP kinases pathways", 
    "pagination": "295-305", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9a3178070004d709d9131e01f78fd1f7c9c84b275b308136dc8856f9f3ac3e82"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18850184"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101280108"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12263-007-0059-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032367243"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12263-007-0059-9", 
      "https://app.dimensions.ai/details/publication/pub.1032367243"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000522.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12263-007-0059-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12263-007-0059-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12263-007-0059-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12263-007-0059-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12263-007-0059-9'


 

This table displays all metadata directly associated to this object as RDF triples.

286 TRIPLES      21 PREDICATES      93 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12263-007-0059-9 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N4b337a242d3244f6bd717c621e724d5c
4 schema:citation sg:pub.10.1007/978-1-4615-5335-9_10
5 sg:pub.10.1007/s00280-003-0726-5
6 sg:pub.10.1038/33308
7 sg:pub.10.1038/sj.cdd.4401754
8 sg:pub.10.1038/sj.onc.1207307
9 sg:pub.10.1186/1476-4598-5-45
10 sg:pub.10.1385/abab:135:3:181
11 https://app.dimensions.ai/details/publication/pub.1074782129
12 https://app.dimensions.ai/details/publication/pub.1074813255
13 https://app.dimensions.ai/details/publication/pub.1074834928
14 https://app.dimensions.ai/details/publication/pub.1076575074
15 https://app.dimensions.ai/details/publication/pub.1076588066
16 https://app.dimensions.ai/details/publication/pub.1076750128
17 https://app.dimensions.ai/details/publication/pub.1083296933
18 https://doi.org/10.1002/arch.940290203
19 https://doi.org/10.1002/cbic.200400421
20 https://doi.org/10.1002/ijc.10932
21 https://doi.org/10.1006/excr.1999.4471
22 https://doi.org/10.1016/0006-2952(86)90461-2
23 https://doi.org/10.1016/0006-2952(88)90253-5
24 https://doi.org/10.1016/0022-1759(91)90198-o
25 https://doi.org/10.1016/j.abb.2005.07.002
26 https://doi.org/10.1016/j.drup.2004.01.004
27 https://doi.org/10.1016/j.febslet.2005.12.059
28 https://doi.org/10.1016/j.freeradbiomed.2004.04.034
29 https://doi.org/10.1016/j.freeradbiomed.2004.10.035
30 https://doi.org/10.1016/j.freeradbiomed.2005.03.022
31 https://doi.org/10.1016/j.taap.2003.08.017
32 https://doi.org/10.1016/j.taap.2005.01.004
33 https://doi.org/10.1016/j.tox.2004.07.022
34 https://doi.org/10.1016/s0006-2952(02)01176-0
35 https://doi.org/10.1016/s0300-483x(02)00198-1
36 https://doi.org/10.1016/s0304-3835(00)00511-5
37 https://doi.org/10.1021/np50051a014
38 https://doi.org/10.1021/tx980271b
39 https://doi.org/10.1054/mehy.1999.0982
40 https://doi.org/10.1074/jbc.m304896200
41 https://doi.org/10.1074/jbc.m501443200
42 https://doi.org/10.1074/jbc.m505537200
43 https://doi.org/10.1074/jbc.m602641200
44 https://doi.org/10.1080/10715760000301141
45 https://doi.org/10.1080/152165400300001471
46 https://doi.org/10.1081/dmr-120000652
47 https://doi.org/10.1089/152308601317203567
48 https://doi.org/10.1089/15230860260196209
49 https://doi.org/10.1089/15230860260196218
50 https://doi.org/10.1089/ars.2005.7.1630
51 https://doi.org/10.1089/ars.2005.7.446
52 https://doi.org/10.1089/ars.2005.7.472
53 https://doi.org/10.1093/carcin/bgi040
54 https://doi.org/10.1093/jn/132.9.2814
55 https://doi.org/10.1096/fj.00-0675fje
56 https://doi.org/10.1096/fj.02-0105fje
57 https://doi.org/10.1096/fj.04-2915fje
58 https://doi.org/10.1111/j.1749-6632.1999.tb08737.x
59 https://doi.org/10.1124/mol.60.1.217
60 https://doi.org/10.1126/science.275.5297.218
61 https://doi.org/10.1158/0008-5472.can-05-3067
62 https://doi.org/10.1158/1078-0432.ccr-04-2273
63 https://doi.org/10.1289/ehp.8564259
64 https://doi.org/10.2174/1381612043384880
65 https://doi.org/10.3892/ijo.12.4.865
66 https://doi.org/10.3892/ijo.23.4.1143
67 https://doi.org/10.4049/jimmunol.164.12.6509
68 schema:datePublished 2007-12
69 schema:datePublishedReg 2007-12-01
70 schema:description Polyphenols represent a large class of plant-derived molecules with a general chemical structure that act as potent free radical scavengers. They have long been recognized to possess several therapeutic activities ranging from anti-thrombotic to antioxidant. Moreover, the capability of polyphenols to act as reducing or oxidizing molecules depends on the presence of environmental metals and on the concentrations used. In this work we demonstrated that the stilbene trans-resveratrol was able to commit human breast cancer MCF-7 cells to apoptosis. Mainly, we evidenced a pivotal role of the mitochondria in this phenomenon as cytochrome c release into the cytosol was found after the treatment. We further showed that trans-resveratrol was able to affect cellular redox state. In particular, it induced an early production of ROS and lipid oxidation, and only later compromised the GSH/GSSG ratio. This mode of action was mirrored by a temporally different activation of JNK and p38(MAPK), with the former rapidly induced and the latter weakly activated at long intervals. The results obtained demonstrate a pro-apoptotic activity for trans-resveratrol, and suggest a preferential activation of different classes of MAP kinases in response to different oxidative stimuli (ROS versus GSH/GSSG alteration).
