Positive selection analysis of VP1 Genes of worldwide human enterovirus 71 viruses View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-02-20

AUTHORS

Wei-feng Shi, Zhong Zhang, Ai-she Dun, Yan-zhou Zhang, Guang-fu Yu, Dong-ming Zhuang, Chao-dong Zhu

ABSTRACT

Human enterovirus 71 viruses have been long circulating throughout the world. In this study, we performed a positive selection analysis of the VP1 genes of capsid proteins from Enterovirus 71 viruses. Our results showed that although most sites were under negative or neutral evolution, four positions of the VP1 genes were under positive selection pressure. This might account for the spread and frequent outbreaks of the viruses and the enhanced neurovirulence. In particular, position 98 might be involved in neutralizing antibodies, modulating the virus-receptor interaction and enhancing the virulence of the viruses. Moreover, both positions 145 and 241 might correlate to determine the receptor specificity. However, these positions did not display much difference in amino acid polymorphism. In addition, no position in the VP1 genes of viruses isolated from China was under positive selection. More... »

PAGES

59-64

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12250-009-2976-9

DOI

http://dx.doi.org/10.1007/s12250-009-2976-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024391036


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Life Sciences, Taishan Medical College, 271000, Taian, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.410638.8", 
          "name": [
            "Institute of Life Sciences, Taishan Medical College, 271000, Taian, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Wei-feng", 
        "id": "sg:person.0711212027.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711212027.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Basic Medicine, Taishan Medical College, 271000, Taian, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.410638.8", 
          "name": [
            "Department of Basic Medicine, Taishan Medical College, 271000, Taian, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Zhong", 
        "id": "sg:person.01206354642.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206354642.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Basic Medicine, Taishan Medical College, 271000, Taian, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.410638.8", 
          "name": [
            "Department of Basic Medicine, Taishan Medical College, 271000, Taian, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dun", 
        "givenName": "Ai-she", 
        "id": "sg:person.01202763355.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202763355.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China", 
          "id": "http://www.grid.ac/institutes/grid.458458.0", 
          "name": [
            "Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Yan-zhou", 
        "id": "sg:person.01206040466.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206040466.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Basic Medicine, Taishan Medical College, 271000, Taian, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.410638.8", 
          "name": [
            "Department of Basic Medicine, Taishan Medical College, 271000, Taian, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Guang-fu", 
        "id": "sg:person.0766412767.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766412767.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Basic Medicine, Taishan Medical College, 271000, Taian, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.410638.8", 
          "name": [
            "Department of Basic Medicine, Taishan Medical College, 271000, Taian, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhuang", 
        "givenName": "Dong-ming", 
        "id": "sg:person.01256747765.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256747765.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China", 
          "id": "http://www.grid.ac/institutes/grid.458458.0", 
          "name": [
            "Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Chao-dong", 
        "id": "sg:person.01145016325.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145016325.32"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/317145a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048446499", 
          "https://doi.org/10.1038/317145a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11434-007-0215-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042657799", 
          "https://doi.org/10.1007/s11434-007-0215-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2180-6-74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015228922", 
          "https://doi.org/10.1186/1471-2180-6-74"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-75602-3_5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003155105", 
          "https://doi.org/10.1007/978-3-642-75602-3_5"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-02-20", 
    "datePublishedReg": "2009-02-20", 
    "description": "Human enterovirus 71 viruses have been long circulating throughout the world. In this study, we performed a positive selection analysis of the VP1 genes of capsid proteins from Enterovirus 71 viruses. Our results showed that although most sites were under negative or neutral evolution, four positions of the VP1 genes were under positive selection pressure. This might account for the spread and frequent outbreaks of the viruses and the enhanced neurovirulence. In particular, position 98 might be involved in neutralizing antibodies, modulating the virus-receptor interaction and enhancing the virulence of the viruses. Moreover, both positions 145 and 241 might correlate to determine the receptor specificity. However, these positions did not display much difference in amino acid polymorphism. In addition, no position in the VP1 genes of viruses isolated from China was under positive selection.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s12250-009-2976-9", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1042024", 
        "issn": [
          "1674-0769", 
          "1995-820X"
        ], 
        "name": "Virologica Sinica", 
        "publisher": "Elsevier", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "keywords": [
      "enterovirus 71 virus", 
      "VP1 gene", 
      "enhanced neurovirulence", 
      "virus-receptor interactions", 
      "receptor specificity", 
      "virus", 
      "amino acid polymorphisms", 
      "position 145", 
      "positive selection analysis", 
      "frequent outbreaks", 
      "capsid protein", 
      "neurovirulence", 
      "selection analysis", 
      "genes", 
      "positive selection pressure", 
      "antibodies", 
      "outbreak", 
      "neutral evolution", 
      "polymorphism", 
      "virulence", 
      "positive selection", 
      "selection pressure", 
      "specificity", 
      "position 98", 
      "differences", 
      "study", 
      "protein", 
      "spread", 
      "analysis", 
      "pressure", 
      "addition", 
      "sites", 
      "most sites", 
      "results", 
      "position", 
      "selection", 
      "interaction", 
      "evolution", 
      "China", 
      "world"
    ], 
    "name": "Positive selection analysis of VP1 Genes of worldwide human enterovirus 71 viruses", 
    "pagination": "59-64", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024391036"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12250-009-2976-9"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12250-009-2976-9", 
      "https://app.dimensions.ai/details/publication/pub.1024391036"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_476.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s12250-009-2976-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12250-009-2976-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12250-009-2976-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12250-009-2976-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12250-009-2976-9'


