Activated partial thromboplastin time-based clot waveform analysis enables measurement of very low levels of factor IX activity in patients with ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-07-21

AUTHORS

Atsuko Nishiyama, Kenichi Ogiwara, Kuniyoshi Mizumachi, Naoki Hashimoto, Masahiro Takeyama, Keiji Nogami

ABSTRACT

The precise measurement of very low levels of factor IX activity (FIX:C < 1 IU/dL) is essential for understanding clinical severity and risk of inhibitor development in patients with severe hemophilia B (Pw-SHB). However, such measurement sensitivity has not yet been achieved. We aimed to establish a measurement method using clot waveform analysis (CWA). Residual FIX:C by adding anti-FIX monoclonal antibody, FIX:C by adding recombinant (r)FIX to the commercial Pw-SHB plasmas, and FIX:C in our Pw-SHB were determined by CS-2000i™/CS-2400™, followed by analysis of CWA parameters. The presence of anti-FIX antibody in the commercial Pw-SHB plasmas significantly decreased coagulation potential compared to its absence. The addition of rFIX to these innate plasma samples produced significant changes in three parameters upon adding FIX:C at 0.1–1 IU/dL, supporting the presence of trace FIX:C in Pw-SHB. Therefore, appropriate FIX-depleted plasma containing minimum residual FIX:C was chosen from reference curves of FIX:C (0.01–1 IU/dL). Among patients with untreated Pw-SHB, two had FIX:C 0.6–0.7 IU/dL and two had lower than detectable levels using FIX-depleted plasma. One of the latter had detectable trough levels post-rFIX administration. In conclusion, CWA enabled measurement of very low levels of FIX:C using appropriate FIX-deficient plasma. More... »

PAGES

778-786

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-022-03419-4

DOI

http://dx.doi.org/10.1007/s12185-022-03419-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1149653472

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35864291


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