Determining The Pressure-Generating Capacity of The Classical and Alternative In Vitro Dissolution Methods Using a Wireless Motility Capsule View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09

AUTHORS

Melita Hribar, Ognen Jakasanovski, Jurij Trontelj, Iztok Grabnar, Igor Legen

ABSTRACT

In vitro dissolution tests are an important tool for prediction of in vivo behavior of pharmaceutical dosage forms. One of the main reasons behind poor in vitro-in vivo correlation is the lack of knowledge about the true in vivo conditions and the failure to replicate them adequately in vitro. The objective of this study was to investigate the conditions during the dissolution testing in terms of their capability to generate the biorelevant pressure values that orally administered dosage forms are exposed to in vivo. Using the SmartPill®, three classical dissolution systems (USP 1–3) were subjected to the pressure measurements. With USP 3, the addition of plastic beads was also examined. Additionally, two novel in vitro dissolution models capable of simulating the peristaltic action were also investigated, namely, the advanced gastric simulator (AGS) and the intestine model for simulating the peristaltic action (IMSPA). The USP 1 and USP 2 systems showed no significant pressure readings, while the USP 3 (and especially its combination with plastic beads) showed measurable pressure peaks but still below the reported in vivo values. The AGS and the IMSPA, on the other hand, offered precise and repeatable controlled contractions of a silicone container resulting in the maximum pressure values very close to the reported in vivo measurements by the SmartPill® device. The results therefore support the in vivo relevance of the newly developed AGS and IMSPA models and present their potential for further optimization of dissolution testing methods. More... »

PAGES

226-236

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12247-018-9317-1

DOI

http://dx.doi.org/10.1007/s12247-018-9317-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101407581


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0299", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Other Physical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/02", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Physical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Novartis (Slovenia)", 
          "id": "https://www.grid.ac/institutes/grid.457257.6", 
          "name": [
            "Lek Pharmaceuticals d.d., a Sandoz Company, Verov\u0161kova 57, 1526, Ljubljana, Slovenia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hribar", 
        "givenName": "Melita", 
        "id": "sg:person.013443431165.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013443431165.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Saints Cyril and Methodius University of Skopje", 
          "id": "https://www.grid.ac/institutes/grid.7858.2", 
          "name": [
            "Faculty of Pharmacy, ss. Cyril and Methodius University of Skopje, Vodnjanska 17, 1000, Skopje, Macedonia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jakasanovski", 
        "givenName": "Ognen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ljubljana", 
          "id": "https://www.grid.ac/institutes/grid.8954.0", 
          "name": [
            "Faculty of Pharmacy, University of Ljubljana, A\u0161ker\u010deva 7, 1000, Ljubljana, Slovenia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trontelj", 
        "givenName": "Jurij", 
        "id": "sg:person.0761721523.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761721523.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ljubljana", 
          "id": "https://www.grid.ac/institutes/grid.8954.0", 
          "name": [
            "Faculty of Pharmacy, University of Ljubljana, A\u0161ker\u010deva 7, 1000, Ljubljana, Slovenia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grabnar", 
        "givenName": "Iztok", 
        "id": "sg:person.0632527117.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632527117.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (Slovenia)", 
          "id": "https://www.grid.ac/institutes/grid.457257.6", 
          "name": [
            "Lek Pharmaceuticals d.d., a Sandoz Company, Verov\u0161kova 57, 1526, Ljubljana, Slovenia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Legen", 
        "givenName": "Igor", 
        "id": "sg:person.01227026603.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227026603.73"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1471-230x-14-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002571708", 
          "https://doi.org/10.1186/1471-230x-14-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/clpt.2011.267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006686624", 
          "https://doi.org/10.1038/clpt.2011.267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1208/s12248-012-9422-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007903512", 
          "https://doi.org/10.1208/s12248-012-9422-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2005.02683.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013364369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2005.02683.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013364369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2015.10.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015095527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1208/s12249-016-0629-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016764710", 
          "https://doi.org/10.1208/s12249-016-0629-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1208/s12249-016-0629-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016764710", 
          "https://doi.org/10.1208/s12249-016-0629-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.2242011412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018238877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2982.2006.00759.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021956058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2982.2006.00759.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021956058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/17474124.2014.922869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022887475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-009-0899-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023883496", 
