Propensity score matching/reweighting analysis comparing autologous and allogeneic stem cell transplantation for B-lineage acute lymphoblastic leukemia View Full Text


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Article Info

DATE

2022-05-10

AUTHORS

Shuichi Mizuta, Tomotaka Ugai, Harumi Kato, Noriko Doki, Shuichi Ota, Toshiro Kawakita, Yuta Katayama, Mineo Kurokawa, Hirohisa Nakamae, Shingo Yano, Yuichiro Nawa, Yoshinobu Kanda, Takahiro Fukuda, Yoshiko Atsuta, Shinichi Kako

ABSTRACT

We compared the outcomes of autologous stem cell transplantation (auto-SCT) with those of allogeneic stem cell transplantation (allo-SCT) from a human leukocyte antigen-matched related donor in patients with Philadelphia chromosome-negative B-lineage acute lymphoblastic leukemia (ALL). Newly diagnosed patients who underwent allo-SCT (n = 486) or auto-SCT (n = 99) after achieving first complete remission (CR) were included. Propensity score matching (PS) and an inverse probability of the treatment weighting (IPTW) analysis were applied to compensate for imbalances in baseline characteristics. The 5 years rates of overall survival (OS) among those in the PS-matched cohorts were 57% [95% confidence interval (CI) 46–67%] for those who received allo-SCT and 44% (95% CI 33–54%) for those who received auto-SCT. Multivariable, propensity score-matched, and IPTW analyses all revealed no statistically significant differences in OS between the two groups [hazard ratios (HR) 0.81, 95% CI 0.53–1.27, p = 0.36; HR 0.84, 95% CI 0.40–1.78, p = 0.65; HR 0.71, 95% CI 0.25–2.02, p = 0.53, respectively]. Prospective trials that include autologous transplantation as a treatment option are needed to examine the potential of autologous transplantation. More... »

PAGES

1-8

References to SciGraph publications

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  • Journal

    TITLE

    International Journal of Hematology

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    N/A

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    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12185-022-03368-y

    DOI

    http://dx.doi.org/10.1007/s12185-022-03368-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1147772839

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35536509


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    53 rate
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