Molecular Profile and Clinicopathologic Features of Follicular Variant Papillary Thyroid Carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-21

AUTHORS

Seo Young Sohn, Jeong-Ju Lee, Jae Hyuk Lee

ABSTRACT

The non-invasive encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) has an indolent clinical behavior. Recently, it was proposed that this tumor type should be reclassified as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). To characterize NIFTPs, we evaluated the molecular and clinicopathologic characteristics of each FVPTC subtype. This study enrolled 29 patients with FVPTC who underwent thyroidectomy between January 2007 and June 2017. They were classified as non-invasive encapsulated FVPTC (NIFTP, n = 10), invasive encapsulated FVPTC (n = 11), and infiltrative FVPTC (n = 8) by two independent pathologists. Genetic alterations were analyzed by targeted next-generation sequencing using formalin-fixed, paraffin-embedded tissue samples and the clinicopathologic characteristics were retrospectively reviewed. There was no difference in preoperative cytologic classification between NIFTPs and invasive encapsulated FVPTCs, whereas infiltrative FVPTC was more likely to be Bethesda class VI than the encapsulated type (50% versus 9.5%; P = 0.033). Lymph node metastasis was not found in NIFTPs. There was no BRAFV600E mutation in NIFTPs, whereas one of 11 invasive encapsulated FVPTCs and three of 8 infiltrative FVPTCs harbored BRAFV600E. RAS mutations were frequently detected in encapsulated FVPTCs (5 of 10 NIFTPs and 4 of 11 invasive encapsulated FVPTCs) but were only detected in one case of the infiltrative type. There were no differences in molecular or clinicopathologic profiles between non-invasive and invasive encapsulated FVPTCs, except for lymph node metastasis and the presence of BRAFV600E. NIFTP has favorable pathologic characteristics with a high frequency of RAS mutations. More... »

PAGES

1-10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12253-019-00639-8

DOI

http://dx.doi.org/10.1007/s12253-019-00639-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112919001

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30900082


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Myongji Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416355.0", 
          "name": [
            "Department of Internal Medicine, Division of Endocrinology and Metabolism, Hanyang University College of Medicine, Myongji Hospital, Goyang, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sohn", 
        "givenName": "Seo Young", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dongguk University Ilsan Hospital", 
          "id": "https://www.grid.ac/institutes/grid.470090.a", 
          "name": [
            "Department of Pathology, Hanyang University College of Medicine, Myongji Hospital, Goyang, South Korea", 
            "Department of Pathology, Dongguk University Ilsan Hospital, Goyang, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jeong-Ju", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Myongji Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416355.0", 
          "name": [
            "Department of Internal Medicine, Division of Endocrinology and Metabolism, Hanyang University College of Medicine, Myongji Hospital, Goyang, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jae Hyuk", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ng.806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010244476", 
          "https://doi.org/10.1038/ng.806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaoncol.2016.0386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012269166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaoncol.2016.0386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012269166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.22138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018321033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2010.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020285106", 
          "https://doi.org/10.1038/modpathol.2010.112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2010.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020285106", 
          "https://doi.org/10.1038/modpathol.2010.112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkq603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020792304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-014-4126-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028134315", 
          "https://doi.org/10.1245/s10434-014-4126-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkr599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032221414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12022-014-9301-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034396199", 
          "https://doi.org/10.1007/s12022-014-9301-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv1222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034754276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181dbee07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035050298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181dbee07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035050298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181dbee07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035050298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2013-2292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035347371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3343/alm.2012.32.3.238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036217718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3343/alm.2012.32.3.238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036217718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddu749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036941016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.138.12.1362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037257459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/his.12680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037266914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/his.12680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037266914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038266369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.11922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038926134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2015-2917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039431359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2015-2917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039431359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/fly.19695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046734556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2005.04.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047595430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19940115)73:2<424::aid-cncr2820730230>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047727934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/ep:16:4:323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051408661", 
