Accuracy and Reproducibility of HER2 Status in Breast Cancer Using Immunohistochemistry: A Quality Control Study in Tuscany Evaluating the Impact ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-11-04

AUTHORS

S. Bianchi, S. Caini, M. Paglierani, C. Saieva, V. Vezzosi, G. Baroni, A. Simoni, D. Palli, On behalf of the Tuscany Breast Cancer Study Group

ABSTRACT

The correct identification of HER2-positive cases is a key point to provide the most appropriate therapy to breast cancer (BC) patients. We aimed at investigating the reproducibility and accuracy of HER2 expression by immunohistochemistry (IHC) in a selected series of 35 invasive BC cases across the pathological anatomy laboratories in Tuscany, Italy. Unstained sections of each BC case were sent to 12 participating laboratories. Pathologists were required to score according to the Food and Drug Administration (FDA) four-tier scoring system (0, 1+, 2+, 3+). Sixteen and nineteen cases were HER2 non-amplified and amplified respectively on fluorescence in situ hybridization. Among 192 readings of the 16 HER2 non-amplified samples, 153 (79.7 %) were coded as 0 or 1+, 39 (20.3 %) were 2+, and none was 3+ (false positive rate 0 %). Among 228 readings of the 19 HER2 amplified samples, 56 (24.6 %) were scored 0 or 1+, 79 (34.6 %) were 2+, and 93 (40.8 %) were 3+. The average sensitivity was 75.4 %, ranging between 47 % and 100 %, and the overall false negative rate was 24.6 %. Participation of pathological anatomy laboratories performing HER2 testing by IHC in external quality assurance programs should be made mandatory, as the system is able to identify laboratories with suboptimal performance that may need technical advice. Updated 2013 ASCO/CAP recommendations should be adopted as the widening of IHC 2+ “equivocal” category would improve overall accuracy of HER2 testing, as more cases would be classified in this category and, consequently, tested with an in situ hybridisation method. More... »

PAGES

477-485

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12253-014-9852-0

DOI

http://dx.doi.org/10.1007/s12253-014-9852-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018829752

