Risk factors and prognosis of non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-01-28

AUTHORS

Makoto Onizuka, Nobuharu Fujii, Hideki Nakasone, Masao Ogata, Yoshiko Atsuta, Ritsuro Suzuki, Naoyuki Uchida, Kazuteru Ohashi, Yukiyasu Ozawa, Tetsuya Eto, Kazuhiro Ikegame, Hirohisa Nakamae, Masami Inoue, Takahiro Fukuda

ABSTRACT

Non-infectious pulmonary complications (NIPCs) following allogeneic hematopoietic stem cell transplantation (HSCT) are relatively rare, but frequently fatal. This study investigated the pre-transplant risk factors for developing NIPCs using Japanese transplant registry database entries from 2001 to 2009. Among 13,573 eligible patients, 535 experienced NIPCs (3.9%). Multivariate analysis identified high recipient age (60 + years: HR 1.85, P = 0.003), HLA mismatch (HR 1.61, P < 0.001), female to male HSCT (HR 1.54, P < 0.001), and unrelated bone marrow transplantation (UR-BMT) (HR 3.88, P < 0.001) as significantly associated with an increased risk of NIPCs. In contrast, a non-total body irradiation (TBI) regimen with reduced intensity conditioning (RIC) were associated with a decreased risk of NIPCs compared with a cyclophosphamide (CY) + TBI regimen (busulfan + CY: HR 0.67, P = 0.009, other non-TBI: HR 0.46, P < 0.001), fludarabine-based RIC (HR 0.52, P < 0.001), and other RIC (HR 0.42, P = 0.003). The mortality rate was significantly worse for patients with NIPCs than those without (HR 1.54, 71 P < 0.001). This large-scale retrospective study suggests that both allo-reactions to donor cells and conditioning regimen toxicity contributed to NIPCs following HSCT. More... »

PAGES

534-544

References to SciGraph publications

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  • Journal

    TITLE

    International Journal of Hematology

    ISSUE

    4

    VOLUME

    115

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12185-021-03282-9

    DOI

    http://dx.doi.org/10.1007/s12185-021-03282-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1145039871

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35088350


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    336 grid-institutes:grid.414932.9 schema:alternateName Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
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    339 grid-institutes:grid.415020.2 schema:alternateName Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
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    342 grid-institutes:grid.415479.a schema:alternateName Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
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    345 grid-institutes:grid.416629.e schema:alternateName Department of Hematology/Oncology, Osaka Women’s and Children’s Hospital, Osaka, Japan
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