Comprehensive blood coagulation potential in patients with acquired hemophilia A: retrospective analyses of plasma samples obtained from nationwide centers across ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-11-01

AUTHORS

Masahiro Takeyama, Kana Sasai, Tomoko Matsumoto, Shoko Furukawa, Kenichi Ogiwara, Koji Yada, Tomoko Onishi, Midori Shima, Keiji Nogami

ABSTRACT

Global coagulation potential was assessed in 59 patients with acquired hemophilia A (PwAHA) by clot waveform analysis (CWA) and/or thrombin and plasmin generation assay. Relationships between factor VIII activity (FVIII:C) and the parameters from CWA and T/P-GA in patients with congenital HA were compared by grading coagulation potential related to FVIII:C: T1 (FVIII:C < 1 IU/dL), T2 (1 ≤ , ≤ 5 IU/dL), T3 (5 < , 12 ≤ IU/dL), and T4 (12 < , ≤ 50 IU/dL). The median FVIII:C and inhibitor titers in PwAHA on admission were 3.3 IU/dL and 63.0 BU/mL, respectively, but global coagulation parameters corresponded to T1 or less. Median FVIII:C levels during follow-up in PwAHA were 1.7–9.6–6.7–40.0–21.7 IU/dL on days 0–14–28–56–93, respectively. CWA-based data corresponded to less than T2 until day 28, but more closely reflected FVIII:C after day 56. Peak thrombin was severely low (near T1) until day 28 and improved modestly after day 56 but remained less than T2. Peak plasmin was lower than T1 until day 56, and returned to T4 on day 93. In conclusion, global coagulation function in PwAHA was impaired to a greater extent than could be anticipated from assays of FVIII:C, until approximately 1 month after immunosuppression and treatment with FVIII-bypassing agents. More... »

PAGES

163-172

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12185-021-03249-w

DOI

http://dx.doi.org/10.1007/s12185-021-03249-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1142327432

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34724152


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