          "https://doi.org/10.1007/s10620-009-0899-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-009-0899-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023883496", 
          "https://doi.org/10.1007/s10620-009-0899-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2982.2012.01955.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026728120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2050640613510161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032170021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2050640613510161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032170021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3841.2008.00766.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035944358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bit.25890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036333046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejps.2013.08.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040235506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-008-0394-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041086356", 
          "https://doi.org/10.1007/s10620-008-0394-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3841.2010.01856.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042925966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jps.20818", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047424898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejpb.2016.09.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048077711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/mp500210c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049981175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2011.01.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051885415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/mp1001203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056212358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/mp1001203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056212358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/mp100149j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056212372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/mp100149j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056212372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/mp300604u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056213138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.1998.441_k.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061946791", 
          "https://doi.org/10.1111/j.1572-0241.1998.441_k.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.14227/dt120105p11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067217327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.14227/dt190312p15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067217539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.14227/dt220315p18", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067217652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejps.2017.06.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090385614"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-09", 
    "datePublishedReg": "2018-09-01", 
    "description": "In vitro dissolution tests are an important tool for prediction of in vivo behavior of pharmaceutical dosage forms. One of the main reasons behind poor in vitro-in vivo correlation is the lack of knowledge about the true in vivo conditions and the failure to replicate them adequately in vitro. The objective of this study was to investigate the conditions during the dissolution testing in terms of their capability to generate the biorelevant pressure values that orally administered dosage forms are exposed to in vivo. Using the SmartPill\u00ae, three classical dissolution systems (USP 1\u20133) were subjected to the pressure measurements. With USP 3, the addition of plastic beads was also examined. Additionally, two novel in vitro dissolution models capable of simulating the peristaltic action were also investigated, namely, the advanced gastric simulator (AGS) and the intestine model for simulating the peristaltic action (IMSPA). The USP 1 and USP 2 systems showed no significant pressure readings, while the USP 3 (and especially its combination with plastic beads) showed measurable pressure peaks but still below the reported in vivo values. The AGS and the IMSPA, on the other hand, offered precise and repeatable controlled contractions of a silicone container resulting in the maximum pressure values very close to the reported in vivo measurements by the SmartPill\u00ae device. The results therefore support the in vivo relevance of the newly developed AGS and IMSPA models and present their potential for further optimization of dissolution testing methods.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12247-018-9317-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1039359", 
        "issn": [
          "1872-5120", 
          "1939-8042"
        ], 
        "name": "Journal of Pharmaceutical Innovation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Determining The Pressure-Generating Capacity of The Classical and Alternative In Vitro Dissolution Methods Using a Wireless Motility Capsule", 
    "pagination": "226-236", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9e903ee42746ad46e4b685df0e81e8378a5af33b9fb7bbaaeba1af2aa5d2a794"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12247-018-9317-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101407581"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12247-018-9317-1", 
      "https://app.dimensions.ai/details/publication/pub.1101407581"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11707_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12247-018-9317-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12247-018-9317-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12247-018-9317-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12247-018-9317-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12247-018-9317-1'