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25367072


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "False Positive Reactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Italy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pathology, Clinical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Practice Guidelines as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quality Control", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, ErbB-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "United States", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Pathological Anatomy Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy", 
          "id": "http://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Pathological Anatomy Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bianchi", 
        "givenName": "S.", 
        "id": "sg:person.07675154000.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07675154000.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy", 
          "id": "http://www.grid.ac/institutes/grid.417623.5", 
          "name": [
            "Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caini", 
        "givenName": "S.", 
        "id": "sg:person.01161605365.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161605365.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pathological Anatomy Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy", 
          "id": "http://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Pathological Anatomy Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paglierani", 
        "givenName": "M.", 
        "id": "sg:person.01204776334.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204776334.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy", 
          "id": "http://www.grid.ac/institutes/grid.417623.5", 
          "name": [
            "Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saieva", 
        "givenName": "C.", 
        "id": "sg:person.0673106145.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673106145.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pathological Anatomy Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy", 
          "id": "http://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Pathological Anatomy Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vezzosi", 
        "givenName": "V.", 
        "id": "sg:person.01041627227.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041627227.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pathological Anatomy Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy", 
          "id": "http://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Pathological Anatomy Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baroni", 
        "givenName": "G.", 
        "id": "sg:person.0611077332.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611077332.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pathological Anatomy Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy", 
          "id": "http://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Pathological Anatomy Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simoni", 
        "givenName": "A.", 
        "id": "sg:person.0731321474.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731321474.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy", 
          "id": "http://www.grid.ac/institutes/grid.417623.5", 
          "name": [
            "Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palli", 
        "givenName": "D.", 
        "id": "sg:person.010014537677.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010014537677.09"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "On behalf of the Tuscany Breast Cancer Study Group", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s12253-008-9079-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008370717", 
          "https://doi.org/10.1007/s12253-008-9079-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049181385", 
          "https://doi.org/10.1038/modpathol.3800208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2013.103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017540202", 
          "https://doi.org/10.1038/modpathol.2013.103"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-11-04", 
    "datePublishedReg": "2014-11-04", 
    "description": "The correct identification of HER2-positive cases is a key point to provide the most appropriate therapy to breast cancer (BC) patients. We aimed at investigating the reproducibility and accuracy of HER2 expression by immunohistochemistry (IHC) in a selected series of 35 invasive BC cases across the pathological anatomy laboratories in Tuscany, Italy. Unstained sections of each BC case were sent to 12 participating laboratories. Pathologists were required to score according to the Food and Drug Administration (FDA) four-tier scoring system (0, 1+, 2+, 3+). Sixteen and nineteen cases were HER2 non-amplified and amplified respectively on fluorescence in situ hybridization. Among 192 readings of the 16 HER2 non-amplified samples, 153 (79.7\u00a0%) were coded as 0 or 1+, 39 (20.3\u00a0%) were 2+, and none was 3+ (false positive rate 0\u00a0%). Among 228 readings of the 19 HER2 amplified samples, 56 (24.6\u00a0%) were scored 0 or 1+, 79 (34.6\u00a0%) were 2+, and 93 (40.8\u00a0%) were 3+. The average sensitivity was 75.4\u00a0%, ranging between 47\u00a0% and 100\u00a0%, and the overall false negative rate was 24.6\u00a0%. Participation of pathological anatomy laboratories performing HER2 testing by IHC in external quality assurance programs should be made mandatory, as the system is able to identify laboratories with suboptimal performance that may need technical advice. Updated 2013 ASCO/CAP recommendations should be adopted as the widening of IHC 2+ \u201cequivocal\u201d category would improve overall accuracy of HER2 testing, as more cases would be classified in this category and, consequently, tested with an in situ hybridisation method.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s12253-014-9852-0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1116758", 
        "issn": [
          "1219-4956", 
          "1532-2807"
        ], 
        "name": "Pathology & Oncology Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "keywords": [
      "ASCO/CAP recommendations", 
      "pathological anatomy laboratories", 
      "HER2 testing", 
      "CAP recommendations", 
      "BC cases", 
      "HER2-positive cases", 
      "breast cancer patients", 
      "invasive BC cases", 
      "overall false-negative rate", 
      "appropriate therapy", 
      "cancer patients", 
      "HER2 expression", 
      "HER2 status", 
      "IHC 2", 
      "breast cancer", 
      "anatomy laboratory", 
      "Drug Administration", 
      "control study", 
      "scoring system", 
      "false negative rate", 
      "immunohistochemistry", 
      "external quality assurance program", 
      "more cases", 
      "quality control study", 
      "quality assurance program", 
      "HER2", 
      "situ hybridisation method", 
      "non-amplified samples", 
      "situ hybridization", 
      "assurance program", 
      "negative rate", 
      "unstained sections", 
      "patients", 
      "therapy", 
      "cases", 
      "cancer", 
      "administration", 
      "hybridisation method", 
      "pathologists", 
      "recommendations", 
      "correct identification", 
      "testing", 
      "status", 
      "laboratory", 
      "expression", 
      "advice", 
      "food", 
      "overall accuracy", 
      "samples", 
      "categories", 
      "reproducibility", 
      "study", 
      "average sensitivity", 
      "sensitivity", 
      "rate", 
      "suboptimal performance", 
      "widening", 
      "hybridization", 
      "program", 
      "identification", 
      "participation", 
      "key points", 
      "Tuscany", 
      "impact", 
      "Italy", 
      "series", 
      "technical advice", 
      "sections", 
      "system", 
      "fluorescence", 
      "reading", 
      "accuracy", 
      "point", 
      "method", 
      "performance", 
      "four-tier scoring system", 
      "HER2 non-amplified samples", 
      "Updated 2013 ASCO/CAP Recommendations"
    ], 
    "name": "Accuracy and Reproducibility of HER2 Status in Breast Cancer Using Immunohistochemistry: A Quality Control Study in Tuscany Evaluating the Impact of Updated 2013 ASCO/CAP Recommendations", 
    "pagination": "477-485", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1018829752"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12253-014-9852-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25367072"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12253-014-9852-0", 
      "https://app.dimensions.ai/details/publication/pub.1018829752"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_645.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s12253-014-9852-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12253-014-9852-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12253-014-9852-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12253-014-9852-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12253-014-9852-0'


 

This table displays all metadata directly associated to this object as RDF triples.

