Low Prevalence of K-RAS, EGF-R and BRAF Mutations in Sinonasal Adenocarcinomas. Implications for Anti-EGFR Treatments View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-12-15

AUTHORS

Alessandro Franchi, Duccio Rossi Degli Innocenti, Annarita Palomba, Lucia Miligi, Fabiola Paiar, Ciro Franzese, Marco Santucci

ABSTRACT

We have previously shown that a subset of sinonasal intestinal-type adenocarcinomas (ITAC) shows activation of the epidermal growth factor-receptor (EGFR) pathway. In this study we examine the status of the EGFR, KRAS and BRAF genes in a series of sinonasal intestinal (ITAC) and non-intestinal type adenocarcinomas (non-ITAC). Eighteen ITACs and 12 non-ITACs were studied immunohistochemically for EGFR expression. Point mutations were analyzed for EGFR exons 19 and 21, KRAS exon 2 and BRAF exon 15 by direct sequencing. Non-ITACs showed significantly higher expression of EGFR (p = 0.015). Mutation analysis revealed one ITAC with EGFR and one ITAC with KRAS mutation, while two non-ITACs presented mutation of BRAF. We conclude that a subset of sinonasal adenocarcinomas shows overexpression of EGFR, while activating mutations of the signaling cascade downstream of EGFR are rare, suggesting that these tumors could be good candidates for anti-EGFR therapies. More... »

PAGES

571-579

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12253-013-9730-1

DOI

http://dx.doi.org/10.1007/s12253-013-9730-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020329893

