Prognostic Importance of Tumor Deposits in the Ipsilateral Axillary Region of Breast Cancer Patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Merih Guray Durak, Tulay Canda, Betul Yilmaz, Nazli Sena Seker, Seda Eryigit Kokkoz, Zumre Arican Alicikus, Nesrin Akturk, Ilknur Bilkay Gorken, Hulya Ellidokuz, Ali Ibrahim Sevinc, Serdar Saydam, Sulen Sarioglu

ABSTRACT

Tumor deposits (TD) are irregular discrete tumor masses in adipose tissue, discontinuous from the primary tumor, that are described in various cancers. The incidence and/or prognostic value of TD in breast carcinomas have not been studied so far. We reevaluated 145 breast cancer patients, diagnosed and treated between 2001 and 2006 at our institution for the presence and incidence of TD. Histologic type, grade, size of the primary tumor, estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2 status of the tumor, and presence of peritumoral lymphovascular invasion were included in the data. TD were detected in 42 cases (29.0%). The mean age of the patients was 52.2 years (27-82). Most patients (79.3%) had either invasive carcinoma of no special type (NST) or invasive lobular carcinoma, and most tumors (86.9%) were either grade 2 or 3. After excluding TD from the number of metastatic lymph nodes, the pN status of 9 patients changed. Univariate analysis of 110 patients with follow-up information revealed that the new pN status (p = 0.036), presence of local recurrence (p = 0.016) and TD (p = 0.003) were significantly correlated with distant metastases. The median follow-up of the patients was 84 months (5-161), 10-year disease-free survival and overall survival were 67.2% and 73.7%, respectively. In multivariate analysis, presence of TD remained independently associated with distant metastasis (p = 0.002). The probability of distant metastasis was 3.3 times higher in patients with TD. These results emphasize that TD are present in breast cancer patients, and that their presence should warn the clinician in terms of possible distant metastasis. Therefore, presence of TD, the evaluation of which is neither time consuming nor require sophisticated methods, should be included in pathology reports. More... »

PAGES

1-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12253-018-0515-4

DOI

http://dx.doi.org/10.1007/s12253-018-0515-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107880857