71 schema:genre research_article
72 schema:inLanguage en
73 schema:isAccessibleForFree true
74 schema:isPartOf N2fa00ced84ee4531964a8c42cf1d6d1b
75 N5604d036af0a42279a8b8a4afd424393
76 sg:journal.1037294
77 schema:name trans-Resveratrol induces apoptosis in human breast cancer cells MCF-7 by the activation of MAP kinases pathways
78 schema:pagination 295-305
79 schema:productId N001be7756fc243f8979fada21bc6ac5e
80 N149867472be649e3bb53c5e29843c586
81 N250de724ea024907a54e04f3a30f001a
82 N51a873d805124da7af0f26b6f32ff617
83 N955981df0e4f44c7a298350fe8088cf5
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032367243
85 https://doi.org/10.1007/s12263-007-0059-9
86 schema:sdDatePublished 2019-04-10T14:12
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher Nc540fbd8a63a4769a2654741ddf93992
89 schema:url http://link.springer.com/10.1007%2Fs12263-007-0059-9
90 sgo:license sg:explorer/license/
91 sgo:sdDataset articles
92 rdf:type schema:ScholarlyArticle
93 N001be7756fc243f8979fada21bc6ac5e schema:name pubmed_id
94 schema:value 18850184
95 rdf:type schema:PropertyValue
96 N149867472be649e3bb53c5e29843c586 schema:name readcube_id
97 schema:value 9a3178070004d709d9131e01f78fd1f7c9c84b275b308136dc8856f9f3ac3e82
98 rdf:type schema:PropertyValue
99 N250de724ea024907a54e04f3a30f001a schema:name dimensions_id
100 schema:value pub.1032367243
101 rdf:type schema:PropertyValue
102 N2fa00ced84ee4531964a8c42cf1d6d1b schema:volumeNumber 2
103 rdf:type schema:PublicationVolume
104 N4b337a242d3244f6bd717c621e724d5c rdf:first sg:person.01000133353.16
105 rdf:rest N99d302faa7cc4ee085ae802dd6e35231
106 N4e314975d66d440ca4f36a715442c661 rdf:first sg:person.01176146700.80
107 rdf:rest rdf:nil
108 N51a873d805124da7af0f26b6f32ff617 schema:name doi
109 schema:value 10.1007/s12263-007-0059-9
110 rdf:type schema:PropertyValue
111 N5604d036af0a42279a8b8a4afd424393 schema:issueNumber 3
112 rdf:type schema:PublicationIssue
113 N7b653698de3342b788c747d2eff8a41c rdf:first sg:person.01143656332.85
114 rdf:rest N4e314975d66d440ca4f36a715442c661
115 N955981df0e4f44c7a298350fe8088cf5 schema:name nlm_unique_id
116 schema:value 101280108
117 rdf:type schema:PropertyValue
118 N99d302faa7cc4ee085ae802dd6e35231 rdf:first sg:person.0715461251.05
119 rdf:rest N7b653698de3342b788c747d2eff8a41c
120 Nc540fbd8a63a4769a2654741ddf93992 schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
123 schema:name Biological Sciences
124 rdf:type schema:DefinedTerm
125 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
126 schema:name Biochemistry and Cell Biology
127 rdf:type schema:DefinedTerm
128 sg:journal.1037294 schema:issn 1555-8932
129 1865-3499
130 schema:name Genes & Nutrition
131 rdf:type schema:Periodical
132 sg:person.01000133353.16 schema:affiliation https://www.grid.ac/institutes/grid.6530.0
133 schema:familyName Filomeni
134 schema:givenName G.
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000133353.16
136 rdf:type schema:Person
137 sg:person.01143656332.85 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
138 schema:familyName Rotilio
139 schema:givenName G.
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143656332.85
141 rdf:type schema:Person
142 sg:person.01176146700.80 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
143 schema:familyName Ciriolo
144 schema:givenName M. R.
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176146700.80
146 rdf:type schema:Person
147 sg:person.0715461251.05 schema:affiliation https://www.grid.ac/institutes/grid.6530.0
148 schema:familyName Graziani
149 schema:givenName I.