 

This table displays all metadata directly associated to this object as RDF triples.

188 TRIPLES      21 PREDICATES      56 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12247-018-9317-1 schema:about anzsrc-for:02
2 anzsrc-for:0299
3 schema:author Nec70e126d9b8432387a61c361e24b538
4 schema:citation sg:pub.10.1007/s10620-008-0394-8
5 sg:pub.10.1007/s10620-009-0899-9
6 sg:pub.10.1038/clpt.2011.267
7 sg:pub.10.1111/j.1572-0241.1998.441_k.x
8 sg:pub.10.1186/1471-230x-14-2
9 sg:pub.10.1208/s12248-012-9422-x
10 sg:pub.10.1208/s12249-016-0629-5
11 https://doi.org/10.1002/bit.25890
12 https://doi.org/10.1002/jps.20818
13 https://doi.org/10.1016/j.ejpb.2016.09.009
14 https://doi.org/10.1016/j.ejps.2013.08.024
15 https://doi.org/10.1016/j.ejps.2017.06.037
16 https://doi.org/10.1016/j.ijpharm.2011.01.010
17 https://doi.org/10.1016/j.jconrel.2015.10.022
18 https://doi.org/10.1021/mp1001203
19 https://doi.org/10.1021/mp100149j
20 https://doi.org/10.1021/mp300604u
21 https://doi.org/10.1021/mp500210c
22 https://doi.org/10.1111/j.1365-2036.2005.02683.x
23 https://doi.org/10.1111/j.1365-2982.2006.00759.x
24 https://doi.org/10.1111/j.1365-2982.2012.01955.x
25 https://doi.org/10.1111/j.1750-3841.2008.00766.x
26 https://doi.org/10.1111/j.1750-3841.2010.01856.x
27 https://doi.org/10.1148/radiol.2242011412
28 https://doi.org/10.1177/2050640613510161
29 https://doi.org/10.14227/dt120105p11
30 https://doi.org/10.14227/dt190312p15
31 https://doi.org/10.14227/dt220315p18
32 https://doi.org/10.1586/17474124.2014.922869
33 schema:datePublished 2018-09
34 schema:datePublishedReg 2018-09-01
35 schema:description In vitro dissolution tests are an important tool for prediction of in vivo behavior of pharmaceutical dosage forms. One of the main reasons behind poor in vitro-in vivo correlation is the lack of knowledge about the true in vivo conditions and the failure to replicate them adequately in vitro. The objective of this study was to investigate the conditions during the dissolution testing in terms of their capability to generate the biorelevant pressure values that orally administered dosage forms are exposed to in vivo. Using the SmartPill®, three classical dissolution systems (USP 1–3) were subjected to the pressure measurements. With USP 3, the addition of plastic beads was also examined. Additionally, two novel in vitro dissolution models capable of simulating the peristaltic action were also investigated, namely, the advanced gastric simulator (AGS) and the intestine model for simulating the peristaltic action (IMSPA). The USP 1 and USP 2 systems showed no significant pressure readings, while the USP 3 (and especially its combination with plastic beads) showed measurable pressure peaks but still below the reported in vivo values. The AGS and the IMSPA, on the other hand, offered precise and repeatable controlled contractions of a silicone container resulting in the maximum pressure values very close to the reported in vivo measurements by the SmartPill® device. The results therefore support the in vivo relevance of the newly developed AGS and IMSPA models and present their potential for further optimization of dissolution testing methods.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree false
39 schema:isPartOf N25d4782ee76244f59e5a739ee47ac991
40 N4333dbb02ed4496589280f377c7f7abe
41 sg:journal.1039359
42 schema:name Determining The Pressure-Generating Capacity of The Classical and Alternative In Vitro Dissolution Methods Using a Wireless Motility Capsule
43 schema:pagination 226-236
44 schema:productId N4454bc2ba9724ea89084c010ede113f0
45 N612a2ee8338d4bc2a40f46f48d28e526
46 N804faf9433c8477c8321e345706288cd
47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101407581
48 https://doi.org/10.1007/s12247-018-9317-1
49 schema:sdDatePublished 2019-04-11T11:19
50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
51 schema:sdPublisher Nd426b0af93704418b407f2ec6cac1892
52 schema:url https://link.springer.com/10.1007%2Fs12247-018-9317-1
53 sgo:license sg:explorer/license/
54 sgo:sdDataset articles
55 rdf:type schema:ScholarlyArticle
56 N0c8406cff08a41a18e6bf41f66165e69 rdf:first sg:person.0632527117.46
57 rdf:rest N83553b8ce93e4fb4834a00f2b0fcab2c
58 N25d4782ee76244f59e5a739ee47ac991 schema:volumeNumber 13
59 rdf:type schema:PublicationVolume
60 N4333dbb02ed4496589280f377c7f7abe schema:issueNumber 3
61 rdf:type schema:PublicationIssue
62 N4454bc2ba9724ea89084c010ede113f0 schema:name readcube_id
63 schema:value 9e903ee42746ad46e4b685df0e81e8378a5af33b9fb7bbaaeba1af2aa5d2a794
64 rdf:type schema:PropertyValue
65 N53440965bdb142678cbe6ad8b72965ef schema:affiliation https://www.grid.ac/institutes/grid.7858.2
66 schema:familyName Jakasanovski
67 schema:givenName Ognen
68 rdf:type schema:Person
69 N612a2ee8338d4bc2a40f46f48d28e526 schema:name doi
70 schema:value 10.1007/s12247-018-9317-1
71 rdf:type schema:PropertyValue
72 N636678bc801242cdbe2889ebd5160eb8 rdf:first sg:person.0761721523.35
73 rdf:rest N0c8406cff08a41a18e6bf41f66165e69
74 N804faf9433c8477c8321e345706288cd schema:name dimensions_id
75 schema:value pub.1101407581
76 rdf:type schema:PropertyValue
77 N83553b8ce93e4fb4834a00f2b0fcab2c rdf:first sg:person.01227026603.73
78 rdf:rest rdf:nil
79 Nd426b0af93704418b407f2ec6cac1892 schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 Nec70e126d9b8432387a61c361e24b538 rdf:first sg:person.013443431165.05
82 rdf:rest Nff6ae89e28124273b5bf1325a06f19e1
83 Nff6ae89e28124273b5bf1325a06f19e1 rdf:first N53440965bdb142678cbe6ad8b72965ef
84 rdf:rest N636678bc801242cdbe2889ebd5160eb8
85 anzsrc-for:02 schema:inDefinedTermSet anzsrc-for:
86 schema:name Physical Sciences
87 rdf:type schema:DefinedTerm
88 anzsrc-for:0299 schema:inDefinedTermSet anzsrc-for:
89 schema:name Other Physical Sciences
90 rdf:type schema:DefinedTerm
91 sg:journal.1039359 schema:issn 1872-5120
92 1939-8042
93 schema:name Journal of Pharmaceutical Innovation
94 rdf:type schema:Periodical