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30368727


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Dokuz Eyl\u00fcl University", 
          "id": "https://www.grid.ac/institutes/grid.21200.31", 
          "name": [
            "Department of Pathology, Dokuz Eylul University Faculty of Medicine, Inciralti, 35340, Izmir, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Durak", 
        "givenName": "Merih Guray", 
        "id": "sg:person.01021300301.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021300301.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dokuz Eyl\u00fcl University", 
          "id": "https://www.grid.ac/institutes/grid.21200.31", 
          "name": [
            "Department of Pathology, Dokuz Eylul University Faculty of Medicine, Inciralti, 35340, Izmir, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Canda", 
        "givenName": "Tulay", 
        "id": "sg:person.01176540360.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176540360.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dokuz Eyl\u00fcl University", 
          "id": "https://www.grid.ac/institutes/grid.21200.31", 
          "name": [
            "Department of Pathology, Dokuz Eylul University Faculty of Medicine, Inciralti, 35340, Izmir, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yilmaz", 
        "givenName": "Betul", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dokuz Eyl\u00fcl University", 
          "id": "https://www.grid.ac/institutes/grid.21200.31", 
          "name": [
            "Department of Pathology, Dokuz Eylul University Faculty of Medicine, Inciralti, 35340, Izmir, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seker", 
        "givenName": "Nazli Sena", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dokuz Eyl\u00fcl University", 
          "id": "https://www.grid.ac/institutes/grid.21200.31", 
          "name": [
            "Department of Pathology, Dokuz Eylul University Faculty of Medicine, Inciralti, 35340, Izmir, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kokkoz", 
        "givenName": "Seda Eryigit", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dokuz Eyl\u00fcl University", 
          "id": "https://www.grid.ac/institutes/grid.21200.31", 
          "name": [
            "Department of Radiation Oncology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alicikus", 
        "givenName": "Zumre Arican", 
        "id": "sg:person.01156370144.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156370144.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dokuz Eyl\u00fcl University", 
          "id": "https://www.grid.ac/institutes/grid.21200.31", 
          "name": [
            "Department of Radiation Oncology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akturk", 
        "givenName": "Nesrin", 
        "id": "sg:person.011627234430.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011627234430.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dokuz Eyl\u00fcl University", 
          "id": "https://www.grid.ac/institutes/grid.21200.31", 
          "name": [
            "Department of Radiation Oncology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gorken", 
        "givenName": "Ilknur Bilkay", 
        "id": "sg:person.01272616544.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272616544.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dokuz Eyl\u00fcl University", 
          "id": "https://www.grid.ac/institutes/grid.21200.31", 
          "name": [
            "Department of Preventive Oncology, Dokuz Eylul University Institute of Oncology, Izmir, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ellidokuz", 
        "givenName": "Hulya", 
        "id": "sg:person.01101605223.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101605223.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dokuz Eyl\u00fcl University", 
          "id": "https://www.grid.ac/institutes/grid.21200.31", 
          "name": [
            "Department of General Surgery, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sevinc", 
        "givenName": "Ali Ibrahim", 
        "id": "sg:person.0630530663.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630530663.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dokuz Eyl\u00fcl University", 
          "id": "https://www.grid.ac/institutes/grid.21200.31", 
          "name": [
            "Department of General Surgery, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saydam", 
        "givenName": "Serdar", 
        "id": "sg:person.01256557057.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256557057.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dokuz Eyl\u00fcl University", 
          "id": "https://www.grid.ac/institutes/grid.21200.31", 
          "name": [
            "Department of Pathology, Dokuz Eylul University Faculty of Medicine, Inciralti, 35340, Izmir, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sarioglu", 
        "givenName": "Sulen", 
        "id": "sg:person.01210516730.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210516730.11"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/modpathol.3800791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002015382", 
          "https://doi.org/10.1038/modpathol.3800791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2007.02720.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006286090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10350-004-6288-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006949215", 
          "https://doi.org/10.1007/s10350-004-6288-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s10350-004-6288-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006949215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s10350-004-6288-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006949215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.23981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008953381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-010-1152-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016825576", 
          "https://doi.org/10.1245/s10434-010-1152-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-010-1152-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016825576", 
          "https://doi.org/10.1245/s10434-010-1152-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/dcr.0b013e3181cf7fd8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019584704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/dcr.0b013e3181cf7fd8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019584704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800239017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021185751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjsurg.2013.04.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022061703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-012-2692-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022594239", 
          "https://doi.org/10.1245/s10434-012-2692-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5858/arpa.2013-0166-oa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022901069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-8-64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023524948", 
          "https://doi.org/10.1186/1471-2407-8-64"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0034087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026956942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.34.6429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027815300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02388217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031677843", 
          "https://doi.org/10.1007/bf02388217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02388217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031677843", 
          "https://doi.org/10.1007/bf02388217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(20000515)88:10<2228::aid-cncr5>3.0.co;2-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032102113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2006.07.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038951860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31821ad8a2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039789487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31821ad8a2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039789487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2008.198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043284110", 
          "https://doi.org/10.1038/modpathol.2008.198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2011.12.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044708356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.prp.2014.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045805730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/903ut10vq3lc7b8l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046582295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-319-40618-3_48", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1087262127", 
          "https://doi.org/10.1007/978-3-319-40618-3_48"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04", 
    "datePublishedReg": "2019-04-01", 
    "description": "Tumor deposits (TD) are irregular discrete tumor masses in adipose tissue, discontinuous from the primary tumor, that are described in various cancers. The incidence and/or prognostic value of TD in breast carcinomas have not been studied so far. We reevaluated 145 breast cancer patients, diagnosed and treated between 2001 and 2006 at our institution for the presence and incidence of TD. Histologic type, grade, size of the primary tumor, estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2 status of the tumor, and presence of peritumoral lymphovascular invasion were included in the data. TD were detected in 42 cases (29.0%). The mean age of the patients was 52.2\u00a0years (27-82). Most patients (79.3%) had either invasive carcinoma of no special type (NST) or invasive lobular carcinoma, and most tumors (86.9%) were either grade 2 or 3. After excluding TD from the number of metastatic lymph nodes, the pN status of 9 patients changed. Univariate analysis of 110 patients with follow-up information revealed that the new pN status (p\u2009=\u20090.036), presence of local recurrence (p\u2009=\u20090.016) and TD (p\u2009=\u20090.003) were significantly correlated with distant metastases. The median follow-up of the patients was 84\u00a0months (5-161), 10-year disease-free survival and overall survival were 67.2% and 73.7%, respectively. In multivariate analysis, presence of TD remained independently associated with distant metastasis (p\u2009=\u20090.002). The probability of distant metastasis was 3.3 times higher in patients with TD. These results emphasize that TD are present in breast cancer patients, and that their presence should warn the clinician in terms of possible distant metastasis. Therefore, presence of TD, the evaluation of which is neither time consuming nor require sophisticated methods, should be included in pathology reports.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12253-018-0515-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1116758", 
        "issn": [
          "1219-4956", 
          "1532-2807"
        ], 
        "name": "Pathology & Oncology Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "25"
      }
    ], 
    "name": "Prognostic Importance of Tumor Deposits in the Ipsilateral Axillary Region of Breast Cancer Patients", 
    "pagination": "1-7", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d24be6bf990d77e67187fc7fca11ed89e8e6532864fb85ba74ecb2efb2efb035"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30368727"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9706087"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12253-018-0515-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107880857"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12253-018-0515-4", 
      "https://app.dimensions.ai/details/publication/pub.1107880857"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:33", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13102_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12253-018-0515-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12253-018-0515-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12253-018-0515-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12253-018-0515-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12253-018-0515-4'


 

This table displays all metadata directly associated to this object as RDF triples.

