In vitro and in vivo investigation for biological activities of neoagarooligosaccharides prepared by hydrolyzing agar with β-agarase View Full Text


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Article Info

DATE

2017-08

AUTHORS

Sun Joo Hong, Je-Hyeon Lee, Eun Joo Kim, Hea Jung Yang, Yong-Keun Chang, Jae-Seon Park, Soon-Kwang Hong

ABSTRACT

Our study investigated the biological functions of three neoagarooligosaccharides (NAOs), neoagarobiose (NA2), neoagarotetraose (NA4), and neoagarohexaose (NA6). NAOs were prepared by hydrolyzing agar with the recombinant β-agarases, DagA and DagB, from Streptomyces coelicolor A3(2). An in vitro DPPH (diphenyl-2,4,6-trinitrophenyliminoazanium) radical scavenging assay revealed that none of the NAOs had any significant antioxidative activity. We also assessed the antibacterial activity of each NAO against several gram-negative and gram-positive bacteria. This revealed weak effects against four of the seven tested strains. NAO treatment resulted in significant inhibition of α-glucosidase, with the strongest effect observed in a NA4 and NA6 mixture, and a decreasing effect was observed in the order NA2>NA4>NA6. Little inhibition was observed against α-amylase, with an effect significantly lower than that of acarbose. No observable cytotoxicity was found in immortalized Melan-a mouse melanocytes by NAO treatment up to a concentration of 2,000 μg/mL. However, melanin synthesis was significantly reduced by NAO treatment, with the strongest effect observed in a NA4 and NA6 mixture and decreasing effects observed in the order NA6>NA4>NA2. The tyrosinase activity of Melan-a cells was also consistently decreased by NAO treatment. Among the tested factors, treatment of NA4 and NA6 mixture showed the highest inhibition effects against α-glucosidase and tyrosinase, and melanin biosynthesis. Further in vivo study to investigate the role of NAO in these biological functions will be necessary for future biotechnological applications. More... »

PAGES

489-496

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12257-017-0049-8

DOI

http://dx.doi.org/10.1007/s12257-017-0049-8

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https://app.dimensions.ai/details/publication/pub.1091507186


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