The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-02

AUTHORS

Lily Oguh-Olayinka, Vijay Agarwal, Dulani Ranatunge, Anne Campbell, Stefan Laufer, Lynn Cawkwell, Michael J. Lind

ABSTRACT

Advanced malignant pleural mesothelioma (MPM) has an extremely poor prognosis with limited chemotherapy options, therefore the identification of new therapeutic targets would aid in disease management. Arachidonic acid is metabolised by cyclooxygenase and lipoxygenase enzymes. The lipoxygenase isoenzymes 5-LOX and 12-LOX have been implicated in carcinogenesis. We aimed to examine 5-LOX and 12-LOX protein expression in a large retrospective series of mesothelioma samples. Further to this, the in vitro cytotoxic effects of lipoxygenase pathway inhibitors were investigated in mesothelioma cells. Archival samples from 83 patients with MPM were examined by immunohistochemistry for expression of the 5-LOX and 12-LOX proteins. The MTS assay was used to assess cell viability following 72 h treatment with the lipoxygenase pathway inhibitors baicalein, licofelone, MK-886 and zileuton in the MPM cell lines NCI-H2052, NCI-H2452 and MSTO-211H. Positive 12-LOX protein expression was recorded in 69/83 (83%) and positive 5-LOX expression was observed in 56/77 (73%) of MPM tissue samples. Co-expression of 5-LOX with 12-LOX was seen in 46/78 (58%) of MPM samples. Positive expression of 5-LOX, 12-LOX and COX-2 proteins was identified in the NCI-H2052, NCI-H2452 and MSTO-211H MPM cell lines. Baicalein (12-LOX and 15-LOX inhibitor) was effective in 3/3 MPM cell lines at low concentrations with an IC50 range of 9.6 μM to 20.7 μM. We have demonstrated that the 5-LOX and 12-LOX proteins are expressed in a significant proportion of MPM samples (73% and 83% respectively) and may represent novel therapeutic targets in this disease. We have demonstrated that the inhibition of the LOX pathway using baicalein may be effective as a novel treatment for MPM, however further human pharmacokinetic studies are required in order to establish whether the concentration used in vitro is clinically achievable. More... »

PAGES

1-11

References to SciGraph publications

  • 2010-03. Eicosanoids and cancer in NATURE REVIEWS CANCER
  • 2011-12. Cyclooxygenases and lipoxygenases in cancer in CANCER AND METASTASIS REVIEWS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12253-019-00652-x

    DOI

    http://dx.doi.org/10.1007/s12253-019-00652-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113180085

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30941737


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Hull York Medical School", 
              "id": "https://www.grid.ac/institutes/grid.413631.2", 
              "name": [
                "Research Laboratories, Hull York Medical School, Daisy Building, Castle Hill Hospital, HU16 5JQ, Hull, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oguh-Olayinka", 
            "givenName": "Lily", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hull and East Yorkshire Hospitals NHS Trust", 
              "id": "https://www.grid.ac/institutes/grid.417700.5", 
              "name": [
                "Research Laboratories, Hull York Medical School, Daisy Building, Castle Hill Hospital, HU16 5JQ, Hull, UK", 
                "Queens Centre for Oncology and Haematology, Hull and East Yorkshire NHS Trust, Hull, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Agarwal", 
            "givenName": "Vijay", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hull York Medical School", 
              "id": "https://www.grid.ac/institutes/grid.413631.2", 
              "name": [
                "Research Laboratories, Hull York Medical School, Daisy Building, Castle Hill Hospital, HU16 5JQ, Hull, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ranatunge", 
            "givenName": "Dulani", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hull and East Yorkshire Hospitals NHS Trust", 
              "id": "https://www.grid.ac/institutes/grid.417700.5", 
              "name": [
                "Histopathology Department, Hull and East Yorkshire NHS Trust, Hull, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Campbell", 
            "givenName": "Anne", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Pharmaceutical Chemistry, Eberhard Karls University, T\u00fcbingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Laufer", 
            "givenName": "Stefan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Hull", 
              "id": "https://www.grid.ac/institutes/grid.9481.4", 
              "name": [
                "Research Laboratories, Hull York Medical School, Daisy Building, Castle Hill Hospital, HU16 5JQ, Hull, UK", 
                "Department of Biomedical Science, University of Hull, Hull, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cawkwell", 
            "givenName": "Lynn", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hull and East Yorkshire Hospitals NHS Trust", 
              "id": "https://www.grid.ac/institutes/grid.417700.5", 
              "name": [
                "Research Laboratories, Hull York Medical School, Daisy Building, Castle Hill Hospital, HU16 5JQ, Hull, UK", 
                "Queens Centre for Oncology and Haematology, Hull and East Yorkshire NHS Trust, Hull, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lind", 