95 sg:person.01227026603.73 schema:affiliation https://www.grid.ac/institutes/grid.457257.6
96 schema:familyName Legen
97 schema:givenName Igor
98 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227026603.73
99 rdf:type schema:Person
100 sg:person.013443431165.05 schema:affiliation https://www.grid.ac/institutes/grid.457257.6
101 schema:familyName Hribar
102 schema:givenName Melita
103 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013443431165.05
104 rdf:type schema:Person
105 sg:person.0632527117.46 schema:affiliation https://www.grid.ac/institutes/grid.8954.0
106 schema:familyName Grabnar
107 schema:givenName Iztok
108 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632527117.46
109 rdf:type schema:Person
110 sg:person.0761721523.35 schema:affiliation https://www.grid.ac/institutes/grid.8954.0
111 schema:familyName Trontelj
112 schema:givenName Jurij
113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761721523.35
114 rdf:type schema:Person
115 sg:pub.10.1007/s10620-008-0394-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041086356
116 https://doi.org/10.1007/s10620-008-0394-8
117 rdf:type schema:CreativeWork
118 sg:pub.10.1007/s10620-009-0899-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023883496
119 https://doi.org/10.1007/s10620-009-0899-9
120 rdf:type schema:CreativeWork
121 sg:pub.10.1038/clpt.2011.267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006686624
122 https://doi.org/10.1038/clpt.2011.267
123 rdf:type schema:CreativeWork
124 sg:pub.10.1111/j.1572-0241.1998.441_k.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1061946791
125 https://doi.org/10.1111/j.1572-0241.1998.441_k.x
126 rdf:type schema:CreativeWork
127 sg:pub.10.1186/1471-230x-14-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002571708
128 https://doi.org/10.1186/1471-230x-14-2
129 rdf:type schema:CreativeWork
130 sg:pub.10.1208/s12248-012-9422-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007903512
131 https://doi.org/10.1208/s12248-012-9422-x
132 rdf:type schema:CreativeWork
133 sg:pub.10.1208/s12249-016-0629-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016764710
134 https://doi.org/10.1208/s12249-016-0629-5
135 rdf:type schema:CreativeWork
136 https://doi.org/10.1002/bit.25890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036333046
137 rdf:type schema:CreativeWork
138 https://doi.org/10.1002/jps.20818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047424898
139 rdf:type schema:CreativeWork
140 https://doi.org/10.1016/j.ejpb.2016.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048077711
141 rdf:type schema:CreativeWork
142 https://doi.org/10.1016/j.ejps.2013.08.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040235506
143 rdf:type schema:CreativeWork
144 https://doi.org/10.1016/j.ejps.2017.06.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090385614
145 rdf:type schema:CreativeWork
146 https://doi.org/10.1016/j.ijpharm.2011.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051885415
147 rdf:type schema:CreativeWork
148 https://doi.org/10.1016/j.jconrel.2015.10.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015095527
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1021/mp1001203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056212358
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1021/mp100149j schema:sameAs https://app.dimensions.ai/details/publication/pub.1056212372
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1021/mp300604u schema:sameAs https://app.dimensions.ai/details/publication/pub.1056213138
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1021/mp500210c schema:sameAs https://app.dimensions.ai/details/publication/pub.1049981175
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1111/j.1365-2036.2005.02683.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013364369
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1111/j.1365-2982.2006.00759.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021956058
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1111/j.1365-2982.2012.01955.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026728120
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1111/j.1750-3841.2008.00766.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035944358
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1111/j.1750-3841.2010.01856.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042925966
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1148/radiol.2242011412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018238877
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1177/2050640613510161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032170021
171 rdf:type schema:CreativeWork
172 https://doi.org/10.14227/dt120105p11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067217327
173 rdf:type schema:CreativeWork
174 https://doi.org/10.14227/dt190312p15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067217539
175 rdf:type schema:CreativeWork
176 https://doi.org/10.14227/dt220315p18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067217652
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1586/17474124.2014.922869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022887475
179 rdf:type schema:CreativeWork
180 https://www.grid.ac/institutes/grid.457257.6 schema:alternateName Novartis (Slovenia)
181 schema:name Lek Pharmaceuticals d.d., a Sandoz Company, Verovškova 57, 1526, Ljubljana, Slovenia
182 rdf:type schema:Organization
183 https://www.grid.ac/institutes/grid.7858.2 schema:alternateName Saints Cyril and Methodius University of Skopje
184 schema:name Faculty of Pharmacy, ss. Cyril and Methodius University of Skopje, Vodnjanska 17, 1000, Skopje, Macedonia
185 rdf:type schema:Organization
186 https://www.grid.ac/institutes/grid.8954.0 schema:alternateName University of Ljubljana
187 schema:name Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia
188 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...