          "https://doi.org/10.1385/ep:16:4:323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/p7ql-16kq-qlf4-xw0m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051633831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2009.0274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059320629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2012.0369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059321506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2012.0369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059321506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2012.0640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059321611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2012.0640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059321611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2013.0018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059321660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2011-0618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064292794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2011-0618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064292794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2014-2611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064295335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2016.0583", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079399337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2016.0628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079399338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncy.21839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083805385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2017.9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084128406", 
          "https://doi.org/10.1038/modpathol.2017.9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2017.9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084128406", 
          "https://doi.org/10.1038/modpathol.2017.9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2017.0079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085376197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/his.13401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091861709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/his.13401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091861709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2016.0671", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100512694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2017.0382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101034403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2018-00277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103773076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaoncol.2018.1446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104599066"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03-21", 
    "datePublishedReg": "2019-03-21", 
    "description": "The non-invasive encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) has an indolent clinical behavior. Recently, it was proposed that this tumor type should be reclassified as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). To characterize NIFTPs, we evaluated the molecular and clinicopathologic characteristics of each FVPTC subtype. This study enrolled 29 patients with FVPTC who underwent thyroidectomy between January 2007 and June 2017. They were classified as non-invasive encapsulated FVPTC (NIFTP, n\u2009=\u200910), invasive encapsulated FVPTC (n\u2009=\u200911), and infiltrative FVPTC (n\u2009=\u20098) by two independent pathologists. Genetic alterations were analyzed by targeted next-generation sequencing using formalin-fixed, paraffin-embedded tissue samples and the clinicopathologic characteristics were retrospectively reviewed. There was no difference in preoperative cytologic classification between NIFTPs and invasive encapsulated FVPTCs, whereas infiltrative FVPTC was more likely to be Bethesda class VI than the encapsulated type (50% versus 9.5%; P\u2009=\u20090.033). Lymph node metastasis was not found in NIFTPs. There was no BRAFV600E mutation in NIFTPs, whereas one of 11 invasive encapsulated FVPTCs and three of 8 infiltrative FVPTCs harbored BRAFV600E. RAS mutations were frequently detected in encapsulated FVPTCs (5 of 10 NIFTPs and 4 of 11 invasive encapsulated FVPTCs) but were only detected in one case of the infiltrative type. There were no differences in molecular or clinicopathologic profiles between non-invasive and invasive encapsulated FVPTCs, except for lymph node metastasis and the presence of BRAFV600E. NIFTP has favorable pathologic characteristics with a high frequency of RAS mutations.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12253-019-00639-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1116758", 
        "issn": [
          "1219-4956", 
          "1532-2807"
        ], 
        "name": "Pathology & Oncology Research", 
        "type": "Periodical"
      }
    ], 
    "name": "Molecular Profile and Clinicopathologic Features of Follicular Variant Papillary Thyroid Carcinoma", 
    "pagination": "1-10", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "38b4507a6e298e16d0bff42ae5eb6429ecde6dc233b929477b1dc81d361cb851"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30900082"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9706087"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12253-019-00639-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112919001"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12253-019-00639-8", 
      "https://app.dimensions.ai/details/publication/pub.1112919001"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000364_0000000364/records_72834_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12253-019-00639-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12253-019-00639-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12253-019-00639-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12253-019-00639-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12253-019-00639-8'