            "givenName": "Michael J.", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1111/bcpt.12114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000332927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molmed.2012.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000615517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.01-0150com", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001120268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-04-0838", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002290961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tips.2007.11.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002827889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbamcr.2011.05.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004087675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-4631", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004323842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0040794", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004865414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1476-5381.2010.00915.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012906014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1476-5381.2010.00915.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012906014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012973605", 
              "https://doi.org/10.1038/nrc2809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012973605", 
              "https://doi.org/10.1038/nrc2809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/fon.12.14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015435243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)64198-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016101249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejcts.2010.02.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016756112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ju.0000080296.54262.c8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017148970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ju.0000080296.54262.c8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017148970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ju.0000080296.54262.c8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017148970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(20010215)91:4<737::aid-cncr1059>3.0.co;2-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017646470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0952-3278(03)00110-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021635988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0952-3278(03)00110-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021635988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1098-8823(03)00042-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022668726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1098-8823(03)00042-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022668726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/sonc.2002.30227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025650818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0065-2571(84)90007-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026371633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0065-2571(84)90007-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026371633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-07-0281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026694261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bcp.2011.06.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027253367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ctrv.2009.09.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027988840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/dmd.108.020347", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029205444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0072927", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031480451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2005.04.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032010584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2005.04.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032010584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-04-1684", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032214070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0215(20000701)87:1<37::aid-ijc6>3.0.co;2-l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033288582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2009.04.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034630190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/thx.2003.008912", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034937334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1254/jphs.fp0060651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035191764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00008390-200209000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036582042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00008390-200209000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036582042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/gast.2003.50011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037412193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/gast.2003.50011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037412193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-12-1103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038981182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmc.2006.01.057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039099754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmc.2006.01.057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039099754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgm265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040449496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.19.8523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040848488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jep.2014.08.