223 TRIPLES      21 PREDICATES      52 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12253-018-0515-4 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nc1f304f425364c29a0508a4268586c19
4 schema:citation sg:pub.10.1007/978-3-319-40618-3_48
5 sg:pub.10.1007/bf02388217
6 sg:pub.10.1007/s10350-004-6288-8
7 sg:pub.10.1038/modpathol.2008.198
8 sg:pub.10.1038/modpathol.3800791
9 sg:pub.10.1186/1471-2407-8-64
10 sg:pub.10.1245/s10434-010-1152-7
11 sg:pub.10.1245/s10434-012-2692-9
12 https://doi.org/10.1002/(sici)1097-0142(20000515)88:10<2228::aid-cncr5>3.0.co;2-1
13 https://doi.org/10.1002/bjs.1800239017
14 https://doi.org/10.1002/hed.23981
15 https://doi.org/10.1007/dcr.0b013e3181cf7fd8
16 https://doi.org/10.1007/s10350-004-6288-8
17 https://doi.org/10.1016/j.amjsurg.2013.04.009
18 https://doi.org/10.1016/j.humpath.2006.07.017
19 https://doi.org/10.1016/j.prp.2014.03.006
20 https://doi.org/10.1016/j.surg.2011.12.027
21 https://doi.org/10.1097/sla.0b013e31821ad8a2
22 https://doi.org/10.1111/j.1365-2559.2007.02720.x
23 https://doi.org/10.1200/jco.2011.34.6429
24 https://doi.org/10.1309/903ut10vq3lc7b8l
25 https://doi.org/10.1371/journal.pone.0034087
26 https://doi.org/10.5858/arpa.2013-0166-oa
27 schema:datePublished 2019-04
28 schema:datePublishedReg 2019-04-01
29 schema:description Tumor deposits (TD) are irregular discrete tumor masses in adipose tissue, discontinuous from the primary tumor, that are described in various cancers. The incidence and/or prognostic value of TD in breast carcinomas have not been studied so far. We reevaluated 145 breast cancer patients, diagnosed and treated between 2001 and 2006 at our institution for the presence and incidence of TD. Histologic type, grade, size of the primary tumor, estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2 status of the tumor, and presence of peritumoral lymphovascular invasion were included in the data. TD were detected in 42 cases (29.0%). The mean age of the patients was 52.2 years (27-82). Most patients (79.3%) had either invasive carcinoma of no special type (NST) or invasive lobular carcinoma, and most tumors (86.9%) were either grade 2 or 3. After excluding TD from the number of metastatic lymph nodes, the pN status of 9 patients changed. Univariate analysis of 110 patients with follow-up information revealed that the new pN status (p = 0.036), presence of local recurrence (p = 0.016) and TD (p = 0.003) were significantly correlated with distant metastases. The median follow-up of the patients was 84 months (5-161), 10-year disease-free survival and overall survival were 67.2% and 73.7%, respectively. In multivariate analysis, presence of TD remained independently associated with distant metastasis (p = 0.002). The probability of distant metastasis was 3.3 times higher in patients with TD. These results emphasize that TD are present in breast cancer patients, and that their presence should warn the clinician in terms of possible distant metastasis. Therefore, presence of TD, the evaluation of which is neither time consuming nor require sophisticated methods, should be included in pathology reports.
30 schema:genre research_article
31 schema:inLanguage en
32 schema:isAccessibleForFree false
33 schema:isPartOf N23c201a28d5e4b7cace63f2503e9e341
34 N532152e7a7ff4b1a997311e3a87f3f35
35 sg:journal.1116758
36 schema:name Prognostic Importance of Tumor Deposits in the Ipsilateral Axillary Region of Breast Cancer Patients
37 schema:pagination 1-7
38 schema:productId N1cdebb09bb0644a4b0faab9e26339ad3
39 N6bfa343c7d0d4f05b32c38183c5c6834
40 N883cddf056fb4b5b9ce9cf7d393c2e6c
41 Na6ff18d63d0e476fa698d90ad3605528
42 Nba359fbc598e4afd83631d471e5204ba
43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107880857
44 https://doi.org/10.1007/s12253-018-0515-4
45 schema:sdDatePublished 2019-04-11T14:33
46 schema:sdLicense https://scigraph.springernature.com/explorer/license/
47 schema:sdPublisher N5c395c5a84924fa393bca32a1c857601
48 schema:url https://link.springer.com/10.1007%2Fs12253-018-0515-4
49 sgo:license sg:explorer/license/
50 sgo:sdDataset articles
51 rdf:type schema:ScholarlyArticle
52 N00bfac0dc6304b50a67f3c6f6a21527f rdf:first sg:person.01272616544.33
53 rdf:rest N20df9c9ab53a4d97b5e0d23e910c93ae
54 N07e1559cec2340939b8ff3f6d2f8a547 rdf:first sg:person.0630530663.67
55 rdf:rest N86ce84aeab2049a6bc9f081e005e7d0b
56 N1a7b500f25d6441baf39577a2cb4c662 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
57 schema:familyName Yilmaz
58 schema:givenName Betul
59 rdf:type schema:Person