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24338245


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ErbB Receptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Grading", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Paranasal Sinus Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins B-raf", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins p21(ras)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Array Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ras Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Section of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy", 
          "id": "http://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Section of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Franchi", 
        "givenName": "Alessandro", 
        "id": "sg:person.0635010402.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635010402.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy", 
          "id": "http://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Innocenti", 
        "givenName": "Duccio Rossi Degli", 
        "id": "sg:person.01140673252.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140673252.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit of Histopathology, Azienda Ospedaliera Universitaria Careggi, Florence, Italy", 
          "id": "http://www.grid.ac/institutes/grid.24704.35", 
          "name": [
            "Unit of Histopathology, Azienda Ospedaliera Universitaria Careggi, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palomba", 
        "givenName": "Annarita", 
        "id": "sg:person.01064004242.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064004242.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit of Environmental and Occupational Epidemiology, ISPO \u2013 Cancer Prevention and Research Institute, Florence, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Unit of Environmental and Occupational Epidemiology, ISPO \u2013 Cancer Prevention and Research Institute, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miligi", 
        "givenName": "Lucia", 
        "id": "sg:person.0643356454.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643356454.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit of Radiation Oncology, Azienda Ospedaliera Universitaria Careggi, Florence, Italy", 
          "id": "http://www.grid.ac/institutes/grid.24704.35", 
          "name": [
            "Unit of Radiation Oncology, Azienda Ospedaliera Universitaria Careggi, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paiar", 
        "givenName": "Fabiola", 
        "id": "sg:person.01116061423.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116061423.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit of Radiation Oncology, Azienda Ospedaliera Universitaria Careggi, Florence, Italy", 
          "id": "http://www.grid.ac/institutes/grid.24704.35", 
          "name": [
            "Unit of Radiation Oncology, Azienda Ospedaliera Universitaria Careggi, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Franzese", 
        "givenName": "Ciro", 
        "id": "sg:person.01146531026.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146531026.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Section of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy", 
          "id": "http://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Section of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santucci", 
        "givenName": "Marco", 
        "id": "sg:person.01010574065.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010574065.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/modpathol.3800315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031391121", 
          "https://doi.org/10.1038/modpathol.3800315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-8-53", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018708614", 
          "https://doi.org/10.1186/1471-2407-8-53"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13402-012-0103-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050235759", 
          "https://doi.org/10.1007/s13402-012-0103-7"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12-15", 
    "datePublishedReg": "2013-12-15", 
    "description": "We have previously shown that a subset of sinonasal intestinal-type adenocarcinomas (ITAC) shows activation of the epidermal growth factor-receptor (EGFR) pathway. In this study we examine the status of the EGFR, KRAS and BRAF genes in a series of sinonasal intestinal (ITAC) and non-intestinal type adenocarcinomas (non-ITAC). Eighteen ITACs and 12 non-ITACs were studied immunohistochemically for EGFR expression. Point mutations were analyzed for EGFR exons 19 and 21, KRAS exon 2 and BRAF exon 15 by direct sequencing. Non-ITACs showed significantly higher expression of EGFR (p\u2009=\u20090.015). Mutation analysis revealed one ITAC with EGFR and one ITAC with KRAS mutation, while two non-ITACs presented mutation of BRAF. We conclude that a subset of sinonasal adenocarcinomas shows overexpression of EGFR, while activating mutations of the signaling cascade downstream of EGFR are rare, suggesting that these tumors could be good candidates for anti-EGFR therapies.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s12253-013-9730-1", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1116758", 
        "issn": [
          "1219-4956", 
          "1532-2807"
        ], 
        "name": "Pathology & Oncology Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "keywords": [
      "intestinal-type adenocarcinoma", 
      "sinonasal adenocarcinoma", 
      "non-intestinal type adenocarcinoma", 
      "sinonasal intestinal-type adenocarcinoma", 
      "anti-EGFR treatment", 
      "EGFR exons 19", 
      "anti-EGFR therapies", 
      "KRAS exon 2", 
      "epidermal growth factor receptor (EGFR) pathway", 
      "growth factor receptor pathway", 
      "mutations of BRAF", 
      "overexpression of EGFR", 
      "type adenocarcinoma", 
      "KRAS mutations", 
      "low prevalence", 
      "BRAF mutations", 
      "EGFR expression", 
      "adenocarcinoma", 
      "EGFR", 
      "BRAF gene", 
      "exon 19", 
      "high expression", 
      "direct sequencing", 
      "BRAF", 
      "mutation analysis", 
      "mutations", 
      "exon 2", 
      "point mutations", 
      "therapy", 
      "expression", 
      "tumors", 
      "KRAS", 
      "prevalence", 
      "subset", 
      "treatment", 
      "activation", 
      "EGF", 
      "overexpression", 
      "status", 
      "pathway", 
      "RAS", 
      "study", 
      "sequencing", 
      "cascade", 
      "genes", 
      "good candidate", 
      "candidates", 
      "analysis", 
      "implications", 
      "series", 
      "factor-receptor (EGFR) pathway"
    ], 
    "name": "Low Prevalence of K-RAS, EGF-R and BRAF Mutations in Sinonasal Adenocarcinomas. Implications for Anti-EGFR Treatments", 
    "pagination": "571-579", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020329893"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12253-013-9730-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24338245"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12253-013-9730-1", 
      "https://app.dimensions.ai/details/publication/pub.1020329893"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_616.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s12253-013-9730-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12253-013-9730-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12253-013-9730-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12253-013-9730-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12253-013-9730-1'


 

This table displays all metadata directly associated to this object as RDF triples.