 

This table displays all metadata directly associated to this object as RDF triples.

161 TRIPLES      22 PREDICATES      69 URIs      57 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12250-009-2976-9 schema:about anzsrc-for:11
2 anzsrc-for:1108
3 schema:author N4d69f3b7320e41aea4ce8c1b9f4fce9d
4 schema:citation sg:pub.10.1007/978-3-642-75602-3_5
5 sg:pub.10.1007/s11434-007-0215-z
6 sg:pub.10.1038/317145a0
7 sg:pub.10.1186/1471-2180-6-74
8 schema:datePublished 2009-02-20
9 schema:datePublishedReg 2009-02-20
10 schema:description Human enterovirus 71 viruses have been long circulating throughout the world. In this study, we performed a positive selection analysis of the VP1 genes of capsid proteins from Enterovirus 71 viruses. Our results showed that although most sites were under negative or neutral evolution, four positions of the VP1 genes were under positive selection pressure. This might account for the spread and frequent outbreaks of the viruses and the enhanced neurovirulence. In particular, position 98 might be involved in neutralizing antibodies, modulating the virus-receptor interaction and enhancing the virulence of the viruses. Moreover, both positions 145 and 241 might correlate to determine the receptor specificity. However, these positions did not display much difference in amino acid polymorphism. In addition, no position in the VP1 genes of viruses isolated from China was under positive selection.
11 schema:genre article
12 schema:inLanguage en
13 schema:isAccessibleForFree false
14 schema:isPartOf N884425b2a9204e54a52d6264493b9538
15 Nc801553a0f574ebda93d007761dfce74
16 sg:journal.1042024
17 schema:keywords China
18 VP1 gene
19 addition
20 amino acid polymorphisms
21 analysis
22 antibodies
23 capsid protein
24 differences
25 enhanced neurovirulence
26 enterovirus 71 virus
27 evolution
28 frequent outbreaks
29 genes
30 interaction
31 most sites
32 neurovirulence
33 neutral evolution
34 outbreak
35 polymorphism
36 position
37 position 145
38 position 98
39 positive selection
40 positive selection analysis
41 positive selection pressure
42 pressure
43 protein
44 receptor specificity
45 results
46 selection
47 selection analysis
48 selection pressure
49 sites
50 specificity
51 spread
52 study
53 virulence
54 virus
55 virus-receptor interactions
56 world
57 schema:name Positive selection analysis of VP1 Genes of worldwide human enterovirus 71 viruses
58 schema:pagination 59-64
59 schema:productId N400c57e7acab429e960202fee1607143
60 Na3495e35818f4ab7ba55fe6fe0da221e
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024391036
62 https://doi.org/10.1007/s12250-009-2976-9
63 schema:sdDatePublished 2022-05-20T07:25
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N26c749767b464f7d987730bf2ff6d925
66 schema:url https://doi.org/10.1007/s12250-009-2976-9
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N26c749767b464f7d987730bf2ff6d925 schema:name Springer Nature - SN SciGraph project
71 rdf:type schema:Organization
72 N400c57e7acab429e960202fee1607143 schema:name dimensions_id
73 schema:value pub.1024391036
74 rdf:type schema:PropertyValue
75 N4d69f3b7320e41aea4ce8c1b9f4fce9d rdf:first sg:person.0711212027.68
76 rdf:rest Nab3dd98627f642a7a4896307194c92e9
77 N73e1d9341d2e4acbbf940080da50ca11 rdf:first sg:person.01256747765.27
78 rdf:rest Na1ef2e7aaae040c1ad62154e5dc2ab07
79 N786fbe18eb3040fda723141e6a216a15 rdf:first sg:person.01206040466.53
80 rdf:rest Nf661d8d03e9c4cd5b921482f867e8ffb
81 N884425b2a9204e54a52d6264493b9538 schema:issueNumber 1
82 rdf:type schema:PublicationIssue
83 Na1ef2e7aaae040c1ad62154e5dc2ab07 rdf:first sg:person.01145016325.32
84 rdf:rest rdf:nil
85 Na3495e35818f4ab7ba55fe6fe0da221e schema:name doi
86 schema:value 10.1007/s12250-009-2976-9
87 rdf:type schema:PropertyValue