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715461251.05
151 rdf:type schema:Person
152 sg:pub.10.1007/978-1-4615-5335-9_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047047209
153 https://doi.org/10.1007/978-1-4615-5335-9_10
154 rdf:type schema:CreativeWork
155 sg:pub.10.1007/s00280-003-0726-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047060975
156 https://doi.org/10.1007/s00280-003-0726-5
157 rdf:type schema:CreativeWork
158 sg:pub.10.1038/33308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003642003
159 https://doi.org/10.1038/33308
160 rdf:type schema:CreativeWork
161 sg:pub.10.1038/sj.cdd.4401754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031918545
162 https://doi.org/10.1038/sj.cdd.4401754
163 rdf:type schema:CreativeWork
164 sg:pub.10.1038/sj.onc.1207307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049721637
165 https://doi.org/10.1038/sj.onc.1207307
166 rdf:type schema:CreativeWork
167 sg:pub.10.1186/1476-4598-5-45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012567609
168 https://doi.org/10.1186/1476-4598-5-45
169 rdf:type schema:CreativeWork
170 sg:pub.10.1385/abab:135:3:181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051287971
171 https://doi.org/10.1385/abab:135:3:181
172 rdf:type schema:CreativeWork
173 https://app.dimensions.ai/details/publication/pub.1074782129 schema:CreativeWork
174 https://app.dimensions.ai/details/publication/pub.1074813255 schema:CreativeWork
175 https://app.dimensions.ai/details/publication/pub.1074834928 schema:CreativeWork
176 https://app.dimensions.ai/details/publication/pub.1076575074 schema:CreativeWork
177 https://app.dimensions.ai/details/publication/pub.1076588066 schema:CreativeWork
178 https://app.dimensions.ai/details/publication/pub.1076750128 schema:CreativeWork
179 https://app.dimensions.ai/details/publication/pub.1083296933 schema:CreativeWork
180 https://doi.org/10.1002/arch.940290203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042700594
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1002/cbic.200400421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017954344
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1002/ijc.10932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052657146
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1006/excr.1999.4471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022073112
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/0006-2952(86)90461-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052959155
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/0006-2952(88)90253-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035769994
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/0022-1759(91)90198-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1041435308
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.abb.2005.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051835139
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.drup.2004.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006053904
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.febslet.2005.12.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021190908
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.freeradbiomed.2004.04.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024439401
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.freeradbiomed.2004.10.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010328975
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.freeradbiomed.2005.03.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035405582
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.taap.2003.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026205113
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.taap.2005.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013914166
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.tox.2004.07.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007338613
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/s0006-2952(02)01176-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025753634
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/s0300-483x(02)00198-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044901601
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/s0304-3835(00)00511-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014792551
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1021/np50051a014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056234409
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1021/tx980271b schema:sameAs https://app.dimensions.ai/details/publication/pub.1056300919
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1054/mehy.1999.0982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004689696
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1074/jbc.m304896200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018433432
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1074/jbc.m501443200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013691243
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1074/jbc.m505537200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002277679
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1074/jbc.m602641200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009722351
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1080/10715760000301141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042361525
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1080/152165400300001471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046063582
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1081/dmr-120000652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044193703
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1089/152308601317203567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059212208
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1089/15230860260196209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059212291
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1089/15230860260196218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000926454
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1089/ars.2005.7.1630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044022489
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1089/ars.2005.7.446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059230248
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1089/ars.2005.7.472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044678598
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1093/carcin/bgi040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009681898
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1093/jn/132.9.2814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075120301
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1096/fj.00-0675fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1048548513
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1096/fj.02-0105fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1036583515
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1096/fj.04-2915fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1039129680
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1111/j.1749-6632.1999.tb08737.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037514703
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1124/mol.60.1.217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074835752
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1126/science.275.5297.218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062555467
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1158/0008-5472.can-05-3067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026554988
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1158/1078-0432.ccr-04-2273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019935241
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1289/ehp.8564259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064743866
271 rdf:type schema:CreativeWork
272 https://doi.org/10.2174/1381612043384880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069165271
273 rdf:type schema:CreativeWork
274 https://doi.org/10.3892/ijo.12.4.865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071510646
275 rdf:type schema:CreativeWork
276 https://doi.org/10.3892/ijo.23.4.1143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071515127
277 rdf:type schema:CreativeWork
278 https://doi.org/10.4049/jimmunol.164.12.6509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027905820
279 rdf:type schema:CreativeWork
280 https://www.grid.ac/institutes/grid.18887.3e schema:alternateName San Raffaele Hospital
281 schema:name Department of Biology, University of Rome “Tor Vergata”, via della Ricerca Scientifica, 00133, Rome, Italy
282 IRCCS San Raffaele Pisana, via della Pisana, 235, 00163, Rome, Italy
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.6530.0 schema:alternateName University of Rome Tor Vergata
285 schema:name Department of Biology, University of Rome “Tor Vergata”, via della Ricerca Scientifica, 00133, Rome, Italy
286 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...