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041954811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-5002(01)00257-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042081771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgi026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044089870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2005.07.166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047071625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2005.07.166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047071625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.294.8.914", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048687714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgp014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049071412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/febs.12969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052442104"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/excr.1994.1240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053098315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10555-011-9310-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053337900", 
              "https://doi.org/10.1007/s10555-011-9310-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.45.3.409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053571357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2003.11.136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064203976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/138161205774370753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069165623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/156802607779941369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069193462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v10.i13.1971", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071362338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ijms18020236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074201764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074273048", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074369228", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075069010", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076785231", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077047443", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-04-02", 
        "datePublishedReg": "2019-04-02", 
        "description": "Advanced malignant pleural mesothelioma (MPM) has an extremely poor prognosis with limited chemotherapy options, therefore the identification of new therapeutic targets would aid in disease management. Arachidonic acid is metabolised by cyclooxygenase and lipoxygenase enzymes. The lipoxygenase isoenzymes 5-LOX and 12-LOX have been implicated in carcinogenesis. We aimed to examine 5-LOX and 12-LOX protein expression in a large retrospective series of mesothelioma samples. Further to this, the in vitro cytotoxic effects of lipoxygenase pathway inhibitors were investigated in mesothelioma cells. Archival samples from 83 patients with MPM were examined by immunohistochemistry for expression of the 5-LOX and 12-LOX proteins. The MTS assay was used to assess cell viability following 72\u00a0h treatment with the lipoxygenase pathway inhibitors baicalein, licofelone, MK-886 and zileuton in the MPM cell lines NCI-H2052, NCI-H2452 and MSTO-211H. Positive 12-LOX protein expression was recorded in 69/83 (83%) and positive 5-LOX expression was observed in 56/77 (73%) of MPM tissue samples. Co-expression of 5-LOX with 12-LOX was seen in 46/78 (58%) of MPM samples. Positive expression of 5-LOX, 12-LOX and COX-2 proteins was identified in the NCI-H2052, NCI-H2452 and MSTO-211H MPM cell lines. Baicalein (12-LOX and 15-LOX inhibitor) was effective in 3/3 MPM cell lines at low concentrations with an IC50 range of 9.6\u00a0\u03bcM to 20.7\u00a0\u03bcM. We have demonstrated that the 5-LOX and 12-LOX proteins are expressed in a significant proportion of MPM samples (73% and 83% respectively) and may represent novel therapeutic targets in this disease. We have demonstrated that the inhibition of the LOX pathway using baicalein may be effective as a novel treatment for MPM, however further human pharmacokinetic studies are required in order to establish whether the concentration used in vitro is clinically achievable.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s12253-019-00652-x", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1116758", 
            "issn": [
              "1219-4956", 
              "1532-2807"
            ], 
            "name": "Pathology & Oncology Research", 
            "type": "Periodical"
          }
        ], 
        "name": "The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma", 
        "pagination": "1-11", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12253-019-00652-x"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "013688fc59a167c49ac561d3e20324e871cf048d58e919d99e68cb7f6eb2f1b7"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113180085"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9706087"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30941737"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12253-019-00652-x", 
