PPI-Delayed Diagnosis of Gastrinoma: Oncologic Victim of Pharmacologic Success View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-03

AUTHORS

Hilda Wong, Thomas Yau, Pierre Chan, Irene O. L. Ng, Gavin Chan, Peter Hui, W. L. Law, C. M. Lo, Antony J. Hedley, Richard J. Epstein

ABSTRACT

Functional neuroendocrine tumors are often low-grade malignant neoplasms that can be cured by surgery if detected early, and such detection may in turn be accelerated by the recognition of neuropeptide hypersecretion syndromes. Uniquely, however, relief of peptic symptoms induced by hypergastrinemia is now available from acid-suppressive drugs such as proton-pump inhibitors (PPIs). Here we describe a clinical case in which time to diagnosis from the onset of peptic symptoms was delayed more than 10 years, in part reflecting symptom masking by continuous prescription of the PPI omeprazole. We propose diagnostic criteria for this under-recognized new clinical syndrome, and recommend that physicians routinely measure serum gastrin levels in persistent cases of PPI-dependent dyspepsia unassociated with H. pylori. More... »

PAGES

87-91

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12253-009-9192-7

DOI

http://dx.doi.org/10.1007/s12253-009-9192-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004412280

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19693706


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