60 N1a894c1466f3477197ec183f344d1860 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
61 schema:familyName Seker
62 schema:givenName Nazli Sena
63 rdf:type schema:Person
64 N1cdebb09bb0644a4b0faab9e26339ad3 schema:name doi
65 schema:value 10.1007/s12253-018-0515-4
66 rdf:type schema:PropertyValue
67 N20df9c9ab53a4d97b5e0d23e910c93ae rdf:first sg:person.01101605223.21
68 rdf:rest N07e1559cec2340939b8ff3f6d2f8a547
69 N23c201a28d5e4b7cace63f2503e9e341 schema:issueNumber 2
70 rdf:type schema:PublicationIssue
71 N4d0a85376e9045eebeeb3feaf5601558 rdf:first sg:person.01156370144.27
72 rdf:rest N9db009ae29c3415289ed8f8d5bbd0461
73 N4df24842dc104c598a806ceb1c126159 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
74 schema:familyName Kokkoz
75 schema:givenName Seda Eryigit
76 rdf:type schema:Person
77 N532152e7a7ff4b1a997311e3a87f3f35 schema:volumeNumber 25
78 rdf:type schema:PublicationVolume
79 N5c395c5a84924fa393bca32a1c857601 schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 N672dcc2ff0624abdb724017b14c02ffe rdf:first sg:person.01176540360.37
82 rdf:rest N7ea724ab4c574d0b9dd585c4300ca159
83 N6bfa343c7d0d4f05b32c38183c5c6834 schema:name readcube_id
84 schema:value d24be6bf990d77e67187fc7fca11ed89e8e6532864fb85ba74ecb2efb2efb035
85 rdf:type schema:PropertyValue
86 N7ea724ab4c574d0b9dd585c4300ca159 rdf:first N1a7b500f25d6441baf39577a2cb4c662
87 rdf:rest Nd4c3a5a0e3b7441f8c2bf5a7ee60a004
88 N86ce84aeab2049a6bc9f081e005e7d0b rdf:first sg:person.01256557057.56
89 rdf:rest Nb2e11d0c69ed43fe9954293f5f4f22b7
90 N883cddf056fb4b5b9ce9cf7d393c2e6c schema:name nlm_unique_id
91 schema:value 9706087
92 rdf:type schema:PropertyValue
93 N9db009ae29c3415289ed8f8d5bbd0461 rdf:first sg:person.011627234430.37
94 rdf:rest N00bfac0dc6304b50a67f3c6f6a21527f
95 Na6ff18d63d0e476fa698d90ad3605528 schema:name pubmed_id
96 schema:value 30368727
97 rdf:type schema:PropertyValue
98 Nb2e11d0c69ed43fe9954293f5f4f22b7 rdf:first sg:person.01210516730.11
99 rdf:rest rdf:nil
100 Nba359fbc598e4afd83631d471e5204ba schema:name dimensions_id
101 schema:value pub.1107880857
102 rdf:type schema:PropertyValue
103 Nc1f304f425364c29a0508a4268586c19 rdf:first sg:person.01021300301.30
104 rdf:rest N672dcc2ff0624abdb724017b14c02ffe
105 Nd4c3a5a0e3b7441f8c2bf5a7ee60a004 rdf:first N1a894c1466f3477197ec183f344d1860
106 rdf:rest Ne8d55c5c01354dd8a258b67568b429fe
107 Ne8d55c5c01354dd8a258b67568b429fe rdf:first N4df24842dc104c598a806ceb1c126159
108 rdf:rest N4d0a85376e9045eebeeb3feaf5601558
109 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
110 schema:name Medical and Health Sciences
111 rdf:type schema:DefinedTerm
112 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
113 schema:name Oncology and Carcinogenesis
114 rdf:type schema:DefinedTerm
115 sg:journal.1116758 schema:issn 1219-4956
116 1532-2807
117 schema:name Pathology & Oncology Research
118 rdf:type schema:Periodical
119 sg:person.01021300301.30 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
120 schema:familyName Durak
121 schema:givenName Merih Guray
122 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021300301.30
123 rdf:type schema:Person
124 sg:person.01101605223.21 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
125 schema:familyName Ellidokuz
126 schema:givenName Hulya
127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101605223.21
128 rdf:type schema:Person
129 sg:person.01156370144.27 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
130 schema:familyName Alicikus
131 schema:givenName Zumre Arican
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156370144.27
133 rdf:type schema:Person
134 sg:person.011627234430.37 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
135 schema:familyName Akturk
136 schema:givenName Nesrin
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011627234430.37
138 rdf:type schema:Person
139 sg:person.01176540360.37 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
140 schema:familyName Canda
141 schema:givenName Tulay
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176540360.37
143 rdf:type schema:Person
144 sg:person.01210516730.11 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
145 schema:familyName Sarioglu
146 schema:givenName Sulen
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210516730.11
148 rdf:type schema:Person
149 sg:person.01256557057.56 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
150 schema:familyName Saydam
151 schema:givenName Serdar
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256557057.56
153 rdf:type schema:Person