          "https://app.dimensions.ai/details/publication/pub.1113180085"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-15T09:22", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56182_00000006.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs12253-019-00652-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12253-019-00652-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12253-019-00652-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12253-019-00652-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12253-019-00652-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    275 TRIPLES      21 PREDICATES      82 URIs      18 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12253-019-00652-x schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N3632cb9c189847a2a6e00b2e4d092d3a
    4 schema:citation sg:pub.10.1007/s10555-011-9310-3
    5 sg:pub.10.1038/nrc2809
    6 https://app.dimensions.ai/details/publication/pub.1074273048
    7 https://app.dimensions.ai/details/publication/pub.1074369228
    8 https://app.dimensions.ai/details/publication/pub.1075069010
    9 https://app.dimensions.ai/details/publication/pub.1076785231
    10 https://app.dimensions.ai/details/publication/pub.1077047443
    11 https://doi.org/10.1001/jama.294.8.914
    12 https://doi.org/10.1002/1097-0142(20010215)91:4<737::aid-cncr1059>3.0.co;2-f
    13 https://doi.org/10.1002/1097-0215(20000701)87:1<37::aid-ijc6>3.0.co;2-l
    14 https://doi.org/10.1006/excr.1994.1240
    15 https://doi.org/10.1016/0065-2571(84)90007-4
    16 https://doi.org/10.1016/j.bbamcr.2011.05.003
    17 https://doi.org/10.1016/j.bbrc.2005.07.166
    18 https://doi.org/10.1016/j.bcp.2011.06.028
    19 https://doi.org/10.1016/j.bmc.2006.01.057
    20 https://doi.org/10.1016/j.ctrv.2009.09.003
    21 https://doi.org/10.1016/j.ejca.2005.04.019
    22 https://doi.org/10.1016/j.ejcts.2010.02.012
    23 https://doi.org/10.1016/j.jep.2014.08.031
    24 https://doi.org/10.1016/j.lungcan.2009.04.008
    25 https://doi.org/10.1016/j.molmed.2012.02.002
    26 https://doi.org/10.1016/j.tips.2007.11.006
    27 https://doi.org/10.1016/s0002-9440(10)64198-3
    28 https://doi.org/10.1016/s0169-5002(01)00257-4
    29 https://doi.org/10.1016/s0952-3278(03)00110-8
    30 https://doi.org/10.1016/s1098-8823(03)00042-x
    31 https://doi.org/10.1053/gast.2003.50011
    32 https://doi.org/10.1053/sonc.2002.30227
    33 https://doi.org/10.1093/carcin/bgi026
    34 https://doi.org/10.1093/carcin/bgm265
    35 https://doi.org/10.1093/carcin/bgp014
    36 https://doi.org/10.1096/fj.01-0150com
    37 https://doi.org/10.1097/00008390-200209000-00003
    38 https://doi.org/10.1097/01.ju.0000080296.54262.c8
    39 https://doi.org/10.1111/bcpt.12114
    40 https://doi.org/10.1111/febs.12969
    41 https://doi.org/10.1111/j.1476-5381.2010.00915.x
    42 https://doi.org/10.1124/dmd.108.020347
    43 https://doi.org/10.1136/gut.45.3.409
    44 https://doi.org/10.1136/thx.2003.008912
    45 https://doi.org/10.1158/1078-0432.ccr-04-0838
    46 https://doi.org/10.1158/1078-0432.ccr-04-1684
    47 https://doi.org/10.1158/1078-0432.ccr-07-4631
    48 https://doi.org/10.1158/1535-7163.mct-07-0281
    49 https://doi.org/10.1158/1535-7163.mct-12-1103
    50 https://doi.org/10.1200/jco.2003.11.136
    51 https://doi.org/10.1200/jco.2008.19.8523
    52 https://doi.org/10.1254/jphs.fp0060651
    53 https://doi.org/10.1371/journal.pone.0040794
    54 https://doi.org/10.1371/journal.pone.0072927
    55 https://doi.org/10.2174/138161205774370753
    56 https://doi.org/10.2174/156802607779941369
    57 https://doi.org/10.2217/fon.12.14
    58 https://doi.org/10.3390/ijms18020236
    59 https://doi.org/10.3748/wjg.v10.i13.1971
    60 schema:datePublished 2019-04-02
    61 schema:datePublishedReg 2019-04-02
    62 schema:description Advanced malignant pleural mesothelioma (MPM) has an extremely poor prognosis with limited chemotherapy options, therefore the identification of new therapeutic targets would aid in disease management. Arachidonic acid is metabolised by cyclooxygenase and lipoxygenase enzymes. The lipoxygenase isoenzymes 5-LOX and 12-LOX have been implicated in carcinogenesis. We aimed to examine 5-LOX and 12-LOX protein expression in a large retrospective series of mesothelioma samples. Further to this, the in vitro cytotoxic effects of lipoxygenase pathway inhibitors were investigated in mesothelioma cells. Archival samples from 83 patients with MPM were examined by immunohistochemistry for expression of the 5-LOX and 12-LOX proteins. The MTS assay was used to assess cell viability following 72 h treatment with the lipoxygenase pathway inhibitors baicalein, licofelone, MK-886 and zileuton in the MPM cell lines NCI-H2052, NCI-H2452 and MSTO-211H. Positive 12-LOX protein expression was recorded in 69/83 (83%) and positive 5-LOX expression was observed in 56/77 (73%) of MPM tissue samples. Co-expression of 5-LOX with 12-LOX was seen in 46/78 (58%) of MPM samples. Positive expression of 5-LOX, 12-LOX and COX-2 proteins was identified in the NCI-H2052, NCI-H2452 and MSTO-211H MPM cell lines. Baicalein (12-LOX and 15-LOX inhibitor) was effective in 3/3 MPM cell lines at low concentrations with an IC50 range of 9.6 μM to 20.7 μM. We have demonstrated that the 5-LOX and 12-LOX proteins are expressed in a significant proportion of MPM samples (73% and 83% respectively) and may represent novel therapeutic targets in this disease. We have demonstrated that the inhibition of the LOX pathway using baicalein may be effective as a novel treatment for MPM, however further human pharmacokinetic studies are required in order to establish whether the concentration used in vitro is clinically achievable.
