JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HSP47 Heat-Shock Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Idiopathic Pulmonary Fibrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "L-Lactate Dehydrogenase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mucin-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pulmonary Surfactant-Associated Protein A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pulmonary Surfactant-Associated Protein D", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ROC Curve", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sensitivity and Specificity", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kakugawa", 
        "givenName": "Tomoyuki", 
        "id": "sg:person.01310021215.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310021215.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology, Sapporo Medical University School of Medicine, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Microbiology, Sapporo Medical University School of Medicine, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yokota", 
        "givenName": "Shin-ichi", 
        "id": "sg:person.0734536172.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734536172.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishimatsu", 
        "givenName": "Yuji", 
        "id": "sg:person.01173572615.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173572615.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Nagasaki University Hospital, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411873.8", 
          "name": [
            "Department of Pathology, Nagasaki University Hospital, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hayashi", 
        "givenName": "Tomayoshi", 
        "id": "sg:person.011043341442.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011043341442.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakashima", 
        "givenName": "Shota", 
        "id": "sg:person.01100163421.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100163421.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hara", 
        "givenName": "Shintaro", 
        "id": "sg:person.016034340252.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016034340252.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakamoto", 
        "givenName": "Noriho", 
        "id": "sg:person.01057344215.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057344215.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Life Science, Faculty and Graduate School of Engineering and Resource Science, Akita University, Akita, Japan", 
          "id": "http://www.grid.ac/institutes/grid.251924.9", 
          "name": [
            "Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan", 
            "Department of Life Science, Faculty and Graduate School of Engineering and Resource Science, Akita University, Akita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kubota", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01115301160.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115301160.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biostatistics Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Biostatistics Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mine", 
        "givenName": "Mariko", 
        "id": "sg:person.01206260304.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206260304.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsuoka", 
        "givenName": "Yasuhiro", 
        "id": "sg:person.0605234321.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605234321.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Respiratory Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mukae", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01143125277.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143125277.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Molecular and Cellular Biology, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258798.9", 
          "name": [
            "Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan", 
            "Laboratory of Molecular and Cellular Biology, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagata", 
        "givenName": "Kazuhiro", 
        "id": "sg:person.016677621322.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016677621322.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kohno", 
        "givenName": "Shigeru", 
        "id": "sg:person.01311530576.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311530576.67"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00428-009-0876-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036541712", 
          "https://doi.org/10.1007/s00428-009-0876-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1465-9921-6-57", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013185483", 
          "https://doi.org/10.1186/1465-9921-6-57"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2466-12-24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028452492", 
          "https://doi.org/10.1186/1471-2466-12-24"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1379/1466-1268(2000)005<0337:aaccih>2.0.co;2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016259936", 
          "https://doi.org/10.1379/1466-1268(2000)005<0337:aaccih>2.0.co;2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1465-9921-8-37", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029335663", 
          "https://doi.org/10.1186/1465-9921-8-37"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-02-22", 
    "datePublishedReg": "2013-02-22", 
    "description": "Little is known about the pathophysiology of acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF). Heat shock protein 47 (HSP47), a collagen-specific molecular chaperone, is essential for biosynthesis and secretion of collagen molecules. Previous studies in experimental animal fibrosis models have shown that downregulation of HSP47 expression reduces collagen production and diminishes fibrosis progression. In this study, serum HSP47 levels were evaluated to elucidate pathogenic differences involving HSP47 between AE-IPF and stable (S)-IPF. Subjects comprised 20 AE-IPF and 33 S-IPF patients. Serum levels of HSP47, Krebs von den Lungen-6 (KL-6), surfactant protein (SP)-A, SP-D, and lactate dehydrogenase (LDH) were measured. Immunohistochemical analysis of lung HSP47 expression was determined in biopsy and autopsy tissues diagnosed as diffuse alveolar damage (DAD) and usual interstitial pneumonia (UIP). Serum levels of HSP47 were significantly higher in AE-IPF than in S-IPF patients, whereas serum levels of KL-6, SP-A, and SP-D did not differ significantly. Receiver operating characteristic curves revealed that HSP47 was superior for discriminating AE-IPF and S-IPF. The cutoff for HSP47 resulting in the highest diagnostic accuracy was 559.4 pg/mL; sensitivity, specificity, and diagnostic accuracy were 100.0\u00a0%, 93.9\u00a0%, and 96.2\u00a0%, respectively. Immunohistochemical analysis revealed that pulmonary HSP47 expression was greater in DAD than UIP tissues. Serum HSP47 was significantly higher in AE-IPF than in S-IPF patients, suggesting that underlying fibrogenic mechanisms involving HSP47 differ in the two conditions.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s12192-013-0411-5", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6081539", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6132953", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6057760", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1115743", 
        "issn": [
          "1355-8145", 
          "1466-1268"
        ], 
        "name": "Cell Stress and Chaperones", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "keywords": [
      "Krebs von den Lungen-6", 
      "idiopathic pulmonary fibrosis", 
      "diffuse alveolar damage", 
      "AE-IPF", 
      "usual interstitial pneumonia", 
      "acute exacerbation", 
      "serum levels", 
      "pulmonary fibrosis", 
      "HSP47 expression", 
      "immunohistochemical analysis", 
      "diagnostic accuracy", 
      "heat shock protein 47", 
      "pg/mL", 
      "shock protein 47", 
      "high diagnostic accuracy", 
      "S-IPF", 
      "Lungen-6", 
      "alveolar damage", 
      "interstitial pneumonia", 
      "collagen-specific molecular chaperone", 
      "fibrosis progression", 
      "fibrogenic mechanisms", 
      "fibrosis model", 
      "autopsy tissue", 
      "HSP47 levels", 
      "pathogenic differences", 
      "patients", 
      "protein 47", 
      "surfactant proteins", 
      "collagen production", 
      "characteristic curve", 
      "exacerbation", 
      "fibrosis", 
      "HSP47", 
      "tissue", 
      "expression", 
      "previous studies", 
      "pneumonia", 
      "levels", 
      "biopsy", 
      "pathophysiology", 
      "secretion", 
      "progression", 
      "downregulation", 
      "study", 
      "subjects", 
      "mL", 
      "cutoff", 
      "specificity", 
      "molecular chaperones", 
      "damage", 
      "differences", 
      "dehydrogenase", 
      "protein", 
      "sensitivity", 
      "collagen molecules", 
      "analysis", 
      "mechanism", 
      "receiver", 
      "chaperones", 
      "curves", 
      "production", 
      "biosynthesis", 
      "molecules", 
      "sp", 
      "conditions", 
      "accuracy", 
      "model"
    ], 
    "name": "Serum heat shock protein 47 levels are elevated in acute exacerbation of idiopathic pulmonary fibrosis", 
    "pagination": "581-590", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022407849"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12192-013-0411-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23435730"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12192-013-0411-5", 
      "https://app.dimensions.ai/details/publication/pub.1022407849"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_596.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s12192-013-0411-5"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

325 TRIPLES      21 PREDICATES      114 URIs      101 LITERALS      23 BLANK NODES