154 sg:person.01272616544.33 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
155 schema:familyName Gorken
156 schema:givenName Ilknur Bilkay
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272616544.33
158 rdf:type schema:Person
159 sg:person.0630530663.67 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
160 schema:familyName Sevinc
161 schema:givenName Ali Ibrahim
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630530663.67
163 rdf:type schema:Person
164 sg:pub.10.1007/978-3-319-40618-3_48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1087262127
165 https://doi.org/10.1007/978-3-319-40618-3_48
166 rdf:type schema:CreativeWork
167 sg:pub.10.1007/bf02388217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031677843
168 https://doi.org/10.1007/bf02388217
169 rdf:type schema:CreativeWork
170 sg:pub.10.1007/s10350-004-6288-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006949215
171 https://doi.org/10.1007/s10350-004-6288-8
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/modpathol.2008.198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043284110
174 https://doi.org/10.1038/modpathol.2008.198
175 rdf:type schema:CreativeWork
176 sg:pub.10.1038/modpathol.3800791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002015382
177 https://doi.org/10.1038/modpathol.3800791
178 rdf:type schema:CreativeWork
179 sg:pub.10.1186/1471-2407-8-64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023524948
180 https://doi.org/10.1186/1471-2407-8-64
181 rdf:type schema:CreativeWork
182 sg:pub.10.1245/s10434-010-1152-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016825576
183 https://doi.org/10.1245/s10434-010-1152-7
184 rdf:type schema:CreativeWork
185 sg:pub.10.1245/s10434-012-2692-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022594239
186 https://doi.org/10.1245/s10434-012-2692-9
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1002/(sici)1097-0142(20000515)88:10<2228::aid-cncr5>3.0.co;2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032102113
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1002/bjs.1800239017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021185751
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1002/hed.23981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008953381
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1007/dcr.0b013e3181cf7fd8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019584704
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1007/s10350-004-6288-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006949215
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.amjsurg.2013.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022061703
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.humpath.2006.07.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038951860
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.prp.2014.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045805730
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.surg.2011.12.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044708356
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1097/sla.0b013e31821ad8a2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039789487
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1111/j.1365-2559.2007.02720.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006286090
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1200/jco.2011.34.6429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027815300
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1309/903ut10vq3lc7b8l schema:sameAs https://app.dimensions.ai/details/publication/pub.1046582295
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1371/journal.pone.0034087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026956942
215 rdf:type schema:CreativeWork
216 https://doi.org/10.5858/arpa.2013-0166-oa schema:sameAs https://app.dimensions.ai/details/publication/pub.1022901069
217 rdf:type schema:CreativeWork
218 https://www.grid.ac/institutes/grid.21200.31 schema:alternateName Dokuz Eylül University
219 schema:name Department of General Surgery, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey
220 Department of Pathology, Dokuz Eylul University Faculty of Medicine, Inciralti, 35340, Izmir, Turkey
221 Department of Preventive Oncology, Dokuz Eylul University Institute of Oncology, Izmir, Turkey
222 Department of Radiation Oncology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey
223 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...