c-kit (CD117) Expression in Human Tumors and its Prognostic Value: An Immunohistochemical Analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-02-23

AUTHORS

Michael Medinger, Manuela Kleinschmidt, Klaus Mross, Barbara Wehmeyer, Clemens Unger, Hans-Eckart Schaefer, Renate Weber, Marc Azemar

ABSTRACT

c-kit functions as a tyrosine kinase receptor and represents a target for small molecule kinase inhibitors. The expression pattern for c-kit was studied in different human tumor types to their correlation with prognosis. Paraffin-embedded tumor tissues from 282 patients were analyzed immunohistochemically for c-kit expression. Survival and follow-up data were available from 192/282 (68%) patients. c-kit immunopositivity was found in 62/282 (22%) cases. c-kit expression was found in 14/83 (17%) colorectal cancers, in 13/62 (21%) breast cancers, in 7/20 sarcomas (35%), in 5/14 (36%) renal cell carcinomas, in 2/12 ovarian cancers (17%) and in 2/12 (17%) hepatocellular carcinomas. We found no significant correlation between c-kit expression and prognosis although a trend to a worse prognosis in patients with c-kit positive tumors could be observed. Expression of c-kit was found in tumor samples with varying intensities and infrequently. More... »

PAGES

295-301

References to SciGraph publications

  • 2004-10. Signal transduction via the stem cell factor receptor/c-Kit in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1986-04. A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family in NATURE
  • 2009-06-09. Quantitative immunohistochemical expression of c Kit in breast carcinomas is predictive of patients' outcome in BRITISH JOURNAL OF CANCER
  • 2007-05-09. A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation in VIRCHOWS ARCHIV
  • 2004-05-06. Expression of the proto-oncogene c-KIT in normal and tumor tissues from colorectal carcinoma patients in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 1994-03. Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in human: immunohistochemical study on formalin-fixed, paraffin-embedded tissues in VIRCHOWS ARCHIV
  • 2003-12-16. Rare KIT (CD117) expression in multiple myeloma abrogates the usefulness of imatinib mesylate treatment in VIRCHOWS ARCHIV
  • 2006-05-23. A loss of c-kit expression is associated with an advanced stage and poor prognosis in breast cancer in BRITISH JOURNAL OF CANCER
  • 2009-03-12. Immunohistochemical detection of receptor tyrosine kinases c-kit, EGF-R, and PDGF-R in colorectal adenocarcinomas in LANGENBECK'S ARCHIVES OF SURGERY
  • 1996-05. Immunohistochemical expression of the c-kit proto-oncogene product in human malignant and non-malignant breast tissues in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12253-010-9247-9

    DOI

    http://dx.doi.org/10.1007/s12253-010-9247-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000010295

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20177846


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