264 TRIPLES      22 PREDICATES      121 URIs      110 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12253-014-9852-0 schema:about N0ea25668ff9043ceb13c4108e44c9e2d
2 N110cee9d7dda48a8a6041b8866537b85
3 N4936dea1ada34ca5a2b711bebf6990af
4 N4d3ec1fb99014e11858409e8b98b57dc
5 N684071aa4eb948a3bbf74c4291cca752
6 N700c009323d5424fa4f2f942eebcdbfb
7 N76efc1f0e27c440cb138f7442c54357d
8 N90afbceb51d447bc83b27f48909415ac
9 N940b81baf2584143b03d1df2db32d838
10 N9511b91e621d4f5fa1fa6e11d0e324fc
11 N9a52b276a3da4fff9766b7a840dda970
12 Na7eaab47d2044747aa9207e6012bc6cb
13 Nbb26e08e282d4dd89a1a0fec955962e9
14 Nd8379fd59f2b4deb9b63337aafe2b398
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author N9618eb903faf46f2beef6baa88d4f2b2
18 schema:citation sg:pub.10.1007/s12253-008-9079-z
19 sg:pub.10.1038/modpathol.2013.103
20 sg:pub.10.1038/modpathol.3800208
21 schema:datePublished 2014-11-04
22 schema:datePublishedReg 2014-11-04
23 schema:description The correct identification of HER2-positive cases is a key point to provide the most appropriate therapy to breast cancer (BC) patients. We aimed at investigating the reproducibility and accuracy of HER2 expression by immunohistochemistry (IHC) in a selected series of 35 invasive BC cases across the pathological anatomy laboratories in Tuscany, Italy. Unstained sections of each BC case were sent to 12 participating laboratories. Pathologists were required to score according to the Food and Drug Administration (FDA) four-tier scoring system (0, 1+, 2+, 3+). Sixteen and nineteen cases were HER2 non-amplified and amplified respectively on fluorescence in situ hybridization. Among 192 readings of the 16 HER2 non-amplified samples, 153 (79.7 %) were coded as 0 or 1+, 39 (20.3 %) were 2+, and none was 3+ (false positive rate 0 %). Among 228 readings of the 19 HER2 amplified samples, 56 (24.6 %) were scored 0 or 1+, 79 (34.6 %) were 2+, and 93 (40.8 %) were 3+. The average sensitivity was 75.4 %, ranging between 47 % and 100 %, and the overall false negative rate was 24.6 %. Participation of pathological anatomy laboratories performing HER2 testing by IHC in external quality assurance programs should be made mandatory, as the system is able to identify laboratories with suboptimal performance that may need technical advice. Updated 2013 ASCO/CAP recommendations should be adopted as the widening of IHC 2+ “equivocal” category would improve overall accuracy of HER2 testing, as more cases would be classified in this category and, consequently, tested with an in situ hybridisation method.
24 schema:genre article
25 schema:inLanguage en
26 schema:isAccessibleForFree false
27 schema:isPartOf N02fd2154888c4a4191f5ace54e82aee6
28 N6682637802b346799adb2da651402a1f
29 sg:journal.1116758
30 schema:keywords ASCO/CAP recommendations
31 BC cases
32 CAP recommendations
33 Drug Administration
34 HER2
35 HER2 expression
36 HER2 non-amplified samples
37 HER2 status
38 HER2 testing
39 HER2-positive cases
40 IHC 2
41 Italy
42 Tuscany
43 Updated 2013 ASCO/CAP Recommendations
44 accuracy
45 administration
46 advice
47 anatomy laboratory
48 appropriate therapy
49 assurance program
50 average sensitivity
51 breast cancer
52 breast cancer patients
53 cancer
54 cancer patients
55 cases
56 categories
57 control study
58 correct identification
59 expression
60 external quality assurance program
61 false negative rate
62 fluorescence
63 food
64 four-tier scoring system
65 hybridisation method
66 hybridization
67 identification
68 immunohistochemistry
69 impact
70 invasive BC cases
71 key points
72 laboratory
73 method
74 more cases
75 negative rate
76 non-amplified samples
77 overall accuracy
78 overall false-negative rate
79 participation
80 pathological anatomy laboratories
81 pathologists
82 patients
83 performance
84 point
85 program
86 quality assurance program
87 quality control study
88 rate
89 reading
90 recommendations
91 reproducibility
92 samples
93 scoring system
94 sections
95 sensitivity
96 series
97 situ hybridisation method
98 situ hybridization
99 status
