Proteotyping: A new approach studying influenza virus evolution at the protein level View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-10

AUTHORS

Wei-feng Shi, Zhong Zhang, Lei Peng, Yan-zhou Zhang, Bin Liu, Chao-dong Zhu

ABSTRACT

Phylogenetic methods have been widely used to detect the evolution of influenza viruses. However, previous phylogenetic studies of influenza viruses do not make full use of the genetic information at the protein level and therefore cannot distinguish the subtle differences among viral genes. Proteotyping is a new approach to study influenza virus evolution. It aimed at mining the potential genetic information of the viral gene at the protein level by visualizing unique amino acid signatures (proteotypes). Neuraminidase gene fragments of some H5N1 avian influenza viruses were used as an example to illustrate how the proteotyping method worked. Bayesian analysis confirmed that the NA gene tree was mainly divided into three lineages. The NA proteotype analysis further suggested there might be multiple proteotypes within these three lineages and even within single genotypes. At the same time, some proteotypes might even involve more than one genotype. In particular, it also discovered some amino acids of viruses of some genotypes might co-reassort. All these results proved this approach could provide additional information in contrast to results from standard phylogenetic tree analysis. More... »

PAGES

405-411

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12250-007-0039-7

DOI

http://dx.doi.org/10.1007/s12250-007-0039-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002234600


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