    63 schema:genre research_article
    64 schema:inLanguage en
    65 schema:isAccessibleForFree false
    66 schema:isPartOf sg:journal.1116758
    67 schema:name The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma
    68 schema:pagination 1-11
    69 schema:productId N17d97b2bbc71478ba73ab84433b7171c
    70 N3e40eac386ab4af1b5f09db8122932ed
    71 Nc1f406b62d3a4bad97d3e865d66ba82c
    72 Nca168c1d7a6b4aa1bab5087e06be0866
    73 Nd9586ace5a1547ab8eaa5b901f0269a9
    74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113180085
    75 https://doi.org/10.1007/s12253-019-00652-x
    76 schema:sdDatePublished 2019-04-15T09:22
    77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    78 schema:sdPublisher Nb42d38f0179e468a9da1bf9a0c3c2dc3
    79 schema:url https://link.springer.com/10.1007%2Fs12253-019-00652-x
    80 sgo:license sg:explorer/license/
    81 sgo:sdDataset articles
    82 rdf:type schema:ScholarlyArticle
    83 N052e39903c324e3d83f187195c7e1725 rdf:first Nc7e1328562d04331891606235f96c555
    84 rdf:rest N31d91ba137504ad9874a55c71ebf5dc3
    85 N15b51d072685483698c615c78f815e58 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    86 schema:familyName Laufer
    87 schema:givenName Stefan
    88 rdf:type schema:Person
    89 N17d97b2bbc71478ba73ab84433b7171c schema:name pubmed_id
    90 schema:value 30941737
    91 rdf:type schema:PropertyValue
    92 N31d91ba137504ad9874a55c71ebf5dc3 rdf:first Ne0f3038da3f64a6dace98e5ff4e5d1cb
    93 rdf:rest rdf:nil
    94 N3632cb9c189847a2a6e00b2e4d092d3a rdf:first Nd4c0eb5404194e4d81d443de8095e055
    95 rdf:rest N3eb1efb0e27e4c64b3efbdaa39ced193
    96 N3e40eac386ab4af1b5f09db8122932ed schema:name nlm_unique_id
    97 schema:value 9706087
    98 rdf:type schema:PropertyValue
    99 N3eb1efb0e27e4c64b3efbdaa39ced193 rdf:first Ne12904b10ea54fd1a6ffc213bab1d9b6
    100 rdf:rest Nab88abf1a358417695defc22f6c825e4
    101 N4fb7716ca6fc4cc1b83672a0793b603a schema:affiliation https://www.grid.ac/institutes/grid.413631.2
    102 schema:familyName Ranatunge
    103 schema:givenName Dulani
    104 rdf:type schema:Person
    105 N67f213d110b541588e29c94b1e184a97 rdf:first N15b51d072685483698c615c78f815e58
    106 rdf:rest N052e39903c324e3d83f187195c7e1725
    107 Na63aadfba42d405fbcdfd9876e453f8b schema:affiliation https://www.grid.ac/institutes/grid.417700.5
    108 schema:familyName Campbell
    109 schema:givenName Anne
    110 rdf:type schema:Person
    111 Nab88abf1a358417695defc22f6c825e4 rdf:first N4fb7716ca6fc4cc1b83672a0793b603a
    112 rdf:rest Nbc0e14f4b8444f8f9e6b55a8bc47de93
    113 Nb42d38f0179e468a9da1bf9a0c3c2dc3 schema:name Springer Nature - SN SciGraph project
    114 rdf:type schema:Organization
    115 Nbc0e14f4b8444f8f9e6b55a8bc47de93 rdf:first Na63aadfba42d405fbcdfd9876e453f8b
    116 rdf:rest N67f213d110b541588e29c94b1e184a97
    117 Nc1f406b62d3a4bad97d3e865d66ba82c schema:name readcube_id
    118 schema:value 013688fc59a167c49ac561d3e20324e871cf048d58e919d99e68cb7f6eb2f1b7
    119 rdf:type schema:PropertyValue
    120 Nc7e1328562d04331891606235f96c555 schema:affiliation https://www.grid.ac/institutes/grid.9481.4
    121 schema:familyName Cawkwell
    122 schema:givenName Lynn
    123 rdf:type schema:Person
    124 Nca168c1d7a6b4aa1bab5087e06be0866 schema:name doi
    125 schema:value 10.1007/s12253-019-00652-x
    126 rdf:type schema:PropertyValue
    127 Nd4c0eb5404194e4d81d443de8095e055 schema:affiliation https://www.grid.ac/institutes/grid.413631.2
    128 schema:familyName Oguh-Olayinka
    129 schema:givenName Lily
    130 rdf:type schema:Person
    131 Nd9586ace5a1547ab8eaa5b901f0269a9 schema:name dimensions_id
    132 schema:value pub.1113180085
    133 rdf:type schema:PropertyValue
    134 Ne0f3038da3f64a6dace98e5ff4e5d1cb schema:affiliation https://www.grid.ac/institutes/grid.417700.5
    135 schema:familyName Lind
    136 schema:givenName Michael J.
    137 rdf:type schema:Person
    138 Ne12904b10ea54fd1a6ffc213bab1d9b6 schema:affiliation https://www.grid.ac/institutes/grid.417700.5
    139 schema:familyName Agarwal
    140 schema:givenName Vijay
    141 rdf:type schema:Person
    142 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    143 schema:name Biological Sciences
    144 rdf:type schema:DefinedTerm
    145 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    146 schema:name Biochemistry and Cell Biology
    147 rdf:type schema:DefinedTerm
    148 sg:journal.1116758 schema:issn 1219-4956
    149 1532-2807
    150 schema:name Pathology & Oncology Research