 

This table displays all metadata directly associated to this object as RDF triples.

201 TRIPLES      21 PREDICATES      65 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12253-019-00639-8 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nc4c3791813d345348003e76578528e7a
4 schema:citation sg:pub.10.1007/s12022-014-9301-3
5 sg:pub.10.1038/modpathol.2010.112
6 sg:pub.10.1038/modpathol.2017.9
7 sg:pub.10.1038/ng.806
8 sg:pub.10.1245/s10434-014-4126-3
9 sg:pub.10.1385/ep:16:4:323
10 https://doi.org/10.1001/archsurg.138.12.1362
11 https://doi.org/10.1001/jamaoncol.2016.0386
12 https://doi.org/10.1001/jamaoncol.2018.1446
13 https://doi.org/10.1002/1097-0142(19940115)73:2<424::aid-cncr2820730230>3.0.co;2-i
14 https://doi.org/10.1002/cncr.22138
15 https://doi.org/10.1002/cncy.21839
16 https://doi.org/10.1016/j.humpath.2005.04.011
17 https://doi.org/10.1089/thy.2009.0274
18 https://doi.org/10.1089/thy.2012.0369
19 https://doi.org/10.1089/thy.2012.0640
20 https://doi.org/10.1089/thy.2013.0018
21 https://doi.org/10.1089/thy.2016.0583
22 https://doi.org/10.1089/thy.2016.0628
23 https://doi.org/10.1089/thy.2016.0671
24 https://doi.org/10.1089/thy.2017.0079
25 https://doi.org/10.1089/thy.2017.0382
26 https://doi.org/10.1093/bioinformatics/btp324
27 https://doi.org/10.1093/hmg/ddu749
28 https://doi.org/10.1093/nar/gkq603
29 https://doi.org/10.1093/nar/gkr599
30 https://doi.org/10.1093/nar/gkv1222
31 https://doi.org/10.1097/pas.0b013e3181dbee07
32 https://doi.org/10.1111/his.12680
33 https://doi.org/10.1111/his.13401
34 https://doi.org/10.1210/jc.2011-0618
35 https://doi.org/10.1210/jc.2013-2292
36 https://doi.org/10.1210/jc.2014-2611
37 https://doi.org/10.1210/jc.2015-2917
38 https://doi.org/10.1210/jc.2018-00277
39 https://doi.org/10.1309/p7ql-16kq-qlf4-xw0m
40 https://doi.org/10.18632/oncotarget.11922
41 https://doi.org/10.3343/alm.2012.32.3.238
42 https://doi.org/10.4161/fly.19695
43 schema:datePublished 2019-03-21
44 schema:datePublishedReg 2019-03-21
45 schema:description The non-invasive encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) has an indolent clinical behavior. Recently, it was proposed that this tumor type should be reclassified as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). To characterize NIFTPs, we evaluated the molecular and clinicopathologic characteristics of each FVPTC subtype. This study enrolled 29 patients with FVPTC who underwent thyroidectomy between January 2007 and June 2017. They were classified as non-invasive encapsulated FVPTC (NIFTP, n = 10), invasive encapsulated FVPTC (n = 11), and infiltrative FVPTC (n = 8) by two independent pathologists. Genetic alterations were analyzed by targeted next-generation sequencing using formalin-fixed, paraffin-embedded tissue samples and the clinicopathologic characteristics were retrospectively reviewed. There was no difference in preoperative cytologic classification between NIFTPs and invasive encapsulated FVPTCs, whereas infiltrative FVPTC was more likely to be Bethesda class VI than the encapsulated type (50% versus 9.5%; P = 0.033). Lymph node metastasis was not found in NIFTPs. There was no BRAF<sup>V600E</sup> mutation in NIFTPs, whereas one of 11 invasive encapsulated FVPTCs and three of 8 infiltrative FVPTCs harbored BRAF<sup>V600E</sup>. RAS mutations were frequently detected in encapsulated FVPTCs (5 of 10 NIFTPs and 4 of 11 invasive encapsulated FVPTCs) but were only detected in one case of the infiltrative type. There were no differences in molecular or clinicopathologic profiles between non-invasive and invasive encapsulated FVPTCs, except for lymph node metastasis and the presence of BRAF<sup>V600E</sup>. NIFTP has favorable pathologic characteristics with a high frequency of RAS mutations.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree false
49 schema:isPartOf sg:journal.1116758
50 schema:name Molecular Profile and Clinicopathologic Features of Follicular Variant Papillary Thyroid Carcinoma
51 schema:pagination 1-10
52 schema:productId N5a851e23eff544ef96f9c299df60be59
53 Nc1e56e09a1634c0db3d6789a4a1761f2
54 Nd01567caa4884775aa431aff0884aacc
55 Nde7bde9b758a4180ad6ff9ea5d63fd23
56 Necb337b13a2548378bc5b3a4f80782fc
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112919001
58 https://doi.org/10.1007/s12253-019-00639-8
59 schema:sdDatePublished 2019-04-11T12:52
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N60d5585ba8ec49e697ce6d8c095c2bb1
62 schema:url https://link.springer.com/10.1007%2Fs12253-019-00639-8
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N07fd72dc458a4e98a128ac295a2e792a schema:affiliation https://www.grid.ac/institutes/grid.416355.0
67 schema:familyName Sohn
68 schema:givenName Seo Young
69 rdf:type schema:Person
70 N4ab70632c6684de8b145053a4e14f9a9 schema:affiliation https://www.grid.ac/institutes/grid.470090.a
71 schema:familyName Lee
72 schema:givenName Jeong-Ju
73 rdf:type schema:Person
74 N5a851e23eff544ef96f9c299df60be59 schema:name dimensions_id
75 schema:value pub.1112919001
76 rdf:type schema:PropertyValue
77 N60d5585ba8ec49e697ce6d8c095c2bb1 schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N87efe36542ca48a0aa6a47a6f3639abd rdf:first N4ab70632c6684de8b145053a4e14f9a9
80 rdf:rest Ndb33b4ff6ed24c4583987ebd97278587
81 Nc1e56e09a1634c0db3d6789a4a1761f2 schema:name pubmed_id
82 schema:value 30900082
83 rdf:type schema:PropertyValue
84 Nc4c3791813d345348003e76578528e7a rdf:first N07fd72dc458a4e98a128ac295a2e792a
85 rdf:rest N87efe36542ca48a0aa6a47a6f3639abd
86 Nccbf33c2fad64659a6f933bd2aedc007 schema:affiliation https://www.grid.ac/institutes/grid.416355.0
87 schema:familyName Lee
88 schema:givenName Jae Hyuk
89 rdf:type schema:Person
90 Nd01567caa4884775aa431aff0884aacc schema:name nlm_unique_id
91 schema:value 9706087
92 rdf:type schema:PropertyValue
93 Ndb33b4ff6ed24c4583987ebd97278587 rdf:first Nccbf33c2fad64659a6f933bd2aedc007
94 rdf:rest rdf:nil
95 Nde7bde9b758a4180ad6ff9ea5d63fd23 schema:name doi
96 schema:value 10.1007/s12253-019-00639-8
97 rdf:type schema:PropertyValue
98 Necb337b13a2548378bc5b3a4f80782fc schema:name readcube_id
99 schema:value 38b4507a6e298e16d0bff42ae5eb6429ecde6dc233b929477b1dc81d361cb851
100 rdf:type schema:PropertyValue
101 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
102 schema:name Medical and Health Sciences
103 rdf:type schema:DefinedTerm
104 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