88 Nab3dd98627f642a7a4896307194c92e9 rdf:first sg:person.01206354642.47
89 rdf:rest Ncf205062d1b84705b574f0273d79e924
90 Nc801553a0f574ebda93d007761dfce74 schema:volumeNumber 24
91 rdf:type schema:PublicationVolume
92 Ncf205062d1b84705b574f0273d79e924 rdf:first sg:person.01202763355.60
93 rdf:rest N786fbe18eb3040fda723141e6a216a15
94 Nf661d8d03e9c4cd5b921482f867e8ffb rdf:first sg:person.0766412767.17
95 rdf:rest N73e1d9341d2e4acbbf940080da50ca11
96 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
97 schema:name Medical and Health Sciences
98 rdf:type schema:DefinedTerm
99 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
100 schema:name Medical Microbiology
101 rdf:type schema:DefinedTerm
102 sg:journal.1042024 schema:issn 1674-0769
103 1995-820X
104 schema:name Virologica Sinica
105 schema:publisher Elsevier
106 rdf:type schema:Periodical
107 sg:person.01145016325.32 schema:affiliation grid-institutes:grid.458458.0
108 schema:familyName Zhu
109 schema:givenName Chao-dong
110 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145016325.32
111 rdf:type schema:Person
112 sg:person.01202763355.60 schema:affiliation grid-institutes:grid.410638.8
113 schema:familyName Dun
114 schema:givenName Ai-she
115 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202763355.60
116 rdf:type schema:Person
117 sg:person.01206040466.53 schema:affiliation grid-institutes:grid.458458.0
118 schema:familyName Zhang
119 schema:givenName Yan-zhou
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206040466.53
121 rdf:type schema:Person
122 sg:person.01206354642.47 schema:affiliation grid-institutes:grid.410638.8
123 schema:familyName Zhang
124 schema:givenName Zhong
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206354642.47
126 rdf:type schema:Person
127 sg:person.01256747765.27 schema:affiliation grid-institutes:grid.410638.8
128 schema:familyName Zhuang
129 schema:givenName Dong-ming
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256747765.27
131 rdf:type schema:Person
132 sg:person.0711212027.68 schema:affiliation grid-institutes:grid.410638.8
133 schema:familyName Shi
134 schema:givenName Wei-feng
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711212027.68
136 rdf:type schema:Person
137 sg:person.0766412767.17 schema:affiliation grid-institutes:grid.410638.8
138 schema:familyName Yu
139 schema:givenName Guang-fu
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766412767.17
141 rdf:type schema:Person
142 sg:pub.10.1007/978-3-642-75602-3_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003155105
143 https://doi.org/10.1007/978-3-642-75602-3_5
144 rdf:type schema:CreativeWork
145 sg:pub.10.1007/s11434-007-0215-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1042657799
146 https://doi.org/10.1007/s11434-007-0215-z
147 rdf:type schema:CreativeWork
148 sg:pub.10.1038/317145a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048446499
149 https://doi.org/10.1038/317145a0
150 rdf:type schema:CreativeWork
151 sg:pub.10.1186/1471-2180-6-74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015228922
152 https://doi.org/10.1186/1471-2180-6-74
153 rdf:type schema:CreativeWork
154 grid-institutes:grid.410638.8 schema:alternateName Department of Basic Medicine, Taishan Medical College, 271000, Taian, Shandong, China
155 Institute of Life Sciences, Taishan Medical College, 271000, Taian, Shandong, China
156 schema:name Department of Basic Medicine, Taishan Medical College, 271000, Taian, Shandong, China
157 Institute of Life Sciences, Taishan Medical College, 271000, Taian, Shandong, China
158 rdf:type schema:Organization
159 grid-institutes:grid.458458.0 schema:alternateName Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China
160 schema:name Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China
161 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...