    151 rdf:type schema:Periodical
    152 sg:pub.10.1007/s10555-011-9310-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053337900
    153 https://doi.org/10.1007/s10555-011-9310-3
    154 rdf:type schema:CreativeWork
    155 sg:pub.10.1038/nrc2809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012973605
    156 https://doi.org/10.1038/nrc2809
    157 rdf:type schema:CreativeWork
    158 https://app.dimensions.ai/details/publication/pub.1074273048 schema:CreativeWork
    159 https://app.dimensions.ai/details/publication/pub.1074369228 schema:CreativeWork
    160 https://app.dimensions.ai/details/publication/pub.1075069010 schema:CreativeWork
    161 https://app.dimensions.ai/details/publication/pub.1076785231 schema:CreativeWork
    162 https://app.dimensions.ai/details/publication/pub.1077047443 schema:CreativeWork
    163 https://doi.org/10.1001/jama.294.8.914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048687714
    164 rdf:type schema:CreativeWork
    165 https://doi.org/10.1002/1097-0142(20010215)91:4<737::aid-cncr1059>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1017646470
    166 rdf:type schema:CreativeWork
    167 https://doi.org/10.1002/1097-0215(20000701)87:1<37::aid-ijc6>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1033288582
    168 rdf:type schema:CreativeWork
    169 https://doi.org/10.1006/excr.1994.1240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053098315
    170 rdf:type schema:CreativeWork
    171 https://doi.org/10.1016/0065-2571(84)90007-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026371633
    172 rdf:type schema:CreativeWork
    173 https://doi.org/10.1016/j.bbamcr.2011.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004087675
    174 rdf:type schema:CreativeWork
    175 https://doi.org/10.1016/j.bbrc.2005.07.166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047071625
    176 rdf:type schema:CreativeWork
    177 https://doi.org/10.1016/j.bcp.2011.06.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027253367
    178 rdf:type schema:CreativeWork
    179 https://doi.org/10.1016/j.bmc.2006.01.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039099754
    180 rdf:type schema:CreativeWork
    181 https://doi.org/10.1016/j.ctrv.2009.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027988840
    182 rdf:type schema:CreativeWork
    183 https://doi.org/10.1016/j.ejca.2005.04.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032010584
    184 rdf:type schema:CreativeWork
    185 https://doi.org/10.1016/j.ejcts.2010.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016756112
    186 rdf:type schema:CreativeWork
    187 https://doi.org/10.1016/j.jep.2014.08.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041954811
    188 rdf:type schema:CreativeWork
    189 https://doi.org/10.1016/j.lungcan.2009.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034630190
    190 rdf:type schema:CreativeWork
    191 https://doi.org/10.1016/j.molmed.2012.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000615517
    192 rdf:type schema:CreativeWork
    193 https://doi.org/10.1016/j.tips.2007.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002827889
    194 rdf:type schema:CreativeWork
    195 https://doi.org/10.1016/s0002-9440(10)64198-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016101249
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1016/s0169-5002(01)00257-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042081771
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1016/s0952-3278(03)00110-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021635988
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1016/s1098-8823(03)00042-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022668726
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1053/gast.2003.50011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037412193
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1053/sonc.2002.30227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025650818
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1093/carcin/bgi026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044089870
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1093/carcin/bgm265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040449496
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1093/carcin/bgp014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049071412
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1096/fj.01-0150com schema:sameAs https://app.dimensions.ai/details/publication/pub.1001120268