105 schema:name Oncology and Carcinogenesis
106 rdf:type schema:DefinedTerm
107 sg:journal.1116758 schema:issn 1219-4956
108 1532-2807
109 schema:name Pathology & Oncology Research
110 rdf:type schema:Periodical
111 sg:pub.10.1007/s12022-014-9301-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034396199
112 https://doi.org/10.1007/s12022-014-9301-3
113 rdf:type schema:CreativeWork
114 sg:pub.10.1038/modpathol.2010.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020285106
115 https://doi.org/10.1038/modpathol.2010.112
116 rdf:type schema:CreativeWork
117 sg:pub.10.1038/modpathol.2017.9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128406
118 https://doi.org/10.1038/modpathol.2017.9
119 rdf:type schema:CreativeWork
120 sg:pub.10.1038/ng.806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010244476
121 https://doi.org/10.1038/ng.806
122 rdf:type schema:CreativeWork
123 sg:pub.10.1245/s10434-014-4126-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028134315
124 https://doi.org/10.1245/s10434-014-4126-3
125 rdf:type schema:CreativeWork
126 sg:pub.10.1385/ep:16:4:323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051408661
127 https://doi.org/10.1385/ep:16:4:323
128 rdf:type schema:CreativeWork
129 https://doi.org/10.1001/archsurg.138.12.1362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037257459
130 rdf:type schema:CreativeWork
131 https://doi.org/10.1001/jamaoncol.2016.0386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012269166
132 rdf:type schema:CreativeWork
133 https://doi.org/10.1001/jamaoncol.2018.1446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104599066
134 rdf:type schema:CreativeWork
135 https://doi.org/10.1002/1097-0142(19940115)73:2<424::aid-cncr2820730230>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1047727934
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1002/cncr.22138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018321033
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1002/cncy.21839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083805385
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1016/j.humpath.2005.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047595430
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1089/thy.2009.0274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059320629
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1089/thy.2012.0369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059321506
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1089/thy.2012.0640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059321611
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1089/thy.2013.0018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059321660
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1089/thy.2016.0583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079399337
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1089/thy.2016.0628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079399338
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1089/thy.2016.0671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100512694
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1089/thy.2017.0079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085376197
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1089/thy.2017.0382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101034403
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1093/bioinformatics/btp324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038266369
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1093/hmg/ddu749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036941016
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1093/nar/gkq603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020792304
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1093/nar/gkr599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032221414
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1093/nar/gkv1222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034754276
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1097/pas.0b013e3181dbee07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035050298
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1111/his.12680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037266914
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1111/his.13401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091861709
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1210/jc.2011-0618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064292794
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1210/jc.2013-2292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035347371
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1210/jc.2014-2611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064295335
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1210/jc.2015-2917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039431359
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1210/jc.2018-00277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103773076
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1309/p7ql-16kq-qlf4-xw0m schema:sameAs https://app.dimensions.ai/details/publication/pub.1051633831
188 rdf:type schema:CreativeWork
189 https://doi.org/10.18632/oncotarget.11922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038926134
190 rdf:type schema:CreativeWork
191 https://doi.org/10.3343/alm.2012.32.3.238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036217718
192 rdf:type schema:CreativeWork
193 https://doi.org/10.4161/fly.19695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046734556
194 rdf:type schema:CreativeWork
195 https://www.grid.ac/institutes/grid.416355.0 schema:alternateName Myongji Hospital
196 schema:name Department of Internal Medicine, Division of Endocrinology and Metabolism, Hanyang University College of Medicine, Myongji Hospital, Goyang, South Korea
197 rdf:type schema:Organization
198 https://www.grid.ac/institutes/grid.470090.a schema:alternateName Dongguk University Ilsan Hospital
199 schema:name Department of Pathology, Dongguk University Ilsan Hospital, Goyang, South Korea
200 Department of Pathology, Hanyang University College of Medicine, Myongji Hospital, Goyang, South Korea
201 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...