Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Mi Na Rhie, Hee Taek Kim, Seo Young Jo, Luan Luong Chu, Kei-Anne Baritugo, Mary Grace Baylon, Jinwon Lee, Jeong-Geol Na, Lyul Ho Kim, Tae Wan Kim, Chulhwan Park, Soon Ho Hong, Jeong Chan Joo, Si Jae Park

ABSTRACT

The production of industrial chemicals from renewable biomass resources is a promising solution to overcome the society’s dependence on petroleum and to mitigate the pollution resulting from petroleum processing. Klebsiella pneumoniae is a nutritionally versatile bacterium with numerous native pathways for the production of well-known and industrially important platform chemicals derived from various sugars. Genomic sequence analyses have shown that the K. pneumoniae genome has a high similarity with that of Escherichia coli, the most studied organism, which is used in industrial biotechnology processes for fuel and chemical production. Hence, K. pneumoniae can be considered as a promising platform microorganism that can be metabolically engineered for the high-level production of bio-based chemicals. This review highlights the substrate metabolism and the metabolic engineering strategies developed in K. pneumoniae for the production of bio-based chemicals. More... »

PAGES

48-64

References to SciGraph publications

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    DOI

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    https://app.dimensions.ai/details/publication/pub.1112020435


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