100 study
101 suboptimal performance
102 system
103 technical advice
104 testing
105 therapy
106 unstained sections
107 widening
108 schema:name Accuracy and Reproducibility of HER2 Status in Breast Cancer Using Immunohistochemistry: A Quality Control Study in Tuscany Evaluating the Impact of Updated 2013 ASCO/CAP Recommendations
109 schema:pagination 477-485
110 schema:productId N142bf64450a54b3eb4796097ebc233dc
111 N2bf1a6264562467b8d013e28cb5d111c
112 N76025321e0784b3a8a742e40d4b54acb
113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018829752
114 https://doi.org/10.1007/s12253-014-9852-0
115 schema:sdDatePublished 2022-01-01T18:34
116 schema:sdLicense https://scigraph.springernature.com/explorer/license/
117 schema:sdPublisher Nc1b0a65527a84678a26713f01f9642d2
118 schema:url https://doi.org/10.1007/s12253-014-9852-0
119 sgo:license sg:explorer/license/
120 sgo:sdDataset articles
121 rdf:type schema:ScholarlyArticle
122 N02fd2154888c4a4191f5ace54e82aee6 schema:volumeNumber 21
123 rdf:type schema:PublicationVolume
124 N0ea25668ff9043ceb13c4108e44c9e2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Receptor, ErbB-2
126 rdf:type schema:DefinedTerm
127 N110cee9d7dda48a8a6041b8866537b85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Reproducibility of Results
129 rdf:type schema:DefinedTerm
130 N142bf64450a54b3eb4796097ebc233dc schema:name pubmed_id
131 schema:value 25367072
132 rdf:type schema:PropertyValue
133 N1b6410eb48544901ac7b3feb97ba50d6 rdf:first sg:person.0731321474.41
134 rdf:rest Nc6f68d51bfb544a887c69b09f335bf42
135 N1dbb05ce22bf443197249c38031d6d83 rdf:first sg:person.01161605365.07
136 rdf:rest Ne43bc31260d74e2ea9ed0912b641f11c
137 N2bf1a6264562467b8d013e28cb5d111c schema:name doi
138 schema:value 10.1007/s12253-014-9852-0
139 rdf:type schema:PropertyValue
140 N4936dea1ada34ca5a2b711bebf6990af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name False Positive Reactions
142 rdf:type schema:DefinedTerm
143 N4d3ec1fb99014e11858409e8b98b57dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Breast Neoplasms
145 rdf:type schema:DefinedTerm
146 N4d5e711fc3064d29b5ced829d9ed5ad9 schema:familyName On behalf of the Tuscany Breast Cancer Study Group
147 rdf:type schema:Person
148 N6682637802b346799adb2da651402a1f schema:issueNumber 2
149 rdf:type schema:PublicationIssue
150 N684071aa4eb948a3bbf74c4291cca752 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Humans
152 rdf:type schema:DefinedTerm
153 N700c009323d5424fa4f2f942eebcdbfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Quality Control
155 rdf:type schema:DefinedTerm
156 N76025321e0784b3a8a742e40d4b54acb schema:name dimensions_id
157 schema:value pub.1018829752
158 rdf:type schema:PropertyValue
159 N76efc1f0e27c440cb138f7442c54357d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Pathology, Clinical
161 rdf:type schema:DefinedTerm
162 N90afbceb51d447bc83b27f48909415ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name In Situ Hybridization, Fluorescence
164 rdf:type schema:DefinedTerm
165 N940b81baf2584143b03d1df2db32d838 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Practice Guidelines as Topic
167 rdf:type schema:DefinedTerm
168 N9511b91e621d4f5fa1fa6e11d0e324fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Immunohistochemistry
170 rdf:type schema:DefinedTerm
171 N9618eb903faf46f2beef6baa88d4f2b2 rdf:first sg:person.07675154000.55
172 rdf:rest N1dbb05ce22bf443197249c38031d6d83
173 N9a52b276a3da4fff9766b7a840dda970 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name United States
175 rdf:type schema:DefinedTerm
176 Na75e1156fe7943eab5bf3d32248f2dba rdf:first sg:person.01041627227.97
177 rdf:rest Nb86bfe81014547c3b15e5b51d99b43d6
178 Na7eaab47d2044747aa9207e6012bc6cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Female
180 rdf:type schema:DefinedTerm
181 Nb86bfe81014547c3b15e5b51d99b43d6 rdf:first sg:person.0611077332.75
182 rdf:rest N1b6410eb48544901ac7b3feb97ba50d6
183 Nbb26e08e282d4dd89a1a0fec955962e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Gene Expression Regulation, Neoplastic