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1097/00008390-200209000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036582042
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1097/01.ju.0000080296.54262.c8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017148970
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1111/bcpt.12114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000332927
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1111/febs.12969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052442104
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1111/j.1476-5381.2010.00915.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012906014
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1124/dmd.108.020347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029205444
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1136/gut.45.3.409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053571357
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1136/thx.2003.008912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034937334
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1158/1078-0432.ccr-04-0838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002290961
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1158/1078-0432.ccr-04-1684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032214070
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1158/1078-0432.ccr-07-4631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004323842
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1158/1535-7163.mct-07-0281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026694261
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1158/1535-7163.mct-12-1103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038981182
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1200/jco.2003.11.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203976
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1200/jco.2008.19.8523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040848488
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1254/jphs.fp0060651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035191764
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1371/journal.pone.0040794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004865414
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1371/journal.pone.0072927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031480451
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.2174/138161205774370753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069165623
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.2174/156802607779941369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069193462
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.2217/fon.12.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015435243
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.3390/ijms18020236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074201764
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.3748/wjg.v10.i13.1971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071362338
    260 rdf:type schema:CreativeWork
    261 https://www.grid.ac/institutes/grid.10392.39 schema:alternateName University of Tübingen
    262 schema:name Department of Pharmaceutical Chemistry, Eberhard Karls University, Tübingen, Germany
    263 rdf:type schema:Organization
    264 https://www.grid.ac/institutes/grid.413631.2 schema:alternateName Hull York Medical School
    265 schema:name Research Laboratories, Hull York Medical School, Daisy Building, Castle Hill Hospital, HU16 5JQ, Hull, UK
    266 rdf:type schema:Organization
    267 https://www.grid.ac/institutes/grid.417700.5 schema:alternateName Hull and East Yorkshire Hospitals NHS Trust
    268 schema:name Histopathology Department, Hull and East Yorkshire NHS Trust, Hull, UK
    269 Queens Centre for Oncology and Haematology, Hull and East Yorkshire NHS Trust, Hull, UK
    270 Research Laboratories, Hull York Medical School, Daisy Building, Castle Hill Hospital, HU16 5JQ, Hull, UK
    271 rdf:type schema:Organization
    272 https://www.grid.ac/institutes/grid.9481.4 schema:alternateName University of Hull
    273 schema:name Department of Biomedical Science, University of Hull, Hull, UK
    274 Research Laboratories, Hull York Medical School, Daisy Building, Castle Hill Hospital, HU16 5JQ, Hull, UK
    275 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...