Trans Complementation of Replication-defective Omsk Hemorrhagic Fever Virus for Antiviral Study. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-04

AUTHORS

Qiuyan Zhang, Na Li, Chenglin Deng, Zherui Zhang, Xiaodan Li, Kentaro Yoshii, Hanqing Ye, Bo Zhang

ABSTRACT

Omsk hemorrhagic fever virus (OHFV) is a tick-borne flavivirus classified as a biosafety level-4 (BSL4) pathogen. Studies of OHFV are restricted to be conducted within BSL4 laboratories. Currently, no commercial vaccines or antiviral drugs are available against OHFV infection. In this study, we recovered a replication-deficient OHFV with an NS1 deletion (OHFV-ΔNS1) and reporter virus replacing NS1 with the Gaussia luciferase (Gluc) (OHFV-ΔNS1-Gluc). Both the defective OHFV-ΔNS1 and OHFV-ΔNS1-Gluc virus could only replicate efficiently in the BHK21 cell line expressing NS1 (BHK21NS1) but not in naïve BHK21 cells. The Gluc reporter gene of OHFV-ΔNS1-Gluc virus was maintained stably after serial passaging of BHK21NS1 cells and was used to surrogate the replication of OHFV. Using NITD008, OHFV-ΔNS1-Gluc virus was validated for antiviral screening, and high-throughput screening parameters were optimized in a 96-well plate format with a calculated Z' value above 0.5. The OHFV-ΔNS1-Gluc reporter virus is a powerful tool for antiviral screening as well as viral replication and pathogenesis studies in BSL2 laboratories. More... »

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12250-019-00109-0

DOI

http://dx.doi.org/10.1007/s12250-019-00109-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113185376

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30949960


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