185 rdf:type schema:DefinedTerm
186 Nc1b0a65527a84678a26713f01f9642d2 schema:name Springer Nature - SN SciGraph project
187 rdf:type schema:Organization
188 Nc6f68d51bfb544a887c69b09f335bf42 rdf:first sg:person.010014537677.09
189 rdf:rest Ne5d6f7ebbccf42cc9c6c576e052b9c3d
190 Nd8379fd59f2b4deb9b63337aafe2b398 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Italy
192 rdf:type schema:DefinedTerm
193 Ne43bc31260d74e2ea9ed0912b641f11c rdf:first sg:person.01204776334.58
194 rdf:rest Nfaad7cd82cc24445bc0bb4479a520beb
195 Ne5d6f7ebbccf42cc9c6c576e052b9c3d rdf:first N4d5e711fc3064d29b5ced829d9ed5ad9
196 rdf:rest rdf:nil
197 Nfaad7cd82cc24445bc0bb4479a520beb rdf:first sg:person.0673106145.95
198 rdf:rest Na75e1156fe7943eab5bf3d32248f2dba
199 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
200 schema:name Medical and Health Sciences
201 rdf:type schema:DefinedTerm
202 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
203 schema:name Oncology and Carcinogenesis
204 rdf:type schema:DefinedTerm
205 sg:journal.1116758 schema:issn 1219-4956
206 1532-2807
207 schema:name Pathology & Oncology Research
208 schema:publisher Springer Nature
209 rdf:type schema:Periodical
210 sg:person.010014537677.09 schema:affiliation grid-institutes:grid.417623.5
211 schema:familyName Palli
212 schema:givenName D.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010014537677.09
214 rdf:type schema:Person
215 sg:person.01041627227.97 schema:affiliation grid-institutes:grid.8404.8
216 schema:familyName Vezzosi
217 schema:givenName V.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041627227.97
219 rdf:type schema:Person
220 sg:person.01161605365.07 schema:affiliation grid-institutes:grid.417623.5
221 schema:familyName Caini
222 schema:givenName S.
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161605365.07
224 rdf:type schema:Person
225 sg:person.01204776334.58 schema:affiliation grid-institutes:grid.8404.8
226 schema:familyName Paglierani
227 schema:givenName M.
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204776334.58
229 rdf:type schema:Person
230 sg:person.0611077332.75 schema:affiliation grid-institutes:grid.8404.8
231 schema:familyName Baroni
232 schema:givenName G.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611077332.75
234 rdf:type schema:Person
235 sg:person.0673106145.95 schema:affiliation grid-institutes:grid.417623.5
236 schema:familyName Saieva
237 schema:givenName C.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673106145.95
239 rdf:type schema:Person
240 sg:person.0731321474.41 schema:affiliation grid-institutes:grid.8404.8
241 schema:familyName Simoni
242 schema:givenName A.
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731321474.41
244 rdf:type schema:Person
245 sg:person.07675154000.55 schema:affiliation grid-institutes:grid.8404.8
246 schema:familyName Bianchi
247 schema:givenName S.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07675154000.55
249 rdf:type schema:Person
250 sg:pub.10.1007/s12253-008-9079-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1008370717
251 https://doi.org/10.1007/s12253-008-9079-z
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/modpathol.2013.103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017540202
254 https://doi.org/10.1038/modpathol.2013.103
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/modpathol.3800208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049181385
257 https://doi.org/10.1038/modpathol.3800208
258 rdf:type schema:CreativeWork
259 grid-institutes:grid.417623.5 schema:alternateName Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy
260 schema:name Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy
261 rdf:type schema:Organization
262 grid-institutes:grid.8404.8 schema:alternateName Pathological Anatomy Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy
263 schema:name Pathological Anatomy Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy
264 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...