Refolding of lysozyme in hydrophobic interaction chromatography: Effects of hydrophobicity of adsorbent and salt concentration in mobile phase View Full Text


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Article Info

DATE

2010-04

AUTHORS

Sung-Mi Hwang, Hye-Jin Kang, Sang-Woo Bae, Woo-Jin Chang, Yoon-Mo Koo

ABSTRACT

The effects of salt concentration in mobile phase, elution strategy, and hydrophobicity of stationary phase on lysozyme refolding in hydrophobic interaction chromatography (HIC) were investigated. Butyl Sepharose 4 Fast Flow, the least hydrophobic HIC resin among the tested adsorbent, showed the best refolding yield. The binding efficiency of unfolded lysozyme on the adsorbent was maximized when 1 and 0.4 M of initial and final concentration of ammonium sulfate was used in mobile phase, respectively. The optimum gradient strategy for refolding and elution of lysozyme was determined as linear increase of urea concentration to 4M. The optimized condition suggests the less hydrophobic environment than conventionally used salt solutions and HIC resins. Consequently, total refolding yield was improved 1.6 times comparing with optimized dilution-based batch refolding method. More... »

PAGES

213-219

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Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12257-009-0216-7

DOI

http://dx.doi.org/10.1007/s12257-009-0216-7

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