269 TRIPLES      22 PREDICATES      103 URIs      92 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12253-013-9730-1 schema:about N08e436f0c719478eb99e94e23651fe0c
2 N0e4a28acdda34a02acca3e5acd32b4d1
3 N15dd9ce651394f27bbc211b1c371497b
4 N19ec4a8ca13b44d9ba27ad19898e366a
5 N26b4fa4d75e14f159410380082858a54
6 N26d633f429204586a2b48817821b4f9d
7 N3877b5b68c684c0e91b10b168f930eea
8 N46d1392f417b44468a5a3b849957bb48
9 N505362be27f94b64a2f911d7cd4ab754
10 N61c87cc4ddbf4a27ad32cc14b3e83b35
11 N756df34948af4778a799fdbe807f051a
12 N81a67f8a8ea84517bf46f95465fce054
13 N83d9cded175648fd920104e72e6a1dd0
14 N87ff54a347d04e839cc1ef5aaee9815a
15 N8800d47e8c4a4b07be0183118100b8e4
16 Na10a294042ab423a9084f4395186dd25
17 Nc57f9612794246f084116135db8b59bf
18 Nca03ae90c4f048c5afb970271587c0c1
19 Ncb533d8efb05435ba6ac851830ff711d
20 Ncc3e2cfdc57048b9b654ca133a0822fe
21 Nddbbed38775540dd867e8321340f15ef
22 Ne07ec0dffd0f4d6889728ef6212fc956
23 Ne0f40fcf1edc460aa4167c8e064d7175
24 anzsrc-for:11
25 anzsrc-for:1112
26 schema:author N9d5ee68ec11d471882be54abf6250e8d
27 schema:citation sg:pub.10.1007/s13402-012-0103-7
28 sg:pub.10.1038/modpathol.3800315
29 sg:pub.10.1186/1471-2407-8-53
30 schema:datePublished 2013-12-15
31 schema:datePublishedReg 2013-12-15
32 schema:description We have previously shown that a subset of sinonasal intestinal-type adenocarcinomas (ITAC) shows activation of the epidermal growth factor-receptor (EGFR) pathway. In this study we examine the status of the EGFR, KRAS and BRAF genes in a series of sinonasal intestinal (ITAC) and non-intestinal type adenocarcinomas (non-ITAC). Eighteen ITACs and 12 non-ITACs were studied immunohistochemically for EGFR expression. Point mutations were analyzed for EGFR exons 19 and 21, KRAS exon 2 and BRAF exon 15 by direct sequencing. Non-ITACs showed significantly higher expression of EGFR (p = 0.015). Mutation analysis revealed one ITAC with EGFR and one ITAC with KRAS mutation, while two non-ITACs presented mutation of BRAF. We conclude that a subset of sinonasal adenocarcinomas shows overexpression of EGFR, while activating mutations of the signaling cascade downstream of EGFR are rare, suggesting that these tumors could be good candidates for anti-EGFR therapies.
33 schema:genre article
34 schema:inLanguage en
35 schema:isAccessibleForFree false
36 schema:isPartOf N26d702697c85468485b2b0495cd5901c
37 N924dd27c689d49bdb168cbc771d1a80e
38 sg:journal.1116758
39 schema:keywords BRAF
40 BRAF gene
41 BRAF mutations
42 EGF
43 EGFR
44 EGFR exons 19
45 EGFR expression
46 KRAS
47 KRAS exon 2
48 KRAS mutations
49 RAS
50 activation
51 adenocarcinoma
52 analysis
53 anti-EGFR therapies
54 anti-EGFR treatment
55 candidates
56 cascade
57 direct sequencing
58 epidermal growth factor receptor (EGFR) pathway
59 exon 19
60 exon 2
61 expression
62 factor-receptor (EGFR) pathway
63 genes
64 good candidate
65 growth factor receptor pathway
66 high expression
67 implications
68 intestinal-type adenocarcinoma
69 low prevalence
70 mutation analysis
71 mutations
72 mutations of BRAF
73 non-intestinal type adenocarcinoma
74 overexpression
75 overexpression of EGFR
76 pathway
77 point mutations
78 prevalence
79 sequencing
80 series
81 sinonasal adenocarcinoma
82 sinonasal intestinal-type adenocarcinoma
83 status
84 study
85 subset
86 therapy
87 treatment
88 tumors
89 type adenocarcinoma
90 schema:name Low Prevalence of K-RAS, EGF-R and BRAF Mutations in Sinonasal Adenocarcinomas. Implications for Anti-EGFR Treatments
91 schema:pagination 571-579
92 schema:productId N4cba8c2a2caa49beb5e23e0b5c67cf5d
93 N8e4fa6c1fbee411588fda8933a6bd432
94 Na4c769174e824dc8b60a6ea1af21b71c
95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020329893
96 https://doi.org/10.1007/s12253-013-9730-1
97 schema:sdDatePublished 2022-01-01T18:31
98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
99 schema:sdPublisher N3b599fc4ec924123a0484b5f360e3ac8
100 schema:url https://doi.org/10.1007/s12253-013-9730-1
101 sgo:license sg:explorer/license/
102 sgo:sdDataset articles
103 rdf:type schema:ScholarlyArticle
104 N08e436f0c719478eb99e94e23651fe0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name ras Proteins
106 rdf:type schema:DefinedTerm
107 N0ac1d594acbc4627b2973aa1e909ff19 rdf:first sg:person.01140673252.54
108 rdf:rest N328c5bee7096429290622f102a682e3d
109 N0e4a28acdda34a02acca3e5acd32b4d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Polymerase Chain Reaction
111 rdf:type schema:DefinedTerm
112 N109434f3207443f99ea0aab81857661c rdf:first sg:person.01010574065.28
113 rdf:rest rdf:nil
114 N15dd9ce651394f27bbc211b1c371497b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Humans
116 rdf:type schema:DefinedTerm
117 N19ec4a8ca13b44d9ba27ad19898e366a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Proto-Oncogene Proteins p21(ras)
119 rdf:type schema:DefinedTerm
120 N26b4fa4d75e14f159410380082858a54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Paranasal Sinus Neoplasms
122 rdf:type schema:DefinedTerm
123 N26d633f429204586a2b48817821b4f9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Aged, 80 and over
125 rdf:type schema:DefinedTerm
126 N26d702697c85468485b2b0495cd5901c schema:issueNumber 3
127 rdf:type schema:PublicationIssue
128 N328c5bee7096429290622f102a682e3d rdf:first sg:person.01064004242.98
129 rdf:rest N5d25e0a360d34ff48086660df205ba53
130 N3877b5b68c684c0e91b10b168f930eea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Female
132 rdf:type schema:DefinedTerm
133 N3b599fc4ec924123a0484b5f360e3ac8 schema:name Springer Nature - SN SciGraph project
134 rdf:type schema:Organization
135 N4155193a587a4d51b8eb91f79b52bf16 rdf:first sg:person.01146531026.52
136 rdf:rest N109434f3207443f99ea0aab81857661c
137 N46d1392f417b44468a5a3b849957bb48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name ErbB Receptors
139 rdf:type schema:DefinedTerm
140 N4cba8c2a2caa49beb5e23e0b5c67cf5d schema:name dimensions_id
141 schema:value pub.1020329893
142 rdf:type schema:PropertyValue
143 N505362be27f94b64a2f911d7cd4ab754 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Follow-Up Studies
145 rdf:type schema:DefinedTerm
146 N5d25e0a360d34ff48086660df205ba53 rdf:first sg:person.0643356454.38
147 rdf:rest Nd1d8495e67404989b081cf8fc89721a1
148 N61c87cc4ddbf4a27ad32cc14b3e83b35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Mutation
150 rdf:type schema:DefinedTerm
151 N756df34948af4778a799fdbe807f051a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Intestinal Neoplasms
153 rdf:type schema:DefinedTerm
154 N81a67f8a8ea84517bf46f95465fce054 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Adenocarcinoma
156 rdf:type schema:DefinedTerm
157 N83d9cded175648fd920104e72e6a1dd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Biomarkers, Tumor
159 rdf:type schema:DefinedTerm
160 N87ff54a347d04e839cc1ef5aaee9815a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Proto-Oncogene Proteins B-raf
162 rdf:type schema:DefinedTerm
163 N8800d47e8c4a4b07be0183118100b8e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Immunoenzyme Techniques
165 rdf:type schema:DefinedTerm
166 N8e4fa6c1fbee411588fda8933a6bd432 schema:name pubmed_id
167 schema:value 24338245
168 rdf:type schema:PropertyValue
169 N924dd27c689d49bdb168cbc771d1a80e schema:volumeNumber 20
170 rdf:type schema:PublicationVolume
171 N9d5ee68ec11d471882be54abf6250e8d rdf:first sg:person.0635010402.27
172 rdf:rest N0ac1d594acbc4627b2973aa1e909ff19
173 Na10a294042ab423a9084f4395186dd25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Neoplasm Grading
175 rdf:type schema:DefinedTerm
176 Na4c769174e824dc8b60a6ea1af21b71c schema:name doi
177 schema:value 10.1007/s12253-013-9730-1
178 rdf:type schema:PropertyValue
179 Nc57f9612794246f084116135db8b59bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Adult
181 rdf:type schema:DefinedTerm
182 Nca03ae90c4f048c5afb970271587c0c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Tissue Array Analysis
184 rdf:type schema:DefinedTerm
185 Ncb533d8efb05435ba6ac851830ff711d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Proto-Oncogene Proteins
187 rdf:type schema:DefinedTerm
188 Ncc3e2cfdc57048b9b654ca133a0822fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Male
190 rdf:type schema:DefinedTerm
191 Nd1d8495e67404989b081cf8fc89721a1 rdf:first sg:person.01116061423.15
192 rdf:rest N4155193a587a4d51b8eb91f79b52bf16
193 Nddbbed38775540dd867e8321340f15ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Aged
195 rdf:type schema:DefinedTerm
196 Ne07ec0dffd0f4d6889728ef6212fc956 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Middle Aged
198 rdf:type schema:DefinedTerm
199 Ne0f40fcf1edc460aa4167c8e064d7175 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Prognosis
201 rdf:type schema:DefinedTerm
202 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
203 schema:name Medical and Health Sciences
204 rdf:type schema:DefinedTerm
205 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
206 schema:name Oncology and Carcinogenesis
207 rdf:type schema:DefinedTerm
208 sg:journal.1116758 schema:issn 1219-4956
209 1532-2807
210 schema:name Pathology & Oncology Research
211 schema:publisher Springer Nature
212 rdf:type schema:Periodical
213 sg:person.01010574065.28 schema:affiliation grid-institutes:grid.8404.8
214 schema:familyName Santucci
215 schema:givenName Marco
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010574065.28
217 rdf:type schema:Person
218 sg:person.01064004242.98 schema:affiliation grid-institutes:grid.24704.35
219 schema:familyName Palomba
220 schema:givenName Annarita
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064004242.98
222 rdf:type schema:Person
223 sg:person.01116061423.15 schema:affiliation grid-institutes:grid.24704.35
224 schema:familyName Paiar
225 schema:givenName Fabiola
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116061423.15
227 rdf:type schema:Person
228 sg:person.01140673252.54 schema:affiliation grid-institutes:grid.8404.8
229 schema:familyName Innocenti
230 schema:givenName Duccio Rossi Degli
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140673252.54
232 rdf:type schema:Person
233 sg:person.01146531026.52 schema:affiliation grid-institutes:grid.24704.35
234 schema:familyName Franzese
235 schema:givenName Ciro
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146531026.52
237 rdf:type schema:Person
238 sg:person.0635010402.27 schema:affiliation grid-institutes:grid.8404.8
239 schema:familyName Franchi
240 schema:givenName Alessandro
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635010402.27
242 rdf:type schema:Person
243 sg:person.0643356454.38 schema:affiliation grid-institutes:None
244 schema:familyName Miligi
245 schema:givenName Lucia
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643356454.38
247 rdf:type schema:Person
248 sg:pub.10.1007/s13402-012-0103-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050235759
249 https://doi.org/10.1007/s13402-012-0103-7
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/modpathol.3800315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031391121
252 https://doi.org/10.1038/modpathol.3800315
253 rdf:type schema:CreativeWork
254 sg:pub.10.1186/1471-2407-8-53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018708614
255 https://doi.org/10.1186/1471-2407-8-53
256 rdf:type schema:CreativeWork
257 grid-institutes:None schema:alternateName Unit of Environmental and Occupational Epidemiology, ISPO – Cancer Prevention and Research Institute, Florence, Italy
258 schema:name Unit of Environmental and Occupational Epidemiology, ISPO – Cancer Prevention and Research Institute, Florence, Italy
259 rdf:type schema:Organization
260 grid-institutes:grid.24704.35 schema:alternateName Unit of Histopathology, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
261 Unit of Radiation Oncology, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
262 schema:name Unit of Histopathology, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
263 Unit of Radiation Oncology, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
264 rdf:type schema:Organization
265 grid-institutes:grid.8404.8 schema:alternateName Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy
266 Section of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy
267 schema:name Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy
268 Section of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy
269 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...